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2'-O-methyltransferase (EC 2.7.7.48) (EC 3.4.19.12) (EC 3.4.22.69) (EC 3.6.4.12) (EC 3.6.4.13) (3C-like proteinase) (Growth factor-like peptide) (Guanine-N7 methyltransferase) (Helicase) (Host translation inhibitor nsp1) (Leader protein) (NendoU) (Non-structural protein 10) (Non-structural protein 2) (Non-structural protein 3) (Non-structural protein 4) (Non-structural protein 6) (Non-structural protein 7) (Non-structural protein 8) (Non-structural protein 9) (ORF1ab polyprotein) (Papain-like proteinase) (RNA-directed RNA polymerase) (Replicase polyprotein 1ab) (Uridylate-specific endoribonuclease) (p65 homolog)

 A0A6H1PRW5_SARS2        Unreviewed;      7096 AA.
A0A6H1PRW5;
12-AUG-2020, integrated into UniProtKB/TrEMBL.
12-AUG-2020, sequence version 1.
19-JAN-2022, entry version 8.
RecName: Full=ORF1ab polyprotein {ECO:0000256|ARBA:ARBA00015878};
AltName: Full=Replicase polyprotein 1ab {ECO:0000256|ARBA:ARBA00022087};
Name=ORF1ab {ECO:0000313|EMBL:QQD88996.1};
Severe acute respiratory syndrome coronavirus 2 (2019-nCoV) (SARS-CoV-2).
Viruses; Riboviria; Orthornavirae; Pisuviricota; Pisoniviricetes;
Nidovirales; Cornidovirineae; Coronaviridae; Orthocoronavirinae;
Betacoronavirus; Sarbecovirus.
NCBI_TaxID=2697049 {ECO:0000313|EMBL:QQD88996.1};
NCBI_TaxID=9606; Homo sapiens (Human).
[1] {ECO:0000313|EMBL:QQV22430.1}
NUCLEOTIDE SEQUENCE.
STRAIN=SARS-CoV-2/human/USA/NYP-WCM-COVSUBJ_0024_1_P/2020
{ECO:0000313|EMBL:QQV23870.1},
SARS-CoV-2/human/USA/NYP-WCM-COVSUBJ_0068_1_P/2020
{ECO:0000313|EMBL:QQV23762.1},
SARS-CoV-2/human/USA/NYP-WCM-COVSUBJ_0251_1_P/2020
{ECO:0000313|EMBL:QQV22430.1},
SARS-CoV-2/human/USA/NYP-WCM-COVSUBJ_0283_1_P/2020
{ECO:0000313|EMBL:QQV22634.1},
SARS-CoV-2/human/USA/NYP-WCM-COVSUBJ_0297_1_P/2020
{ECO:0000313|EMBL:QQV22790.1},
SARS-CoV-2/human/USA/NYP-WCM-COVSUBJ_0346_1_P/2020
{ECO:0000313|EMBL:QQV23390.1},
SARS-CoV-2/human/USA/NYP-WCM-COVSUBJ_0350_1_P/2020
{ECO:0000313|EMBL:QQV22898.1},
SARS-CoV-2/human/USA/NYP-WCM-COVSUBJ_0352_1_P/2020
{ECO:0000313|EMBL:QQV23138.1},
SARS-CoV-2/human/USA/NYP-WCM-COVSUBJ_0376_1_N/2020
{ECO:0000313|EMBL:QQV23366.1},
SARS-CoV-2/human/USA/NYP-WCM-COVSUBJ_0428_1_P/2020
{ECO:0000313|EMBL:QQV23318.1},
SARS-CoV-2/human/USA/NYP-WCM-COVSUBJ_0509_1_P/2020
{ECO:0000313|EMBL:QQV22814.1},
SARS-CoV-2/human/USA/NYP-WCM-COVSUBJ_0522_1_P/2020
{ECO:0000313|EMBL:QQV23042.1},
SARS-CoV-2/human/USA/NYP-WCM-COVSUBJ_0604_1_P/2020
{ECO:0000313|EMBL:QQV22610.1},
SARS-CoV-2/human/USA/NYP-WCM-COVSUBJ_0642_1_P/2020
{ECO:0000313|EMBL:QQV22994.1},
SARS-CoV-2/human/USA/NYP-WCM-COVSUBJ_0643_1_P/2020
{ECO:0000313|EMBL:QQV23054.1}, and
SARS-CoV-2/human/USA/NYP-WCM-COVSUBJ_0650_1_P/2020
{ECO:0000313|EMBL:QQV23546.1};
PubMed=32511352;
Butler D.J., Mozsary C., Meydan C., Danko D., Foox J., Rosiene J.,
Shaiber A., Afshinnekoo E., MacKay M., Sedlazeck F.J., Ivanov N.A.,
Sierra M., Pohle D., Zietz M., Gisladottir U., Ramlall V., Westover C.D.,
Ryon K., Young B., Bhattacharya C., Ruggiero P., Langhorst B.W., Tanner N.,
Gawrys J., Meleshko D., Xu D., Steel P.A.D., Shemesh A.J., Xiang J.,
Thierry-Mieg J., Thierry-Mieg D., Schwartz R.E., Iftner A., Bezdan D.,
Sipley J., Cong L., Craney A., Velu P., Melnick A.M., Hajirasouliha I.,
Horner S.M., Iftner T., Salvatore M., Loda M., Westblade L.F., Cushing M.,
Levy S., Wu S., Tatonetti N., Imielinski M., Rennert H., Mason C.E.;
"Shotgun Transcriptome and Isothermal Profiling of SARS-CoV-2 Infection
Reveals Unique Host Responses, Viral Diversification, and Drug
Interactions.";
bioRxiv 0:0-0(2020).
[2] {ECO:0000313|EMBL:QJY78186.1}
NUCLEOTIDE SEQUENCE.
STRAIN=SARS-CoV-2/human/USA/hCoV-19-USA-CA-UCSF- UC40/2020
{ECO:0000313|EMBL:QJY78186.1},
SARS-CoV-2/human/USA/hCoV-19-USA-CA-UCSF- UC45/2020
{ECO:0000313|EMBL:QJY78246.1}, and
SARS-CoV-2/human/USA/hCoV-19-USA-CA-UCSF- UC46/2020
{ECO:0000313|EMBL:QJY78258.1};
PubMed=32436571;
Gu W., Deng X., Reyes K., Hsu E., Wang C., Sotomayor-Gonzalez A.,
Federman S., Bushnell B., Miller S., Chiu C.;
"Associations of Early COVID-19 Cases in San Francisco with Domestic and
International Travel.";
Clin. Infect. Dis. 0:0-0(2020).
[3] {ECO:0000313|EMBL:QKE32974.1}
NUCLEOTIDE SEQUENCE.
STRAIN=SARS-CoV-2/human/ITA/INMI10/2020 {ECO:0000313|EMBL:QKE43725.1},
SARS-CoV-2/human/ITA/INMI3/2020 {ECO:0000313|EMBL:QKE32974.1},
SARS-CoV-2/human/ITA/INMI4/2020 {ECO:0000313|EMBL:QKE43665.1},
SARS-CoV-2/human/ITA/INMI6/2020 {ECO:0000313|EMBL:QKE43677.1}, and
SARS-CoV-2/human/ITA/INMI8/2020 {ECO:0000313|EMBL:QKE43701.1};
PubMed=32459984;
Bartolini B., Rueca M., Gruber C.E.M., Messina F., Carletti F.,
Giombini E., Lalle E., Bordi L., Matusali G., Colavita F., Castilletti C.,
Vairo F., Ippolito G., Capobianchi M.R., Di Caro A.;
"SARS-CoV-2 Phylogenetic Analysis, Lazio Region, Italy, February-March
2020.";
Emerg. Infect. Dis. 26:0-0(2020).
[4] {ECO:0000313|EMBL:QOF07587.1}
NUCLEOTIDE SEQUENCE.
STRAIN=SARS-CoV-2/Cat/CHL/UCH_NRL_007/2020 {ECO:0000313|EMBL:QOF07634.1},
SARS-CoV-2/Cat/CHL/UCH_NRL_009/2020 {ECO:0000313|EMBL:QOF07599.1},
SARS-CoV-2/Cat/CHL/UCH_NRL_014/2020 {ECO:0000313|EMBL:QOF07587.1}, and
SARS-CoV-2/Cat/CHL/UCH_NRL_025/2020 {ECO:0000313|EMBL:QOF07646.1};
PubMed=33317424;
Neira V., Brito B., Aguero B., Berrios F., Valdes V., Gutierrez A.,
Ariyama N., Espinoza P., Retamal P., Holmes E.C., Gonzalez-Reiche A.S.,
Khan Z., Guchte A.V., Dutta J., Miorin L., Kehrer T., Galarce N.,
Almonacid L.I., Levican J., Bakel H.V., Garcia-Sastre A., Medina R.A.;
"A household case evidences shorter shedding of SARS-CoV-2 in naturally
infected cats compared to their human owners.";
Emerg. Microbes Infect. 2020:1-22(2020).
[5] {ECO:0000313|EMBL:QQD88996.1}
NUCLEOTIDE SEQUENCE.
STRAIN=SARS-CoV-2/human/ITA/Nuoro-CoV130/2020
{ECO:0000313|EMBL:QQD89020.1},
SARS-CoV-2/human/ITA/Nuoro-CoV134/2020 {ECO:0000313|EMBL:QQD89008.1},
SARS-CoV-2/human/ITA/Nuoro-CoV135/2020 {ECO:0000313|EMBL:QQD88996.1},
SARS-CoV-2/human/ITA/Nuoro-CoV3/2020 {ECO:0000313|EMBL:QQD89128.1},
SARS-CoV-2/human/ITA/Nuoro-CoV40/2020 {ECO:0000313|EMBL:QQD89080.1},
SARS-CoV-2/human/ITA/Nuoro-CoV5/2020 {ECO:0000313|EMBL:QQD89116.1}, and
SARS-CoV-2/human/ITA/Nuoro-CoV54/2020 {ECO:0000313|EMBL:QQD89068.1};
Piras G., Grandi N., Monne M., Asproni R., Fancello T., Fiamma M.,
Mameli G., Casu G., lo Maglio I., Palmas A.D., Tramontano E.;
"Early diffusion of SARS-CoV-2 infection in the inner area of the Italian
Sardinia island.";
Front. Microbiol. 0:0-0(2020).
[6] {ECO:0000313|EMBL:QJD47798.1}
NUCLEOTIDE SEQUENCE.
