Did you know ? If you order before Friday 14h we deliver 90PCT of the the time next Tuesday, GENTAUR another in time delivery

Pubmed ID :20308324
Publication Date : //

Positive regulation of interferon regulatory factor 3 activation by Herc5 via ISG15 modification.


Virus infection induces host antiviral responses, including induction of type I interferons. Transcription factor interferon regulatory factor 3 (IRF3) plays a pivotal role and is tightly regulated in this process. Here, we identify HERC5 (HECT domain and RLD 5) as a specific binding protein of IRF3 by immunoprecipitation. Ectopic expression or knockdown of HERC5 could, respectively, enhance or impair IRF3-mediated gene expression. Mechanistically, HERC5 catalyzes the conjugation of ubiquitin-like protein ISG15 onto IRF3 (Lys193, -360, and -366), thus attenuating the interaction between Pin1 and IRF3, resulting in sustained IRF3 activation. In contrast to results for wild-type IRF3, the mutant IRF3(K193,360,366R) interacts tightly with Pin1, is highly polyubiquitinated, and becomes less stable upon Sendai virus (SeV) infection. Consistently, host antiviral responses are obviously boosted or crippled in the presence or absence of HERC5, respectively. Collectively, this study characterizes HERC5 as a positive regulator of innate antiviral responses. It sustains IRF3 activation via a novel posttranslational modification, ISGylation.

Authors : Shi He-Xin , Yang Kai , Liu Xing , Liu Xin-Yi , Wei Bo , Shan Yu-Fei , Zhu Lian-Hui , Wang Chen ,

Related products :

Catalog number Product name Quantity
31-154 IRF2 encodes interferon regulatory factor 2, a member of the interferon regulatory transcription factor (IRF) family. IRF2 competitively inhibits the IRF1-mediated transcriptional activation of interf 0.05 mg
CSB-EL010303HU Human E3 ISG15--protein ligase HERC5(HERC5) ELISA kit SpeciesHuman 96T
CSB-EL010303HU Human E3 ISG15--protein ligase HERC5(HERC5) ELISA kit 96T
EIAAB32304 Beta-interferon gene positive regulatory domain I-binding factor,BLIMP1,BLIMP-1,Homo sapiens,Human,Positive regulatory domain I-binding factor 1,PR domain zinc finger protein 1,PR domain-containing pr
31-202 Interferon regulatory factor 8 (IRF8, interferon consensus sequence-binding protein, Ion ChannelSBP) is a transcription factor of the interferon (IFN) regulatory factor (IRF) family. Proteins of this 0.05 mg
18-003-44056 PR domain zinc finger protein 1 - PR domain-containing protein 1; Beta-interferon gene positive regulatory domain I-binding factor; BLIMP-1; Positive regulatory domain I-binding factor 1; PRDI-binding 0.1 mg Protein A
28-795 IRF5 is a member of the interferon regulatory factor (IRF) family, a group of transcription factors with diverse roles, including virus-mediated activation of interferon, and modulation of cell growth 0.1 mg
18-003-42263 Interferon regulatory factor 4 - IRF-4; Lymphocyte-specific interferon regulatory factor; LSIRF; NF-EM5; Multiple myeloma oncogene 1 Polyclonal 0.1 mg Protein A
orb80393 Human Interferon Regulatory Factor-1 protein Interferon Regulatory Factor-1 Human Recombinant produced in E.coli is a single, non-glycosylated, polypeptide chain containing 134 amino acids (1-114) wit 5
orb80394 Human Interferon Regulatory Factor-2 protein Interferon Regulatory Factor-2 Human Recombinant produced in E.coli is a single, non-glycosylated, polypeptide chain containing 133 amino acids (1-113) wit 10
28-780 IRF3 is interferon regulatory factor 3, a member of the interferon regulatory transcription factor (IRF) family. IRF3 is found in an inactive cytoplasmic form that upon serine_threonine phosphorylatio 0.1 mg
27-469 IRF3 is interferon regulatory factor 3, a member of the interferon regulatory transcription factor (IRF) family. IRF3 is found in an inactive cytoplasmic form that upon serine_threonine phosphorylatio 0.05 mg
LF-PA41488 anti-Interferon Regulatory Factor 4, Rabbit polyclonal to Interferon Regulatory Factor 4, Isotype IgG, Host Rabbit 50 ug
LF-PA41805 anti-Interferon Regulatory Factor 3, Rabbit polyclonal to Interferon Regulatory Factor 3, Isotype IgG, Host Rabbit 50 ul
28-794 IRF1 is interferon regulatory factor 1, a member of the interferon regulatory transcription factor (IRF) family. IRF1 serves as an activator of interferons alpha and beta transcription, and in mouse i 0.05 mg
31-232 IRF2 is a member of the interferon regulatory transcription factor (IRF) family. IRF2 competitively inhibits the IRF1-mediated transcriptional activation of interferons alpha and beta, and presumably 0.1 mg
28-991 MYST4 is a histone acetyltransferase which may be involved in both positive and negative regulation of transcription. It is required for RUNX2-dependent transcriptional activation and May be involved 0.05 mg
EIAAB32305 B lymphocyte-induced maturation protein 1,Beta-interferon gene positive regulatory domain I-binding factor,Blimp1,Blimp-1,Mouse,Mus musculus,PR domain zinc finger protein 1,PR domain-containing protei
31-203 Interferon consensus sequence-binding protein (Ion ChannelSBP) is a transcription factor of the interferon (IFN) regulatory factor (IRF) family. Proteins of this family are composed of a conserved DNA 0.1 mg
18-003-43029 Interferon regulatory factor 8 - IRF-8; Interferon consensus sequence-binding protein; ICSBP Polyclonal 0.1 mg Protein A
18-003-43029 Interferon regulatory factor 8 - IRF-8; Interferon consensus sequence-binding protein; ICSBP Polyclonal 0.05 mg Aff Pur
18-003-43028 Interferon regulatory factor 8 - IRF-8; Interferon consensus sequence-binding protein; ICSBP Polyclonal 0.1 mg Protein A
18-003-43028 Interferon regulatory factor 8 - IRF-8; Interferon consensus sequence-binding protein; ICSBP Polyclonal 0.05 mg Aff Pur
18-661-15212 Interferon regulatory factor 8 - IRF-8; Interferon consensus sequence-binding protein; ICSBP Polyclonal 0.1 mg
18-003-42030 Transcriptional regulator ISGF3 subunit gamma - Interferon regulatory factor 9; IRF-9; IFN-alpha-responsive transcription factor subunit; Interferon-stimulated gene factor 3 gamma; ISGF3 p48 subunit; 0.05 mg Aff Pur


