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2,3-diketo-5-methylthiopentyl-1-phosphate enolase (DK-MTP-1-P enolase) (EC 5 3 2 5) (RuBisCO-like protein) (RLP)

 MTNW_GEOKA              Reviewed;         413 AA.
Q5L1E2;
08-NOV-2005, integrated into UniProtKB/Swiss-Prot.
01-FEB-2005, sequence version 1.
26-FEB-2020, entry version 100.
RecName: Full=2,3-diketo-5-methylthiopentyl-1-phosphate enolase;
Short=DK-MTP-1-P enolase;
EC=5.3.2.5;
AltName: Full=RuBisCO-like protein;
Short=RLP;
Name=mtnW; OrderedLocusNames=GK0953;
Geobacillus kaustophilus (strain HTA426).
Bacteria; Firmicutes; Bacilli; Bacillales; Bacillaceae; Geobacillus;
Geobacillus thermoleovorans group.
NCBI_TaxID=235909;
[1]
NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
STRAIN=HTA426;
PubMed=15576355; DOI=10.1093/nar/gkh970;
Takami H., Takaki Y., Chee G.-J., Nishi S., Shimamura S., Suzuki H.,
Matsui S., Uchiyama I.;
"Thermoadaptation trait revealed by the genome sequence of thermophilic
Geobacillus kaustophilus.";
Nucleic Acids Res. 32:6292-6303(2004).
[2]
X-RAY CRYSTALLOGRAPHY (1.7 ANGSTROMS) IN COMPLEX WITH SUBSTRATE ANALOG AND
MAGNESIUM IONS, FUNCTION, COFACTOR, SUBUNIT, MUTAGENESIS OF LYS-98; LYS-147
AND LYS-173, AND CARBOXYLATION AT LYS-173.
PubMed=17352497; DOI=10.1021/bi7000483;
Imker H.J., Fedorov A.A., Fedorov E.V., Almo S.C., Gerlt J.A.;
"Mechanistic diversity in the RuBisCO superfamily: the 'enolase' in the
methionine salvage pathway in Geobacillus kaustophilus.";
Biochemistry 46:4077-4089(2007).
-!- FUNCTION: Catalyzes the enolization of 2,3-diketo-5-methylthiopentyl-1-
phosphate (DK-MTP-1-P) into 2-hydroxy-3-keto-5-methylthiopentenyl-1-
phosphate (HK-MTPenyl-1-P). {ECO:0000269|PubMed:17352497}.
-!- CATALYTIC ACTIVITY:
Reaction=5-methylsulfanyl-2,3-dioxopentyl phosphate = 2-hydroxy-5-
methylsulfanyl-3-oxopent-1-enyl phosphate; Xref=Rhea:RHEA:18769,
ChEBI:CHEBI:58828, ChEBI:CHEBI:59505; EC=5.3.2.5;
-!- COFACTOR:
Name=Mg(2+); Xref=ChEBI:CHEBI:18420;
Evidence={ECO:0000269|PubMed:17352497};
Note=Binds 1 Mg(2+) ion per subunit. {ECO:0000269|PubMed:17352497};
-!- PATHWAY: Amino-acid biosynthesis; L-methionine biosynthesis via salvage
pathway; L-methionine from S-methyl-5-thio-alpha-D-ribose 1-phosphate:
step 3/6.
-!- SUBUNIT: Homodimer. {ECO:0000269|PubMed:17352497}.
-!- MISCELLANEOUS: Has no RuBP-carboxylation activity.
-!- SIMILARITY: Belongs to the RuBisCO large chain family. Type IV
subfamily. {ECO:0000305}.
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EMBL; BA000043; BAD75238.1; -; Genomic_DNA.
RefSeq; WP_011230454.1; NC_006510.1.
PDB; 2OEJ; X-ray; 2.55 A; A/B=1-413.
PDB; 2OEK; X-ray; 1.80 A; A/B=1-413.
PDB; 2OEL; X-ray; 1.80 A; A/B=1-413.
PDB; 2OEM; X-ray; 1.70 A; A/B=1-413.
PDBsum; 2OEJ; -.
PDBsum; 2OEK; -.
PDBsum; 2OEL; -.
PDBsum; 2OEM; -.
SMR; Q5L1E2; -.
STRING; 235909.GK0953; -.
DrugBank; DB06881; (1Z)-2-HYDROXY-3-OXOHEX-1-EN-1-YL DIHYDROGEN PHOSPHATE.
PRIDE; Q5L1E2; -.
EnsemblBacteria; BAD75238; BAD75238; GK0953.
KEGG; gka:GK0953; -.
PATRIC; fig|235909.7.peg.1041; -.
eggNOG; ENOG4105DT1; Bacteria.
eggNOG; COG1850; LUCA.
HOGENOM; CLU_031450_3_1_9; -.
KO; K08965; -.
OMA; IHGHPDG; -.
BRENDA; 5.3.2.5; 8138.
UniPathway; UPA00904; UER00876.
EvolutionaryTrace; Q5L1E2; -.
Proteomes; UP000001172; Chromosome.
GO; GO:0043715; F:2,3-diketo-5-methylthiopentyl-1-phosphate enolase activity; IEA:UniProtKB-UniRule.
GO; GO:0000287; F:magnesium ion binding; IEA:UniProtKB-UniRule.
GO; GO:0016984; F:ribulose-bisphosphate carboxylase activity; IEA:InterPro.
GO; GO:0015977; P:carbon fixation; IEA:InterPro.
GO; GO:0019509; P:L-methionine salvage from methylthioadenosine; IEA:UniProtKB-UniPathway.
GO; GO:0019284; P:L-methionine salvage from S-adenosylmethionine; IEA:UniProtKB-UniRule.
CDD; cd08209; RLP_DK-MTP-1-P-enolase; 1.
Gene3D; 3.20.20.110; -; 1.
Gene3D; 3.30.70.150; -; 1.
HAMAP; MF_01679; Salvage_MtnW; 1.
InterPro; IPR017717; Diketo-Methiopentyl-P_enolase.
InterPro; IPR033966; RuBisCO.
InterPro; IPR000685; RuBisCO_lsu_C.
InterPro; IPR036376; RuBisCO_lsu_C_sf.
InterPro; IPR017443; RuBisCO_lsu_fd_N.
InterPro; IPR036422; RuBisCO_lsu_N_sf.
PANTHER; PTHR42704; PTHR42704; 1.
