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Pubmed ID :8670280
Publication Date : //

A protein AA-variant derived from a novel serum AA protein, SAA1 delta, in an individual from Papua New Guinea.


A major protein AA amyloid protein was purified and characterised from a Papua New Guinnean individual. This AA protein differed from all previously characterised SAA variants by the combination of Ala52, Val57, Asn60, Phe68, Phe69 and Gly72. Since the prevalence of AA-amyloidosis is unusually high in Papua New Guinea this AAdelta must originate from a novel SAAdelta which may represent a particularly amyloidogenic variant.

Authors : Westermark P , Sletten K , Westermark G T , Raynes J , McAdam K P ,

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