Did you know ? If you order before Friday 14h we deliver 90PCT of the the time next Tuesday, GENTAUR another in time delivery

Pubmed ID :21571647
Publication Date : //

Ubiquitin-recognition protein Ufd1 couples the endoplasmic reticulum (ER) stress response to cell cycle control.


The ubiquitin-recognition protein Ufd1 facilitates clearance of misfolded proteins through the endoplasmic reticulum (ER)-associated degradation (ERAD) pathway. Here we report that prolonged ER stress represses Ufd1 expression to trigger cell cycle delay, which contributes to ERAD. Remarkably, down-regulation of Ufd1 enhances ubiquitination and destabilization of Skp2 mediated by the anaphase-promoting complex or cyclosome bound to Cdh1 (APC/C(Cdh1)), resulting in accumulation of the cyclin-dependent kinase inhibitor p27 and a concomitant cell cycle delay during the G1 phase that enables more efficient clearance of misfolded proteins. Mechanistically, nuclear Ufd1 recruits the deubiquitinating enzyme USP13 to counteract APC/C(Cdh1)-mediated ubiquitination of Skp2. Our data identify a coordinated cell cycle response to prolonged ER stress through regulation of the Cdh1-Skp2-p27 axis by Ufd1 and USP13.

Authors : Chen Meifan , Gutierrez Gustavo J , Ronai Ze'ev A ,

Related products :

Catalog number Product name Quantity
EIAAB43017 Endoplasmic reticulum stress-response protein 25,ERS25,Ers25,Mouse,Mus musculus,p26,Tmed4,Transmembrane emp24 domain-containing protein 4
EIAAB43018 Endoplasmic reticulum stress-response protein 25,ERS25,ERS25,Homo sapiens,Human,Putative NF-kappa-B-activating protein 156,TMED4,Transmembrane emp24 domain-containing protein 4
27-305 In response to DNA damage and replication blocks, cell cycle progression is halted through the control of critical cell cycle regulators. CHEK2 is a cell cycle checkpoint regulator and putative tumor 0.05 mg
201-20-2515 HERPUD1{homocysteine-inducible, endoplasmic reticulum stress-inducible, ubiquitin-like domain member 1}rabbit.pAb 0.2ml
HERV-V1 HERPUD1 Gene homocysteine-inducible, endoplasmic reticulum stress-inducible, ubiquitin-like domain member 1
H3371 Stress-associated endoplasmic reticulum protein 1 (SERP1), Rat, ELISA Kit 96T
CSB-EL021051RA Rat Stress-associated endoplasmic reticulum protein 1(SERP1) ELISA kit 96T
MDSP_MOUSE Mouse ELISA Kit FOR Stress-associated endoplasmic reticulum protein 2 96T
E0482d Mouse ELISA Kit FOR Stress-associated endoplasmic reticulum protein 2 96T
SERP2_BOVIN Bovine ELISA Kit FOR Stress-associated endoplasmic reticulum protein 2 96T
201-20-5201 SERP1{stress-associated endoplasmic reticulum protein 1}rabbit.pAb 0.2ml
SERP2_HUMAN Human ELISA Kit FOR Stress-associated endoplasmic reticulum protein 2 96T
CSB-EL021051RA Rat Stress-associated endoplasmic reticulum protein 1(SERP1) ELISA kit SpeciesRat 96T
CSB-EL021052BO Bovine Stress-associated endoplasmic reticulum protein 2(SERP2) ELISA kit 96T
CSB-EL021051BO Bovine Stress-associated endoplasmic reticulum protein 1(SERP1) ELISA kit 96T
YHB2854Hu Human Stress-associated endoplasmic reticulum protein 1,SERP1 ELISA Kit 96T
CSB-EL021051HU Human Stress-associated endoplasmic reticulum protein 1(SERP1) ELISA kit 96T
YHB2854Hu Human Stress-associated endoplasmic reticulum protein 1,SERP1 ELISA Kit 48T
H3368 Stress-associated endoplasmic reticulum protein 1 (SERP1), Bovine, ELISA Kit 96T
CSB-EL021052MO Mouse Stress-associated endoplasmic reticulum protein 2(SERP2) ELISA kit 96T
CSB-EL021051MO Mouse Stress-associated endoplasmic reticulum protein 1(SERP1) ELISA kit 96T
H3373 Stress-associated endoplasmic reticulum protein 2 (SERP2), Human, ELISA Kit 96T
H3372 Stress-associated endoplasmic reticulum protein 2 (SERP2), Bovine, ELISA Kit 96T
H3374 Stress-associated endoplasmic reticulum protein 2 (SERP2), Mouse, ELISA Kit 96T
H3370 Stress-associated endoplasmic reticulum protein 1 (SERP1), Mouse, ELISA Kit 96T