STRAIN=SARS-CoV-2/human/TWN/CGMH-CGU-12/2020 {ECO:0000313|EMBL:QJD47798.1},
SARS-CoV-2/human/TWN/CGMH-CGU-15/2020 {ECO:0000313|EMBL:QJD47834.1},
SARS-CoV-2/human/TWN/CGMH-CGU-18/2020 {ECO:0000313|EMBL:QJD47870.1},
SARS-CoV-2/human/TWN/CGMH-CGU-19/2020 {ECO:0000313|EMBL:QJD47882.1}, and
SARS-CoV-2/human/TWN/CGMH-CGU-20/2020 {ECO:0000313|EMBL:QJD47894.1};
Gong Y.-N., Tsao K.-C., Hsiao M.-J., Huang C.-G., Huang P.-N., Huang P.-W.,
Lee K.-M., Liu Y.-C., Yang S.-L., Kuo R.-L., Liu M.-T., Yang J.-R.,
Chiu C.-H., Yang C.-T., Shih S.-R., Chen G.-W.;
"Sequence variation among SARS-CoV-2 isolates in Taiwan.";
J. ISSAAS 0:0-0(2020).
[7] {ECO:0000313|EMBL:QIX07429.1}
NUCLEOTIDE SEQUENCE.
STRAIN=SARS-CoV-2/human/DEU/HH-1/2020 {ECO:0000313|EMBL:QIX07429.1};
PubMed=32499358;
Pfefferle S., Huang J., Norz D., Indenbirken D., Lutgehetmann M.,
Oestereich L., Gunther T., Grundhoff A., Aepfelbacher M., Fischer N.;
"Complete Genome Sequence of a SARS-CoV-2 Strain Isolated in Northern
Germany.";
Microbiol. Resour. Announc. 9:e00520-20(2020).
[8] {ECO:0000313|EMBL:QIT08290.1}
NUCLEOTIDE SEQUENCE.
STRAIN=SARS-CoV-2/canine/HKG/20-03695/2020 {ECO:0000313|EMBL:QIT08290.1},
and SARS-CoV-2/human/HKG/case163_VM20009579/2020
{ECO:0000313|EMBL:QIT08302.1};
PubMed=32408337;
Sit T.H.C., Brackman C.J., Ip S.M., Tam K.W.S., Law P.Y.T., To E.M.W.,
Yu V.Y.T., Sims L.D., Tsang D.N.C., Chu D.K.W., Perera R.A.P.M.,
Poon L.L.M., Peiris M.;
"Infection of dogs with SARS-CoV-2.";
Nature 0:0-0(2020).
[9] {ECO:0000313|EMBL:QSS76491.1}
NUCLEOTIDE SEQUENCE.
STRAIN=SARS-CoV-2/human/Finland/FIN-UH25M-Caco2-P1/2020
{ECO:0000313|EMBL:QSS76503.1},
SARS-CoV-2/human/Finland/FIN-UH25M-Caco2-P3/2020
{ECO:0000313|EMBL:QSS76515.1}, and
SARS-CoV-2/human/Finland/FIN-UH25M-Nasopharynx/2020
{ECO:0000313|EMBL:QSS76491.1};
PubMed=33082293; DOI=10.1126/science.abd2985;
Cantuti-Castelvetri L., Ojha R., Pedro L.D., Djannatian M., Franz J.,
Kuivanen S., van der Meer F., Kallio K., Kaya T., Anastasina M., Smura T.,
Levanov L., Szirovicza L., Tobi A., Kallio-Kokko H., Osterlund P.,
Joensuu M., Meunier F.A., Butcher S.J., Winkler M.S., Mollenhauer B.,
Helenius A., Gokce O., Teesalu T., Hepojoki J., Vapalahti O.,
Stadelmann C., Balistreri G., Simons M.;
"Neuropilin-1 facilitates SARS-CoV-2 cell entry and infectivity.";
Science 370:856-860(2020).
[10] {ECO:0000313|EMBL:QKE23313.1}
NUCLEOTIDE SEQUENCE.
STRAIN=SARS-CoV-2/human/CHN/OS3/2020 {ECO:0000313|EMBL:QKE23313.1}, and
SARS-CoV-2/human/CHN/OS4/2020 {ECO:0000313|EMBL:QKE23337.1};
PubMed=32376603;
Gao Q., Bao L., Mao H., Wang L., Xu K., Yang M., Li Y., Zhu L., Wang N.,
Lv Z., Gao H., Ge X., Kan B., Hu Y., Liu J., Cai F., Jiang D., Yin Y.,
Qin C., Li J., Gong X., Lou X., Shi W., Wu D., Zhang H., Zhu L., Deng W.,
Li Y., Lu J., Li C., Wang X., Yin W., Zhang Y., Qin C.;
"Rapid development of an inactivated vaccine candidate for SARS-CoV-2.";
Science 0:0-0(2020).
[11] {ECO:0000313|EMBL:QIT08290.1}
NUCLEOTIDE SEQUENCE.
STRAIN=SARS-CoV-2/canine/HKG/20-03695/2020 {ECO:0000313|EMBL:QIT08290.1},
and SARS-CoV-2/human/HKG/case163_VM20009579/2020
{ECO:0000313|EMBL:QIT08302.1};
Sit T.H.S., Brackman C.J., Sims L.D., Tsang D.N.C., Chu D.K.W.,
Perera R.A.P.M., Poon L.L.M., Peiris M.;
Submitted (MAR-2020) to the EMBL/GenBank/DDBJ databases.
[12] {ECO:0000313|EMBL:QTP71235.1}
NUCLEOTIDE SEQUENCE.
STRAIN=SARS-CoV-2/human/USA/02-P005175-S054-R01_D1/2020
{ECO:0000313|EMBL:QTP71235.1}, and
SARS-CoV-2/human/USA/02-P166169-S038-R01_D3/2020
{ECO:0000313|EMBL:QTP71259.1};
PubMed=33655247;
Delorey T.M., Ziegler C.G.K., Heimberg G., Normand R., Yang Y.,
Segerstolpe A., Abbondanza D., Fleming S.J., Subramanian A., Montoro D.T.,
Jagadeesh K.A., Dey K.K., Sen P., Slyper M., Pita-Juarez Y.H., Phillips D.,
Bloom-Ackerman Z., Barkas N., Ganna A., Gomez J., Normandin E., Naderi P.,
Popov Y.V., Raju S.S., Niezen S., Tsai L.T., Siddle K.J., Sud M.,
Tran V.M., Vellarikkal S.K., Amir-Zilberstein L., Atri D.S., Beechem J.,
Brook O.R., Chen J., Divakar P., Dorceus P., Engreitz J.M., Essene A.,
Fitzgerald D.M., Fropf R., Gazal S., Gould J., Grzyb J., Harvey T.,
Hecht J., Hether T., Jane-Valbuena J., Leney-Greene M., Ma H., McCabe C.,
McLoughlin D.E., Miller E.M., Muus C., Niemi M., Padera R., Pan L.,
Pant D., Pe'er C., Pfiffner-Borges J., Pinto C.J., Plaisted J., Reeves J.,
Ross M., Rudy M., Rueckert E.H., Siciliano M., Sturm A., Todres E.,
Waghray A., Warren S., Zhang S., Zollinger D.R., Cosimi L., Gupta R.M.,
Hacohen N., Hide W., Price A.L., Rajagopal J., Tata P.R., Riedel S.,
Szabo G., Tickle T.L., Hung D., Sabeti P.C., Novak R., Rogers R.,
Ingber D.E., Gordon Jiang Z., Juric D., Babadi M., Farhi S.L., Stone J.R.,
Vlachos I.S., Solomon I.H., Ashenberg O., Porter C.B.M., Li B.,
Shalek A.K., Villani A.C., Rozenblatt-Rosen O., Regev A.;
"A single-cell and spatial atlas of autopsy tissues reveals pathology and
cellular targets of SARS-CoV-2.";
bioRxiv 0:0-0(2021).
[13] {ECO:0000313|EMBL:QQL14049.1}
NUCLEOTIDE SEQUENCE.
STRAIN=SARS-CoV-2/human/PAK/JRCGR-KHI02/2020 {ECO:0000313|EMBL:QQL14049.1},
and SARS-CoV-2/human/PAK/JRCGR-KHI16/2020 {ECO:0000313|EMBL:QQL14250.1};
Shakeel M., Irfan M., Zaibunnisa, Rashid M., Ansari S.K., Khan I.A.;
"Surveillance of genetic diversity and evolution in locally transmitted
SARS-CoV-2 in Pakistan during the first wave of the COVID-19 pandemic.";
bioRxiv 0:0-0(2021).
[14] {ECO:0000313|EMBL:QTM63796.1}
NUCLEOTIDE SEQUENCE.
STRAIN=SARS-CoV-2/human/USA/MT-BHDH-1450/2020
{ECO:0000313|EMBL:QTM63796.1},
SARS-CoV-2/human/USA/MT-BHDH-1508/2020 {ECO:0000313|EMBL:QTM63808.1},
SARS-CoV-2/human/USA/MT-BHDH-2045/2020 {ECO:0000313|EMBL:QTM63832.1},
SARS-CoV-2/human/USA/MT-BHDH-2346/2020 {ECO:0000313|EMBL:QTM63844.1}, and
SARS-CoV-2/human/USA/MT-BHDH-2973/2020 {ECO:0000313|EMBL:QTM63856.1};
PubMed=33655280;
Nemudryi A., Nemudraia A., Wiegand T., Nichols J., Snyder D.T.,
Hedges J.F., Cicha C., Lee H., Vanderwood K.K., Bimczok D., Jutila M.,
Wiedenheft B.;
"SARS-CoV-2 genomic surveillance identifies naturally occurring truncations
of ORF7a that limit immune suppression.";
medRxiv 0:0-0(2021).
[15] {ECO:0000313|EMBL:QTZ35043.1}
NUCLEOTIDE SEQUENCE.
