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4-hydroxyproline 2-epimerase (4Hyp 2-epimerase) (4HypE) (EC 5.1.1.8)

 4HYPE_RUEPO             Reviewed;         313 AA.
Q5LKW3;
04-MAR-2015, integrated into UniProtKB/Swiss-Prot.
01-FEB-2005, sequence version 1.
08-MAY-2019, entry version 74.
RecName: Full=4-hydroxyproline 2-epimerase {ECO:0000303|PubMed:24980702};
Short=4Hyp 2-epimerase;
Short=4HypE {ECO:0000303|PubMed:24980702};
EC=5.1.1.8 {ECO:0000269|PubMed:24980702};
OrderedLocusNames=SPOA0266 {ECO:0000312|EMBL:AAV97400.1};
Ruegeria pomeroyi (strain ATCC 700808 / DSM 15171 / DSS-3)
(Silicibacter pomeroyi).
Plasmid megaplasmid Spo.
Bacteria; Proteobacteria; Alphaproteobacteria; Rhodobacterales;
Rhodobacteraceae; Ruegeria.
NCBI_TaxID=246200;
[1]
NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
STRAIN=ATCC 700808 / DSM 15171 / DSS-3;
PubMed=15602564; DOI=10.1038/nature03170;
Moran M.A., Buchan A., Gonzalez J.M., Heidelberg J.F., Whitman W.B.,
Kiene R.P., Henriksen J.R., King G.M., Belas R., Fuqua C.,
Brinkac L.M., Lewis M., Johri S., Weaver B., Pai G., Eisen J.A.,
Rahe E., Sheldon W.M., Ye W., Miller T.R., Carlton J., Rasko D.A.,
Paulsen I.T., Ren Q., Daugherty S.C., DeBoy R.T., Dodson R.J.,
Durkin A.S., Madupu R., Nelson W.C., Sullivan S.A., Rosovitz M.J.,
Haft D.H., Selengut J., Ward N.;
"Genome sequence of Silicibacter pomeroyi reveals adaptations to the
marine environment.";
Nature 432:910-913(2004).
[2]
GENOME REANNOTATION.
STRAIN=ATCC 700808 / DSM 15171 / DSS-3;
PubMed=25780504; DOI=10.1186/1944-3277-9-11;
Rivers A.R., Smith C.B., Moran M.A.;
"An updated genome annotation for the model marine bacterium Ruegeria
pomeroyi DSS-3.";
Stand. Genomic Sci. 9:11-11(2014).
[3]
FUNCTION, AND CATALYTIC ACTIVITY.
PubMed=24980702; DOI=10.7554/eLife.03275;
Zhao S., Sakai A., Zhang X., Vetting M.W., Kumar R., Hillerich B.,
San Francisco B., Solbiati J., Steves A., Brown S., Akiva E.,
Barber A., Seidel R.D., Babbitt P.C., Almo S.C., Gerlt J.A.,
Jacobson M.P.;
"Prediction and characterization of enzymatic activities guided by
sequence similarity and genome neighborhood networks.";
Elife 3:E03275-E03275(2014).
-!- FUNCTION: Catalyzes the epimerization of trans-4-hydroxy-L-proline
(t4LHyp) to cis-4-hydroxy-D-proline (c4DHyp). Is likely involved
in a degradation pathway that converts t4LHyp to alpha-
ketoglutarate. Displays no proline racemase activity.
{ECO:0000269|PubMed:24980702, ECO:0000305}.
-!- CATALYTIC ACTIVITY:
Reaction=trans-4-hydroxy-L-proline = cis-4-hydroxy-D-proline;
Xref=Rhea:RHEA:21152, ChEBI:CHEBI:57690, ChEBI:CHEBI:58375;
EC=5.1.1.8; Evidence={ECO:0000269|PubMed:24980702};
-!- SIMILARITY: Belongs to the proline racemase family. {ECO:0000305}.
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EMBL; CP000032; AAV97400.1; -; Genomic_DNA.
RefSeq; WP_011242045.1; NC_006569.1.
SMR; Q5LKW3; -.
STRING; 246200.SPOA0266; -.
EnsemblBacteria; AAV97400; AAV97400; SPOA0266.
KEGG; sil:SPOA0266; -.
HOGENOM; HOG000084335; -.
KO; K12658; -.
OMA; CPCGLVT; -.
