Did you know ? If you order before Friday 14h we deliver 90PCT of the the time next Tuesday, GENTAUR another in time delivery

Pubmed ID :2531657
Publication Date : //

Lipoprotein(a) binds to fibronectin and has serine proteinase activity capable of cleaving it.


The plasma concentration of human lipoprotein(a) [Lp(a)] is correlated with the risk of heart disease. A distinct feature of the Lp(a) particle is the apolipoprotein (a) [apo(a)], which is associated with apoB-100, the main protein component of low-density lipoprotein. We now report that apo(a), which has extensive homology to plasminogen, binds to immobilized fibronectin. The binding of Lp(a) was localized to the C-terminal heparin-binding domain of fibronectin. Incubation of Lp(a) with fibronectin resulted in fragmentation of fibronectin. The cleavage pattern, as visualized by gel electrophoresis and immunoblotting, was reproducibly obtained with Lp(a) purified from five different individuals and was distinct from that obtained upon proteolysis of fibronectin by plasmin or kallikrein. The use of synthetic peptide substrates demonstrated that the amino acid specificity for Lp(a) was arginine rather than lysine. The proteolytic activity of Lp(a) was localized to apo(a) and experiments with inhibitors indicated that the proteolytic activity was of serine proteinase-type.

Authors : Salonen E M , Jauhiainen M , Zardi L , Vaheri A , Ehnholm C ,

Related products :

Catalog number Product name Quantity
EIAAB32602 Implantation serine proteinase 1,Isp1,ISP-1,Mouse,Mus musculus,Prss28,Serine protease 28,Strypsin,Tryptase-like proteinase
27-881 PIK3R3 binds to activated (phosphorylated) protein-tyrosine kinases through its SH2 domain and regulates their kinase activity. During insulin stimulation, it also binds to IRS-1. 0.1 mg
EIAAB32603 Implantation serine proteinase 2,Isp2,ISP-2,Mouse,Mus musculus,Prss29,Serine protease 29,Strypsin-2,Strypsin-related protein,Tryptase-like proteinase
25-618 OASL does not have 2'-5'-OAS activity, but binds double-stranded RNA and DNA. 0.05 mg
EIAAB39439 Bos taurus,Bovine,Proteinase inhibitor 6,Serine proteinase inhibitor B-43,Serpin B6,SERPINB6
M1377 MarkerGene™ LysoLive™ Lysosomal Sulfatase Assay Kit, Useful for labeling lysosomes in a live_cell format and capable of monitoring lysosomal metabolic activity, 1 kit
M1376 MarkerGene™ LysoLive™ Lysosomal Phosphatase Assay Kit, Useful for labeling lysosomes in a live_cell format and capable of monitoring lysosomal metabolic activity, 1 kit
26-097 SKAP1 Is a T cell adaptor protein, a class of intracellular molecules with modular domains capable of recruiting additional proteins but that exhibit no intrinsic enzymatic activity. The encoded prote 0.05 mg
27-780 POU4F3 is capable of activating both BDNF and NT-3 promoters in inner ear sensory epithelial cell lines. Mutant POU4F3 loses most of its transcriptional activity and most of its ability to bind to DNA 0.1 mg
M1377 MarkerGene™ LysoLive™ Lysosomal Sulfatase Assay Kit, Useful for labeling lysosomes in a live-cell format and capable of monitoring lysosomal metabolic activity, 1 kit
M1376 MarkerGene™ LysoLive™ Lysosomal Phosphatase Assay Kit, Useful for labeling lysosomes in a live-cell format and capable of monitoring lysosomal metabolic activity, 1 kit
18-661-15188 Serine protease HTRA2. mitochondrial - EC 3.4.21.-; High temperature requirement protein A2; HtrA2; Omi stress-regulated endoprotease; Serine proteinase OMI Polyclonal 0.1 mg
20-321-175213 PROTEINASE 3 (PR3) - MONOCLONAL ANTIBODY TO HUMAN PROTEINASE 3 (PR3); EC 3.4.21.76; Leukocyte proteinase 3; PR-3; PR3; AGP7; Wegener autoantigen; P29; C-ANCA antigen; Neutrophil proteinase 4; NP-4 Mon 0.1 mg
30-655 DNTTIP1 binds DNA and enhances the activity of terminal deoxynucleotidyltransferase (TDT, or DNTT), a DNA polymerase that catalyzes the polymerization of DNA in the absence of a DNA template. 0.1 mg
42-701 Proteinase K Specific Activity > 30units_ 500mg/Unit
42-700 Proteinase K Specific Activity > 30units_ 100mg/Unit
42-701 Proteinase K Specific Activity > 30units per 500mg/Unit
42-700 Proteinase K Specific Activity > 30units per 100mg/Unit
YSRTMCA2174 raf_1, binds at Phos.serine 233 (NOT resting), Clone Roy_28_1, Rat anti_; WB 0.1 mg.
MEBE039 Proteinase K Activity≥30 U mg protein,Lyophilized Powder <10g
IQ449 Mouse Anti-Lipoprotein Lipase (LPL) Target Antigen Lipoprotein Lipase (LPL) Host Isotype Mouse IgG Application Inhibition of LPL activity, ELISA, immuno-affinity work 0.1ml (1mg/ml)
EIAAB32604 Homo sapiens,Human,Implantation serine proteinase 2-like protein,ISP2,ISP2-like protein,PRSS29P,Putative serine protease 29
EIAAB08673 Atrial natriuretic peptide-converting enzyme,Corin,CORIN,CRN,Heart-specific serine proteinase ATC2,Homo sapiens,Human,Pro-ANP-converting enzyme,TMPRSS10,Transmembrane protease serine 10
30-381 PEBP1 binds ATP, opioids and phosphatidylethanolamine. It has lower affinity for phosphatidylinositol and phosphatidylcholine. It is also a serine protease inhibitor which inhibits thrombin, neuropsin 0.1 mg
EIAAB39365 Contrapsin-like protease inhibitor 1,CPI-21,GHR-P63,Growth hormone-regulated proteinase inhibitor,Kallikrein-binding protein,KBP,Rat,Rattus norvegicus,Serine protease inhibitor 2,Serine protease inhib