STRAIN=SARS-CoV-2/human/USA/CA-CDPH-UC1488/2020
{ECO:0000313|EMBL:QTZ35043.1},
SARS-CoV-2/human/USA/CA-CDPH-UC1494/2020 {ECO:0000313|EMBL:QTZ35115.1},
SARS-CoV-2/human/USA/CA-CDPH-UC1499/2020 {ECO:0000313|EMBL:QTZ35163.1},
SARS-CoV-2/human/USA/CA-CDPH-UC1533/2020 {ECO:0000313|EMBL:QTZ35559.1},
SARS-CoV-2/human/USA/CA-CDPH-UC482/2020 {ECO:0000313|EMBL:QTZ54886.1},
SARS-CoV-2/human/USA/CA-UCSF-UC695/2020 {ECO:0000313|EMBL:QTZ41728.1},
SARS-CoV-2/human/USA/CA-UCSF-UC963/2021 {ECO:0000313|EMBL:QTZ44132.1}, and
SARS-CoV-2/human/USA/CA-UCSF-UC964/2021 {ECO:0000313|EMBL:QTZ44144.1};
PubMed=33758899;
Deng X., Garcia-Knight M.A., Khalid M.M., Servellita V., Wang C.,
Morris M.K., Sotomayor-Gonzalez A., Glasner D.R., Reyes K.R., Gliwa A.S.,
Reddy N.P., Sanchez San Martin C., Federman S., Cheng J., Balcerek J.,
Taylor J., Streithorst J.A., Miller S., Kumar G.R., Sreekumar B.,
Chen P.Y., Schulze-Gahmen U., Taha T.Y., Hayashi J., Simoneau C.R.,
McMahon S., Lidsky P.V., Xiao Y., Hemarajata P., Green N.M., Espinosa A.,
Kath C., Haw M., Bell J., Hacker J.K., Hanson C., Wadford D.A., Anaya C.,
Ferguson D., Lareau L.F., Frankino P.A., Shivram H., Wyman S.K., Ott M.,
Andino R., Chiu C.Y.;
"Transmission, infectivity, and antibody neutralization of an emerging
SARS-CoV-2 variant in California carrying a L452R spike protein mutation.";
medRxiv 0:0-0(2021).
[16] {ECO:0000313|EMBL:QKX45511.1}
NUCLEOTIDE SEQUENCE.
STRAIN=SARS-CoV-2/human/BEN/197/2020 {ECO:0000313|EMBL:QKX45511.1};
PubMed=33441410;
Sander A.L., Yadouleton A., Moreira-Soto A., Tchibozo C., Hounkanrin G.,
Badou Y., Fischer C., Krause N., Akogbeto P., F de Oliveira Filho E.,
Dossou A., Brunink S., Drosten C., Aissi M.A.J., Harouna Djingarey M.,
Hounkpatin B., Nagel M., Drexler J.F.;
"An Observational Laboratory-Based Assessment of SARS-CoV-2 Molecular
Diagnostics in Benin, Western Africa.";
MSphere 6:e00979-20(2021).
[17] {ECO:0000313|EMBL:QSE99539.1}
NUCLEOTIDE SEQUENCE.
STRAIN=SARS-CoV-2/human/ISR/hCov-19-Israel-CVL-n-10261/2020
{ECO:0000313|EMBL:QSF12942.1},
SARS-CoV-2/human/ISR/hCov-19-Israel-CVL-n-10864/2020
{ECO:0000313|EMBL:QSF12858.1},
SARS-CoV-2/human/ISR/hCov-19-Israel-CVL-n-11594/2020
{ECO:0000313|EMBL:QSF13254.1},
SARS-CoV-2/human/ISR/hCov-19-Israel-CVL-n-5908/2020
{ECO:0000313|EMBL:QSF13206.1},
SARS-CoV-2/human/ISR/hCov-19-Israel-CVL-n-5999/2020
{ECO:0000313|EMBL:QSF13218.1},
SARS-CoV-2/human/ISR/hCov-19-Israel-CVL-n-6051/2020
{ECO:0000313|EMBL:QSF13362.1},
SARS-CoV-2/human/ISR/hCov-19-Israel-CVL-n-6104/2020
{ECO:0000313|EMBL:QSF13038.1},
SARS-CoV-2/human/ISR/hCov-19-Israel-CVL-n-6106/2020
{ECO:0000313|EMBL:QSF12954.1},
SARS-CoV-2/human/ISR/hCov-19-Israel-CVL-n-6108/2020
{ECO:0000313|EMBL:QSF12738.1},
SARS-CoV-2/human/ISR/hCov-19-Israel-CVL-n-6118/2020
{ECO:0000313|EMBL:QSF12906.1},
SARS-CoV-2/human/ISR/hCov-19-Israel-CVL-n-6140/2020
{ECO:0000313|EMBL:QSF12822.1},
SARS-CoV-2/human/ISR/hCov-19-Israel-CVL-n-6142/2020
{ECO:0000313|EMBL:QSF13230.1},
SARS-CoV-2/human/ISR/hCov-19-Israel-CVL-n-6656/2020
{ECO:0000313|EMBL:QSF12570.1},
SARS-CoV-2/human/ISR/hCov-19-Israel-CVL-n-6735/2020
{ECO:0000313|EMBL:QSF12762.1},
SARS-CoV-2/human/ISR/hCov-19-Israel-CVL-n-6750/2020
{ECO:0000313|EMBL:QSF12786.1},
SARS-CoV-2/human/ISR/hCov-19-Israel-CVL-n-6751/2020
{ECO:0000313|EMBL:QSF13122.1},
SARS-CoV-2/human/ISR/hCov-19-Israel-CVL-n1541/2020
{ECO:0000313|EMBL:QSF00032.1},
SARS-CoV-2/human/ISR/hCov-19-Israel-CVL-n1749/2020
{ECO:0000313|EMBL:QSE99731.1},
SARS-CoV-2/human/ISR/hCov-19-Israel-CVL-n1750/2020
{ECO:0000313|EMBL:QSE99827.1},
SARS-CoV-2/human/ISR/hCov-19-Israel-CVL-n2361/2020
{ECO:0000313|EMBL:QSE99863.1},
SARS-CoV-2/human/ISR/hCov-19-Israel-CVL-n2487/2020
{ECO:0000313|EMBL:QSE99659.1},
SARS-CoV-2/human/ISR/hCov-19-Israel-CVL-n2494/2020
{ECO:0000313|EMBL:QSE99767.1},
SARS-CoV-2/human/ISR/hCov-19-Israel-CVL-n2888/2020
{ECO:0000313|EMBL:QSE99887.1},
SARS-CoV-2/human/ISR/hCov-19-Israel-CVL-n3807/2020
{ECO:0000313|EMBL:QSE99743.1},
SARS-CoV-2/human/ISR/hCov-19-Israel-CVL-n4065/2020
{ECO:0000313|EMBL:QSE99539.1},
SARS-CoV-2/human/ISR/hCov-19-Israel-CVL-n4097/2020
{ECO:0000313|EMBL:QSF00008.1},
SARS-CoV-2/human/ISR/hCov-19-Israel-CVL-n4115/2020
{ECO:0000313|EMBL:QSE99839.1},
SARS-CoV-2/human/ISR/hCov-19-Israel-CVL-n4414/2020
{ECO:0000313|EMBL:QSE99719.1}, and
SARS-CoV-2/human/ISR/hCov-19-Israel-CVL-n4431/2020
{ECO:0000313|EMBL:QSF00044.1};
Zuckerman N., Mandelboim M.;
"Genomic epidemiology of SARS-CoV-2 importation and early circulation in
Israel.";
PLoS ONE 0:0-0(2021).
[18] {ECO:0000313|EMBL:QQV22430.1}
NUCLEOTIDE SEQUENCE.
STRAIN=SARS-CoV-2/human/USA/NYP-WCM-COVSUBJ_0024_1_P/2020
{ECO:0000313|EMBL:QQV23870.1},
SARS-CoV-2/human/USA/NYP-WCM-COVSUBJ_0068_1_P/2020
{ECO:0000313|EMBL:QQV23762.1},
SARS-CoV-2/human/USA/NYP-WCM-COVSUBJ_0251_1_P/2020
{ECO:0000313|EMBL:QQV22430.1},
SARS-CoV-2/human/USA/NYP-WCM-COVSUBJ_0283_1_P/2020
{ECO:0000313|EMBL:QQV22634.1},
SARS-CoV-2/human/USA/NYP-WCM-COVSUBJ_0297_1_P/2020
{ECO:0000313|EMBL:QQV22790.1},
SARS-CoV-2/human/USA/NYP-WCM-COVSUBJ_0346_1_P/2020
{ECO:0000313|EMBL:QQV23390.1},
SARS-CoV-2/human/USA/NYP-WCM-COVSUBJ_0350_1_P/2020
{ECO:0000313|EMBL:QQV22898.1},
SARS-CoV-2/human/USA/NYP-WCM-COVSUBJ_0352_1_P/2020
{ECO:0000313|EMBL:QQV23138.1},
SARS-CoV-2/human/USA/NYP-WCM-COVSUBJ_0376_1_N/2020
{ECO:0000313|EMBL:QQV23366.1},
SARS-CoV-2/human/USA/NYP-WCM-COVSUBJ_0428_1_P/2020
{ECO:0000313|EMBL:QQV23318.1},
SARS-CoV-2/human/USA/NYP-WCM-COVSUBJ_0509_1_P/2020
{ECO:0000313|EMBL:QQV22814.1},
SARS-CoV-2/human/USA/NYP-WCM-COVSUBJ_0522_1_P/2020
{ECO:0000313|EMBL:QQV23042.1},
SARS-CoV-2/human/USA/NYP-WCM-COVSUBJ_0604_1_P/2020
{ECO:0000313|EMBL:QQV22610.1},
SARS-CoV-2/human/USA/NYP-WCM-COVSUBJ_0642_1_P/2020
{ECO:0000313|EMBL:QQV22994.1},
SARS-CoV-2/human/USA/NYP-WCM-COVSUBJ_0643_1_P/2020
{ECO:0000313|EMBL:QQV23054.1}, and
SARS-CoV-2/human/USA/NYP-WCM-COVSUBJ_0650_1_P/2020
{ECO:0000313|EMBL:QQV23546.1};
Foox J.;
Submitted (JAN-2021) to the EMBL/GenBank/DDBJ databases.
[19] {ECO:0000313|EMBL:QSS76491.1}
NUCLEOTIDE SEQUENCE.
STRAIN=SARS-CoV-2/human/Finland/FIN-UH25M-Caco2-P1/2020
{ECO:0000313|EMBL:QSS76503.1},
SARS-CoV-2/human/Finland/FIN-UH25M-Caco2-P3/2020
{ECO:0000313|EMBL:QSS76515.1}, and
SARS-CoV-2/human/Finland/FIN-UH25M-Nasopharynx/2020
{ECO:0000313|EMBL:QSS76491.1};
Smura T., Kuivanen S., Hepojoki J., Kakkola L., Kolehmainen P.,
Jalkanen P., Julkunen I., Vapalahti O.;
Submitted (MAR-2021) to the EMBL/GenBank/DDBJ databases.
