Did you know ? If you order before Friday 14h we deliver 90PCT of the the time next Tuesday, GENTAUR another in time delivery

Pubmed ID :22207244
Publication Date : //

Epithelial sodium channels (ENaC) are uniformly distributed on motile cilia in the oviduct and the respiratory airways.


Epithelial sodium channels (ENaCs) are located on the apical surface of cells and funnel Na(+) ions from the lumen into the cell. ENaC function also regulates extracellular fluid volume as water flows across membranes accompanying Na(+) ions to maintain osmolarity. To examine the sites of expression and intracellular localization of ENaC, we generated polyclonal antibodies against the extracellular domain of human α-ENaC subunit that we expressed in E. coli. Three-dimensional (3D) confocal microscopy of immunofluorescence using these antibodies for the first time revealed that ENaCs are uniformly distributed on the ciliary surface in all epithelial cells with motile cilia lining the bronchus in human lung and female reproductive tract, all along the fimbrial end of the fallopian tube, the ampulla and rare cells in the uterine glands. Quantitative analysis indicated that cilia increase cell surface area >70-fold and the amount of ENaC on cilia is >1,000-fold higher than on non-ciliated cell surface. These findings indicate that ENaC functions as a regulator of the osmolarity of the periciliary fluid bathing the cilia. In contrast to ENaC, cystic fibrosis transmembrane conductance regulator (CFTR) that channels chloride ions from the cytoplasm to the lumen is located mainly on the apical side, but not on cilia. The cilial localization of ENaC requires reevaluation of the mechanisms of action of CFTR and other modulators of ENaC function. ENaC on motile cilia should be essential for diverse functions of motile cilia, such as germ cell transport, fertilization, implantation, clearance of respiratory airways and cell migration.

Authors : Enuka Yehoshua , Hanukoglu Israel , Edelheit Oded , Vaknine Hananya , Hanukoglu Aaron ,

Related products :

Catalog number Product name Quantity
28-308 ACCN4 belongs to the superfamily of acid-sensing ion channels, which are proton-gated, amiloride-sensitive sodium channels. These channels have been implicated in synaptic transmission, pain perceptio 0.05 mg
EIAAB37630 Alpha-ENaC,Alpha-NaCH,Amiloride-sensitive sodium channel subunit alpha,Chicken,ENAC,Epithelial Na(+) channel subunit alpha,Gallus gallus,Nonvoltage-gated sodium channel 1 subunit alpha,SCNEA,SCNN1A
orb60693 Amiloride hydrochloride Amiloride hydrochloride(Midamor), a pyrazine compound inhibiting sodium reabsorption through sodium channels in renal epithelial cells. For research use only. 200 mg
SMART-R30 CARB, Cilia-Associated Respiratory Bacillus (Rat Sera) EIA, 96 Test Kit
SMART-R30 CARB, Cilia-Associated Respiratory Bacillus (Rat Sera) EIA, 96 Test_Kit
SMART-M30 CARB, Cilia-Associated Respiratory Bacillus (Mouse Sera) EIA, 96-Tests Kit
SMART-R30 Rat Sera ELISA Assays: CARB, Cilia-Associated Respiratory Bacillus
SMART-M30 CARB, Cilia-Associated Respiratory Bacillus (Mouse Sera) EIA, 96-Tests_Kit
SMART-M30 Mouse Sera ELISA Assays: CARB, Cilia-Associated Respiratory Bacillus
EIAAB37638 Amiloride-sensitive sodium channel subunit delta,Delta-ENaC,Delta-NaCH,DNACH,ENaCD,Epithelial Na(+) channel subunit delta,Homo sapiens,Human,Nonvoltage-gated sodium channel 1 subunit delta,SCNED,SCNN1
EIAAB37642 Amiloride-sensitive sodium channel subunit gamma,ENaCG,Epithelial Na(+) channel subunit gamma,Gamma-ENaC,Gamma-NaCH,Homo sapiens,Human,Nonvoltage-gated sodium channel 1 subunit gamma,SCNEG,SCNN1G
EIAAB37636 Amiloride-sensitive sodium channel subunit beta,Beta-ENaC,Beta-NaCH,ENaCB,Epithelial Na(+) channel subunit beta,Homo sapiens,Human,Nonvoltage-gated sodium channel 1 subunit beta,SCNEB,SCNN1B
EIAAB37637 Amiloride-sensitive sodium channel subunit beta,Beta-ENaC,Beta-NaCH,Epithelial Na(+) channel subunit beta,Nonvoltage-gated sodium channel 1 subunit beta,Oryctolagus cuniculus,Rabbit,SCNEB,SCNN1B
EIAAB37631 Alpha-ENaC,Alpha-NaCH,Amiloride-sensitive sodium channel subunit alpha,Epithelial Na(+) channel subunit alpha,Nonvoltage-gated sodium channel 1 subunit alpha,Oryctolagus cuniculus,Rabbit,SCNEA,SCNN1A
EIAAB37628 Alpha-ENaC,Alpha-NaCH,Amiloride-sensitive sodium channel subunit alpha,Epithelial Na(+) channel subunit alpha,Nonvoltage-gated sodium channel 1 subunit alpha,Rat,Rattus norvegicus,Renac,SCNEA,Scnn1a
EIAAB37641 Amiloride-sensitive sodium channel subunit gamma,Epithelial Na(+) channel subunit gamma,Gamma-ENaC,Gamma-NaCH,Nonvoltage-gated sodium channel 1 subunit gamma,Oryctolagus cuniculus,Rabbit,SCNEG,SCNN1G
EIAAB37640 Amiloride-sensitive sodium channel subunit gamma,Epithelial Na(+) channel subunit gamma,Gamma-ENaC,Gamma-NaCH,Mouse,Mus musculus,Nonvoltage-gated sodium channel 1 subunit gamma,SCNEG,Scnn1g
EIAAB37629 Alpha-ENaC,Alpha-NaCH,Amiloride-sensitive sodium channel subunit alpha,Bos taurus,Bovine,Epithelial Na(+) channel subunit alpha,Nonvoltage-gated sodium channel 1 subunit alpha,SCNEA,SCNN1A
EIAAB37639 Amiloride-sensitive sodium channel subunit gamma,Epithelial Na(+) channel subunit gamma,Gamma-ENaC,Gamma-NaCH,Nonvoltage-gated sodium channel 1 subunit gamma,Rat,Rattus norvegicus,SCNEG,Scnn1g
EIAAB37632 Alpha-ENaC,Alpha-NaCH,Amiloride-sensitive sodium channel subunit alpha,Epithelial Na(+) channel subunit alpha,Mouse,Mus musculus,Nonvoltage-gated sodium channel 1 subunit alpha,SCNEA,Scnn1a
EIAAB37633 Amiloride-sensitive sodium channel subunit beta,Beta-ENaC,Beta-NaCH,Epithelial Na(+) channel subunit beta,Mouse,Mus musculus,Nonvoltage-gated sodium channel 1 subunit beta,SCNEB,Scnn1b
EIAAB37635 Amiloride-sensitive sodium channel subunit beta,Beta-ENaC,Beta-NaCH,Epithelial Na(+) channel subunit beta,Nonvoltage-gated sodium channel 1 subunit beta,Rat,Rattus norvegicus,SCNEB,Scnn1b
18-003-42608 Amiloride-sensitive sodium channel subunit beta - Epithelial Na+ channel subunit beta; Beta ENaC; Nonvoltage-gated sodium channel 1 subunit beta; SCNEB; Beta NaCH; ENaCB Polyclonal 0.05 mg Aff Pur
EIAAB37627 Alpha-ENaC,Alpha-NaCH,Amiloride-sensitive sodium channel subunit alpha,ENaCA,Epithelial Na(+) channel subunit alpha,Homo sapiens,Human,Nonvoltage-gated sodium channel 1 subunit alpha,SCNEA,SCNN1,SCNN1
28-564 TRPM3 belongs to the family of transient receptor potential (TRP) channels. TRP channels are cation-selective channels important for cellular calcium signaling and homeostasis. The protein encoded by 0.05 mg


