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Global Analysis of CPEBs Reveals Sequential and Non-Redundant Functions in Mitotic Cell Cycle.
CPEB (Cytoplasmic Polyadenylation Element Binding) proteins are a family of four RNA-binding proteins that regulate the translation of maternal mRNAs controlling meiotic cell cycle progression. But CPEBs are not limited to the transcriptionally silent germline; they are also expressed, in various combinations, in somatic cells, yet their role in regulation of mitosis-related gene expression is largely unknown. Deregulation of CPEB1 and CPEB4 have been linked to tumor development. However, a systematic analysis addressing their requirements for the temporal regulation of mitotic gene expression has yet to be performed. This study addresses the requirements of each of the four CPEBs for mitotic phase transitions, with a particular focus on cytoplasmic polyadenylation and translational regulation. We demonstrate that CPEB3 is the only member dispensable for mitotic cell division, whereas the other three members, CPEB1, 2, and 4, are essential to successful mitotic cell division. Thus, CPEB1 is required for prophase entry, CPEB2 for metaphase and CPEB4 for cytokinesis. These three CPEBs have sequential non-redundant functions that promote the phase-specific polyadenylation and translational activation of CPE-regulated transcripts in the mitotic cell cycle.
Authors : Giangarrà Valeria , Igea Ana , Castellazzi Chiara Lara , Bava Felice-Alessio , Mendez Raul ,
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Pathways :
WP1792: Cell Cycle, Mitotic
WP1900: Regulation of mitotic cell cycle
WP1078: G1 to S cell cycle control
WP1083: Cell cycle
WP1195: G1 to S cell cycle control
WP1200: Cell cycle
WP1393: Cell cycle
WP1775: Cell Cycle Checkpoints
WP1782: APC/C-mediated degradation of cell cycle proteins
WP179: Cell cycle
WP190: Cell cycle
WP31: Cell cycle
WP348: G1 to S cell cycle control
WP413: G1 to S cell cycle control
WP414: Cell Cycle and Cell Division
WP429: Cell cycle
WP445: G1 to S cell cycle control
WP45: G1 to S cell cycle control
WP840: G1 to S cell cycle control
WP844: Cell cycle
WP959: G1 to S cell cycle control
WP964: Cell cycle
WP1011: T Cell Receptor Signaling Pathway
WP1025: B Cell Receptor Signaling Pathway
WP1043: Calcium Regulation in the Cardiac Cell
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Bibliography :
[26398195] Global Analysis of CPEBs Reveals Sequential and Non-Redundant Functions in Mitotic Cell Cycle.
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