Pfam; PF00016; RuBisCO_large; 1.
Pfam; PF02788; RuBisCO_large_N; 1.
SFLD; SFLDF00157; 2_3-diketo-5-methylthiopentyl-; 1.
SUPFAM; SSF51649; SSF51649; 1.
SUPFAM; SSF54966; SSF54966; 1.
TIGRFAMs; TIGR03332; salvage_mtnW; 1.
1: Evidence at protein level;
3D-structure; Amino-acid biosynthesis; Isomerase; Magnesium; Metal-binding;
Methionine biosynthesis; Reference proteome.
CHAIN 1..413
/note="2,3-diketo-5-methylthiopentyl-1-phosphate enolase"
/id="PRO_0000062694"
REGION 173..176
/note="Substrate binding"
REGION 359..360
/note="Substrate binding"
ACT_SITE 98
/note="Proton acceptor"
METAL 173
/note="Magnesium; via carbamate group"
METAL 175
/note="Magnesium"
METAL 176
/note="Magnesium"
BINDING 147
/note="Substrate"
BINDING 264
/note="Substrate"
BINDING 337
/note="Substrate; via amide nitrogen"
MOD_RES 173
/note="N6-carboxylysine"
/evidence="ECO:0000269|PubMed:17352497"
MUTAGEN 98
/note="K->A: Loss of enolase activity."
/evidence="ECO:0000269|PubMed:17352497"
MUTAGEN 147
/note="K->A: Same activity as the wild-type."
/evidence="ECO:0000269|PubMed:17352497"
MUTAGEN 173
/note="K->A: Same activity as the wild-type."
/evidence="ECO:0000269|PubMed:17352497"
STRAND 3..14
/evidence="ECO:0000244|PDB:2OEM"
HELIX 16..26
/evidence="ECO:0000244|PDB:2OEM"
TURN 27..29
/evidence="ECO:0000244|PDB:2OEM"
HELIX 37..43
/evidence="ECO:0000244|PDB:2OEM"
HELIX 44..46
/evidence="ECO:0000244|PDB:2OEM"
STRAND 49..55
/evidence="ECO:0000244|PDB:2OEM"
HELIX 60..66
/evidence="ECO:0000244|PDB:2OEM"
STRAND 71..80
/evidence="ECO:0000244|PDB:2OEM"
HELIX 81..83
/evidence="ECO:0000244|PDB:2OEM"
HELIX 88..96
/evidence="ECO:0000244|PDB:2OEM"
HELIX 98..101
/evidence="ECO:0000244|PDB:2OEM"
STRAND 102..111
/evidence="ECO:0000244|PDB:2OEM"
HELIX 114..117
/evidence="ECO:0000244|PDB:2OEM"
HELIX 126..134
/evidence="ECO:0000244|PDB:2OEM"
STRAND 141..145
/evidence="ECO:0000244|PDB:2OEM"
HELIX 154..166
/evidence="ECO:0000244|PDB:2OEM"
STRAND 170..173
/evidence="ECO:0000244|PDB:2OEM"
STRAND 182..184
/evidence="ECO:0000244|PDB:2OEM"
HELIX 186..204
/evidence="ECO:0000244|PDB:2OEM"
STRAND 209..213
/evidence="ECO:0000244|PDB:2OEM"
HELIX 218..220
/evidence="ECO:0000244|PDB:2OEM"
HELIX 221..230
/evidence="ECO:0000244|PDB:2OEM"
STRAND 234..238
/evidence="ECO:0000244|PDB:2OEM"
HELIX 240..242
/evidence="ECO:0000244|PDB:2OEM"
HELIX 245..253
/evidence="ECO:0000244|PDB:2OEM"
TURN 255..257
/evidence="ECO:0000244|PDB:2OEM"
STRAND 261..263
/evidence="ECO:0000244|PDB:2OEM"
HELIX 268..270
/evidence="ECO:0000244|PDB:2OEM"
STRAND 275..279
/evidence="ECO:0000244|PDB:2OEM"
HELIX 281..284
/evidence="ECO:0000244|PDB:2OEM"
HELIX 287..292
/evidence="ECO:0000244|PDB:2OEM"
STRAND 295..300
/evidence="ECO:0000244|PDB:2OEM"
STRAND 302..306
/evidence="ECO:0000244|PDB:2OEM"
HELIX 310..321
/evidence="ECO:0000244|PDB:2OEM"
STRAND 325..327
/evidence="ECO:0000244|PDB:2OEM"
STRAND 331..337
/evidence="ECO:0000244|PDB:2OEM"
HELIX 340..342
/evidence="ECO:0000244|PDB:2OEM"
HELIX 343..350
/evidence="ECO:0000244|PDB:2OEM"
STRAND 352..359
/evidence="ECO:0000244|PDB:2OEM"
HELIX 360..363
/evidence="ECO:0000244|PDB:2OEM"
HELIX 368..385
/evidence="ECO:0000244|PDB:2OEM"
HELIX 389..393
/evidence="ECO:0000244|PDB:2OEM"
HELIX 397..406
/evidence="ECO:0000244|PDB:2OEM"
SEQUENCE 413 AA; 44906 MW; 560DBEA2E17E0310 CRC64;
MSAVMATYLL HDETDIRKKA EGIALGLTIG TWTDLPALEQ EQLRKHKGEV VAIEELGESE
RVNAYFGKRL KRAIVKIAYP TVNFSADLPA LLVTTFGKLS LDGEVRLLDL EFPDEWKRQF
PGPRFGIDGI RDRVGVHNRP LLMSIFKGMI GRDLAYLTSE LKKQALGGVD LVKDDEILFD
SELLPFEKRI TEGKAALQEV YEQTGKRTLY AVNLTGKTFA LKDKAKRAAE LGADVLLFNV
FAYGLDVLQA LREDEEIAVP IMAHPAFSGA VTPSEFYGVA PSLWLGKLLR LAGADFVLFP
SPYGSVALER EQALGIARAL TDDQEPFARA FPVPSAGIHP GLVPLIIRDF GLDTIVNAGG
GIHGHPDGAI GGGRAFRAAI DAVLAGRPLR AAAAENEALQ KAIDRWGVVE VEA


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[mtnW C3744_11765] 2,3-diketo-5-methylthiopentyl-1-phosphate enolase (DK-MTP-1-P enolase) (EC 5.3.2.5) (RuBisCO-like protein) (RLP)
