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Pubmed ID :25214632
Publication Date : //

Genomic surveillance elucidates Ebola virus origin and transmission during the 2014 outbreak.


In its largest outbreak, Ebola virus disease is spreading through Guinea, Liberia, Sierra Leone, and Nigeria. We sequenced 99 Ebola virus genomes from 78 patients in Sierra Leone to ~2000× coverage. We observed a rapid accumulation of interhost and intrahost genetic variation, allowing us to characterize patterns of viral transmission over the initial weeks of the epidemic. This West African variant likely diverged from central African lineages around 2004, crossed from Guinea to Sierra Leone in May 2014, and has exhibited sustained human-to-human transmission subsequently, with no evidence of additional zoonotic sources. Because many of the mutations alter protein sequences and other biologically meaningful targets, they should be monitored for impact on diagnostics, vaccines, and therapies critical to outbreak response.

Authors : Gire Stephen K , Goba Augustine , Andersen Kristian G , Sealfon Rachel S G , Park Daniel J , Kanneh Lansana , Jalloh Simbirie , Momoh Mambu , Fullah Mohamed , Dudas Gytis , Wohl Shirlee , Moses Lina M , Yozwiak Nathan L , Winnicki Sarah , Matranga Christian B , Malboeuf Christine M , Qu James , Gladden Adrianne D , Schaffner Stephen F , Yang Xiao , Jiang Pan-Pan , Nekoui Mahan , Colubri Andres , Coomber Moinya Ruth , Fonnie Mbalu , Moigboi Alex , Gbakie Michael , Kamara Fatima K , Tucker Veronica , Konuwa Edwin , Saffa Sidiki , Sellu Josephine , Jalloh Abdul Azziz , Kovoma Alice , Koninga James , Mustapha Ibrahim , Kargbo Kandeh , Foday Momoh , Yillah Mohamed , Kanneh Franklyn , Robert Willie , Massally James L B , Chapman Sinéad B , Bochicchio James , Murphy Cheryl , Nusbaum Chad , Young Sarah , Birren Bruce W , Grant Donald S , Scheiffelin John S , Lander Eric S , Happi Christian , Gevao Sahr M , Gnirke Andreas , Rambaut Andrew , Garry Robert F , Khan S Humarr , Sabeti Pardis C ,

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