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Publication Date : //
Isolation and identification of islet amyloid polypeptide in normal human pancreas.
To identify islet amyloid polypeptide (IAPP) present in normal human pancreas, we isolated the peptide from a soluble peptide fraction of amyloid deposit-free pancreata of two non-diabetic patients by using reverse-phase high performance liquid chromatography coupled with a radioimmunoassay specific for human IAPP. IAPP(1-37) and IAPP(17-37) were isolated and their complete amino acid sequences were determined up to the C-terminus. Identification of IAPP in normal human pancreas suggests the possible biological function of IAPP as a novel pancreatic hormone in humans.
Authors : Nakazato M , Asai J , Miyazato M , Matsukura S , Kangawa K , Matsuo H ,
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Pathways :
WP2107: pathways in human cancer
Related Genes :
[] Cytochrome c oxidase subunit 1 (EC 1.9.3.1) (Fragment)
[ATG8 APG8 AUT7 CVT5 YBL078C YBL0732] Autophagy-related protein 8 (Autophagy-related ubiquitin-like modifier ATG8) (Cytoplasm to vacuole targeting protein 5)
[POMC] Pro-opiomelanocortin (POMC) (Corticotropin-lipotropin) [Cleaved into: NPP; Melanotropin gamma (Gamma-MSH); Corticotropin (Adrenocorticotropic hormone) (ACTH); Melanocyte-stimulating hormone alpha (Alpha-MSH) (Melanotropin alpha); Corticotropin-like intermediary peptide (CLIP); Lipotropin beta (Beta-LPH); Lipotropin gamma (Gamma-LPH); Melanocyte-stimulating hormone beta (Beta-MSH) (Melanotropin beta); Beta-endorphin; Met-enkephalin]
[APOA1] Apolipoprotein A-I (Apo-AI) (ApoA-I) (Apolipoprotein A1) [Cleaved into: Proapolipoprotein A-I (ProapoA-I); Truncated apolipoprotein A-I (Apolipoprotein A-I(1-242))]
[ATG1 APG1 AUT3 CVT10 YGL180W G1615] Serine/threonine-protein kinase ATG1 (EC 2.7.11.1) (Autophagy protein 3) (Autophagy-related protein 1) (Cytoplasm to vacuole targeting protein 10)
[] Conglutin-7 (2S protein 1) (Seed storage protein SSP1) (Seed storage protein SSP2) (allergen Ara h 2)
[colG] Collagenase ColG (EC 3.4.24.3) (Class I collagenase) (Gelatinase ColG) (Microbial collagenase)
[colH] Collagenase ColH (EC 3.4.24.3) (Class II collagenase) (Gelatinase ColH) (Microbial collagenase)
[VPS30 APG6 ATG6 VPT30 YPL120W LPH7] Vacuolar protein sorting-associated protein 30 (Autophagy-related protein 6)
[calA camA DDB_G0279407] Calmodulin (CaM)
[SEMG1 SEMG] Semenogelin-1 (Cancer/testis antigen 103) (Semenogelin I) (SGI) [Cleaved into: Alpha-inhibin-92; Alpha-inhibin-31; Seminal basic protein]
[MBP] Myelin basic protein (MBP) (Myelin A1 protein) (Myelin membrane encephalitogenic protein)
[Atg5 Apg5l] Autophagy protein 5 (APG5-like)
[ATG5 APG5 YPL149W P2601] Autophagy protein 5
[APOB] Apolipoprotein B-100 (Apo B-100) [Cleaved into: Apolipoprotein B-48 (Apo B-48)]
[ATP7A MC1 MNK] Copper-transporting ATPase 1 (EC 3.6.3.54) (Copper pump 1) (Menkes disease-associated protein)
[brlA AN0973] C2H2 type master regulator of conidiophore development brlA (Bristle A protein)
[COL2A1] Collagen alpha-1(II) chain (Alpha-1 type II collagen) [Cleaved into: Collagen alpha-1(II) chain; Chondrocalcin]
[ATG9 APG9 AUT9 CVT7 YDL149W D1560] Autophagy-related protein 9 (Cytoplasm to vacuole targeting protein 7)
[APE1 API LAP4 YSC1 YKL103C YKL455] Vacuolar aminopeptidase 1 (EC 3.4.11.22) (Aminopeptidase yscI) (Leucine aminopeptidase IV) (LAPIV) (Lysosomal aminopeptidase III) (Polypeptidase) (Vacuolar aminopeptidase I)
[APOC3] Apolipoprotein C-III (Apo-CIII) (ApoC-III) (Apolipoprotein C3)
[CHGA] Chromogranin-A (CgA) (Pituitary secretory protein I) (SP-I) [Cleaved into: Vasostatin-1 (Vasostatin I); Vasostatin-2 (Vasostatin II); EA-92; ES-43; Pancreastatin; SS-18; WA-8; WE-14; LF-19; Catestatin (SL21); AL-11; GV-19; GR-44; ER-37; GE-25; Serpinin-RRG; Serpinin; p-Glu serpinin precursor]
[IGFBP6 IBP6] Insulin-like growth factor-binding protein 6 (IBP-6) (IGF-binding protein 6) (IGFBP-6)
[IGF2 PP1446] Insulin-like growth factor II (IGF-II) (Somatomedin-A) (T3M-11-derived growth factor) [Cleaved into: Insulin-like growth factor II; Insulin-like growth factor II Ala-25 Del; Preptin]
[GSH1 CAD2 GCL PAD2 RML1 At4g23100 F7H19.290] Glutamate--cysteine ligase, chloroplastic (EC 6.3.2.2) (Gamma-ECS) (GCS) (Gamma-glutamylcysteine synthetase) (Protein ROOT MERISTEMLESS 1) (AtGCL) (Protein cadmium-sensitive 2) (Protein phytoalexin-deficient 2)
[GAPDH GAPD CDABP0047 OK/SW-cl.12] Glyceraldehyde-3-phosphate dehydrogenase (GAPDH) (EC 1.2.1.12) (Peptidyl-cysteine S-nitrosylase GAPDH) (EC 2.6.99.-)
[GCK] Glucokinase (EC 2.7.1.2) (Hexokinase type IV) (HK IV) (Hexokinase-4) (HK4) (Hexokinase-D)
[GB1 At4g34460 T4L20.40] Guanine nucleotide-binding protein subunit beta (AGB1) (transducin)
[FMRFa Fmrf CG2346] FMRFamide-related peptides [Cleaved into: FMRFamide A; Corticotropin-releasing factor-like; AAMDRY-amide; DPKQDFMRF-amide; TPAEDFMRF-amide; SDNFMRF-amide; SPKQDFMRF-amide; PDNFMRF-amide; SAPQDFVRS-amide; MDSNFIRF-amide]
[ITIH1 IGHEP1] Inter-alpha-trypsin inhibitor heavy chain H1 (ITI heavy chain H1) (ITI-HC1) (Inter-alpha-inhibitor heavy chain 1) (Inter-alpha-trypsin inhibitor complex component III) (Serum-derived hyaluronan-associated protein) (SHAP)
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