[20] {ECO:0000313|EMBL:QTM63796.1}
NUCLEOTIDE SEQUENCE.
STRAIN=SARS-CoV-2/human/USA/MT-BHDH-1450/2020
{ECO:0000313|EMBL:QTM63796.1},
SARS-CoV-2/human/USA/MT-BHDH-1508/2020 {ECO:0000313|EMBL:QTM63808.1},
SARS-CoV-2/human/USA/MT-BHDH-2045/2020 {ECO:0000313|EMBL:QTM63832.1},
SARS-CoV-2/human/USA/MT-BHDH-2346/2020 {ECO:0000313|EMBL:QTM63844.1}, and
SARS-CoV-2/human/USA/MT-BHDH-2973/2020 {ECO:0000313|EMBL:QTM63856.1};
Nemudryi A.A., Nemudraia A.A., Cicha C., Wiegand T., Wiedenheft B.A.;
Submitted (APR-2021) to the EMBL/GenBank/DDBJ databases.
[21] {ECO:0000313|EMBL:QNC68216.1}
NUCLEOTIDE SEQUENCE.
STRAIN=SARS-CoV-2/human/GBR/CVR-GLA-1/2020 {ECO:0000313|EMBL:QNC68216.1};
PubMed=33630831;
Rihn S.J., Merits A., Bakshi S., Turnbull M.L., Wickenhagen A.,
Alexander A.J.T., Baillie C., Brennan B., Brown F., Brunker K.,
Bryden S.R., Burness K.A., Carmichael S., Cole S.J., Cowton V.M.,
Davies P., Davis C., De Lorenzo G., Donald C.L., Dorward M., Dunlop J.I.,
Elliott M., Fares M., da Silva Filipe A., Freitas J.R., Furnon W.,
Gestuveo R.J., Geyer A., Giesel D., Goldfarb D.M., Goodman N., Gunson R.,
Hastie C.J., Herder V., Hughes J., Johnson C., Johnson N., Kohl A.,
Kerr K., Leech H., Lello L.S., Li K., Lieber G., Liu X., Lingala R.,
Loney C., Mair D., McElwee M.J., McFarlane S., Nichols J., Nomikou K.,
Orr A., Orton R.J., Palmarini M., Parr Y.A., Pinto R.M., Raggett S.,
Reid E., Robertson D.L., Royle J., Cameron-Ruiz N., Shepherd J.G.,
Smollett K., Stewart D.G., Stewart M., Sugrue E., Szemiel A.M., Taggart A.,
Thomson E.C., Tong L., Torrie L.S., Toth R., Varjak M., Wang S.,
Wilkinson S.G., Wyatt P.G., Zusinaite E., Alessi D.R., Patel A.H., Zaid A.,
Wilson S.J., Mahalingam S.;
"A plasmid DNA-launched SARS-CoV-2 reverse genetics system and coronavirus
toolkit for COVID-19 research.";
PLoS Biol. 19:0-0(0).
-!- FUNCTION: Plays a pivotal role in viral transcription by stimulating
both nsp14 3'-5' exoribonuclease and nsp16 2'-O-methyltransferase
activities. Therefore plays an essential role in viral mRNAs cap
methylation. {ECO:0000256|ARBA:ARBA00002697}.
-!- FUNCTION: Responsible for replication and transcription of the viral
RNA genome. {ECO:0000256|ARBA:ARBA00003927}.
-!- CATALYTIC ACTIVITY:
Reaction=ATP + H2O = ADP + H(+) + phosphate; Xref=Rhea:RHEA:13065,
ChEBI:CHEBI:15377, ChEBI:CHEBI:15378, ChEBI:CHEBI:30616,
ChEBI:CHEBI:43474, ChEBI:CHEBI:456216; EC=3.6.4.12;
Evidence={ECO:0000256|ARBA:ARBA00001665};
-!- CATALYTIC ACTIVITY:
Reaction=ATP + H2O = ADP + H(+) + phosphate; Xref=Rhea:RHEA:13065,
ChEBI:CHEBI:15377, ChEBI:CHEBI:15378, ChEBI:CHEBI:30616,
ChEBI:CHEBI:43474, ChEBI:CHEBI:456216; EC=3.6.4.13;
Evidence={ECO:0000256|ARBA:ARBA00001556};
-!- CATALYTIC ACTIVITY:
Reaction=Thiol-dependent hydrolysis of ester, thioester, amide, peptide
and isopeptide bonds formed by the C-terminal Gly of ubiquitin (a 76-
residue protein attached to proteins as an intracellular targeting
signal).; EC=3.4.19.12; Evidence={ECO:0000256|ARBA:ARBA00000707};
-!- CATALYTIC ACTIVITY:
Reaction=a 5'-end (N(7)-methyl 5'-triphosphoguanosine)-ribonucleoside
in mRNA + S-adenosyl-L-methionine = a 5'-end (N(7)-methyl 5'-
triphosphoguanosine)-(2'-O-methyl-ribonucleoside) in mRNA + H(+) + S-
adenosyl-L-homocysteine; Xref=Rhea:RHEA:67020, Rhea:RHEA-COMP:17167,
Rhea:RHEA-COMP:17168, ChEBI:CHEBI:15378, ChEBI:CHEBI:57856,
ChEBI:CHEBI:59789, ChEBI:CHEBI:156461, ChEBI:CHEBI:167609;
EC=2.1.1.57; Evidence={ECO:0000256|ARBA:ARBA00024256};
-!- CATALYTIC ACTIVITY:
Reaction=uridylyl-uridylyl-ribonucleotide-RNA = a 3'-end uridylyl-
2',3'-cyclophospho-uridine-RNA + a 5'-end dephospho-ribonucleoside-
RNA; Xref=Rhea:RHEA:67732, Rhea:RHEA-COMP:13936, Rhea:RHEA-
COMP:17334, Rhea:RHEA-COMP:17335, ChEBI:CHEBI:138284,
ChEBI:CHEBI:173079, ChEBI:CHEBI:173080;
Evidence={ECO:0000256|ARBA:ARBA00024600};
-!- COFACTOR:
Name=Mn(2+); Xref=ChEBI:CHEBI:29035;
Evidence={ECO:0000256|ARBA:ARBA00001936};
-!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000256|ARBA:ARBA00004496}.
Endoplasmic reticulum-Golgi intermediate compartment
{ECO:0000256|ARBA:ARBA00004399}. Host cytoplasm, host perinuclear
region {ECO:0000256|ARBA:ARBA00004407}. Host endoplasmic reticulum-
Golgi intermediate compartment {ECO:0000256|ARBA:ARBA00004452}. Host
membrane {ECO:0000256|ARBA:ARBA00004301}; Multi-pass membrane protein
{ECO:0000256|ARBA:ARBA00004301}. Membrane
{ECO:0000256|ARBA:ARBA00004141}; Multi-pass membrane protein
{ECO:0000256|ARBA:ARBA00004141}.
-!- SIMILARITY: Belongs to the coronaviruses polyprotein 1ab family.
{ECO:0000256|ARBA:ARBA00008087}.
---------------------------------------------------------------------------
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EMBL; MT270814; QIT08290.1; -; Genomic_RNA.
EMBL; MT270815; QIT08302.1; -; Genomic_RNA.
EMBL; MT318827; QIX07429.1; -; Genomic_RNA.
EMBL; MT374108; QJD47798.1; -; Genomic_RNA.
EMBL; MT374111; QJD47834.1; -; Genomic_RNA.
EMBL; MT374114; QJD47870.1; -; Genomic_RNA.
EMBL; MT374115; QJD47882.1; -; Genomic_RNA.
EMBL; MT374116; QJD47894.1; -; Genomic_RNA.
EMBL; MT510718; QJY78186.1; -; Genomic_RNA.
EMBL; MT510723; QJY78246.1; -; Genomic_RNA.
EMBL; MT510724; QJY78258.1; -; Genomic_RNA.
EMBL; MT407657; QKE23313.1; -; Genomic_RNA.
EMBL; MT407659; QKE23337.1; -; Genomic_RNA.
EMBL; MT525950; QKE32974.1; -; Genomic_RNA.
EMBL; MT527178; QKE43665.1; -; Genomic_RNA.
EMBL; MT527184; QKE43677.1; -; Genomic_RNA.
EMBL; MT528237; QKE43701.1; -; Genomic_RNA.
EMBL; MT528239; QKE43725.1; -; Genomic_RNA.
EMBL; MT653071; QKX45511.1; -; Genomic_RNA.
EMBL; MT882022; QNC68216.1; -; Genomic_RNA.
EMBL; MW064259; QOF07587.1; -; Genomic_RNA.
EMBL; MW064260; QOF07599.1; -; Genomic_RNA.
EMBL; MW064263; QOF07634.1; -; Genomic_RNA.
EMBL; MW064264; QOF07646.1; -; Genomic_RNA.
EMBL; MW403692; QQD88996.1; -; Genomic_RNA.
EMBL; MW403693; QQD89008.1; -; Genomic_RNA.
EMBL; MW403694; QQD89020.1; -; Genomic_RNA.
EMBL; MW403698; QQD89068.1; -; Genomic_RNA.
EMBL; MW403699; QQD89080.1; -; Genomic_RNA.
EMBL; MW403702; QQD89116.1; -; Genomic_RNA.
EMBL; MW403703; QQD89128.1; -; Genomic_RNA.
EMBL; MW447624; QQL14049.1; -; Genomic_RNA.
EMBL; MW447641; QQL14250.1; -; Genomic_RNA.
EMBL; MW493736; QQV22430.1; -; Genomic_RNA.
EMBL; MW493751; QQV22610.1; -; Genomic_RNA.
EMBL; MW493753; QQV22634.1; -; Genomic_RNA.
EMBL; MW493766; QQV22790.1; -; Genomic_RNA.
EMBL; MW493768; QQV22814.1; -; Genomic_RNA.
EMBL; MW493775; QQV22898.1; -; Genomic_RNA.
EMBL; MW493783; QQV22994.1; -; Genomic_RNA.
EMBL; MW493787; QQV23042.1; -; Genomic_RNA.
EMBL; MW493788; QQV23054.1; -; Genomic_RNA.
EMBL; MW493795; QQV23138.1; -; Genomic_RNA.
EMBL; MW493810; QQV23318.1; -; Genomic_RNA.
EMBL; MW493814; QQV23366.1; -; Genomic_RNA.
EMBL; MW493816; QQV23390.1; -; Genomic_RNA.
EMBL; MW493829; QQV23546.1; -; Genomic_RNA.
