Did you know ? If you order before Friday 14h we deliver 90PCT of the the time next Tuesday, GENTAUR another in time delivery

Pubmed ID :3654650
Publication Date : //

Isolation, characterization, and pharmacological actions of peptide histidine valine 42, a novel prepro-vasoactive intestinal peptide-derived peptide.


The primary structure and biological activity of a novel prepro-vasoactive intestinal peptide (prepro-VIP)-derived peptide has been determined from an adrenal pheochromocytoma. The peptide was purified sufficiently for characterization by fast atom bombardment mapping after cation-exchange and reverse-phase fast protein liquid chromatography. The sequence of this novel peptide corresponds exactly to prepro-VIP-81-122 and has been designated peptide histidine valine 42 (PHV-42). Synthetic PHV-42 reduced both the force and frequency of spontaneous contractions of isolated rat uterus and was at least 12 times more potent than peptide histidine methionine (prepro-VIP-81-107), and over a hundred times more potent than noradrenaline. PHV-42 was also more potent than peptide histidine methionine in relaxing smooth muscle preparations of rat stomach and guinea pig trachea, but was approximately 4-fold less potent in reducing blood pressure than VIP. PHV-42 thus forms a separate subsystem in the VIP family of peptides and may be the most biologically active product of prepro-VIP in certain tissues such as the uterus and trachea.

Authors : Yiangou Y , Di Marzo V , Spokes R A , Panico M , Morris H R , Bloom S R ,

Related products :

Catalog number Product name Quantity
PEPA41T RABBIT ANTI PIG VASOACTIVE INTESTINAL PEPTIDE, Product Type Polyclonal Antibody, Specificity VASOACTIVE INTESTINAL PEPTIDE, Target Species Pig, Host Rabbit, Format Serum, Isotypes Polyclonal IgG 20 µl
SCH-PEPA41T RABBIT ANTI PIG VASOACTIVE INTESTINAL PEPTIDE, Product Type Polyclonal Antibody, Specificity VASOACTIVE INTESTINAL PEPTIDE, Target Species Pig, Host Rabbit, Format Serum, Isotypes Polyclonal IgG 20 µl
9535-0204 RABBIT ANTI VASOACTIVE INTESTINAL PEPTIDE, Product Type Polyclonal Antibody, Specificity VASOACTIVE INTESTINAL PEPTIDE, Target Species Human, Host Rabbit, Format Purified, Isotypes Polyclonal Ig 0.5 ml
SCH-9535-0204 RABBIT ANTI VASOACTIVE INTESTINAL PEPTIDE, Product Type Polyclonal Antibody, Specificity VASOACTIVE INTESTINAL PEPTIDE, Target Species Human, Host Rabbit, Format Purified, Isotypes Polyclonal Ig 0.5 ml
orb72032 Vasoactive Intestinal peptide This is Vasoactive Intestinal peptide. For research use only. 1 mg
AE6302AG.2 Vasoactive Intestinal Peptide-Receptor 2 (VIP-R2) antigen: human Vasoactive Intestinal Peptide-Receptor 2 1 mg
AE6302AG.1 Vasoactive Intestinal Peptide-Receptor 2 (VIP-R2) antigen: human Vasoactive Intestinal Peptide-Receptor 2 100
orb72031 Vasoactive Intestinal Contractor [VIC] peptide This is Vasoactive Intestinal Contractor [VIC] peptide. For research use only. 1 mg
orb72033 Vasoactive Intestinal Constractor [VIC] peptide This is Vasoactive Intestinal Constractor [VIC] peptide. For research use only. 1 mg
AE6302AG.1 human Vasoactive Intestinal Peptide-Receptor 2 form: Synthetic peptide 100
VIPR11-P Mouse Vasoactive intestinal peptide receptor (VIPR1_VPAC1) Control_blocking peptide 1 100 ug
064-10 Vasoactive Intestinal Peptide (VIP)(PHM)(111_122) _Prepro (PHM_VIP Space Peptide) _ 500ug 500 µg
AE6302AG.2 human Vasoactive Intestinal Peptide-Receptor 2 form: Synthetic peptide 1 mg
VIP16-P Mouse Vasoactive intestinal peptide (VIP) Control blocking peptide #1 100 ug
VIPR21-P Rat Vasoactive intestinal peptide receptor (VIPR2_VPAC2) Control_blocking peptide 1 100 ug
VIPRRP11-P Rat Vasoactive intestinal peptide receptor_gene repressor protein (VIPRRP) Control_blocking peptide 1 100 ug
VIPR21-P Rat Vasoactive intestinal peptide receptor (VIPR2 VPAC2) Control blocking peptide #1 100 ug
VIPR11-P Mouse Vasoactive intestinal peptide receptor (VIPR1 VPAC1) Control blocking peptide #1 100 ug
VIP16-P Mouse Vasoactive intestinal peptide (VIP) Control_blocking peptide 1 100 ug
VIPRRP11-P Rat Vasoactive intestinal peptide receptor-gene repressor protein (VIPRRP) Control blocking peptide #1 100 ug
5-43233 Vasoactive Intestinal peptide, peptide reagents 0.5 mg
5-43235 Vasoactive Intestinal peptide, peptide reagents 2.5 mg
5-43234 Vasoactive Intestinal peptide, peptide reagents 1 mg
E0380c ELISA Canis familiaris,Canis lupus familiaris,Dog,Vasoactive intestinal peptide,Vasoactive intestinal polypeptide,VIP,VIP 96T
E0380c ELISA kit Canis familiaris,Canis lupus familiaris,Dog,Vasoactive intestinal peptide,Vasoactive intestinal polypeptide,VIP,VIP 96T