OrthoDB; 559014at2; -.
BioCyc; RPOM246200:G1G48-4237-MONOMER; -.
Proteomes; UP000001023; Plasmid megaplasmid Spo.
GO; GO:0047580; F:4-hydroxyproline epimerase activity; IEA:UniProtKB-EC.
InterPro; IPR008794; Pro_racemase_fam.
PANTHER; PTHR33442; PTHR33442; 1.
Pfam; PF05544; Pro_racemase; 1.
PIRSF; PIRSF029792; Pro_racemase; 1.
SFLD; SFLDS00028; Proline_Racemase; 1.
1: Evidence at protein level;
Complete proteome; Isomerase; Plasmid; Reference proteome.
CHAIN 1 313 4-hydroxyproline 2-epimerase.
/FTId=PRO_0000432260.
REGION 86 87 Substrate binding.
{ECO:0000250|UniProtKB:Q4KGU2}.
REGION 236 237 Substrate binding.
{ECO:0000250|UniProtKB:Q4KGU2}.
ACT_SITE 85 85 Proton acceptor.
{ECO:0000250|UniProtKB:Q4KGU2}.
ACT_SITE 235 235 Proton donor.
{ECO:0000250|UniProtKB:Q4KGU2}.
BINDING 205 205 Substrate.
{ECO:0000250|UniProtKB:Q4KGU2}.
BINDING 231 231 Substrate.
{ECO:0000250|UniProtKB:Q4KGU2}.
SEQUENCE 313 AA; 33285 MW; 3AAF4829FE917BAF CRC64;
MHVIDSHTGG EPTRVILSGG PHLGSGPLSE RAARLARESR AFYRSVMLEP RGQPAMVGAL
LVEPVDPDCI TGVIFFDAEA VLGMCGHGTI GLTVTLAHMG RIRAGTHKIE TPVGIVEVCL
SDANTVTITN IESRRVHRAR QVDVDGFGPV TGDVAYGGNW FFIVDPSPIP IERTNIRALS
DAALAIRTAV IANGIGGEEG QPIDHVIFYE MSPRSAVHSR SFVFCPDGTY DRSPCGTGSS
ARLACLAAEG LLNAGEEIIQ ESVIGSTYRL SYQPGPNGGV IPKITGQAHV MAESTLHFHT
DDPYRNGICH APQ


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Related Genes :
[PA1268] 4-hydroxyproline 2-epimerase (4Hyp 2-epimerase) (4HypE) (EC 5.1.1.8) (Hydroxyproline-2-epimerase) (PaHyPRE)
[hypF Pden_4859] 4-hydroxyproline 2-epimerase (4Hyp 2-epimerase) (4HypE) (EC 5.1.1.8)
[Atu4684] Trans-3-hydroxy-L-proline dehydratase (T3LHyp dehydratase) (t3HypD) (EC 4.2.1.77) (4-hydroxyproline 2-epimerase) (4Hyp 2-epimerase) (4HypE) (EC 5.1.1.8) (Trans-L-3-hydroxyproline dehydratase)
[Atu0398] 4-hydroxyproline 2-epimerase (4Hyp 2-epimerase) (4HypE) (EC 5.1.1.8)
[SIAM614_28492] 4-hydroxyproline 2-epimerase (4Hyp 2-epimerase) (4HypE) (EC 5.1.1.8)
[hpbD Pden_1187] 4-hydroxyproline betaine 2-epimerase (Hyp-B 2-epimerase) (EC 5.1.1.22) ((4R)-4-hydroxyproline betaine 2-epimerase)
[hchA A8C65_13880 A9R57_25255 AKG99_20940 AMK83_16550 B7C53_22525 B9M99_11580 B9T59_01945 BJJ90_15205 BMT49_12710 BMT53_00170 BUE81_10670 BvCms12BK_01457 BvCms28BK_04168 BvCmsHHP001_02632 BvCmsKKP061_00566 BvCmsKSP008_02510 BvCmsKSP015_01352 BvCmsKSP036_04668 BvCmsKSP045_04450 BvCmsKSP058_03204 BvCmsKSP067_02879 BvCmsKSP083_03900 BvCmsNSNP027_04914 BvCmsNSP006_03750 BvCmsNSP007_03329 BvCmsNSP039_03266 BvCmsNSP047_03567 BvCmsNSP078_03451 BvCmsSINP011_04162 BvCmsSIP006_05510 BvCmsSIP082_02402 BW690_17225 BZL69_29425 C2U48_24800 C5715_19445 C5N07_21380 C6669_19295 C7B06_02290 C7B07_03930 CDL37_00765 CIJ94_05515 COD46_23180 CQP61_17160 CRD98_26150 