 

GENTAUR Belgium BVBA BE0473327336
Voortstraat 49, 1910 Kampenhout BELGIUM
Tel 0032 16 58 90 45

Fax 0032 16 50 90 45
info@gentaur.com | Gentaur





GENTAUR Ltd.
Howard Frank Turnberry House
1404-1410 High Road
Whetstone London N20 9BH
Tel 020 3393 8531 Fax 020 8445 9411
uk@gentaur.com | Gentaur

 

 




GENTAUR France SARL
9, rue Lagrange, 75005 Paris
Tel 01 43 25 01 50

Fax 01 43 25 01 60
RCS Paris B 484 237 888

SIRET 48423788800017

BNP PARIBAS PARIS PL MAUBERT BIC BNPAFRPPPRG

france@gentaur.com | Gentaur

GENTAUR GmbH
Marienbongard 20
52062 Aachen Deutschland
Support Karolina Elandt
Tel: 0035929830070
Fax: (+49) 241 56 00 47 88

Logistic :0241 40 08 90 86
Bankleitzahl 39050000
IBAN lautet DE8839050000107569353
Handelsregister Aachen HR B 16058
Umsatzsteuer-Identifikationsnummer *** DE 815175831
Steuernummer 201/5961/3925
de@gentaur.com | Gentaur

GENTAUR U.S.A
Genprice Inc, Logistics
547, Yurok Circle
San Jose, CA 95123
CA 95123
Tel (408) 780-0908,
Fax (408) 780-0908,
sales@genprice.com

Genprice Inc, Invoices and accounting
6017 Snell Ave, Ste 357
San Jose, CA 95123




GENTAUR Nederland BV
NL850396268B01 KVK nummer 52327027
Kuiper 1
5521 DG Eersel Nederland
Tel:  0208-080893  Fax: 0497-517897
nl@gentaur.com | Gentaur
IBAN: NL04 RABO 0156 9854 62   SWIFT RABONL2U






GENTAUR Spain
tel:0911876558
spain@gentaur.com | Gentaur






ГЕНТАУЪР БЪЛГАРИЯ
ID # 201 358 931 /BULSTAT
София 1000, ул. "Граф Игнатиев" 53 вх. В, ет. 2
Tel 0035924682280 Fax 0035924808322
e-mail: Sofia@gentaur.com | Gentaur
IBAN: BG11FINV91501014771636
BIC: FINVBGSF

GENTAUR Poland Sp. z o.o.


ul. Grunwaldzka 88/A m.2
81-771 Sopot, Poland
TEL Gdansk 058 710 33 44 FAX  058 710 33 48              

poland@gentaur.com | Gentaur

Other countries

Österreich +43720880899

Canada Montreal +15149077481

Ceská republika Praha +420246019719

Danmark +4569918806

Finland Helsset +358942419041

Magyarország Budapest +3619980547

Ireland Dublin+35316526556

Luxembourg+35220880274

Norge Oslo+4721031366

Sverige Stockholm+46852503438

Schweiz Züri+41435006251

US New York+17185132983

GENTAUR Italy
SRL IVA IT03841300167
Piazza Giacomo Matteotti, 6
24122 Bergamo Tel 02 36 00 65 93
Fax 02 36 00 65 94
italia@gentaur.com | Gentaur