Did you know ? If you order before Friday 14h we deliver 90PCT of the the time next Tuesday, GENTAUR another in time delivery

Pubmed ID :8046438
Publication Date : //

Localization of Kv1.1 and Kv1.2, two K channel proteins, to synaptic terminals, somata, and dendrites in the mouse brain.


Multiple voltage-gated potassium (K) channel gene products are likely to be involved in regulating neuronal excitability of any single neuron in the mammalian brain. Here we show that two closely related voltage-gated K channel proteins, mKv1.1 and mKv1.2, are present in multiple subcellular locations including cell somata, juxta-paranodal regions of myelinated axons, synaptic terminals, unmyelinated axons, specialized junctions among axons, and proximal dendrites. Staining patterns of the two channel polypeptides overlap in some areas of the brain, yet each has a unique pattern of expression. For example, in the hippocampus, both mKv1.1 and mKv1.2 proteins are present in axons, often near or at synaptic terminals in the middle molecular layer of the dentate gyrus, while only mKv1.1 is detected in axons and synaptic terminals in the hilar/CA3 region. In the cerebellum, both channel proteins are localized to axon terminals and specialized junctions among axons in the plexus region of basket cells. Strong differential staining is observed in the olfactory bulb, where mKv1.2 is localized to cell somata and axons, as well as to proximal dendrites of the mitral cells. This overlapping yet differential pattern of expression and specific subcellular localization may contribute to the unique profile of excitability displayed by a particular neuron.

Authors : Wang H , Kunkel D D , Schwartzkroin P A , Tempel B L ,

Related products :

Catalog number Product name Quantity
E1344m ELISA kit BI,Brain calcium channel I,Caca1a,Cach4,Cacn3,Cacna1a,Cacnl1a4,Calcium channel, L type, alpha-1 polypeptide isoform 4,Ccha1a,Mouse,Mus musculus,Voltage-dependent P_Q-type calcium channel su 96T
U1344m CLIA BI,Brain calcium channel I,Caca1a,Cach4,Cacn3,Cacna1a,Cacnl1a4,Calcium channel, L type, alpha-1 polypeptide isoform 4,Ccha1a,Mouse,Mus musculus,Voltage-dependent P_Q-type calcium channel subunit 96T
E1344m ELISA BI,Brain calcium channel I,Caca1a,Cach4,Cacn3,Cacna1a,Cacnl1a4,Calcium channel, L type, alpha-1 polypeptide isoform 4,Ccha1a,Mouse,Mus musculus,Voltage-dependent P_Q-type calcium channel subunit 96T
E1344r ELISA kit BI,Brain calcium channel I,Cach4,Cacn3,Cacna1a,Cacnl1a4,Calcium channel, L type, alpha-1 polypeptide, isoform 4,Rat,Rat brain class A,Rattus norvegicus,RBA-I,Voltage-dependent P_Q-type calc 96T
U1344r CLIA BI,Brain calcium channel I,Cach4,Cacn3,Cacna1a,Cacnl1a4,Calcium channel, L type, alpha-1 polypeptide, isoform 4,Rat,Rat brain class A,Rattus norvegicus,RBA-I,Voltage-dependent P_Q-type calcium ch 96T
E1344r ELISA BI,Brain calcium channel I,Cach4,Cacn3,Cacna1a,Cacnl1a4,Calcium channel, L type, alpha-1 polypeptide, isoform 4,Rat,Rat brain class A,Rattus norvegicus,RBA-I,Voltage-dependent P_Q-type calcium c 96T
26-912 The nuclear import of karyophilic proteins is directed by short amino acid sequences termed nuclear localization signals (NLSs). Karyopherins, or importins, are cytoplasmic proteins that recognize NLS 0.05 mg
EIAAB40624 Calcium regulator SV2A,Kiaa0736,Mouse,Mus musculus,Sv2,Sv2a,Synaptic vesicle glycoprotein 2A,Synaptic vesicle protein 2,Synaptic vesicle protein 2A
SMC-181C Syntaxin Antibody Monoclonal, Clone number: SP-6 Host: Mouse, Isotype: IgG1 Immunogen: Raised against synaptic vasicle-containing fractions of immunoprecipitated human brain homogenate 25ug
SMC-181D Syntaxin Antibody Monoclonal, Clone number: SP-6 Host: Mouse, Isotype: IgG1 Immunogen: Raised against synaptic vasicle-containing fractions of immunoprecipitated human brain homogenate 100ug
SMC-180D SNAP-25 Antibody Monoclonal, Clone number: SP-12 Host: Mouse, Isotype: IgG1 Immunogen: Raised against a crude synaptic preparation from the post mortem human brain 100ug
SMC-180C SNAP-25 Antibody Monoclonal, Clone number: SP-12 Host: Mouse, Isotype: IgG1 Immunogen: Raised against a crude synaptic preparation from the post mortem human brain 25ug
EIAAB05015 Cach2,Cacn2,Cacna1c,Cacnl1a1,Calcium channel, L type, alpha-1 polypeptide, isoform 1, cardiac muscle,Cchl1a1,MBC,MELC-CC,Mouse,Mouse brain class C,Mus musculus,Voltage-dependent L-type calcium channel
EIAAB05010 BIII,Brain calcium channel III,Cach5,Cacna1b,Cacnl1a5,Calcium channel, L type, alpha-1 polypeptide isoform 5,Cchn1a,Mouse,Mus musculus,Voltage-dependent N-type calcium channel subunit alpha-1B,Voltage
EIAAB05024 BII,Brain calcium channel II,Cach6,Cacna1e,Cacnl1a6,Calcium channel, L type, alpha-1 polypeptide, isoform 6,Cchra1,Mouse,Mus musculus,Voltage-dependent R-type calcium channel subunit alpha-1E,Voltage-
26-910 Imported proteins require a nuclear localization sequence (NLS) which generally consists of a short region of basic amino acids or 2 such regions spaced about 10 amino acids apart. Proteins involved i 0.05 mg
EIAAB40629 Kiaa1054,Mouse,Mus musculus,Sv2c,Synaptic vesicle glycoprotein 2C,Synaptic vesicle protein 2C
EIAAB40626 Kiaa0735,Mouse,Mus musculus,Sv2b,Synaptic vesicle glycoprotein 2B,Synaptic vesicle protein 2B
MA1057 Monoclonal Anti-MAP2, Clone number: MP-2, Ig type: mouse IgG1, Immunogen: Rat brain microtubule-associated proteins (MAPs)., Specificity: Human;mouse;rat. No cross reactivity with other proteins. 100μg/vial
E1344Rb ELISA kit BI,Brain calcium channel I,CACH4,CACN3,CACNA1A,CACNL1A4,Calcium channel, L type, alpha-1 polypeptide isoform 4,Oryctolagus cuniculus,Rabbit,Voltage-dependent P_Q-type calcium channel subuni 96T
E1344Rb ELISA BI,Brain calcium channel I,CACH4,CACN3,CACNA1A,CACNL1A4,Calcium channel, L type, alpha-1 polypeptide isoform 4,Oryctolagus cuniculus,Rabbit,Voltage-dependent P_Q-type calcium channel subunit alp 96T
U1344Rb CLIA BI,Brain calcium channel I,CACH4,CACN3,CACNA1A,CACNL1A4,Calcium channel, L type, alpha-1 polypeptide isoform 4,Oryctolagus cuniculus,Rabbit,Voltage-dependent P_Q-type calcium channel subunit alph 96T
SMC-180C SNAP-25, SP-12 Monoclonals AntibodiesSP-12 Raised against a crude synaptic preparation from the post mortem human brain 25ug
SMC-181D Syntaxin, SP-6 Monoclonals AntibodiesSP-6 Raised against synaptic vasicle-containing fractions of immunoprecipitated human brain homogenate 100ug
SMC-181C Syntaxin, SP-6 Monoclonals AntibodiesSP-6 Raised against synaptic vasicle-containing fractions of immunoprecipitated human brain homogenate 25ug