 

GENTAUR Belgium BVBA BE0473327336
Voortstraat 49, 1910 Kampenhout BELGIUM
Tel 0032 16 58 90 45

Fax 0032 16 50 90 45
info@gentaur.com | Gentaur | Gentaur





GENTAUR Ltd.
Unicorn House, Station Cl
Hertfordshire, Potters Bar EN6 1TL
Whetstone London N20 9BH
Tel 020 3393 8531 Fax 020 8445 9411
uk@gentaur.com | Gentaur | Gentaur

 

 




GENTAUR France SARL
9, rue Lagrange, 75005 Paris
Tel 01 43 25 01 50

Fax 01 43 25 01 60
RCS Paris B 484 237 888

SIRET 48423788800017
RIB 30004 00187 00010092253 10
BNP PARIBAS PARIS PL MAUBERT BIC BNPAFRPPPRG
IBAN FR76 3000 4001 8700 0100 9225 310
france@gentaur.com | Gentaur | Gentaur

GENTAUR GmbH
Marienbongard 20
52062 Aachen Deutschland
Support Karolina Elandt
Tel: 0035929830070
Fax: (+49) 241 56 00 47 88

Logistic :0241 40 08 90 86
Bankleitzahl 39050000
IBAN lautet DE8839050000107569353
Handelsregister Aachen HR B 16058
Umsatzsteuer-Identifikationsnummer *** DE 815175831
Steuernummer 201/5961/3925
de@gentaur.com | Gentaur | Gentaur

GENTAUR U.S.A
Genprice Inc, Logistics
547, Yurok Circle
San Jose, CA 95123
CA 95123
Tel (408) 780-0908,
Fax (408) 780-0908,
sales@genprice.com

Genprice Inc, Invoices and accounting
6017 Snell Ave, Ste 357
San Jose, CA 95123




GENTAUR Nederland BV
NL850396268B01 KVK nummer 52327027
Kuiper 1
5521 DG Eersel Nederland
Tel:  0208-080893  Fax: 0497-517897
nl@gentaur.com | Gentaur | Gentaur
IBAN: NL04 RABO 0156 9854 62   SWIFT RABONL2U






GENTAUR Spain
tel:0911876558
spain@gentaur.com | Gentaur | Gentaur






ГЕНТАУЪР БЪЛГАРИЯ
ID # 201 358 931 /BULSTAT
София 1000, ул. "Граф Игнатиев" 53 вх. В, ет. 2
Tel 0035924682280 Fax 0035924808322
e-mail: Sofia@gentaur.com | Gentaur | Gentaur
IBAN: BG11FINV91501014771636
BIC: FINVBGSF

GENTAUR Poland Sp. z o.o.


ul. Grunwaldzka 88/A m.2
81-771 Sopot, Poland
TEL Gdansk 058 710 33 44 FAX  058 710 33 48              

poland@gentaur.com | Gentaur | Gentaur

Other countries

Österreich +43720880899

Canada Montreal +15149077481

Ceská republika Praha +420246019719

Danmark +4569918806

Finland Helsset +358942419041

Magyarország Budapest +3619980547

Ireland Dublin+35316526556

Luxembourg+35220880274

Norge Oslo+4721031366

Sverige Stockholm+46852503438

Schweiz Züri+41435006251

US New York+17185132983

GENTAUR Italy
SRL IVA IT03841300167
Piazza Giacomo Matteotti, 6
24122 Bergamo Tel 02 36 00 65 93
Fax 02 36 00 65 94
italia@gentaur.com | Gentaur | Gentaur