[] Genome polyprotein [Cleaved into: Capsid protein C (Capsid protein) (Core protein); Protein prM (Precursor membrane protein); Peptide pr (Peptide precursor); Small envelope protein M (Matrix protein); Envelope protein E; Non-structural protein 1 (NS1); Non-structural protein 2A (NS2A); Serine protease subunit NS2B (Flavivirin protease NS2B regulatory subunit) (Non-structural protein 2B); Serine protease NS3 (EC 3.4.21.91) (EC 3.6.1.15) (EC 3.6.4.13) (Flavivirin protease NS3 catalytic subunit) (Non-structural protein 3); Non-structural protein 4A (NS4A); Peptide 2k; Non-structural protein 4B (NS4B); RNA-directed RNA polymerase NS5 (EC 2.1.1.56) (EC 2.1.1.57) (EC 2.7.7.48) (Non-structural protein 5)]
[yjeF nnrD nnrE A6V01_16625 AC789_1c45800 ACN002_4392 AW106_17115 BB545_04070 BN17_41441 BOH76_10905 BON72_19710 BON76_04155 BON95_14955 BTQ06_07255 BVL39_04290 C5N07_07145 C6669_06565 C7235_22665 C7B02_22745 C9162_14280 C9306_16010 C9Z28_08925 C9Z37_19300 C9Z69_17100 C9Z89_19770 CA593_04975 COD30_21525 CR538_23135 CRD98_04165 CRM83_17370 D0X26_12915 D2184_07750 D6T60_21965 D9J44_09440 D9K48_15185 DAH18_07435 DAH32_17635 DBQ99_23525 DEN97_13975 DEO19_11825 DIV22_15595 DL800_29085 DP277_02605 DQF57_15735 DS732_02620 E5S35_05440 ED600_08260 EHH55_18965 EJC75_20595 EKI52_12685 EYD11_20595 EYY78_08665 F1E03_05325 F7F23_18595 FQ915_09945] Bifunctional NAD(P)H-hydrate repair enzyme (Nicotinamide nucleotide repair protein) [Includes: ADP-dependent (S)-NAD(P)H-hydrate dehydratase (EC 4.2.1.136) (ADP-dependent NAD(P)HX dehydratase); NAD(P)H-hydrate epimerase (EC 5.1.99.6)]
[hmpA hmp A6V01_10200 A8C65_03855 A9R57_17040 ACN002_2592 ACN68_11055 ACN81_26320 ACU57_10360 ACU90_01485 AM270_07210 AM464_04560 AML07_10430 APZ14_05505 AUQ13_13215 AUS26_21665 AW106_11070 BANRA_01097 BANRA_03418 BANRA_04525 BB545_05760 BHS81_15570 BHS87_14445 BJJ90_06510 BK292_20760 BMT91_09730 BN17_18391 BOH76_09290 BON63_10755 BON69_13990 BON71_13675 BON75_17540 BUE81_08005 BvCms12BK_01774 BvCms2454_04468 BvCmsHHP001_04806 BvCmsHHP019_04806 BvCmsHHP056_01828 BvCmsKSP026_04305 BvCmsNSP072_00267 BvCmsOUP014_02948 BvCmsSIP019_03821 BvCmsSIP044_05092 BVL39_14050 BW690_11150 BZL31_13550 C2U48_21325 C5N07_10115 C5P01_05560 C7235_06805 C9098_02900 C9114_06110 C9141_01855 C9160_04920 C9182_05955 C9201_01350 C9306_06605 C9E25_16695 C9Z03_13455 C9Z37_03155 C9Z39_18350 C9Z89_02035 CI641_005655 CI694_19335 COD30_01045 COD46_11500 CRM83_27495 CWS33_10010 D2184_18725 D2185_06690 D3821_11445 D3O91_03570 D3Y67_23905 D9H68_00985 D9I18_09865 D9I97_07905 D9J11_04290 D9J44_00060 D9K48_25840 DAH18_00220 DAH32_12610 DAH34_18605 DAH37_19275 DEN89_09990 DEO04_07795 DIV22_11300 DJ503_18890 DL545_07245 DL800_19195 DP277_03620 DTL43_01910 DXT69_13075 DXT71_19935 E0I42_02095 E0J34_17430 E0K84_11045 E2119_10050 E2127_03890 E2128_10370 E2129_06190 E2134_09855 E2135_00930 E2855_03303 E2863_03210 E5P22_05385 E5P28_04540 E5S35_08630 E5S47_00200 EAI42_06330 EC1094V2_1116 EC3234A_44c01590 EC95NR1_01777 ECTO6_01279 ED600_07770 EEP23_02350 EHH55_21860 EKI52_21980 ELT20_16535 ELV08_03290 EPT01_18845 ERS085365_01518 ERS085374_00038 ERS085416_03760 ERS139211_00868 ERS150873_01392 ERS150876_00857 EXX71_04790 EXX78_07615 EYD11_06210 EYY78_04395 F0312_14660 F1E19_02170 F7F23_03720 FORC82_1263 FQR64_06320 FRV13_24300 FV293_03855 FWK02_18305 HmCms184_00603 HmCmsJML079_04829 HW43_17160 NCTC11022_02631 NCTC11181_03552 NCTC13148_02382 NCTC8500_01411 NCTC8960_04037 NCTC8985_06124 NCTC9036_01390 NCTC9058_00631 NCTC9062_01812 NCTC9073_04581 NCTC9706_04593 NCTC9962_00729 PGD_00684 PU06_05410 RG28_09110 RK56_022045 SAMEA3472043_01058 SAMEA3472044_03009 SAMEA3472070_00042 SAMEA3472080_01630 SAMEA3484427_00463 SAMEA3484429_00572 SAMEA3752553_02327 SAMEA3752557_00946 SAMEA3753097_02775 SK85_02808 WQ89_05840] Flavohemoprotein (Flavohemoglobin) (Hemoglobin-like protein) (Nitric oxide dioxygenase) (NO oxygenase) (NOD) (EC 1.14.12.17)
[] Protein VP3 [Includes: 2',5'-phosphodiesterase (EC 3.1.4.-); mRNA guanylyltransferase (EC 2.7.7.50); mRNA (guanine-N(7)-)-methyltransferase (EC 2.1.1.56)]
