Did you know ? If you order before Friday 14h we deliver 90PCT of the the time next Tuesday, GENTAUR another in time delivery
Publication Date : //
Neurotrophins and their signaling receptors, the Trk family of protein tyrosine kinases, play a major role in the development of the mammalian nervous system. To determine the precise stages that require Trk receptor signaling during development of the sympathetic system, we have analyzed the superior cervical ganglion (SCG) of embryonic and postnatal mice defective for each of the known Trk receptors. Transcripts encoding TrkC are detected in early sympathetic development, before the coalescence of the SCG. trkA expression appears at E13.5, becoming robust from E15.5 onward. In contrast, trkC expression decreases significantly after E15.5 and remains detectable only in a small subpopulation of cells. No significant trkB expression could be detected in the SCG at any developmental stage. Ablation of TrkA receptors does not affect neurogenesis, expression of neuronal markers, or initial axonal growth. However, these receptors are absolutely necessary for the survival of sympathetic neurons after E15.5 and for proper innervation of their distal targets. In contrast, mice defective for either TrkC or TrkB tyrosine kinase receptors do not display detectable defects in their SCGs. These results illustrate the differential roles of the Trk family of receptors during SCG development and define a critical role for TrkA signaling in the survival, but not differentiation, of SCG neurons. Moreover, these observations raise the possibility that at least some SCG neurons become neurotrophin-dependent before complete target innervation.
Authors : Fagan A M , Zhang H , Landis S , Smeyne R J , Silos-Santiago I , Barbacid M ,
Related products :
52062 Aachen Deutschland
Support Karolina Elandt
Tel: +49 0241 40 08 90 86, +49 0241 95 78 94 78, +49 0241 40 08 90 86
Fax: (+49) 241 56 00 47 88
Logistic :0241 40 08 90 86
IBAN lautet DE8839050000107569353
Handelsregister Aachen HR B 16058
Umsatzsteuer-Identifikationsnummer *** DE 815175831
firstname.lastname@example.org | Gentaur | Gentaur
Genprice Inc, Logistics
547, Yurok Circle
San Jose, CA 95123
Tel (408) 780-0908,
Fax (408) 780-0908,
Genprice Inc, Invoices and accounting
6017 Snell Ave, Ste 357
San Jose, CA 95123
Canada Montreal +15149077481
Ceská republika Praha +420246019719
Finland Helsset +358942419041
Magyarország Budapest +3619980547
US New York+17185132983
WP1068: Nuclear Receptors
WP1099: Nuclear receptors in lipid metabolism and toxicity
WP1184: Nuclear Receptors
WP1326: Nuclear receptors in lipid metabolism and toxicity
WP1385: Nuclear Receptors
WP139: Nuclear receptors in lipid metabolism and toxicity
WP1401: Neurotransm. release in cholinergic motor neurons
WP1602: Nicotine Activity on Dopaminergic Neurons
WP170: Nuclear Receptors
WP1873: NGF signalling via TRKA from the plasma membrane
WP1929: Thrombin signalling through proteinase activated receptors (PARs)
WP2083: Nicotine Activity on Dopaminergic Neurons
WP217: Nuclear Receptors
WP299: Nuclear receptors in lipid metabolism and toxicity
WP431: Nuclear receptors in lipid metabolism and toxicity
WP509: Nuclear Receptors
WP755: Nuclear receptors in lipid metabolism and toxicity
WP831: Nuclear Receptors
WP863: Nuclear receptors in lipid metabolism and toxicity
WP950: Nuclear Receptors
WP981: Nuclear receptors in lipid metabolism and toxicity
Related Genes :
 Re: TRAF4-Mediated Ubiquitination of NGF Receptor TrkA Regulates Prostate Cancer Metastasis.
 Genomic landscape of pediatric B-other acute lymphoblastic leukemia in a consecutive European cohort.
 ERG deletions in childhood acute lymphoblastic leukemia with DUX4 rearrangements are mostly polyclonal, prognostically relevant and their detection rate strongly depends on method's sensitivity.
 NGF-Dependent Changes in Ubiquitin Homeostasis Trigger Early Cholinergic Degeneration in Cellular and Animal AD-Model.
 Radioligands for Tropomyosin Receptor Kinase (Trk) Positron Emission Tomography Imaging.
 Characterization of gene expression in naturally occurring feline degenerative joint disease-associated pain.
 Enriched environment modulates behavior, myelination and augments molecules governing the plasticity in the forebrain region of rats exposed to chronic immobilization stress.
 Optogenetic Delineation of Receptor Tyrosine Kinase Subcircuits in PC12 Cell Differentiation.
 TRK Fusion Cancers in Children: A Clinical Review and Recommendations for Screening.
 Electroacupuncture improves neurogenic bladder dysfunction through activation of NGF/TrkA signaling in a rat model.
Enter catalog number :