CY655_12940 D5618_21870 D9D20_21030 D9D43_06110 D9H68_20750 D9H70_25730 D9I87_15275 DL800_09215 DNQ41_14245 DQE83_22775 DTL43_21780 DTM25_06080 DU321_04440 E2855_02503 E2863_02392 EC95NR1_00961 ED648_25045 EFB45_10990 EPS97_16570 EPT01_11070 EQ825_23250 ERS085379_01273 ERS085386_05041 EVY21_22520 ExPECSC038_01920 EXX32_14605 EXX71_02385 EXX78_21815 EYD11_09165 HmCmsJML079_02678 HMPREF3040_01583 HW43_13705 NCTC10082_04431 NCTC10418_03071 NCTC10767_03558 NCTC11022_01867 NCTC11126_04427 NCTC11181_05650 NCTC12950_02263 NCTC13462_05714 NCTC8985_00529 NCTC9111_05933 NCTC9703_00277 PU06_24500 SAMEA3472043_00447 SAMEA3472055_03589 SAMEA3472056_01268 SAMEA3472070_00654 SAMEA3472080_04213 SAMEA3472090_03376 SAMEA3472110_00060 SAMEA3472112_00448 SAMEA3752372_00752 UN91_23615 WQ89_10695] Protein/nucleic acid deglycase HchA (EC 3.1.2.-) (EC 3.5.1.-) (EC 3.5.1.124) (Maillard deglycase)
[yjeF nnrD nnrE AC789_1c45800 ACN002_4392 AW106_17115 B1K96_02980 BB545_04070 BN17_41441 BTQ06_07255 BVL39_04290 C5N07_07145 C6669_06565 C7235_22665 C7B02_22745 CA593_04975 COD30_21525 CR538_23135 CRD98_04165 CRM83_17370 D0X26_12915 D2184_07750 D5618_06875 D9J44_09440 D9K48_15185 DIV22_15595 DL800_29085 DNQ41_02460 DP277_02605 DQF57_15735 DS732_02620 E4Z89_21040 ED600_08260 EFV07_08605 EJC48_15055 EJC75_20595 EKI52_12685 EYD11_20595 EYY78_08665 FORC28_5503] Multifunctional fusion protein [Includes: ADP-dependent (S)-NAD(P)H-hydrate dehydratase (EC 4.2.1.136) (ADP-dependent NAD(P)HX dehydratase); NAD(P)H-hydrate epimerase (EC 5.1.99.6) (NAD(P)HX epimerase)]
[nnrD nnrE BHS81_24940 BUE81_24185 BW690_00535 C4J69_05655 C5P01_11605 C5P43_09775 CG692_00180 COD46_22200 CWS33_03515 D2185_07770 D3821_07085 D3O91_01535 D3Y67_00680 D9D20_08295 D9H68_15720 D9H94_06330 D9I11_08035 D9I18_04405 D9J11_13510 EAI42_08035 EAI42_19730 EAI46_08330 EEP23_07485 EFB45_24975 EFV08_07420 EL75_3998 EL79_4176 EL80_4091 EPS71_04025 EPT01_09990 EXX24_09350 EXX32_00990 EXX78_19455 RK56_012375] Multifunctional fusion protein [Includes: ADP-dependent (S)-NAD(P)H-hydrate dehydratase (EC 4.2.1.136) (ADP-dependent NAD(P)HX dehydratase); NAD(P)H-hydrate epimerase (EC 5.1.99.6) (NAD(P)HX epimerase)]
[nnrD nnrE DKM28_03295 DU31_11450 DU33_17155 DU34_07685 DU35_07085 DU36_09790 DU37_12565 DU38_10935 DU39_12815 DU40_12880 DU41_14740 DU42_07270 DU44_01295 DU45_16155 DU46_10990 DU47_01255 DU48_07720 DU49_14655 DU50_12285 DU51_19805 DU54_00670 DU55_05370 DU56_15760 DU57_06830 DU59_03855 DU60_14595 DU61_11015 DU62_06475 DU63_06395 DU64_18510 DU65_03810 DU66_17325 DU68_15815 DU69_04530 DU71_00795 DU72_19440 DU73_09980 DU74_18275 DU75_11940 DU76_10140 DU77_00515 DU78_12025 DU79_00590 DU80_09755 DU81_02350 DU82_01250 DU83_01980 DU84_01080 DU85_13135 DU86_12110 DU88_12415] Multifunctional fusion protein [Includes: ADP-dependent (S)-NAD(P)H-hydrate dehydratase (EC 4.2.1.136) (ADP-dependent NAD(P)HX dehydratase); NAD(P)H-hydrate epimerase (EC 5.1.99.6) (NAD(P)HX epimerase)]
