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p53 is a tumor-suppressor protein that can activate and repress transcription. Using the yeast two-hybrid system, we identified two previously uncharacterized human proteins, designated 53BP1 and 53BP2, that bind to p53. 53BP1 shows no significant homology to proteins in available databases, whereas 53BP2 contains two adjacent ankyrin repeats and a Src homology 3 domain. In vitro binding analyses indicate that both of these proteins bind to the central domain of p53 (residues 80-320) required for site-specific DNA binding. Consistent with this finding, p53 cannot bind simultaneously to 53BP1 or 53BP2 and to a DNA fragment containing a consensus p53 binding site. Unlike other cellular proteins whose binding to p53 has been characterized, both 53BP1 and 53BP2 bind to the wild-type but not to two mutant p53 proteins identified in human tumors, suggesting that binding is dependent on p53 conformation. The characteristics of these interactions argue that 53BP1 and 53BP2 are involved in some aspect of p53-mediated tumor suppression.
Authors : Iwabuchi K , Bartel P L , Li B , Marraccino R , Fields S ,
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WP1017: Type II interferon signaling (IFNG)
WP1032: NLR proteins
WP1071: Cytoplasmic Ribosomal Proteins
WP1136: Type II interferon signaling (IFNG)
WP1187: Cytoplasmic Ribosomal Proteins
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WP1294: NLR proteins
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WP163: Cytoplasmic Ribosomal Proteins
WP1780: ABC-family proteins mediated transport
WP1782: APC/C-mediated degradation of cell cycle proteins
WP1789: Binding of RNA by Insulin-like Growth Factor-2 mRNA Binding Proteins (IGF2BPs/IMPs/VICKZs)
WP1834: Interactions of the immunoglobulin superfamily (IgSF) member proteins
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WP1887: Post-translational modification: synthesis of GPI-anchored proteins
WP1899: Regulation of Insulin-like Growth Factor (IGF) Activity by Insulin-like Growth Factor Binding Proteins (IGFBPs)
WP1902: Respiratory electron transport, ATP synthesis by chemiosmotic coupling, and heat production by uncoupling proteins.
WP1963: The effect of Glucocorticoids on target gene expression
WP1983: Splicing factor NOVA regulated synpatic proteins
WP20: Cytoplasmic Ribosomal Proteins
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