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Pubmed ID :8590020
Publication Date : //

Crystal structure of interleukin-10 reveals the functional dimer with an unexpected topological similarity to interferon gamma.


Interleukin (IL)-10 is a cytokine that inhibits production of other regulatory factors, including interferon gamma (IFN-gamma) and IL-2. A dimer of IL-10 is present in solution and is presumed to participate in receptor binding, but the nature of the dimer has not been previously reported. An atomic model is necessary to interpret biological activity of IL-10 and to design mutants with agonistic or antagonistic properties.

Authors : Zdanov A , Schalk-Hihi C , Gustchina A , Tsang M , Weatherbee J , Wlodawer A ,

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