[gale-1 C47B2.6] UDP-glucose 4-epimerase (EC 5.1.3.2) (Galactowaldenase) (UDP-N-acetylgalactosamine 4-epimerase) (UDP-GalNAc 4-epimerase) (UDP-N-acetylglucosamine 4-epimerase) (UDP-GlcNAc 4-epimerase) (EC 5.1.3.7) (UDP-galactose 4-epimerase)
[RHM2 MUM4 At1g53500 F22G10.13 T3F20.18] Trifunctional UDP-glucose 4,6-dehydratase/UDP-4-keto-6-deoxy-D-glucose 3,5-epimerase/UDP-4-keto-L-rhamnose-reductase RHM2 (NDP-rhamnose synthase) (Protein MUCILAGE-MODIFIED 4) (Protein RHAMNOSE BIOSYNTHESIS 2) (Rhamnose biosynthetic enzyme 2) (AtRHM2) (UDP-L-rhamnose synthase MUM4) [Includes: UDP-glucose 4,6-dehydratase (EC 4.2.1.76); UDP-4-keto-6-deoxy-D-glucose 3,5-epimerase/UDP-4-keto-L-rhamnose 4-keto-reductase (EC 1.1.1.-) (EC 5.1.3.-)]
[nnrE nnrD AGK71_18405 AIB59_16950 AIB60_15880 AMA70_13760 C4792_15690 E2E37_17200 E2E38_17190 E2E40_17530 E2E41_17185 E2E42_17855 E2E43_17200 E2E44_17195 E2E45_17525 E2E46_17205 E2E47_17855 E2E54_17000 E2E57_17200 E2E59_17510 E2E61_17855 E2E69_17520 EGK72_17530 QW66_17005 WP21_13730] Multifunctional fusion protein [Includes: ADP-dependent (S)-NAD(P)H-hydrate dehydratase (EC 4.2.1.136) (ADP-dependent NAD(P)HX dehydratase); NAD(P)H-hydrate epimerase (EC 5.1.99.6) (NAD(P)HX epimerase)]
[RHM1 ROL1 At1g78570 T30F21.10] Trifunctional UDP-glucose 4,6-dehydratase/UDP-4-keto-6-deoxy-D-glucose 3,5-epimerase/UDP-4-keto-L-rhamnose-reductase RHM1 (Protein REPRESSOR OF LRX1 1) (Rhamnose biosynthetic enzyme 1) (AtRHM1) [Includes: UDP-glucose 4,6-dehydratase (EC 4.2.1.76); UDP-4-keto-6-deoxy-D-glucose 3,5-epimerase/UDP-4-keto-L-rhamnose 4-keto-reductase (EC 1.1.1.-) (EC 5.1.3.-)]
[RB0258 SM_b20268] Probable 4-hydroxyproline 2-epimerase (4Hyp 2-epimerase) (4HypE) (EC 5.1.1.8)
[dprE1 MSMEG_6382 MSMEI_6214 LJ00_31545] Decaprenylphosphoryl-beta-D-ribose oxidase (EC 1.1.98.3) (Decaprenylphospho-beta-D-ribofuranose 2-dehydrogenase) (Decaprenylphosphoryl-beta-D-ribofuranose 2'-epimerase subunit DprE1) (Decaprenyl-phosphoribose 2'-epimerase subunit 1) (Decaprenylphosphoryl-beta-D-ribofuranose 2'-oxidase) (Decaprenylphosphoryl-beta-D-ribose 2-epimerase flavoprotein subunit) (FAD-dependent decaprenylphosphoryl-beta-D-ribofuranose 2-oxidase)