[hchA A9819_11910 ACN81_03425 AML35_08765 AW059_23935 BANRA_00208 BANRA_00433 BANRA_02614 BHF46_18455 BMT91_24760 BON76_21885 BvCmsC61A_00149 BvCmsKSNP120_04693 BvCmsKSP026_03873 BvCmsKSP076_04891 C7B08_25495 C9Z39_20510 CR538_10415 D3Y67_22910 D9G42_11130 D9I97_22010 D9J11_25195 DJ503_24045 DP258_02540 E3B71_05970 EC3234A_36c00010 EC382_21100 ECTO6_01955 EHH55_07135 FORC82_1921 FV293_07100 NCTC8500_02249 NCTC9117_02637 NCTC9969_02156 SAMEA3472108_01151 SAMEA3484427_04795 SAMEA3484429_02051 SAMEA3752557_05476 SAMEA3752559_04333] Protein/nucleic acid deglycase HchA (EC 3.1.2.-) (EC 3.5.1.124) (Maillard deglycase)
[Eno3 Eno-3] Beta-enolase (EC 4.2.1.11) (2-phospho-D-glycerate hydro-lyase) (Enolase 3) (Muscle-specific enolase) (MSE) (Skeletal muscle enolase)
[1a] Replicase polyprotein 1a (pp1a) (ORF1a polyprotein) [Cleaved into: Non-structural protein 1 (nsp1) (p28); Non-structural protein 2 (nsp2) (p65); Non-structural protein 3 (nsp3) (EC 3.4.19.12) (EC 3.4.22.69) (PL1-PRO/PL2-PRO) (PL1/PL2) (Papain-like proteinases 1/2) (p210); Non-structural protein 4 (nsp4) (Peptide HD2) (p44); 3C-like proteinase (3CL-PRO) (3CLp) (EC 3.4.22.-) (M-PRO) (nsp5) (p27); Non-structural protein 6 (nsp6); Non-structural protein 7 (nsp7) (p10); Non-structural protein 8 (nsp8) (p22); Non-structural protein 9 (nsp9) (p12); Non-structural protein 10 (nsp10) (Growth factor-like peptide) (GFL) (p15); Non-structural protein 11 (nsp11)]
[1a] Replicase polyprotein 1a (pp1a) (ORF1a polyprotein) [Cleaved into: Non-structural protein 1 (nsp1) (Leader protein); Non-structural protein 2 (nsp2) (p65 homolog); Non-structural protein 3 (nsp3) (EC 3.4.19.12) (EC 3.4.22.69) (PL2-PRO) (Papain-like proteinase) (PL-PRO) (SARS coronavirus main proteinase); Non-structural protein 4 (nsp4); 3C-like proteinase (3CL-PRO) (3CLp) (EC 3.4.22.-) (nsp5); Non-structural protein 6 (nsp6); Non-structural protein 7 (nsp7); Non-structural protein 8 (nsp8); Non-structural protein 9 (nsp9); Non-structural protein 10 (nsp10) (Growth factor-like peptide) (GFL); Non-structural protein 11 (nsp11)]
[utr4 NCU06228] Enolase-phosphatase E1 (EC 3.1.3.77) (2,3-diketo-5-methylthio-1-phosphopentane phosphatase)
[NHL3 At5g06320 MHF15.16] NDR1/HIN1-like protein 3
[] Probable bifunctional methylthioribulose-1-phosphate dehydratase/enolase-phosphatase E1 [Includes: Methylthioribulose-1-phosphate dehydratase (MTRu-1-P dehydratase) (EC 4.2.1.109); Enolase-phosphatase E1 (EC 3.1.3.77) (2,3-diketo-5-methylthio-1-phosphopentane phosphatase)]
[Eno1 Eno-1] Alpha-enolase (EC 4.2.1.11) (2-phospho-D-glycerate hydro-lyase) (Enolase 1) (Non-neural enolase) (NNE)
[1a] Replicase polyprotein 1a (pp1a) (ORF1a polyprotein) [Cleaved into: Non-structural protein 1 (nsp1) (Leader protein); Non-structural protein 2 (nsp2) (p65 homolog); Non-structural protein 3 (nsp3) (EC 3.4.19.12) (EC 3.4.22.69) (PL2-PRO) (Papain-like proteinase) (PL-PRO); Non-structural protein 4 (nsp4); 3C-like proteinase (3CL-PRO) (3CLp) (EC 3.4.22.-) (nsp5); Non-structural protein 6 (nsp6); Non-structural protein 7 (nsp7); Non-structural protein 8 (nsp8); Non-structural protein 9 (nsp9); Non-structural protein 10 (nsp10) (Growth factor-like peptide) (GFL); Non-structural protein 11 (nsp11)]
[hchA BTQ06_22200 BvCmsKSNP073_00121 BvCmsKSNP081_01198 BvCmsSIP019_01881 C9098_21280 C9182_07595 C9Z03_04330 C9Z69_21385 DEN97_23425 DEO19_24275 DQO13_23265 F1E03_20105 F1E13_00185 RG28_12135] Protein/nucleic acid deglycase HchA (EC 3.1.2.-) (EC 3.5.1.124) (Maillard deglycase)
[gag-pol] Gag-Pol polyprotein (Pr160Gag-Pol) [Cleaved into: Matrix protein p17 (MA); Capsid protein p24 (CA); Spacer peptide 1 (SP1) (p2); Nucleocapsid protein p7 (NC); Transframe peptide (TF); p6-pol (p6*); Protease (EC 3.4.23.16) (PR) (Retropepsin); Reverse transcriptase/ribonuclease H (EC 2.7.7.49) (EC 2.7.7.7) (EC 3.1.26.13) (Exoribonuclease H) (EC 3.1.13.2) (p66 RT); p51 RT; p15; Integrase (IN) (EC 2.7.7.-) (EC 3.1.-.-)]
[] Genome polyprotein [Cleaved into: Core protein p21 (Capsid protein C) (p21); Core protein p19; Envelope glycoprotein E1 (gp32) (gp35); Envelope glycoprotein E2 (NS1) (gp68) (gp70); p7; Protease NS2-3 (p23) (EC 3.4.22.-); Serine protease NS3 (EC 3.4.21.98) (EC 3.6.1.15) (EC 3.6.4.13) (Hepacivirin) (NS3P) (p70); Non-structural protein 4A (NS4A) (p8); Non-structural protein 4B (NS4B) (p27); Non-structural protein 5A (NS5A) (p56); RNA-directed RNA polymerase (EC 2.7.7.48) (NS5B) (p68)]