 

GENTAUR Belgium BVBA BE0473327336
Voortstraat 49, 1910 Kampenhout BELGIUM
Tel 0032 16 58 90 45

Fax 0032 16 50 90 45
info@gentaur.com | Gentaur





GENTAUR Ltd.
Howard Frank Turnberry House
1404-1410 High Road
Whetstone London N20 9BH
Tel 020 3393 8531 Fax 020 8445 9411
uk@gentaur.com | Gentaur

 

 




GENTAUR France SARL
9, rue Lagrange, 75005 Paris
Tel 01 43 25 01 50

Fax 01 43 25 01 60
RCS Paris B 484 237 888

SIRET 48423788800017

BNP PARIBAS PARIS PL MAUBERT BIC BNPAFRPPPRG

france@gentaur.com | Gentaur

GENTAUR GmbH
Marienbongard 20
52062 Aachen Deutschland
Support Karolina Elandt
Tel: 0035929830070
Fax: (+49) 241 56 00 47 88

Logistic :0241 40 08 90 86
Bankleitzahl 39050000
IBAN lautet DE8839050000107569353
Handelsregister Aachen HR B 16058
Umsatzsteuer-Identifikationsnummer *** DE 815175831
Steuernummer 201/5961/3925
de@gentaur.com | Gentaur

GENTAUR U.S.A
Genprice Inc, Logistics
547, Yurok Circle
San Jose, CA 95123
CA 95123
Tel (408) 780-0908,
Fax (408) 780-0908,
sales@genprice.com

Genprice Inc, Invoices and accounting
6017 Snell Ave, Ste 357
San Jose, CA 95123




GENTAUR Nederland BV
NL850396268B01 KVK nummer 52327027
Kuiper 1
5521 DG Eersel Nederland
Tel:  0208-080893  Fax: 0497-517897
nl@gentaur.com | Gentaur
IBAN: NL04 RABO 0156 9854 62   SWIFT RABONL2U






GENTAUR Spain
tel:0911876558
spain@gentaur.com | Gentaur






ГЕНТАУЪР БЪЛГАРИЯ
ID # 201 358 931 /BULSTAT
София 1000, ул. "Граф Игнатиев" 53 вх. В, ет. 2
Tel 0035924682280 Fax 0035924808322
e-mail: Sofia@gentaur.com | Gentaur
IBAN: BG11FINV91501014771636
BIC: FINVBGSF

GENTAUR Poland Sp. z o.o.


ul. Grunwaldzka 88/A m.2
81-771 Sopot, Poland
TEL Gdansk 058 710 33 44 FAX  058 710 33 48              

poland@gentaur.com | Gentaur

Other countries

Österreich +43720880899

Canada Montreal +15149077481

Ceská republika Praha +420246019719

Danmark +4569918806

Finland Helsset +358942419041

Magyarország Budapest +3619980547

Ireland Dublin+35316526556

Luxembourg+35220880274

Norge Oslo+4721031366

Sverige Stockholm+46852503438

Schweiz Züri+41435006251

US New York+17185132983

GENTAUR Italy
SRL IVA IT03841300167
Piazza Giacomo Matteotti, 6
24122 Bergamo Tel 02 36 00 65 93
Fax 02 36 00 65 94
italia@gentaur.com | Gentaur