[hchA A9819_11910 ACN81_03425 AML35_08765 AW059_23935 BANRA_00208 BANRA_00433 BANRA_02614 BHF46_18455 BMT91_24760 BvCmsC61A_00149 BvCmsH15A_00510 BvCmsKSNP120_04693 BvCmsKSP026_03873 BvCmsKSP076_04891 C4J69_22715 C7B08_25495 CR538_10415 D2F89_25795 D3Y67_22910 D9G42_11130 D9I97_22010 D9J11_25195 DP258_02540 E5M00_18610 EC3234A_36c00010 EC382_21100 ECTO6_01955 EFV06_13085 EPS71_23885 FORC82_1921 NCTC8500_02249 NCTC9037_02122 NCTC9117_02637 NCTC9969_02156 SAMEA3472108_01151 SAMEA3484427_04795 SAMEA3484429_02051 SAMEA3752557_05476 SAMEA3752559_04333] Protein/nucleic acid deglycase HchA (EC 3.1.2.-) (EC 3.5.1.-) (EC 3.5.1.124) (Maillard deglycase)
[] Genome polyprotein [Cleaved into: Capsid protein C (Capsid protein) (Core protein); Protein prM (Precursor membrane protein); Peptide pr (Peptide precursor); Small envelope protein M (Matrix protein); Envelope protein E; Non-structural protein 1 (NS1); Non-structural protein 2A (NS2A); Serine protease subunit NS2B (Flavivirin protease NS2B regulatory subunit) (Non-structural protein 2B); Serine protease NS3 (EC 3.4.21.91) (EC 3.6.1.15) (EC 3.6.4.13) (Flavivirin protease NS3 catalytic subunit) (Non-structural protein 3); Non-structural protein 4A (NS4A); Peptide 2k; Non-structural protein 4B (NS4B); RNA-directed RNA polymerase NS5 (EC 2.1.1.56) (EC 2.1.1.57) (EC 2.7.7.48) (Non-structural protein 5)]
[GALE] UDP-glucose 4-epimerase (EC 5.1.3.2) (Galactowaldenase) (UDP-N-acetylgalactosamine 4-epimerase) (UDP-GalNAc 4-epimerase) (UDP-N-acetylglucosamine 4-epimerase) (UDP-GlcNAc 4-epimerase) (EC 5.1.3.7) (UDP-galactose 4-epimerase)
[] Genome polyprotein [Cleaved into: Core protein p21 (Capsid protein C) (p21); Core protein p19; Envelope glycoprotein E1 (gp32) (gp35); Envelope glycoprotein E2 (NS1) (gp68) (gp70); p7; Protease NS2-3 (p23) (EC 3.4.22.-); Serine protease NS3 (EC 3.4.21.98) (EC 3.6.1.15) (EC 3.6.4.13) (Hepacivirin) (NS3P) (p70); Non-structural protein 4A (NS4A) (p8); Non-structural protein 4B (NS4B) (p27); Non-structural protein 5A (NS5A) (p56); RNA-directed RNA polymerase (EC 2.7.7.48) (NS5B) (p68)]
[Gale CG12030] UDP-glucose 4-epimerase (EC 5.1.3.2) (Galactowaldenase) (UDP-N-acetylgalactosamine 4-epimerase) (UDP-GalNAc 4-epimerase) (UDP-N-acetylglucosamine 4-epimerase) (UDP-GlcNAc 4-epimerase) (EC 5.1.3.7) (UDP-galactose 4-epimerase)
[nnr nnrD nnrE OR1_02963] Multifunctional fusion protein [Includes: ADP-dependent (S)-NAD(P)H-hydrate dehydratase (EC 4.2.1.136) (ADP-dependent NAD(P)HX dehydratase); NAD(P)H-hydrate epimerase (EC 5.1.99.6) (NAD(P)HX epimerase)]
[nnrE nnrD A6581_03005 BTQ04_18255 BWP17_13485 C5P44_18675 C9E67_27615 CRE06_02245 CVH05_06805 D4M06_23395 D7K63_02170 D7K66_01520 D9H70_08725 D9L89_02165 D9X97_13480 DL455_22110 DMI04_22175 DNB37_06865 DOY56_08285 DTL90_17285 EB509_04120 EB510_02725 EB515_02120 ECs5142 ED225_08520 ED607_06855 ED611_08790 ED903_07005 ED944_02120 EEA45_03685 EF173_02115 EO241_14890 EXM29_20650 EXX06_20710 EXX23_19010 EXX53_17380 EXX55_21245 EXX87_19040] Multifunctional fusion protein [Includes: ADP-dependent (S)-NAD(P)H-hydrate dehydratase (EC 4.2.1.136) (ADP-dependent NAD(P)HX dehydratase); NAD(P)H-hydrate epimerase (EC 5.1.99.6) (NAD(P)HX epimerase)]
