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Pubmed ID :25970247
Publication Date : //

Genetic diversity and evolutionary dynamics of Ebola virus in Sierra Leone.


A novel Ebola virus (EBOV) first identified in March 2014 has infected more than 25,000 people in West Africa, resulting in more than 10,000 deaths. Preliminary analyses of genome sequences of 81 EBOV collected from March to June 2014 from Guinea and Sierra Leone suggest that the 2014 EBOV originated from an independent transmission event from its natural reservoir followed by sustained human-to-human infections. It has been reported that the EBOV genome variation might have an effect on the efficacy of sequence-based virus detection and candidate therapeutics. However, only limited viral information has been available since July 2014, when the outbreak entered a rapid growth phase. Here we describe 175 full-length EBOV genome sequences from five severely stricken districts in Sierra Leone from 28 September to 11 November 2014. We found that the 2014 EBOV has become more phylogenetically and genetically diverse from July to November 2014, characterized by the emergence of multiple novel lineages. The substitution rate for the 2014 EBOV was estimated to be 1.23 × 10(-3) substitutions per site per year (95% highest posterior density interval, 1.04 × 10(-3) to 1.41 × 10(-3) substitutions per site per year), approximating to that observed between previous EBOV outbreaks. The sharp increase in genetic diversity of the 2014 EBOV warrants extensive EBOV surveillance in Sierra Leone, Guinea and Liberia to better understand the viral evolution and transmission dynamics of the ongoing outbreak. These data will facilitate the international efforts to develop vaccines and therapeutics.

Authors : Tong Yi-Gang , Shi Wei-Feng , Liu Di , Qian Jun , Liang Long , Bo Xiao-Chen , Liu Jun , Ren Hong-Guang , Fan Hang , Ni Ming , Sun Yang , Jin Yuan , Teng Yue , Li Zhen , Kargbo David , Dafae Foday , Kanu Alex , Chen Cheng-Chao , Lan Zhi-Heng , Jiang Hui , Luo Yang , Lu Hui-Jun , Zhang Xiao-Guang , Yang Fan , Hu Yi , Cao Yu-Xi , Deng Yong-Qiang , Su Hao-Xiang , Sun Yu , Liu Wen-Sen , Wang Zhuang , Wang Cheng-Yu , Bu Zhao-Yang , Guo Zhen-Dong , Zhang Liu-Bo , Nie Wei-Min , Bai Chang-Qing , Sun Chun-Hua , An Xiao-Ping , Xu Pei-Song , Zhang Xiang-Li-Lan , Huang Yong , Mi Zhi-Qiang , Yu Dong , Yao Hong-Wu , Feng Yong , Xia Zhi-Ping , Zheng Xue-Xing , Yang Song-Tao , Lu Bing , Jiang Jia-Fu , Kargbo Brima , He Fu-Chu , Gao George F , Cao Wu-Chun , ,

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