[] Genome polyprotein [Cleaved into: Core protein p21 (Capsid protein C) (p21); Core protein p19; Envelope glycoprotein E1 (gp32) (gp35); Envelope glycoprotein E2 (NS1) (gp68) (gp70); p7; Protease NS2-3 (p23) (EC 3.4.22.-); Serine protease NS3 (EC 3.4.21.98) (EC 3.6.1.15) (EC 3.6.4.13) (Hepacivirin) (NS3P) (p70); Non-structural protein 4A (NS4A) (p8); Non-structural protein 4B (NS4B) (p27); Non-structural protein 5A (NS5A) (p56); RNA-directed RNA polymerase (EC 2.7.7.48) (NS5B) (p68)]
[pyrG A6592_02570 A6V01_01290 A8M42_16405 A9R57_06965 AC067_22330 AC789_1c31020 ACN002_2797 ACN68_00955 ACN81_20385 ACU57_24415 ACU90_23015 AJ318_22735 AKG99_03555 AM270_00945 AM446_06950 AM464_05605 AM465_10605 AML07_12460 AML35_05300 APT94_17890 APU18_18535 APZ14_09290 ARC77_10140 AU473_08010 AUQ13_17535 AUS26_15660 AW059_10675 AW106_00665 AWE53_025360 AWF59_014510 AWG78_018325 AWP75_20610 AZZ83_003241 B6V57_15035 B7C53_10055 B9M99_21725 B9N33_09475 B9T59_19685 BANRA_01301 BANRA_03509 BANRA_03630 BANRA_04324 BB545_13920 BE963_03670 BEN53_16995 BFD68_17190 BHF46_05050 BHS81_16640 BHS87_15735 BIQ87_15835 BIU72_09520 BIZ41_16885 BJJ90_05265 BK248_12970 BK292_23205 BK334_11935 BK373_15870 BK375_10085 BK383_11680 BMT49_17330 BMT91_11105 BN17_26661 BOH76_24715 BON63_19880 BON65_10470 BON66_19055 BON69_14990 BON71_18475 BON75_14060 BON76_10430 BON83_26590 BON86_03420 BON87_20865 BON91_20235 BON92_09140 BON96_25385 BTQ04_11510 BTQ06_23845 BUE81_06975 BvCms12BK_05148 BvCms2454_02052 BvCms35BK_01272 BvCmsC61A_01055 BvCmsHHP001_01156 BvCmsHHP019_01127 BvCmsHHP056_01979 BvCmsKKP036_03980 BvCmsKKP061_04391 BvCmsKSNP073_04203 BvCmsKSNP081_03790 BvCmsKSNP120_03969 BvCmsKSP011_02434 BvCmsKSP024_03358 BvCmsKSP026_00102 BvCmsKSP045_02208 BvCmsKSP058_00862 BvCmsKSP067_03640 BvCmsKSP076_05173 BvCmsNSNP036_03047 BvCmsNSP007_01096 BvCmsNSP047_01557 BvCmsNSP072_00181 BvCmsOUP014_01917 BvCmsSINP011_00512 BvCmsSINP022_00781 BvCmsSIP019_01766 BvCmsSIP044_01614 BVL39_12970 BW690_04975 BWI89_25410 BWP17_05185 BXT93_24405 BZL31_00820 BZL69_02125 C2M16_17770 C2U48_20025 C4K41_05275 C4M78_00835 C5715_23540 C5N07_06155 C5P01_05005 C5P44_09340 C6669_14670 C6B13_03370 C7235_05745 C7B02_19400 C7B06_11630 C7B07_14530 C7B08_01430 C7B18_14945 C9098_13720 C9114_10610 C9141_08815 C9160_11785 C9162_15350 C9182_00370 C9201_02025 C9306_10515 C9E25_03325 C9E67_05815 C9Z03_03520 C9Z23_09225 C9Z37_12455 C9Z39_03205 C9Z43_07790 C9Z69_03200 C9Z70_05405 C9Z78_15545 C9Z89_02595 CA593_12975 CCZ14_04445 CCZ17_10850 CDC27_14650 CDL37_13440 CG692_07005 CI641_006865 CI694_13655 COD30_01795 COD46_07095 CQP61_06810 CR538_05495 CR539_18815 CRE06_03485 CRM83_26360 CRT43_16405 CRX46_18850 CSB64_15850 CT143_09630 CT146_00680 CUB99_19065 CV83915_03339 CVH05_06295 CWM24_00790 CWS33_03125 D0X26_06660 D2184_01135 D2185_02785 D2188_08435 D3821_11140 D3O91_13425 D3P01_10795 D3Y67_06430 D4M06_10805 D6T60_21710 D7K63_03745 D7K66_09735 D7Y10_03025 D9D20_04450 D9D33_19300 D9D43_17525 D9E35_20180 D9F17_11720 D9G11_05335 D9G42_05640 D9G48_11875 D9H53_12755 D9H68_17340 D9H70_12195 D9H94_16855 D9I18_10690 D9I20_00375 D9I87_07250 D9I88_14405 D9I97_09750 D9J03_22055 D9J11_17735 D9J44_16360 D9J46_14445 D9J60_10045 D9K48_23835 D9K54_13555 D9L89_10810 D9L99_02095 D9X97_06540 DAH18_08260 DAH26_03580 DAH30_04675 DAH32_02015 DAH34_11000 DAH37_01335 DAH43_05325 DB359_08835 DBQ99_06250 DD762_13665 DEN89_06185 DEN97_03935 DEO04_02940 DEO19_03715 DIV22_29760 DJ487_00440 DJ492_07250 DJ503_09945 DL455_11645 DL545_05995 DL800_20505 DM102_10625 DM129_10705 DMI04_14240 DNB37_12630 DNR41_08670 DNX30_08935 DOY56_02000 DP258_16075 DP277_11440 DQE83_04685 DQO13_13250 DS732_20695 DS966_06010 DTL43_09355 DTL90_02675 DTM10_03745 DTM45_13530 DU321_06150 DU333_12515 DW236_13020 DWB25_05920 DXT69_20555 DXT71_17355 DXT73_08070 DXX80_007370 E0I42_10500 E0J34_05310 E0K84_20120 E0L04_10915 E0L12_01040 E2112_20720 E2115_08690 E2116_15025 E2119_13595 E2127_11355 E2128_06395 E2129_11320 E2134_08140 E2135_07675 E2148_10650 E2855_03617 E2863_03463 E3B71_10195 E5P22_15685 E5P28_02240 E5P37_16160 E5S35_16655 E5S46_13510 E5S47_04995 