 

GENTAUR Belgium BVBA BE0473327336
Voortstraat 49, 1910 Kampenhout BELGIUM
Tel 0032 16 58 90 45

Fax 0032 16 50 90 45
info@gentaur.com | Gentaur





GENTAUR Ltd.
Howard Frank Turnberry House
1404-1410 High Road
Whetstone London N20 9BH
Tel 020 3393 8531 Fax 020 8445 9411
uk@gentaur.com | Gentaur

 

 




GENTAUR France SARL
9, rue Lagrange, 75005 Paris
Tel 01 43 25 01 50

Fax 01 43 25 01 60
RCS Paris B 484 237 888

SIRET 48423788800017

BNP PARIBAS PARIS PL MAUBERT BIC BNPAFRPPPRG

france@gentaur.com | Gentaur

GENTAUR GmbH
Marienbongard 20
52062 Aachen Deutschland
Support Karolina Elandt
Tel: 0035929830070
Fax: (+49) 241 56 00 47 88

Logistic :0241 40 08 90 86
Bankleitzahl 39050000
IBAN lautet DE8839050000107569353
Handelsregister Aachen HR B 16058
Umsatzsteuer-Identifikationsnummer *** DE 815175831
Steuernummer 201/5961/3925
de@gentaur.com | Gentaur

GENTAUR U.S.A
Genprice Inc, Logistics
547, Yurok Circle
San Jose, CA 95123
CA 95123
Tel (408) 780-0908,
Fax (408) 780-0908,
sales@genprice.com

Genprice Inc, Invoices and accounting
6017 Snell Ave, Ste 357
San Jose, CA 95123




GENTAUR Nederland BV
NL850396268B01 KVK nummer 52327027
Kuiper 1
5521 DG Eersel Nederland
Tel:  0208-080893  Fax: 0497-517897
nl@gentaur.com | Gentaur
IBAN: NL04 RABO 0156 9854 62   SWIFT RABONL2U






GENTAUR Spain
tel:0911876558
spain@gentaur.com | Gentaur






ГЕНТАУЪР БЪЛГАРИЯ
ID # 201 358 931 /BULSTAT
София 1000, ул. "Граф Игнатиев" 53 вх. В, ет. 2
Tel 0035924682280 Fax 0035924808322
e-mail: Sofia@gentaur.com | Gentaur
IBAN: BG11FINV91501014771636
BIC: FINVBGSF

GENTAUR Poland Sp. z o.o.


ul. Grunwaldzka 88/A m.2
81-771 Sopot, Poland
TEL Gdansk 058 710 33 44 FAX  058 710 33 48              

poland@gentaur.com | Gentaur

Other countries

Österreich +43720880899

Canada Montreal +15149077481

Ceská republika Praha +420246019719

Danmark +4569918806

Finland Helsset +358942419041

Magyarország Budapest +3619980547

Ireland Dublin+35316526556

Luxembourg+35220880274

Norge Oslo+4721031366

Sverige Stockholm+46852503438

Schweiz Züri+41435006251

US New York+17185132983

GENTAUR Italy
SRL IVA IT03841300167
Piazza Giacomo Matteotti, 6
24122 Bergamo Tel 02 36 00 65 93
Fax 02 36 00 65 94
italia@gentaur.com | Gentaur