 

GENTAUR Belgium BVBA BE0473327336
Voortstraat 49, 1910 Kampenhout BELGIUM
Tel 0032 16 58 90 45

Fax 0032 16 50 90 45
info@gentaur.com | Gentaur





GENTAUR Ltd.
Howard Frank Turnberry House
1404-1410 High Road
Whetstone London N20 9BH
Tel 020 3393 8531 Fax 020 8445 9411
uk@gentaur.com | Gentaur

 

 




GENTAUR France SARL
9, rue Lagrange, 75005 Paris
Tel 01 43 25 01 50

Fax 01 43 25 01 60
RCS Paris B 484 237 888

SIRET 48423788800017

BNP PARIBAS PARIS PL MAUBERT BIC BNPAFRPPPRG

france@gentaur.com | Gentaur

GENTAUR GmbH
Marienbongard 20
52062 Aachen Deutschland
Support Karolina Elandt
Tel: 0035929830070
Fax: (+49) 241 56 00 47 88

Logistic :0241 40 08 90 86
Bankleitzahl 39050000
IBAN lautet DE8839050000107569353
Handelsregister Aachen HR B 16058
Umsatzsteuer-Identifikationsnummer *** DE 815175831
Steuernummer 201/5961/3925
de@gentaur.com | Gentaur

GENTAUR U.S.A
Genprice Inc, Logistics
547, Yurok Circle
San Jose, CA 95123
CA 95123
Tel (408) 780-0908,
Fax (408) 780-0908,
sales@genprice.com

Genprice Inc, Invoices and accounting
6017 Snell Ave, Ste 357
San Jose, CA 95123




GENTAUR Nederland BV
NL850396268B01 KVK nummer 52327027
Kuiper 1
5521 DG Eersel Nederland
Tel:  0208-080893  Fax: 0497-517897
nl@gentaur.com | Gentaur
IBAN: NL04 RABO 0156 9854 62   SWIFT RABONL2U






GENTAUR Spain
tel:0911876558
spain@gentaur.com | Gentaur






ГЕНТАУЪР БЪЛГАРИЯ
ID # 201 358 931 /BULSTAT
София 1000, ул. "Граф Игнатиев" 53 вх. В, ет. 2
Tel 0035924682280 Fax 0035924808322
e-mail: Sofia@gentaur.com | Gentaur
IBAN: BG11FINV91501014771636
BIC: FINVBGSF

GENTAUR Poland Sp. z o.o.


ul. Grunwaldzka 88/A m.2
81-771 Sopot, Poland
TEL Gdansk 058 710 33 44 FAX  058 710 33 48              

poland@gentaur.com | Gentaur

Other countries

Österreich +43720880899

Canada Montreal +15149077481

Ceská republika Praha +420246019719

Danmark +4569918806

Finland Helsset +358942419041

Magyarország Budapest +3619980547

Ireland Dublin+35316526556

Luxembourg+35220880274

Norge Oslo+4721031366

Sverige Stockholm+46852503438

Schweiz Züri+41435006251

US New York+17185132983

GENTAUR Italy
SRL IVA IT03841300167
Piazza Giacomo Matteotti, 6
24122 Bergamo Tel 02 36 00 65 93
Fax 02 36 00 65 94
italia@gentaur.com | Gentaur