E5S58_00660 E5S61_16625 EA834_09100 EAI42_07155 EAI46_14335 EAI52_12500 EB509_19080 EB510_16355 EB515_03490 EC1094V2_904 EC3234A_48c00890 EC3426_03921 EC382_15705 EC95NR1_02021 ECONIH1_15890 ECs3640 ECTO124_01152 ECTO6_01068 ED225_00710 ED600_14885 ED607_09825 ED611_00710 ED648_01520 ED903_09700 ED944_03505 EEA45_12675 EEP23_14050 EF173_03685 EGT48_09620 EHH55_20810 EIA08_07275 EIA21_04795 EJC75_12775 EKI52_20580 EL75_0914 EL79_0915 EL80_0918 ELT20_14390 ELT23_08310 ELT33_11340 ELT34_08915 ELT49_03005 ELT58_07520 ELU82_04890 ELU96_10810 ELV08_21905 ELV13_07545 ELV26_19460 ELV28_16420 ELV32_09970 ELX83_17325 EO241_20205 EPS91_16285 EPS94_11415 EPT01_17055 EQ820_17285 EQ823_14605 EQ825_07980 EQ830_01100 ERL57_14345 ERS085365_02427 ERS085366_03042 ERS085374_03279 ERS085386_03410 ERS085416_02898 ERS139211_02072 ERS150873_02003 ERS150876_01467 EVY14_17325 EWK56_05345 ExPECSC038_01963 ExPECSC065_01289 EXX06_06960 EXX13_05855 EXX23_03700 EXX24_19085 EXX53_03685 EXX55_06445 EXX71_16235 EXX78_11575 EXX87_15385 EYD11_05205 EYX82_06265 EYX99_17285 EYY27_21685 EYY34_09650 EYY78_11015 F0312_15020 F1E03_07420 F1E13_12850 F1E19_13585 F7F11_01115 F7F23_00665 F7G03_02700 FAF34_010195 FKO60_03565 FNJ67_06370 FNJ69_12285 FNJ79_10590 FNJ83_17875 FORC82_1067 FQR64_05280 FQU83_07080 FRV13_23300 FTV93_23860 FV293_15850 FV295_08510 FV438_15285 FY127_14515 GJ11_18025 HmCms184_04776 HmCmsJML074_04422 HmCmsJML079_03779 HmCmsJML146_01816 HmCmsJML204_00525 HMPREF3040_01161 HW43_18180 MJ49_17095 MS6198_30910 MS8345_02965 NCTC10082_03473 NCTC10090_04050 NCTC10418_01701 NCTC10764_00296 NCTC10766_00690 NCTC10767_02309 NCTC11022_02860 NCTC11112_00121 NCTC11181_03277 NCTC12950_01251 NCTC13127_01436 NCTC13846_01212 NCTC7927_01209 NCTC8500_01090 NCTC8960_03783 NCTC9007_03892 NCTC9036_01135 NCTC9044_00576 NCTC9045_01221 NCTC9050_04166 NCTC9058_00847 NCTC9062_02131 NCTC9075_01630 NCTC9077_01409 NCTC9081_05851 NCTC9117_01609 NCTC9119_01271 NCTC9434_01004 NCTC9702_01298 NCTC9706_03296 NCTC9777_02704 NCTC9969_01292 PGD_04325 PU06_02080 RG28_07675 RK56_023165 SAMEA3472043_01265 SAMEA3472044_02272 SAMEA3472047_00339 SAMEA3472056_05455 SAMEA3472070_01673 SAMEA3472080_03155 SAMEA3472090_00131 SAMEA3472108_00527 SAMEA3472110_03462 SAMEA3472112_03722 SAMEA3472114_02432 SAMEA3472147_03296 SAMEA3484427_03298 SAMEA3484429_03415 SAMEA3484434_01581 SAMEA3485101_02257 SAMEA3485113_02257 SAMEA3752372_03639 SAMEA3752553_01510 SAMEA3752557_03040 SAMEA3752559_02995 SAMEA3752620_01282 SAMEA3753064_02287 SAMEA3753097_02219 SAMEA3753164_01192 SAMEA3753290_02847 SAMEA3753300_01107 SK85_03024 SY51_15605 U12A_02895 U14A_02898 UC41_20365 UN91_03645 WQ89_10170 WR15_06090 YDC107_1339] CTP synthase (EC 6.3.4.2) (Cytidine 5'-triphosphate synthase) (Cytidine triphosphate synthetase) (CTP synthetase) (CTPS) (UTP--ammonia ligase)
[] Genome polyprotein [Cleaved into: P1; Capsid protein VP0 (VP4-VP2); Capsid protein VP4 (P1A) (Virion protein 4); Capsid protein VP2 (P1B) (Virion protein 2); Capsid protein VP3 (P1C) (Virion protein 3); Capsid protein VP1 (P1D) (Virion protein 1); P2; Protease 2A (P2A) (EC 3.4.22.29) (Picornain 2A) (Protein 2A); Protein 2B (P2B); Protein 2C (P2C) (EC 3.6.1.15); P3; Protein 3AB; Protein 3A (P3A); Viral protein genome-linked (VPg) (Protein 3B) (P3B); Protein 3CD (EC 3.4.22.28); Protease 3C (EC 3.4.22.28) (Picornain 3C) (P3C); RNA-directed RNA polymerase (RdRp) (EC 2.7.7.48) (3D polymerase) (3Dpol) (Protein 3D) (3D)]
[L] Large structural protein (Protein L) (Replicase) (Transcriptase) [Includes: RNA-directed RNA polymerase (EC 2.7.7.48); mRNA (guanine-N(7)-)-methyltransferase (EC 2.1.1.56); GDP polyribonucleotidyltransferase (EC 2.7.7.88); Cap-specific mRNA (nucleoside-2'-O-)-methyltransferase 2 (EC 2.1.1.296)]
[ENO1 CAALFM_C108500CA CaO19.395 CaO19.8025] Enolase 1 (EC 4.2.1.11) (2-phospho-D-glycerate hydro-lyase) (2-phosphoglycerate dehydratase)
