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Pubmed ID :25731774
Publication Date : //

Identification and functional prediction of mitochondrial complex III and IV mutations associated with glioblastoma.


Glioblastoma (GBM) is the most common primary brain tumor in adults, with a dismal prognosis. Treatment is hampered by GBM's unique biology, including differential cell response to therapy. Although several mitochondrial abnormalities have been identified, how mitochondrial DNA (mtDNA) mutations contribute to GBM biology and therapeutic response remains poorly described. We sought to determine the spectrum of functional complex III and IV mtDNA mutations in GBM.

Authors : Lloyd Rhiannon E , Keatley Kathleen , Littlewood D Timothy J , Meunier Brigitte , Holt William V , An Qian , Higgins Samantha C , Polyzoidis Stavros , Stephenson Katie F , Ashkan Keyoumars , Fillmore Helen L , Pilkington Geoffrey J , McGeehan John E ,

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