[nnr nnrD nnrE BHV80_07630 CK234_02041 DW105_22015 DW783_06900 DW857_12270 DW935_15075 DWV70_13170 DWW27_12225 DWX60_10735 DWY53_18150 DWZ06_10195 DWZ36_20490 DWZ72_15350 DXA04_08775 DXB34_15415 DXC16_15575 DXC44_16465 EAJ12_17260 ERS852457_04220 ERS852556_03990 SAMN04487923_104912] Multifunctional fusion protein [Includes: ADP-dependent (S)-NAD(P)H-hydrate dehydratase (EC 4.2.1.136) (ADP-dependent NAD(P)HX dehydratase); NAD(P)H-hydrate epimerase (EC 5.1.99.6) (NAD(P)HX epimerase)]
[rep 1a-1b] Replicase polyprotein 1ab (ORF1ab polyprotein) [Cleaved into: Nsp1 (EC 3.4.22.-); Nsp1-alpha papain-like cysteine proteinase (EC 3.4.22.-) (PCP1-alpha); Nsp1-beta papain-like cysteine proteinase (EC 3.4.22.-) (PCP1-beta); Nsp2 cysteine proteinase (EC 3.4.19.12) (EC 3.4.22.-) (CP2) (CP); Non-structural protein 3 (Nsp3); Serine protease nsp4 (3CLSP) (EC 3.4.21.-) (3C-like serine proteinase) (Nsp4); Non-structural protein 5-6-7 (Nsp5-6-7); Non-structural protein 5 (Nsp5); Non-structural protein 6 (Nsp6); Non-structural protein 7-alpha (Nsp7-alpha); Non-structural protein 7-beta (Nsp7-beta); Non-structural protein 8 (Nsp8); RNA-directed RNA polymerase (Pol) (RdRp) (EC 2.7.7.48) (Nsp9); Helicase nsp10 (Hel) (EC 3.6.4.12) (EC 3.6.4.13) (Nsp10); Non-structural protein 11 (Nsp11); Non-structural protein 12 (Nsp12)]
[nnrD nnrE EO96_08705] Multifunctional fusion protein [Includes: ADP-dependent (S)-NAD(P)H-hydrate dehydratase (EC 4.2.1.136) (ADP-dependent NAD(P)HX dehydratase); NAD(P)H-hydrate epimerase (EC 5.1.99.6) (NAD(P)HX epimerase)]
[nnrE nnrD LD85_0067] Multifunctional fusion protein [Includes: ADP-dependent (S)-NAD(P)H-hydrate dehydratase (EC 4.2.1.136) (ADP-dependent NAD(P)HX dehydratase); NAD(P)H-hydrate epimerase (EC 5.1.99.6) (NAD(P)HX epimerase)]
[galE galD b0759 JW0742] UDP-glucose 4-epimerase (EC 5.1.3.2) (Galactowaldenase) (UDP-galactose 4-epimerase)
[RHM3 At3g14790 T21E2_4] Trifunctional UDP-glucose 4,6-dehydratase/UDP-4-keto-6-deoxy-D-glucose 3,5-epimerase/UDP-4-keto-L-rhamnose-reductase RHM3 (Probable rhamnose biosynthetic enzyme 3) (AtRHM3) [Includes: UDP-glucose 4,6-dehydratase (EC 4.2.1.76); UDP-4-keto-6-deoxy-D-glucose 3,5-epimerase/UDP-4-keto-L-rhamnose 4-keto-reductase (EC 1.1.1.-) (EC 5.1.3.-)]
[nnrD nnrE DU30_04190 DU43_08465 DU52_07060 DU58_04160 DU67_00490] Multifunctional fusion protein [Includes: ADP-dependent (S)-NAD(P)H-hydrate dehydratase (EC 4.2.1.136) (ADP-dependent NAD(P)HX dehydratase); NAD(P)H-hydrate epimerase (EC 5.1.99.6) (NAD(P)HX epimerase)]

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