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4-hydroxyproline 2-epimerase (4Hyp 2-epimerase) (4HypE) (EC 5.1.1.8)

 4HYPE_RUEPO             Reviewed;         313 AA.
Q5LKW3;
04-MAR-2015, integrated into UniProtKB/Swiss-Prot.
01-FEB-2005, sequence version 1.
11-DEC-2019, entry version 77.
RecName: Full=4-hydroxyproline 2-epimerase {ECO:0000303|PubMed:24980702};
Short=4Hyp 2-epimerase;
Short=4HypE {ECO:0000303|PubMed:24980702};
EC=5.1.1.8 {ECO:0000269|PubMed:24980702};
OrderedLocusNames=SPOA0266 {ECO:0000312|EMBL:AAV97400.1};
Ruegeria pomeroyi (strain ATCC 700808 / DSM 15171 / DSS-3) (Silicibacter
pomeroyi).
Plasmid megaplasmid Spo.
Bacteria; Proteobacteria; Alphaproteobacteria; Rhodobacterales;
Rhodobacteraceae; Ruegeria.
NCBI_TaxID=246200;
[1]
NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
STRAIN=ATCC 700808 / DSM 15171 / DSS-3;
PubMed=15602564; DOI=10.1038/nature03170;
Moran M.A., Buchan A., Gonzalez J.M., Heidelberg J.F., Whitman W.B.,
Kiene R.P., Henriksen J.R., King G.M., Belas R., Fuqua C., Brinkac L.M.,
Lewis M., Johri S., Weaver B., Pai G., Eisen J.A., Rahe E., Sheldon W.M.,
Ye W., Miller T.R., Carlton J., Rasko D.A., Paulsen I.T., Ren Q.,
Daugherty S.C., DeBoy R.T., Dodson R.J., Durkin A.S., Madupu R.,
Nelson W.C., Sullivan S.A., Rosovitz M.J., Haft D.H., Selengut J., Ward N.;
"Genome sequence of Silicibacter pomeroyi reveals adaptations to the marine
environment.";
Nature 432:910-913(2004).
[2]
GENOME REANNOTATION.
STRAIN=ATCC 700808 / DSM 15171 / DSS-3;
PubMed=25780504; DOI=10.1186/1944-3277-9-11;
Rivers A.R., Smith C.B., Moran M.A.;
"An updated genome annotation for the model marine bacterium Ruegeria
pomeroyi DSS-3.";
Stand. Genomic Sci. 9:11-11(2014).
[3]
FUNCTION, AND CATALYTIC ACTIVITY.
PubMed=24980702; DOI=10.7554/elife.03275;
Zhao S., Sakai A., Zhang X., Vetting M.W., Kumar R., Hillerich B.,
San Francisco B., Solbiati J., Steves A., Brown S., Akiva E., Barber A.,
Seidel R.D., Babbitt P.C., Almo S.C., Gerlt J.A., Jacobson M.P.;
"Prediction and characterization of enzymatic activities guided by sequence
similarity and genome neighborhood networks.";
Elife 3:E03275-E03275(2014).
-!- FUNCTION: Catalyzes the epimerization of trans-4-hydroxy-L-proline
(t4LHyp) to cis-4-hydroxy-D-proline (c4DHyp). Is likely involved in a
degradation pathway that converts t4LHyp to alpha-ketoglutarate.
Displays no proline racemase activity. {ECO:0000269|PubMed:24980702,
ECO:0000305}.
-!- CATALYTIC ACTIVITY:
Reaction=trans-4-hydroxy-L-proline = cis-4-hydroxy-D-proline;
Xref=Rhea:RHEA:21152, ChEBI:CHEBI:57690, ChEBI:CHEBI:58375;
EC=5.1.1.8; Evidence={ECO:0000269|PubMed:24980702};
-!- SIMILARITY: Belongs to the proline racemase family. {ECO:0000305}.
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EMBL; CP000032; AAV97400.1; -; Genomic_DNA.
RefSeq; WP_011242045.1; NC_006569.1.
SMR; Q5LKW3; -.