 

GENTAUR Belgium BVBA BE0473327336
Voortstraat 49, 1910 Kampenhout BELGIUM
Tel 0032 16 58 90 45

Fax 0032 16 50 90 45
info@gentaur.com | Gentaur





GENTAUR Ltd.
Howard Frank Turnberry House
1404-1410 High Road
Whetstone London N20 9BH
Tel 020 3393 8531 Fax 020 8445 9411
uk@gentaur.com | Gentaur

 

 




GENTAUR France SARL
9, rue Lagrange, 75005 Paris
Tel 01 43 25 01 50

Fax 01 43 25 01 60
RCS Paris B 484 237 888

SIRET 48423788800017

BNP PARIBAS PARIS PL MAUBERT BIC BNPAFRPPPRG

france@gentaur.com | Gentaur

GENTAUR GmbH
Marienbongard 20
52062 Aachen Deutschland
Support Karolina Elandt
Tel: 0035929830070
Fax: (+49) 241 56 00 47 88

Logistic :0241 40 08 90 86
Bankleitzahl 39050000
IBAN lautet DE8839050000107569353
Handelsregister Aachen HR B 16058
Umsatzsteuer-Identifikationsnummer *** DE 815175831
Steuernummer 201/5961/3925
de@gentaur.com | Gentaur

GENTAUR U.S.A
Genprice Inc, Logistics
547, Yurok Circle
San Jose, CA 95123
CA 95123
Tel (408) 780-0908,
Fax (408) 780-0908,
sales@genprice.com

Genprice Inc, Invoices and accounting
6017 Snell Ave, Ste 357
San Jose, CA 95123




GENTAUR Nederland BV
NL850396268B01 KVK nummer 52327027
Kuiper 1
5521 DG Eersel Nederland
Tel:  0208-080893  Fax: 0497-517897
nl@gentaur.com | Gentaur
IBAN: NL04 RABO 0156 9854 62   SWIFT RABONL2U






GENTAUR Spain
tel:0911876558
spain@gentaur.com | Gentaur






ГЕНТАУЪР БЪЛГАРИЯ
ID # 201 358 931 /BULSTAT
София 1000, ул. "Граф Игнатиев" 53 вх. В, ет. 2
Tel 0035924682280 Fax 0035924808322
e-mail: Sofia@gentaur.com | Gentaur
IBAN: BG11FINV91501014771636
BIC: FINVBGSF

GENTAUR Poland Sp. z o.o.


ul. Grunwaldzka 88/A m.2
81-771 Sopot, Poland
TEL Gdansk 058 710 33 44 FAX  058 710 33 48              

poland@gentaur.com | Gentaur

Other countries

Österreich +43720880899

Canada Montreal +15149077481

Ceská republika Praha +420246019719

Danmark +4569918806

Finland Helsset +358942419041

Magyarország Budapest +3619980547

Ireland Dublin+35316526556

Luxembourg+35220880274

Norge Oslo+4721031366

Sverige Stockholm+46852503438

Schweiz Züri+41435006251

US New York+17185132983

GENTAUR Italy
SRL IVA IT03841300167
Piazza Giacomo Matteotti, 6
24122 Bergamo Tel 02 36 00 65 93
Fax 02 36 00 65 94
italia@gentaur.com | Gentaur