EMBL; MW493847; QQV23762.1; -; Genomic_RNA.
EMBL; MW493856; QQV23870.1; -; Genomic_RNA.
EMBL; MW494188; QQV27082.1; -; Genomic_RNA.
EMBL; MW494203; QQV27262.1; -; Genomic_RNA.
EMBL; MW494205; QQV27286.1; -; Genomic_RNA.
EMBL; MW494218; QQV27442.1; -; Genomic_RNA.
EMBL; MW494220; QQV27466.1; -; Genomic_RNA.
EMBL; MW494227; QQV27550.1; -; Genomic_RNA.
EMBL; MW494235; QQV27646.1; -; Genomic_RNA.
EMBL; MW494239; QQV27694.1; -; Genomic_RNA.
EMBL; MW494240; QQV27706.1; -; Genomic_RNA.
EMBL; MW494247; QQV27790.1; -; Genomic_RNA.
EMBL; MW494262; QQV27970.1; -; Genomic_RNA.
EMBL; MW494266; QQV28018.1; -; Genomic_RNA.
EMBL; MW494268; QQV28042.1; -; Genomic_RNA.
EMBL; MW494281; QQV28198.1; -; Genomic_RNA.
EMBL; MW494299; QQV28414.1; -; Genomic_RNA.
EMBL; MW494308; QQV28522.1; -; Genomic_RNA.
EMBL; MW672625; QSE99539.1; -; Genomic_RNA.
EMBL; MW672635; QSE99659.1; -; Genomic_RNA.
EMBL; MW672640; QSE99719.1; -; Genomic_RNA.
EMBL; MW672641; QSE99731.1; -; Genomic_RNA.
EMBL; MW672642; QSE99743.1; -; Genomic_RNA.
EMBL; MW672644; QSE99767.1; -; Genomic_RNA.
EMBL; MW672649; QSE99827.1; -; Genomic_RNA.
EMBL; MW672650; QSE99839.1; -; Genomic_RNA.
EMBL; MW672652; QSE99863.1; -; Genomic_RNA.
EMBL; MW672654; QSE99887.1; -; Genomic_RNA.
EMBL; MW672664; QSF00008.1; -; Genomic_RNA.
EMBL; MW672666; QSF00032.1; -; Genomic_RNA.
EMBL; MW672667; QSF00044.1; -; Genomic_RNA.
EMBL; MW674808; QSF12570.1; -; Genomic_RNA.
EMBL; MW674822; QSF12738.1; -; Genomic_RNA.
EMBL; MW674824; QSF12762.1; -; Genomic_RNA.
EMBL; MW674826; QSF12786.1; -; Genomic_RNA.
EMBL; MW674829; QSF12822.1; -; Genomic_RNA.
EMBL; MW674832; QSF12858.1; -; Genomic_RNA.
EMBL; MW674836; QSF12906.1; -; Genomic_RNA.
EMBL; MW674839; QSF12942.1; -; Genomic_RNA.
EMBL; MW674840; QSF12954.1; -; Genomic_RNA.
EMBL; MW674847; QSF13038.1; -; Genomic_RNA.
EMBL; MW674854; QSF13122.1; -; Genomic_RNA.
EMBL; MW674861; QSF13206.1; -; Genomic_RNA.
EMBL; MW674862; QSF13218.1; -; Genomic_RNA.
EMBL; MW674863; QSF13230.1; -; Genomic_RNA.
EMBL; MW674865; QSF13254.1; -; Genomic_RNA.
EMBL; MW674874; QSF13362.1; -; Genomic_RNA.
EMBL; MW718188; QSS76491.1; -; Genomic_RNA.
EMBL; MW718189; QSS76503.1; -; Genomic_RNA.
EMBL; MW718190; QSS76515.1; -; Genomic_RNA.
EMBL; MW861385; QTM63796.1; -; Genomic_RNA.
EMBL; MW861386; QTM63808.1; -; Genomic_RNA.
EMBL; MW861388; QTM63832.1; -; Genomic_RNA.
EMBL; MW861389; QTM63844.1; -; Genomic_RNA.
EMBL; MW861390; QTM63856.1; -; Genomic_RNA.
EMBL; MW885875; QTP71235.1; -; Genomic_RNA.
EMBL; MW885877; QTP71259.1; -; Genomic_RNA.
EMBL; MW972855; QTZ35043.1; -; Genomic_RNA.
EMBL; MW972861; QTZ35115.1; -; Genomic_RNA.
EMBL; MW972865; QTZ35163.1; -; Genomic_RNA.
EMBL; MW972898; QTZ35559.1; -; Genomic_RNA.
EMBL; MW973413; QTZ41728.1; -; Genomic_RNA.
EMBL; MW973614; QTZ44132.1; -; Genomic_RNA.
EMBL; MW973615; QTZ44144.1; -; Genomic_RNA.
EMBL; MW974512; QTZ54886.1; -; Genomic_RNA.
GO; GO:0005793; C:endoplasmic reticulum-Golgi intermediate compartment; IEA:UniProtKB-SubCell.
GO; GO:0044172; C:host cell endoplasmic reticulum-Golgi intermediate compartment; IEA:UniProtKB-SubCell.
GO; GO:0033644; C:host cell membrane; IEA:UniProtKB-SubCell.
GO; GO:0044220; C:host cell perinuclear region of cytoplasm; IEA:UniProtKB-SubCell.
GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
GO; GO:0005524; F:ATP binding; IEA:UniProtKB-KW.
GO; GO:0004197; F:cysteine-type endopeptidase activity; IEA:InterPro.
GO; GO:0003678; F:DNA helicase activity; IEA:UniProtKB-EC.
GO; GO:0004519; F:endonuclease activity; IEA:UniProtKB-KW.
GO; GO:0004532; F:exoribonuclease activity; IEA:InterPro.
GO; GO:0002151; F:G-quadruplex RNA binding; IEA:InterPro.
GO; GO:0042802; F:identical protein binding; IEA:UniProt.
GO; GO:0008168; F:methyltransferase activity; IEA:UniProtKB-KW.
GO; GO:0003724; F:RNA helicase activity; IEA:UniProtKB-EC.
GO; GO:0003968; F:RNA-directed 5'-3' RNA polymerase activity; IEA:UniProtKB-KW.
GO; GO:0003727; F:single-stranded RNA binding; IEA:InterPro.
GO; GO:0004843; F:thiol-dependent deubiquitinase; IEA:UniProtKB-EC.
GO; GO:0008270; F:zinc ion binding; IEA:InterPro.
GO; GO:0039595; P:induction by virus of catabolism of host mRNA; IEA:UniProtKB-KW.
GO; GO:0039520; P:induction by virus of host autophagy; IEA:UniProtKB-KW.
GO; GO:0032259; P:methylation; IEA:UniProtKB-KW.
GO; GO:0039648; P:modulation by virus of host protein ubiquitination; IEA:UniProtKB-KW.
GO; GO:0039657; P:suppression by virus of host gene expression; IEA:UniProtKB-KW.
GO; GO:0039579; P:suppression by virus of host ISG15-protein conjugation; IEA:UniProtKB-KW.
GO; GO:0039644; P:suppression by virus of host NF-kappaB cascade; IEA:UniProtKB-KW.
GO; GO:0039502; P:suppression by virus of host type I interferon-mediated signaling pathway; IEA:UniProtKB-KW.
GO; GO:0006351; P:transcription, DNA-templated; IEA:InterPro.
GO; GO:0019082; P:viral protein processing; IEA:InterPro.
GO; GO:0039694; P:viral RNA genome replication; IEA:InterPro.
CDD; cd21409; 1B_cv_Nsp13-like; 1.
CDD; cd21560; betaCoV-Nsp6; 1.
CDD; cd21659; betaCoV_Nsp14; 1.
CDD; cd21666; betaCoV_Nsp5_Mpro; 1.
CDD; cd20762; capping_2-OMTase_Nidovirales; 1.
CDD; cd21516; cv_beta_Nsp2_SARS-like; 1.
CDD; cd21473; cv_Nsp4_TM; 1.
CDD; cd21167; M_alpha_beta_cv_Nsp15-like; 1.
CDD; cd21563; Macro_cv_SUD-M_Nsp3-like; 1.
CDD; cd21557; Macro_X_Nsp3-like; 1.
CDD; cd21161; NendoU_cv_Nsp15-like; 1.
CDD; cd21171; NTD_alpha_beta_cv_Nsp15-like; 1.
CDD; cd21591; SARS-CoV-like_RdRp; 1.
CDD; cd21525; SUD_C_SARS-CoV_Nsp3; 1.
CDD; cd21467; Ubl1_cv_Nsp3_N-like; 1.
CDD; cd21466; Ubl2_cv_PLpro_N_Nsp3-like; 1.
CDD; cd21401; ZBD_cv_Nsp13-like; 1.
Gene3D; 1.10.150.420; -; 1.
Gene3D; 1.10.1840.10; -; 1.
Gene3D; 1.10.8.1190; -; 1.
Gene3D; 1.10.8.370; -; 1.
Gene3D; 2.40.10.10; -; 2.
Gene3D; 2.40.10.250; -; 1.
Gene3D; 2.60.120.1680; -; 1.
Gene3D; 3.10.20.350; -; 1.
Gene3D; 3.10.20.540; -; 1.
Gene3D; 3.30.160.820; -; 1.
Gene3D; 3.30.70.3540; -; 1.
Gene3D; 3.40.220.10; -; 1.
Gene3D; 3.40.220.20; -; 1.
Gene3D; 3.40.220.30; -; 1.
Gene3D; 3.40.30.150; -; 1.
Gene3D; 3.40.50.11020; -; 1.
Gene3D; 3.40.50.11580; -; 1.
Gene3D; 3.40.50.300; -; 2.
InterPro; IPR027351; (+)RNA_virus_helicase_core_dom.
InterPro; IPR043608; CoV_NSP15_M.
InterPro; IPR043606; CoV_NSP15_N.
InterPro; IPR043613; CoV_NSP2_C.
InterPro; IPR043611; CoV_NSP3_C.
InterPro; IPR043612; CoV_NSP4_N.
InterPro; IPR043502; DNA/RNA_pol_sf.
InterPro; IPR022733; DPUP_SUD_C_bCoV.
InterPro; IPR037227; EndoU-like.
InterPro; IPR002589; Macro_dom.
InterPro; IPR043472; Macro_dom-like.
InterPro; IPR044371; Macro_X_NSP3-like.
InterPro; IPR042570; NAR_sf.
