Did you know ? If you order before Friday 14h we deliver 90PCT of the the time next Tuesday, GENTAUR another in time delivery

Pubmed ID :22673903
Publication Date : //

Quantitative maps of protein phosphorylation sites across 14 different rat organs and tissues.


Deregulated cellular signalling is a common hallmark of disease, and delineating tissue phosphoproteomes is key to unravelling the underlying mechanisms. Here we present the broadest tissue catalogue of phosphoproteins to date, covering 31,480 phosphorylation sites on 7,280 proteins quantified across 14 rat organs and tissues. We provide the data set as an easily accessible resource via a web-based database, the CPR PTM Resource. A major fraction of the presented phosphorylation sites are tissue-specific and modulate protein interaction networks that are essential for the function of individual organs. For skeletal muscle, we find that phosphotyrosines are over-represented, which is mainly due to proteins involved in glycogenolysis and muscle contraction, a finding we validate in human skeletal muscle biopsies. Tyrosine phosphorylation is involved in both skeletal and cardiac muscle contraction, whereas glycogenolytic enzymes are tyrosine phosphorylated in skeletal muscle but not in the liver. The presented phosphoproteomic method is simple and rapid, making it applicable for screening of diseased tissue samples.

Authors : Lundby Alicia , Secher Anna , Lage Kasper , Nordsborg Nikolai B , Dmytriyev Anatoliy , Lundby Carsten , Olsen Jesper V ,

Related products :

Catalog number Product name Quantity
MNO341 Multi-normal human tissues, FDA, 34 samples, 33 organs sites (1.5mm) >3 Cases
MNO1021 Multi-normal human tissues, FDA, 102 samples, 35 organs sites from three individuals (1.5mm) >3 Cases
MNO661 Multi-normal human tissues, FDA, 66 samples, 33 organs sites in duplicates (1.5mm) >3 Cases
MNO961 Multi-normal human tissues, FDA, 96 samples, 35 organs sites from three individuals (1.5mm) >3 Cases
'CC00-01-009 Human Squamous cell carcinoma, multiple organs tissues (22 different tissues) tissue array tissues 7 x 9
'CC00-11-004 Human Multiple organs, self-matched tumor and not tissues (esophagus_stomach_colon_rectum_ liver_lung_kidney_breast_cervix_ovary tissues 7 x 9
'CC00-11-005 Human Multiple organs, tumors paired not tumor tissues (esophagus_colon_thyroid_cervix_uterus_ intestine_lung_stomach_pancreas) tissues 8 x 8
MTU1021 Multi-tumor tissue array, 102 cases of 40 types from >28 organs sites (1.5mm) 102 Cases
MTU951 Multi-tumor tissue array, 95 cases of 40 types from 27 organs sites (1.5mm) 95 Cases
'CC00-01-002 Human Multiple organs, tumor tissues (total 9 different solid tumors) tissue array tissues 6 x 10
'CC00-11-003 Human Multiple organs, tumors paired with not tumor tissues (liver_lung_brain_breast_prostate_ intestine_kidney_mesenter) tissue tissues 6 x 8
'CC00-11-005 Human Multiple organs, tumors paired not tumor tissues (esophagus colon thyroid cervix uterus intestine lung stomach pancreas) tissues 8 x 8
'CC00-11-004 Human Multiple organs, self-matched tumor and not tissues (esophagus stomach colon rectum liver lung kidney breast cervix ovary tissues 7 x 9
'CC00-11-003 Human Multiple organs, tumors paired with not tumor tissues (liver lung brain breast prostate intestine kidney mesenter) tissue tissues 6 x 8
Z7020003 Monkey Tissue Array _ 22 types of cyno monkey normal tissues covering all major organs. All the tissues were originated 5 slides
Z7020003 Monkey Tissue Array _ 22 types of cyno monkey normal tissues covering all major organs. All the tissues were originated 5 slides
'CC00-11-001 Human Multiple organs, tumor and paired with not tumor tissues (esophagus_stomach_colon_rectum_ liver_lung_cervix_kidney_breast_ tissues 7 x 9
'CC00-11-002 Human Multiple organs, tumor paired with not tumor tissues (liver_colon_prostate_breast_brain_lung_kidney_ stomach_epiploon) tis tissues 7 x 9
'CC00-11-001 Human Multiple organs, tumor and paired with not tumor tissues (esophagus stomach colon rectum liver lung cervix kidney breast tissues 7 x 9
'CC00-11-002 Human Multiple organs, tumor paired with not tumor tissues (liver colon prostate breast brain lung kidney stomach epiploon) tis tissues 7 x 9
Animal - ASM221 22 types of cyno monkey normal tissues covering all major organs. All the tissues were originated from a single cyno monkey 2mm
EERK-100 EnzyFluo™ ERK Phosphorylation Assay Kit, Quantitative fluorescent immunoenzymatic assay for ERK1_2 phosphorylation status in cultured cells. This simple assay eliminates the need for cell lysate prepa 100tests
CC00-11-004 Human Multiple organs, self_matched tumor and not tissues (esophagus_stomach_colon_rectum_ liver_lung_kidney_breast_cervix_ovary 7 x 9
CC00-11-004 Human Multiple organs, self_matched tumor and not tissues (esophagus_stomach_colon_rectum_ liver_lung_kidney_breast_cervix_ovary 7 x 9
CC00-11-004 Human Multiple organs, self_matched tumor and not tissues (esophagus_stomach_colon_rectum_ liver_lung_kidney_breast_cervix_ovary 7 x 9