[kbaY agaY agaY_1 agaY_2 kbaY_1 kbaY_2 A6581_06135 A6592_14490 A6V01_00345 A8C65_02445 A9819_18030 A9R57_12875 AC789_1c35070 ACN002_3231 ACN68_12640 ACN81_18735 ACU57_14720 ACU90_11840 AKG99_18810 AM270_10360 AM446_04575 AM464_08310 AMK83_06615 AML07_27945 AML35_14160 APT94_22945 APU18_16660 APZ14_04020 ARC77_12125 AU473_06025 AUQ13_02800 AUS26_18535 AW059_15450 AWE53_007900 AWF59_011940 AWG78_015980 AZZ83_001415 B6V57_17765 B7C53_19450 BANRA_01755 BANRA_03860 BANRA_03945 BANRA_04152 BB545_10055 BEN53_19445 BHF46_07040 BHS81_18925 BIZ41_14335 BJJ90_03045 BK248_21775 BK292_10495 BK334_09815 BK383_15710 BMT49_25850 BN17_30821 BOH76_21350 BON63_14520 BON65_19970 BON69_17715 BON71_25485 BON72_17420 BON75_23430 BON76_05810 BON83_08980 BON87_18455 BON91_03785 BON92_11295 BON94_12620 BON95_22300 BON96_06620 BTQ04_16760 BTQ06_20745 BvCms12BK_01059 BvCms2454_04876 BvCms28BK_03320 BvCms35BK_02871 BvCmsC61A_01449 BvCmsHHP019_03099 BvCmsHHP056_01387 BvCmsKKP036_00297 BvCmsKKP061_04194 BvCmsKSNP073_02108 BvCmsKSNP081_00232 BvCmsKSP011_02104 BvCmsKSP024_00337 BvCmsKSP026_00448 BvCmsKSP045_01596 BvCmsKSP067_01410 BvCmsKSP076_01576 BvCmsNSNP036_02097 BvCmsNSP006_01535 BvCmsNSP047_04172 BvCmsNSP072_03133 BvCmsOUP014_03793 BvCmsSINP011_04023 BvCmsSIP019_04336 BvCmsSIP044_00083 BVL39_10420 BW690_01005 BWP17_07060 BXT93_18380 BZL31_25275 BZL69_07435 C2U48_17840 C4K41_03525 C5715_12280 C5N07_16465 C5P01_19110 C6669_12295 C6B13_15150 C7235_03500 C7B02_08945 C7B06_16525 C7B07_10875 C7B08_03310 C7B18_13575 C9098_08065 C9114_23190 C9141_00665 C9160_02615 C9162_04385 C9182_14250 C9201_13600 C9306_00690 C9E25_21030 C9E67_03660 C9Z03_14870 C9Z28_00660 C9Z29_06915 C9Z37_20625 C9Z39_07090 C9Z43_00635 C9Z69_20375 C9Z70_07040 C9Z89_03945 CA593_10600 CDC27_16810 CG692_22965 CI641_008980 CI694_21115 COD30_05970 COD46_22025 CQB02_14305 CR538_03350 CR539_20970 CRD98_04990 CRE06_06550 CRM83_23775 CRX46_04000 CSB64_06340 CT143_11135 CT146_02800 CVH05_07665 CWS33_08100 D0X26_08835 D2184_10230 D2185_00720 D3821_08600 D3C88_24210 D3O91_09400 D3Y67_18565 D4M06_13285 D6T60_15115 D7K63_11945 D7K66_04220 D7Y10_03335 D9D20_06000 D9D33_00665 D9D43_03360 D9E35_01570 D9G11_03125 D9H53_00925 D9H68_22415 D9H70_01695 D9H94_03245 D9I18_19825 D9I87_04785 D9I88_19640 D9I97_07685 D9J11_00855 D9J44_07575 D9J46_08360 D9K48_11980 D9K54_17765 D9L89_05095 D9L99_02405 D9X97_02845 DAH18_13690 DAH26_15475 DAH30_13150 DAH32_06790 DAH34_01705 DAH37_04530 DAH43_12645 DB359_10525 DBQ99_04295 DEN89_09130 DEN97_11805 DEO04_13180 DEO19_06155 DIV22_09280 DJ487_13020 DJ503_10700 DL455_14245 DL545_03915 DL800_22990 DM102_14910 DM129_03750 DMI04_03995 DNB37_08385 DNR41_10930 DOY56_09825 DP258_01785 DP277_21220 DQE83_16800 DQF57_03340 DQO13_01020 DTL43_04020 DTL90_07295 DTM45_14255 DU333_16665 DW236_11830 DWB25_03465 DXT69_05795 DXT71_00715 DXT73_20265 DXX80_009305 E0I42_14065 E0J34_10475 E0K84_20755 E2112_24545 E2115_05885 E2116_08050 E2119_05595 E2127_02300 E2128_21615 E2129_05485 E2134_15870 E2135_07805 E2148_12230 E2855_04088 E2863_03913 E3B71_12240 E5P22_18545 E5P37_13400 E5S35_12935 E5S46_04090 E5S47_03035 E5S58_02680 E5S61_05960 EAI42_23155 EAI46_22680 EAI52_19230 EB509_22250 EB510_08515 EB515_06750 EC1094V2_507 EC3234A_53c00160 EC3426_04288 EC382_14380 EC95NR1_02516 ECONIH1_18600 ECs4017 ECTO6_00621 ED600_22505 ED607_21350 ED611_04005 ED903_20285 ED944_06985 EEA45_19825 EEP23_19385 EF173_13905 EHH55_24075 EIA08_12755 EIA21_02605 EJC75_14950 EKI52_18520 EL75_0549 EL79_0572 EL80_0564 ELT20_05320 ELT23_07020 ELT58_00690 ELV08_22210 ELV26_10145 ELV28_06090 EO241_09305 EPS94_08200 EPT01_00690 EQ820_11290 EQ825_07115 ERS085365_00596 ERS085366_00607 ERS085374_01873 ERS085379_00428 ERS085383_00753 ERS085386_00541 ERS085404_02243 ERS085406_03651 ERS085416_00299 ERS139211_00539 ERS150873_01748 ERS150876_00972 EVY14_07470 EXM29_19720 EXX06_09415 EXX13_07390 EXX23_07605 EXX24_06085 EXX53_05385 EXX55_09110 EXX71_13125 EXX78_09740 EXX87_04315 EYD11_02925 EYX99_26520 EYY27_17600 EYY34_08530 EYY78_22045 F0312_20795 F1E03_06735 F1E13_04585 F7F23_04280 F7F29_05390 F7G03_12990 FAF34_019140 FKO60_05985 FNJ69_14610 FNJ79_12810 FQ915_26405 FQR64_03310 FQU83_04765 FRV13_20820 FV293_19275 FV438_19845 HmCms184_00889 HmCmsJML074_04828 HmCmsJML079_03462 HmCmsJML146_01125 HMPREF3040_01995 HW43_20655 MS6198_36220 MS8345_03490 NCTC10082_03001 NCTC10764_04039 NCTC10767_01694 