InterPro; IPR043609; NendoU_nidovirus.
InterPro; IPR044863; NIRAN.
InterPro; IPR036333; NSP10_sf_CoV.
InterPro; IPR044343; NSP13_1B_dom_CoV.
InterPro; IPR027352; NSP13_ZBD_CoV-like.
InterPro; IPR044315; NSP14_betaCoV.
InterPro; IPR009466; NSP14_CoV.
InterPro; IPR044330; NSP15_alpha_betaCoV_N.
InterPro; IPR044322; NSP15_M_alpha_beta_CoV.
InterPro; IPR043174; NSP15_middle_sf.
InterPro; IPR042515; NSP15_N_CoV.
InterPro; IPR044401; NSP15_NendoU_CoV.
InterPro; IPR009461; NSP16_CoV-like.
InterPro; IPR021590; NSP1_bCoV.
InterPro; IPR038030; NSP1_sf_bCoV.
InterPro; IPR043615; NSP2_N_CoV.
InterPro; IPR044389; NSP2_SARS-CoV-like.
InterPro; IPR024375; NSP3_bCoV.
InterPro; IPR024358; NSP3_N_bCoV.
InterPro; IPR032592; NSP3_NAB_bCoV.
InterPro; IPR038166; NSP3_PL2pro_sf_CoV.
InterPro; IPR038400; NSP3_SUD-M_sf_bCoV.
InterPro; IPR044864; NSP3_SUD-N_bCoV.
InterPro; IPR043478; NSP3_SUD-N_sf_bCoV.
InterPro; IPR044357; NSP3_Ubl1_dom_CoV.
InterPro; IPR044353; Nsp3_Ubl2_dom_CoV.
InterPro; IPR038083; NSP3A-like.
InterPro; IPR032505; NSP4_C_CoV.
InterPro; IPR038123; NSP4_C_sf_CoV.
InterPro; IPR044367; NSP6_betaCoV.
InterPro; IPR043610; NSP6_CoV.
InterPro; IPR014828; NSP7_CoV.
InterPro; IPR037204; NSP7_sf_CoV.
InterPro; IPR014829; NSP8_CoV-like.
InterPro; IPR037230; NSP8_sf_CoV.
InterPro; IPR014822; NSP9_CoV.
InterPro; IPR036499; NSP9_sf_CoV.
InterPro; IPR027417; P-loop_NTPase.
InterPro; IPR013016; Peptidase_C16_CoV.
InterPro; IPR008740; Peptidase_C30_CoV.
InterPro; IPR043477; Peptidase_C30_dom3_CoV.
InterPro; IPR009003; Peptidase_S1_PA.
InterPro; IPR043504; Peptidase_S1_PA_chymotrypsin.
InterPro; IPR043177; PLpro_N_sf_CoV.
InterPro; IPR043503; PLpro_palm_finger_dom_CoV.
InterPro; IPR043178; PLpro_thumb_sf_CoV.
InterPro; IPR044351; RdRp_SARS-CoV-like.
InterPro; IPR001205; RNA-dir_pol_C.
InterPro; IPR007094; RNA-dir_pol_PSvirus.
InterPro; IPR009469; RNA_pol_N_coronovir.
InterPro; IPR018995; RNA_synth_NSP10_CoV.
InterPro; IPR029063; SAM-dependent_MTases.
Pfam; PF16251; bCoV_NAR; 1.
Pfam; PF11501; bCoV_NSP1; 1.
Pfam; PF12379; bCoV_NSP3_N; 1.
Pfam; PF12124; bCoV_SUD_C; 1.
Pfam; PF11633; bCoV_SUD_M; 1.
Pfam; PF06471; CoV_ExoN; 1.
Pfam; PF06460; CoV_Methyltr_2; 1.
Pfam; PF09401; CoV_NSP10; 1.
Pfam; PF19215; CoV_NSP15_C; 1.
Pfam; PF19216; CoV_NSP15_M; 1.
Pfam; PF19219; CoV_NSP15_N; 1.
Pfam; PF19212; CoV_NSP2_C; 1.
Pfam; PF19211; CoV_NSP2_N; 1.
Pfam; PF19218; CoV_NSP3_C; 1.
Pfam; PF16348; CoV_NSP4_C; 1.
Pfam; PF19217; CoV_NSP4_N; 1.
Pfam; PF19213; CoV_NSP6; 1.
Pfam; PF08716; CoV_NSP7; 1.
Pfam; PF08717; CoV_NSP8; 1.
Pfam; PF08710; CoV_NSP9; 1.
Pfam; PF08715; CoV_peptidase; 1.
Pfam; PF06478; CoV_RPol_N; 1.
Pfam; PF01661; Macro; 1.
Pfam; PF05409; Peptidase_C30; 1.
Pfam; PF00680; RdRP_1; 1.
Pfam; PF01443; Viral_helicase1; 1.
SMART; SM00506; A1pp; 1.
SUPFAM; SSF101816; SSF101816; 1.
SUPFAM; SSF140367; SSF140367; 1.
SUPFAM; SSF142877; SSF142877; 1.
SUPFAM; SSF143076; SSF143076; 1.
SUPFAM; SSF144246; SSF144246; 1.
SUPFAM; SSF159936; SSF159936; 1.
SUPFAM; SSF160099; SSF160099; 1.
SUPFAM; SSF50494; SSF50494; 1.
SUPFAM; SSF52540; SSF52540; 1.
SUPFAM; SSF52949; SSF52949; 1.
SUPFAM; SSF53335; SSF53335; 1.
SUPFAM; SSF56672; SSF56672; 1.
PROSITE; PS51942; BCOV_NSP3C_C; 1.
PROSITE; PS51941; BCOV_NSP3C_M; 1.
PROSITE; PS51945; BCOV_NSP3E_NAB; 1.
PROSITE; PS51943; COV_NSP3A_UBL; 1.
PROSITE; PS51944; COV_NSP3D_UBL; 1.
PROSITE; PS51946; COV_NSP4C; 1.
PROSITE; PS51653; CV_ZBD; 1.
PROSITE; PS51442; M_PRO; 1.
PROSITE; PS51154; MACRO; 1.
PROSITE; PS51947; NIRAN; 1.
PROSITE; PS51124; PEPTIDASE_C16; 1.
PROSITE; PS51657; PSRV_HELICASE; 1.
PROSITE; PS50507; RDRP_SSRNA_POS; 1.
PROSITE; PS51940; SARS_NSP3C_N; 1.
3: Inferred from homology;
Activation of host autophagy by virus {ECO:0000256|ARBA:ARBA00023050};
ATP-binding {ECO:0000256|ARBA:ARBA00022806};
Decay of host mRNAs by virus {ECO:0000256|ARBA:ARBA00022616};
Endonuclease {ECO:0000256|ARBA:ARBA00022759};
Eukaryotic host gene expression shutoff by virus
{ECO:0000256|ARBA:ARBA00022616, ECO:0000256|ARBA:ARBA00022809};
Eukaryotic host translation shutoff by virus
{ECO:0000256|ARBA:ARBA00022809};
Exonuclease {ECO:0000256|ARBA:ARBA00022839};
Helicase {ECO:0000256|ARBA:ARBA00022806};
Host cytoplasm {ECO:0000256|ARBA:ARBA00023200};
Host gene expression shutoff by virus {ECO:0000256|ARBA:ARBA00022616,
ECO:0000256|ARBA:ARBA00022809};
Host membrane {ECO:0000256|ARBA:ARBA00022870};
Host mRNA suppression by virus {ECO:0000256|ARBA:ARBA00022616};
Host-virus interaction {ECO:0000256|ARBA:ARBA00022616,
ECO:0000256|ARBA:ARBA00022809, ECO:0000256|ARBA:ARBA00022863,
ECO:0000256|ARBA:ARBA00022876, ECO:0000256|ARBA:ARBA00023050,
ECO:0000256|ARBA:ARBA00023208};
Hydrolase {ECO:0000256|ARBA:ARBA00022759, ECO:0000256|ARBA:ARBA00022806,
ECO:0000256|ARBA:ARBA00022807, ECO:0000256|ARBA:ARBA00022839};
Inhibition of host innate immune response by virus
{ECO:0000256|ARBA:ARBA00023208};
Inhibition of host interferon signaling pathway by virus
{ECO:0000256|ARBA:ARBA00023208};
Inhibition of host ISG15 by virus {ECO:0000256|ARBA:ARBA00023208};
Inhibition of host NF-kappa-B by virus {ECO:0000256|ARBA:ARBA00022863};
Lyase {ECO:0000256|ARBA:ARBA00023239};
Membrane {ECO:0000256|ARBA:ARBA00022870, ECO:0000256|ARBA:ARBA00022989,
ECO:0000256|SAM:Phobius};
Metal-binding {ECO:0000256|ARBA:ARBA00022771, ECO:0000256|PROSITE-
ProRule:PRU00986}; Methyltransferase {ECO:0000256|ARBA:ARBA00022603};
Modulation of host ubiquitin pathway by viral deubiquitinase
{ECO:0000256|ARBA:ARBA00022876};
Modulation of host ubiquitin pathway by virus
{ECO:0000256|ARBA:ARBA00022876};
Nuclease {ECO:0000256|ARBA:ARBA00022759, ECO:0000256|ARBA:ARBA00022839};
Nucleotide-binding {ECO:0000256|ARBA:ARBA00022806};
Nucleotidyltransferase {ECO:0000256|ARBA:ARBA00022484};
Protease {ECO:0000256|ARBA:ARBA00022807};
Repeat {ECO:0000256|ARBA:ARBA00022737};
Ribosomal frameshifting {ECO:0000256|ARBA:ARBA00022758};
RNA-binding {ECO:0000256|ARBA:ARBA00022884, ECO:0000256|PROSITE-
ProRule:PRU01289};
RNA-directed RNA polymerase {ECO:0000256|ARBA:ARBA00022484};
Thiol protease {ECO:0000256|ARBA:ARBA00022807};
Transferase {ECO:0000256|ARBA:ARBA00022484, ECO:0000256|ARBA:ARBA00022603};
Transmembrane {ECO:0000256|ARBA:ARBA00022989, ECO:0000256|SAM:Phobius};
Transmembrane helix {ECO:0000256|ARBA:ARBA00022989,
ECO:0000256|SAM:Phobius};
Ubl conjugation pathway {ECO:0000256|ARBA:ARBA00022786};
Viral immunoevasion {ECO:0000256|ARBA:ARBA00023208};
Viral RNA replication {ECO:0000256|ARBA:ARBA00022953};
Zinc {ECO:0000256|ARBA:ARBA00022771, ECO:0000256|PROSITE-ProRule:PRU00986};
Zinc-finger {ECO:0000256|ARBA:ARBA00022771, ECO:0000256|PROSITE-
ProRule:PRU00986}.
