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Pubmed ID :8723348
Publication Date : //

Multiple forms of an inositol polyphosphate 5-phosphatase form signaling complexes with Shc and Grb2.


Shc and Grb2 form a complex in cells in response to growth factor stimulation and link tyrosine kinases to Ras during the resulting signaling process. Shc and Grb2 each contain domains that mediate interactions with other unidentified intracellular proteins. For example, the Shc PTB domain binds to 130 kDa and 145 kDa tyrosine-phosphorylated proteins in response to stimulation of cells by growth factors, cytokines and crosslinking of antigen receptors. The Grb2 SH3 domains bind to an unidentified 116 kDa protein in T cells. We have identified three proteins, of 110 kDa, 130 kDa and 145 kDa, as a new family of molecules encoded by the same gene. In vivo studies show that these proteins form signal transduction complexes with Shc and with Grb2.

Authors : Kavanaugh W M , Pot D A , Chin S M , Deuter-Reinhard M , Jefferson A B , Norris F A , Masiarz F R , Cousens L S , Majerus P W , Williams L T ,

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