STRING; 246200.SPOA0266; -.
EnsemblBacteria; AAV97400; AAV97400; SPOA0266.
KEGG; sil:SPOA0266; -.
HOGENOM; HOG000084335; -.
KO; K12658; -.
OMA; QVNIHCP; -.
OrthoDB; 559014at2; -.
BioCyc; RPOM246200:G1G48-4237-MONOMER; -.
Proteomes; UP000001023; Plasmid megaplasmid Spo.
GO; GO:0047580; F:4-hydroxyproline epimerase activity; IEA:UniProtKB-EC.
InterPro; IPR008794; Pro_racemase_fam.
PANTHER; PTHR33442; PTHR33442; 1.
Pfam; PF05544; Pro_racemase; 1.
PIRSF; PIRSF029792; Pro_racemase; 1.
SFLD; SFLDS00028; Proline_Racemase; 1.
1: Evidence at protein level;
Isomerase; Plasmid; Reference proteome.
CHAIN 1..313
/note="4-hydroxyproline 2-epimerase"
/id="PRO_0000432260"
REGION 86..87
/note="Substrate binding"
/evidence="ECO:0000250|UniProtKB:Q4KGU2"
REGION 236..237
/note="Substrate binding"
/evidence="ECO:0000250|UniProtKB:Q4KGU2"
ACT_SITE 85
/note="Proton acceptor"
/evidence="ECO:0000250|UniProtKB:Q4KGU2"
ACT_SITE 235
/note="Proton donor"
/evidence="ECO:0000250|UniProtKB:Q4KGU2"
BINDING 205
/note="Substrate"
/evidence="ECO:0000250|UniProtKB:Q4KGU2"
BINDING 231
/note="Substrate"
/evidence="ECO:0000250|UniProtKB:Q4KGU2"
SEQUENCE 313 AA; 33285 MW; 3AAF4829FE917BAF CRC64;
MHVIDSHTGG EPTRVILSGG PHLGSGPLSE RAARLARESR AFYRSVMLEP RGQPAMVGAL
LVEPVDPDCI TGVIFFDAEA VLGMCGHGTI GLTVTLAHMG RIRAGTHKIE TPVGIVEVCL
SDANTVTITN IESRRVHRAR QVDVDGFGPV TGDVAYGGNW FFIVDPSPIP IERTNIRALS
DAALAIRTAV IANGIGGEEG QPIDHVIFYE MSPRSAVHSR SFVFCPDGTY DRSPCGTGSS
ARLACLAAEG LLNAGEEIIQ ESVIGSTYRL SYQPGPNGGV IPKITGQAHV MAESTLHFHT
DDPYRNGICH APQ


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Related Genes :
[PA1268] 4-hydroxyproline 2-epimerase (4Hyp 2-epimerase) (4HypE) (EC 5.1.1.8) (Hydroxyproline-2-epimerase) (PaHyPRE)
[hypF Pden_4859] 4-hydroxyproline 2-epimerase (4Hyp 2-epimerase) (4HypE) (EC 5.1.1.8)
[Atu4684] Trans-3-hydroxy-L-proline dehydratase (T3LHyp dehydratase) (t3HypD) (EC 4.2.1.77) (4-hydroxyproline 2-epimerase) (4Hyp 2-epimerase) (4HypE) (EC 5.1.1.8) (Trans-L-3-hydroxyproline dehydratase)
[Atu0398] 4-hydroxyproline 2-epimerase (4Hyp 2-epimerase) (4HypE) (EC 5.1.1.8)
[SIAM614_28492] 4-hydroxyproline 2-epimerase (4Hyp 2-epimerase) (4HypE) (EC 5.1.1.8)
[hpbD Pden_1187] 4-hydroxyproline betaine 2-epimerase (Hyp-B 2-epimerase) (EC 5.1.1.22) ((4R)-4-hydroxyproline betaine 2-epimerase)