NCTC10865_00851 NCTC11022_03300 NCTC11341_01695 NCTC12950_00651 NCTC13148_03216 NCTC13846_00667 NCTC8009_01738 NCTC8622_00268 NCTC8960_03245 NCTC8985_05190 NCTC9036_00713 NCTC9044_01179 NCTC9045_00750 NCTC9050_03774 NCTC9055_02547 NCTC9062_02519 NCTC9111_01031 NCTC9117_00956 NCTC9119_00687 NCTC9434_00595 NCTC9701_00743 NCTC9702_00706 NCTC9703_05134 NCTC9706_02907 NCTC9969_00822 PGD_03977 PU06_20125 RG28_20800 RK56_014885 RX35_04224 SAMEA3472043_01768 SAMEA3472044_03367 SAMEA3472047_01838 SAMEA3472055_00433 SAMEA3472056_03039 SAMEA3472070_01205 SAMEA3472080_00912 SAMEA3472108_00133 SAMEA3472110_01572 SAMEA3472112_01556 SAMEA3472114_00516 SAMEA3472147_03318 SAMEA3484427_00641 SAMEA3484429_00701 SAMEA3484434_03283 SAMEA3485101_01677 SAMEA3752372_01750 SAMEA3752553_01220 SAMEA3752557_01908 SAMEA3752559_03865 SAMEA3753064_02903 SAMEA3753097_03267 SAMEA3753290_00181 SAMEA3753300_02165 SK85_03447 UC41_11540 UN86_15655 WQ89_06915 WR15_24715 YDC107_1814] D-tagatose-1,6-bisphosphate aldolase subunit KbaY (TBPA) (TagBP aldolase) (EC 4.1.2.40) (D-tagatose-bisphosphate aldolase class II) (Ketose 1,6-bisphosphate aldolase class II) (Tagatose-bisphosphate aldolase)
[] Genome polyprotein [Cleaved into: Core protein p21 (Capsid protein C) (p21); Core protein p19; Envelope glycoprotein E1 (gp32) (gp35); Envelope glycoprotein E2 (NS1) (gp68) (gp70); p7; Protease NS2-3 (p23) (EC 3.4.22.-); Serine protease NS3 (EC 3.4.21.98) (EC 3.6.1.15) (EC 3.6.4.13) (Hepacivirin) (NS3P) (p70); Non-structural protein 4A (NS4A) (p8); Non-structural protein 4B (NS4B) (p27); Non-structural protein 5A (NS5A) (p56); RNA-directed RNA polymerase (EC 2.7.7.48) (NS5B) (p68)]
[hchA ECH74115_2746] Protein/nucleic acid deglycase HchA (EC 3.1.2.-) (EC 3.5.1.-) (EC 3.5.1.124) (Maillard deglycase)
[] Genome polyprotein [Cleaved into: Capsid protein C (Core protein); Protein prM; Peptide pr; Small envelope protein M (Matrix protein); Envelope protein E; Non-structural protein 1 (NS1); Non-structural protein 2A (NS2A); Non-structural protein 2A-alpha (NS2A-alpha); Serine protease subunit NS2B (Flavivirin protease NS2B regulatory subunit) (Non-structural protein 2B); Serine protease NS3 (EC 3.4.21.91) (EC 3.6.1.15) (EC 3.6.4.13) (Flavivirin protease NS3 catalytic subunit) (Non-structural protein 3); Non-structural protein 4A (NS4A); Peptide 2k; Non-structural protein 4B (NS4B); RNA-directed RNA polymerase NS5 (EC 2.1.1.56) (EC 2.1.1.57) (EC 2.7.7.48) (Non-structural protein 5)]
[] Genome polyprotein [Cleaved into: P1; Capsid protein VP0 (VP4-VP2); Capsid protein VP4 (P1A) (Virion protein 4); Capsid protein VP2 (P1B) (Virion protein 2); Capsid protein VP3 (P1C) (Virion protein 3); Capsid protein VP1 (P1D) (Virion protein 1); P2; Protease 2A (P2A) (EC 3.4.22.29) (Picornain 2A) (Protein 2A); Protein 2B (P2B); Protein 2C (P2C) (EC 3.6.1.15); P3; Protein 3AB; Protein 3A (P3A); Viral protein genome-linked (VPg) (Protein 3B) (P3B); Protein 3CD (EC 3.4.22.28); Protease 3C (EC 3.4.22.28) (Picornain 3C) (P3C); RNA-directed RNA polymerase (RdRp) (EC 2.7.7.48) (3D polymerase) (3Dpol) (Protein 3D) (3D)]
[] Genome polyprotein [Cleaved into: Core protein p21 (Capsid protein C) (p21); Core protein p19; Envelope glycoprotein E1 (gp32) (gp35); Envelope glycoprotein E2 (NS1) (gp68) (gp70); p7; Protease NS2-3 (p23) (EC 3.4.22.-); Serine protease NS3 (EC 3.4.21.98) (EC 3.6.1.15) (EC 3.6.4.13) (Hepacivirin) (NS3P) (p70); Non-structural protein 4A (NS4A) (p8); Non-structural protein 4B (NS4B) (p27); Non-structural protein 5A (NS5A) (p56); RNA-directed RNA polymerase (EC 2.7.7.48) (NS5B) (p68)]
[] Genome polyprotein [Cleaved into: Core protein p21 (Capsid protein C) (p21); Core protein p19; Envelope glycoprotein E1 (gp32) (gp35); Envelope glycoprotein E2 (NS1) (gp68) (gp70); p7; Protease NS2-3 (p23) (EC 3.4.22.-); Serine protease NS3 (EC 3.4.21.98) (EC 3.6.1.15) (EC 3.6.4.13) (Hepacivirin) (NS3P) (p70); Non-structural protein 4A (NS4A) (p8); Non-structural protein 4B (NS4B) (p27); Non-structural protein 5A (NS5A) (p56); RNA-directed RNA polymerase (EC 2.7.7.48) (NS5B) (p68)]

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