TRANSMEM 2229..2253
/note="Helical"
/evidence="ECO:0000256|SAM:Phobius"
TRANSMEM 2328..2351
/note="Helical"
/evidence="ECO:0000256|SAM:Phobius"
TRANSMEM 2363..2387
/note="Helical"
/evidence="ECO:0000256|SAM:Phobius"
TRANSMEM 2773..2790
/note="Helical"
/evidence="ECO:0000256|SAM:Phobius"
TRANSMEM 3043..3065
/note="Helical"
/evidence="ECO:0000256|SAM:Phobius"
TRANSMEM 3077..3098
/note="Helical"
/evidence="ECO:0000256|SAM:Phobius"
TRANSMEM 3104..3124
/note="Helical"
/evidence="ECO:0000256|SAM:Phobius"
TRANSMEM 3136..3154
/note="Helical"
/evidence="ECO:0000256|SAM:Phobius"
TRANSMEM 3582..3605
/note="Helical"
/evidence="ECO:0000256|SAM:Phobius"
TRANSMEM 3611..3629
/note="Helical"
/evidence="ECO:0000256|SAM:Phobius"
TRANSMEM 3636..3657
/note="Helical"
/evidence="ECO:0000256|SAM:Phobius"
TRANSMEM 3683..3701
/note="Helical"
/evidence="ECO:0000256|SAM:Phobius"
TRANSMEM 3731..3755
/note="Helical"
/evidence="ECO:0000256|SAM:Phobius"
TRANSMEM 3767..3789
/note="Helical"
/evidence="ECO:0000256|SAM:Phobius"
DOMAIN 820..929
/note="Ubiquitin-like"
/evidence="ECO:0000259|PROSITE:PS51943"
DOMAIN 1025..1194
/note="Macro"
/evidence="ECO:0000259|PROSITE:PS51154"
DOMAIN 1231..1359
/note="Macro"
/evidence="ECO:0000259|PROSITE:PS51940"
DOMAIN 1367..1494
/note="Macro"
/evidence="ECO:0000259|PROSITE:PS51941"
DOMAIN 1496..1561
/note="DPUP"
/evidence="ECO:0000259|PROSITE:PS51942"
DOMAIN 1565..1620
/note="Ubiquitin-like"
/evidence="ECO:0000259|PROSITE:PS51944"
DOMAIN 1634..1898
/note="Peptidase C16"
/evidence="ECO:0000259|PROSITE:PS51124"
DOMAIN 1911..2021
/note="Nucleic acid-binding"
/evidence="ECO:0000259|PROSITE:PS51945"
DOMAIN 3165..3263
/note="Nsp4C"
/evidence="ECO:0000259|PROSITE:PS51946"
DOMAIN 3264..3569
/note="Peptidase C30"
/evidence="ECO:0000259|PROSITE:PS51442"
DOMAIN 4399..4653
/note="NiRAN"
/evidence="ECO:0000259|PROSITE:PS51947"
DOMAIN 5004..5166
/note="RdRp catalytic"
/evidence="ECO:0000259|PROSITE:PS50507"
DOMAIN 5325..5408
/note="CV ZBD"
/evidence="ECO:0000259|PROSITE:PS51653"
DOMAIN 5581..5932
/note="(+)RNA virus helicase C-terminal"
/evidence="ECO:0000259|PROSITE:PS51657"
REGION 926..999
/note="Disordered"
/evidence="ECO:0000256|SAM:MobiDB-lite"
COMPBIAS 927..947
/note="Acidic residues"
/evidence="ECO:0000256|SAM:MobiDB-lite"
COMPBIAS 984..999
/note="Polar residues"
/evidence="ECO:0000256|SAM:MobiDB-lite"
SEQUENCE 7096 AA; 794074 MW; 6EE9574AB5132B5E CRC64;
MESLVPGFNE KTHVQLSLPV LQVRDVLVRG FGDSVEEVLS EARQHLKDGT CGLVEVEKGV
LPQLEQPYVF IKRSDARTAP HGHVMVELVA ELEGIQYGRS GETLGVLVPH VGEIPVAYRK
VLLRKNGNKG AGGHSYGADL KSFDLGDELG TDPYEDFQEN WNTKHSSGVT RELMRELNGG
AYTRYVDNNF CGPDGYPLEC IKDLLARAGK ASCTLSEQLD FIDTKRGVYC CREHEHEIAW
YTERSEKSYE LQTPFEIKLA KKFDTFNGEC PNFVFPLNSI IKTIQPRVEK KKLDGFMGRI
RSVYPVASPN ECNQMCLSTL MKCDHCGETS WQTGDFVKAT CEFCGTENLT KEGATTCGYL
PQNAVVKIYC PACHNSEVGP EHSLAEYHNE SGLKTILRKG GRTIAFGGCV FSYVGCHNKC
AYWVPRASAN IGCNHTGVVG EGSEGLNDNL LEILQKEKVN INIVGDFKLN EEIAIILASF
SASTSAFVET VKGLDYKAFK QIVESCGNFK VTKGKAKKGA WNIGEQKSIL SPLYAFASEA
ARVVRSIFSR TLETAQNSVR VLQKAAITIL DGISQYSLRL IDAMMFTSDL ATNNLVVMAY
ITGGVVQLTS QWLTNIFGTV YEKLKPVLDW LEEKFKEGVE FLRDGWEIVK FISTCACEIV
GGQIVTCAKE IKESVQTFFK LVNKFLALCA DSIIIGGAKL KALNLGETFV THSKGLYRKC
VKSREETGLL MPLKAPKEII FLEGETLPTE VLTEEVVLKT GDLQPLEQPT SEAVEAPLVG
TPVCINGLML LEIKDTEKYC ALAPNMMVTN NTFTLKGGAP TKVTFGDDTV IEVQGYKSVN
ITFELDERID KVLNEKCSAY TVELGTEVNE FACVVADAVI KTLQPVSELL TPLGIDLDEW
SMATYYLFDE SGEFKLASHM YCSFYPPDED EEEGDCEEEE FEPSTQYEYG TEDDYQGKPL
EFGATSAALQ PEEEQEEDWL DDDSQQTVGQ QDGSEDNQTT TIQTIVEVQP QLEMELTPVV
QTIEVNSFSG YLKLTDNVYI KNADIVEEAK KVKPTVVVNA ANVYLKHGGG VAGALNKATN
NAMQVESDDY IATNGPLKVG GSCVLSGHNL AKHCLHVVGP NVNKGEDIQL LKSAYENFNQ
HEVLLAPLLS AGIFGADPIH SLRVCVDTVR TNVYLAVFDK NLYDKLVSSF LEMKSEKQVE
QKIAEIPKEE VKPFITESKP SVEQRKQDDK KIKACVEEVT TTLEETKFLT ENLLLYIDIN
GNLHPDSATL VSDIDITFLK KDAPYIVGDV VQEGVLTAVV IPTKKAGGTT EMLAKALRKV
PTDNYITTYP GQGLNGYTVE EAKTVLKKCK SAFYILPSII SNEKQEILGT VSWNLREMLA
HAEETRKLMP VCVETKAIVS TIQRKYKGIK IQEGVVDYGA RFYFYTSKTT VASLINTLND
LNETLVTMPL GYVTHGLNLE EAARYMRSLK VPATVSVSSP DAVTAYNGYL TSSSKTPEEH
FIETISLAGS YKDWSYSGQS TQLGIEFLKR GDKSVYYTSN PTTFHLDGEV ITFDNLKTLL
SLREVRTIKV FTTVDNINLH TQVVDMSMTY GQQFGPTYLD GADVTKIKPH NSHEGKTFYV
LPNDDTLRVE AFEYYHTTDP SFLGRYMSAL NHTKKWKYPQ VNGLTSIKWA DNNCYLATAL
LTLQQIELKF NPPALQDAYY RARAGEAANF CALILAYCNK TVGELGDVRE TMSYLFQHAN
LDSCKRVLNV VCKTCGQQQT TLKGVEAVMY MGTLSYEQFK KGVQIPCTCG KQATKYLVQQ
ESPFVMMSAP PAQYELKHGT FTCASEYTGN YQCGHYKHIT SKETLYCIDG ALLTKSSEYK
GPITDVFYKE NSYTTTIKPV TYKLDGVVCT EIDPKLDNYY KKDNSYFTEQ PIDLVPNQPY
PNASFDNFKF VCDNIKFADD LNQLTGYKKP ASRELKVTFF PDLNGDVVAI DYKHYTPSFK
KGAKLLHKPI VWHVNNATNK ATYKPNTWCI RCLWSTKPVE TSNSFDVLKS EDAQGMDNLA
CEDLKPVSEE VVENPTIQKD VLECNVKTTE VVGDIILKPA NNSLKITEEV GHTDLMAAYV
DNSSLTIKKP NELSRVLGLK TLATHGLAAV NSVPWDTIAN YAKPFLNKVV STTTNIVTRC
LNRVCTNYMP YFFTLLLQLC TFTRSTNSRI KASMPTTIAK NTVKSVGKFC LEASFNYLKS
PNFSKLINII IWFLLLSVCL GSLIYSTAAL GVLMSNLGMP SYCTGYREGY LNSTNVTIAT
YCTGSIPCSV CLSGLDSLDT YPSLETIQIT ISSFKWDLTA FGLVAEWFLA YILFTRFFYV
LGLAAIMQLF FSYFAVHFIS NSWLMWLIIN LVQMAPISAM VRMYIFFASF YYVWKSYVHV
VDGCNSSTCM MCYKRNRATR VECTTIVNGV RRSFYVYANG GKGFCKLHNW NCVNCDTFCA
GSTFISDEVA RDLSLQFKRP INPTDQSSYI VDSVTVKNGS IHLYFDKAGQ KTYERHSLSH