 

GENTAUR Belgium BVBA BE0473327336
Voortstraat 49, 1910 Kampenhout BELGIUM
Tel 0032 16 58 90 45

Fax 0032 16 50 90 45
info@gentaur.com | Gentaur





GENTAUR Ltd.
Howard Frank Turnberry House
1404-1410 High Road
Whetstone London N20 9BH
Tel 020 3393 8531 Fax 020 8445 9411
uk@gentaur.com | Gentaur

 

 




GENTAUR France SARL
9, rue Lagrange, 75005 Paris
Tel 01 43 25 01 50

Fax 01 43 25 01 60
RCS Paris B 484 237 888

SIRET 48423788800017

BNP PARIBAS PARIS PL MAUBERT BIC BNPAFRPPPRG

france@gentaur.com | Gentaur

GENTAUR GmbH
Marienbongard 20
52062 Aachen Deutschland
Support Karolina Elandt
Tel: 0035929830070
Fax: (+49) 241 56 00 47 88

Logistic :0241 40 08 90 86
Bankleitzahl 39050000
IBAN lautet DE8839050000107569353
Handelsregister Aachen HR B 16058
Umsatzsteuer-Identifikationsnummer *** DE 815175831
Steuernummer 201/5961/3925
de@gentaur.com | Gentaur

GENTAUR U.S.A
Genprice Inc, Logistics
547, Yurok Circle
San Jose, CA 95123
CA 95123
Tel (408) 780-0908,
Fax (408) 780-0908,
sales@genprice.com

Genprice Inc, Invoices and accounting
6017 Snell Ave, Ste 357
San Jose, CA 95123




GENTAUR Nederland BV
NL850396268B01 KVK nummer 52327027
Kuiper 1
5521 DG Eersel Nederland
Tel:  0208-080893  Fax: 0497-517897
nl@gentaur.com | Gentaur
IBAN: NL04 RABO 0156 9854 62   SWIFT RABONL2U






GENTAUR Spain
tel:0911876558
spain@gentaur.com | Gentaur






ГЕНТАУЪР БЪЛГАРИЯ
ID # 201 358 931 /BULSTAT
София 1000, ул. "Граф Игнатиев" 53 вх. В, ет. 2
Tel 0035924682280 Fax 0035924808322
e-mail: Sofia@gentaur.com | Gentaur
IBAN: BG11FINV91501014771636
BIC: FINVBGSF

GENTAUR Poland Sp. z o.o.


ul. Grunwaldzka 88/A m.2
81-771 Sopot, Poland
TEL Gdansk 058 710 33 44 FAX  058 710 33 48              

poland@gentaur.com | Gentaur

Other countries

Österreich +43720880899

Canada Montreal +15149077481

Ceská republika Praha +420246019719

Danmark +4569918806

Finland Helsset +358942419041

Magyarország Budapest +3619980547

Ireland Dublin+35316526556

Luxembourg+35220880274

Norge Oslo+4721031366

Sverige Stockholm+46852503438

Schweiz Züri+41435006251

US New York+17185132983

GENTAUR Italy
SRL IVA IT03841300167
Piazza Giacomo Matteotti, 6
24122 Bergamo Tel 02 36 00 65 93
Fax 02 36 00 65 94
italia@gentaur.com | Gentaur