FVNLDNLRAN NTKGSLPINV IVFDGKSKCE ESSAKSASVY YSQLMCQPIL LLDQALVSDV
GDSAEVAVKM FDAYVNTFSS TFNVPMEKLK TLVATAEAEL AKNVSLDNVL STFISAARQG
FVDSDVETKD VVECLKLSHQ SDIEVTGDSC NNYMLTYNKV ENMTPRDLGA CIDCSARHIN
AQVAKSHNIA LIWNVKDFMS LSEQLRKQIR SAAKKNNLPF KLTCATTRQV VNVVTTKIAL
KGGKIVNNWL KQLIKVTLVF LFVAAIFYLI TPVHVMSKHT DFSSEIIGYK AIDGGVTRDI
ASTDTCFANK HADFDTWFSQ RGGSYTNDKA CPLIAAVITR EVGFVVPGLP GTILRTTNGD
FLHFLPRVFS AVGNICYTPS KLIEYTDFAT SACVLAAECT IFKDASGKPV PYCYDTNVLE
GSVAYESLRP DTRYVLMDGS IIQFPNTYLE GSVRVVTTFD SEYCRHGTCE RSEAGVCVST
SGRWVLNNDY YRSLPGVFCG VDAVNLLTNM FTPLIQPIGA LDISASIVAG GIVAIVVTCL
AYYFMRFRRA FGEYSHVVAF NTLLFLMSFT VLCLTPVYSF LPGVYSVIYL YLTFYLTNDV
SFLAHIQWMV MFTPLVPFWI TIAYIICIST KHFYWFFSNY LKRRVVFNGV SFSTFEEAAL
CTFLLNKEMY LKLRSDVLLP LTQYNRYLAL YNKYKYFSGA MDTTSYREAA CCHLAKALND
FSNSGSDVLY QPPQTSITSA VLQSGFRKMA FPSGKVEGCM VQVTCGTTTL NGLWLDDVVY
CPRHVICTSE DMLNPNYEDL LIRKSNHNFL VQAGNVQLRV IGHSMQNCVL KLKVDTANPK
TPKYKFVRIQ PGQTFSVLAC YNGSPSGVYQ CAMRPNFTIK GSFLNGSCGS VGFNIDYDCV
SFCYMHHMEL PTGVHAGTDL EGNFYGPFVD RQTAQAAGTD TTITVNVLAW LYAAVINGDR
WFLNRFTTTL NDFNLVAMKY NYEPLTQDHV DILGPLSAQT GIAVLDMCAS LKELLQNGMN
GRTILGSALL EDEFTPFDVV RQCSGVTFQS AVKRTIKGTH HWLLLTILTS LLVLVQSTQW
SLFFFLYENA FLPFAMGIIA MSAFAMMFVK HKHAFLCLFL LPSLATVAYF NMVYMPASWV
MRIMTWLDMV DTSLSGFKLK DCVMYASAVV LLILMTARTV YDDGARRVWT LMNVLTLVYK
VYYGNALDQA ISMWALIISV TSNYSGVVTT VMFLARGIVF MCVEYCPIFF ITGNTLQCIM
LVYCFLGYFC TCYFGLFCLL NRYFRLTLGV YDYLVSTQEF RYMNSQGLLP PKNSIDAFKL
NIKLLGVGGK PCIKVATVQS KMSDVKCTSV VLLSVLQQLR VESSSKLWAQ CVQLHNDILL
AKDTTEAFEK MVSLLSVLLS MQGAVDINKL CEEMLDNRAT LQAIASEFSS LPSYAAFATA
QEAYEQAVAN GDSEVVLKKL KKSLNVAKSE FDRDAAMQRK LEKMADQAMT QMYKQARSED
KRAKVTSAMQ TMLFTMLRKL DNDALNNIIN NARDGCVPLN IIPLTTAAKL MVVIPDYNTY
KNTCDGTTFT YASALWEIQQ VVDADSKIVQ LSEISMDNSP NLAWPLIVTA LRANSAVKLQ
NNELSPVALR QMSCAAGTTQ TACTDDNALA YYNTTKGGRF VLALLSDLQD LKWARFPKSD
GTGTIYTELE PPCRFVTDTP KGPKVKYLYF IKGLNNLNRG MVLGSLAATV RLQAGNATEV
PANSTVLSFC AFAVDAAKAY KDYLASGGQP ITNCVKMLCT HTGTGQAITV TPEANMDQES
FGGASCCLYC RCHIDHPNPK GFCDLKGKYV QIPTTCANDP VGFTLKNTVC TVCGMWKGYG
CSCDQLREPM LQSADAQSFL NRVCGVSAAR LTPCGTGTST DVVYRAFDIY NDKVAGFAKF
LKTNCCRFQE KDEDDNLIDS YFVVKRHTFS NYQHEETIYN LLKDCPAVAK HDFFKFRIDG
DMVPHISRQR LTKYTMADLV YALRHFDEGN CDTLKEILVT YNCCDDDYFN KKDWYDFVEN
PDILRVYANL GERVRQALLK TVQFCDAMRN AGIVGVLTLD NQDLNGNWYD FGDFIQTTPG
SGVPVVDSYY SLLMPILTLT RALTAESHVD TDLTKPYIKW DLLKYDFTEE RLKLFDRYFK
YWDQTYHPNC VNCLDDRCIL HCANFNVLFS TVFPLTSFGP LVRKIFVDGV PFVVSTGYHF
RELGVVHNQD VNLHSSRLSF KELLVYAADP AMHAASGNLL LDKRTTCFSV AALTNNVAFQ
TVKPGNFNKD FYDFAVSKGF FKEGSSVELK HFFFAQDGNA AISDYDYYRY NLPTMCDIRQ
LLFVVEVVDK YFDCYDGGCI NANQVIVNNL DKSAGFPFNK WGKARLYYDS MSYEDQDALF
AYTKRNVIPT ITQMNLKYAI SAKNRARTVA GVSICSTMTN RQFHQKLLKS IAATRGATVV
IGTSKFYGGW HNMLKTVYSD VENPHLMGWD YPKCDRAMPN MLRIMASLVL ARKHTTCCSL
SHRFYRLANE CAQVLSEMVM CGGSLYVKPG GTSSGDATTA YANSVFNICQ AVTANVNALL
STDGNKIADK YVRNLQHRLY ECLYRNRDVD TDFVNEFYAY LRKHFSMMIL SDDAVVCFNS
TYASQGLVAS IKNFKSVLYY QNNVFMSEAK CWTETDLTKG PHEFCSQHTM LVKQGDDYVY
LPYPDPSRIL GAGCFVDDIV KTDGTLMIER FVSLAIDAYP LTKHPNQEYA DVFHLYLQYI
RKLHDELTGH MLDMYSVMLT NDNTSRYWEP EFYEAMYTPH TVLQAVGACV LCNSQTSLRC
GACIRRPFLC CKCCYDHVIS TSHKLVLSVN PYVCNAPGCD VTDVTQLYLG GMSYYCKSHK
PPISFPLCAN GQVFGLYKNT CVGSDNVTDF NAIATCDWTN AGDYILANTC TERLKLFAAE
TLKATEETFK LSYGIATVRE VLSDRELHLS WEVGKPRPPL NRNYVFTGYR VTKNSKVQIG
EYTFEKGDYG DAVVYRGTTT YKLNVGDYFV LTSHTVMPLS APTLVPQEHY VRITGLYPTL
NISDEFSSNV ANYQKVGMQK YSTLQGPPGT GKSHFAIGLA LYYPSARIVY TACSHAAVDA
LCEKALKYLP IDKCSRIIPA RARVECFDKF KVNSTLEQYV FCTVNALPET TADIVVFDEI
SMATNYDLSV VNARLRAKHY VYIGDPAQLP APRTLLTKGT LEPEYFNSVC RLMKTIGPDM
FLGTCRRCPA EIVDTVSALV YDNKLKAHKD KSAQCFKMFY KGVITHDVSS AINRPQIGVV
REFLTRNPAW RKAVFISPYN SQNAVASKIL GLPTQTVDSS QGSEYDYVIF TQTTETAHSC
NVNRFNVAIT RAKVGILCIM SDRDLYDKLQ FTSLEIPRRN VATLQAENVT GLFKDCSKVI
TGLHPTQAPT HLSVDTKFKT EGLCVDIPGI PKDMTYRRLI SMMGFKMNYQ VNGYPNMFIT
REEAIRHVRA WIGFDVEGCH ATREAVGTNL PLQLGFSTGV NLVAVPTGYV DTPNNTDFSR
VSAKPPPGDQ FKHLIPLMYK GLPWNVVRIK IVQMLSDTLK NLSDRVVFVL WAHGFELTSM
KYFVKIGPER TCCLCDRRAT CFSTASDTYA CWHHSIGFDY VYNPFMIDVQ QWGFTGNLQS
NHDLYCQVHG NAHVASCDAI MTRCLAVHEC FVKRVDWTIE YPIIGDELKI NAACRKVQHM
VVKAALLADK FPVLHDIGNP KAIKCVPQAD VEWKFYDAQP CSDKAYKIEE LFYSYATHSD
KFTDGVCLFW NCNVDRYPAN SIVCRFDTRV LSNLNLPGCD GGSLYVNKHA FHTPAFDKSA
FVNLKQLPFF YYSDSPCESH GKQVVSDIDY VPLKSATCIT RCNLGGAVCR HHANEYRLYL
DAYNMMISAG FSLWVYKQFD TYNLWNTFTR LQSLENVAFN VVNKGHFDGQ QGEVPVSIIN
NTVYTKVDGV DVELFENKTT LPVNVAFELW AKRNIKPVPE VKILNNLGVD IAANTVIWDY
KRDAPAHIST IGVCSMTDIA KKPTETICAP LTVFFDGRVD GQVDLFRNAR NGVLITEGSV
KGLQPSVGPK QASLNGVTLI GEAVKTQFNY YKKVDGVVQQ LPETYFTQSR NLQEFKPRSQ
MEIDFLELAM DEFIERYKLE GYAFEHIVYG DFSHSQLGGL HLLIGLAKRF KESPFELEDF
IPMDSTVKNY FITDAQTGSS KCVCSVIDLL LDDFVEIIKS QDLSVVSKVV KVTIDYTEIS
FMLWCKDGHV ETFYPKLQSS QAWQPGVAMP NLYKMQRMLL EKCDLQNYGD SATLPKGIMM
NVAKYTQLCQ YLNTLTLAVP YNMRVIHFGA GSDKGVAPGT AVLRQWLPTG TLLVDSDLND
FVSDADSTLI GDCATVHTAN KWDLIISDMY DPKTKNVTKE NDSKEGFFTY ICGFIQQKLA
LGGSVAIKIT EHSWNADLYK LMGHFAWWTA FVTNVNASSS EAFLIGCNYL GKPREQIDGY
VMHANYIFWR NTNPIQLSSY SLFDMSKFPL KLRGTAVMSL KEGQINDMIL SLLSKGRLII
RENNRVVISS DVLVNN


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Pathways :