[hchA A8C65_13880 A9R57_25255 AKG99_20940 AMK83_16550 B7C53_22525 B9M99_11580 B9T59_01945 BJJ90_15205 BMT49_12710 BON66_15955 BON86_06490 BON95_14610 BUE81_10670 BvCms12BK_01457 BvCms28BK_04168 BvCmsHHP001_02632 BvCmsKKP061_00566 BvCmsKSP015_01352 BvCmsKSP045_04450 BvCmsKSP058_03204 BvCmsKSP067_02879 BvCmsKSP083_03900 BvCmsNSP006_03750 BvCmsNSP007_03329 BvCmsNSP047_03567 BvCmsSINP011_04162 BW690_17225 BZL69_29425 C2U48_24800 C5715_19445 C5N07_21380 C6669_19295 C7B06_02290 C7B07_03930 C9025_17620 C9077_19550 C9078_12950 C9083_21590 C9212_13125 C9Y80_10480 C9Y95_17520 C9Z12_18550 CDC27_10055 CDL37_00765 CI694_25210 CIJ94_05515 COD46_23180 CQP61_17160 CRD98_26150 D2188_01360 D6W60_25270 D9D20_21030 D9D43_06110 D9H68_20750 D9H70_25730 D9I87_15275 DEN89_24995 DEO04_05510 DL800_09215 DNQ41_14245 DQE83_22775 DTL43_21780 DTM25_06080 DU321_04440 DXT73_20690 E2134_24005 E2135_17195 E2855_02503 E2863_02392 E5P22_21380 E5S46_06650 EB575_25290 EC95NR1_00961 ED648_25045 ELT20_21515 ELV08_24970 EPS97_16570 EPT01_11070 EQ825_23250 ERS085379_01273 ERS085386_05041 ExPECSC038_01920 EXX71_02385 EXX78_21815 EYD11_09165 FNJ83_13175 FQ915_04255 FQR64_09390 FWK02_18105 HmCmsJML079_02678 HMPREF3040_01583 HW43_13705 NCTC10082_04431 NCTC10418_03071 NCTC10767_03558 NCTC11022_01867 NCTC11126_04427 NCTC11181_05650 NCTC12950_02263 NCTC8985_00529 NCTC9111_05933 NCTC9703_00277 PGD_01271 PU06_24500 SAMEA3472043_00447 SAMEA3472055_03589 SAMEA3472056_01268 SAMEA3472070_00654 SAMEA3472080_04213 SAMEA3472090_03376 SAMEA3472110_00060 SAMEA3472112_00448 SAMEA3752372_00752 UN91_23615 WQ89_10695] Protein/nucleic acid deglycase HchA (EC 3.1.2.-) (EC 3.5.1.-) (EC 3.5.1.124) (Maillard deglycase)
[yjeF nnrD nnrE A6V01_16625 AC789_1c45800 ACN002_4392 AW106_17115 BB545_04070 BN17_41441 BOH76_10905 BON76_04155 BON95_14955 BTQ06_07255 BVL39_04290 C5N07_07145 C6669_06565 C7235_22665 C7B02_22745 C9025_06235 C9063_17080 C9083_18120 C9212_05065 C9299_20685 C9Y80_28020 C9Y91_10970 CA593_04975 COD30_21525 CR538_23135 CRD98_04165 CRM83_17370 D2184_07750 D6W60_04790 D9J44_09440 D9K48_15185 DAH18_07435 DAH32_17635 DBQ99_23525 DEN97_13975 DEO19_11825 DIV22_15595 DL800_29085 DNQ41_02460 DP277_02605 DQF57_15735 DS732_02620 E5S35_05440 EB575_05670 ED600_08260 EHH55_18965 EJC75_20595 EKI52_12685 EYD11_20595 EYY78_08665 FORC28_5503 FQ915_09945] Multifunctional fusion protein [Includes: ADP-dependent (S)-NAD(P)H-hydrate dehydratase (EC 4.2.1.136) (ADP-dependent NAD(P)HX dehydratase); NAD(P)H-hydrate epimerase (EC 5.1.99.6) (NAD(P)HX epimerase)]
[nnrD nnrE DKM28_03295 DU31_11450 DU33_17155 DU34_07685 DU35_07085 DU36_09790 DU37_12565 DU38_10935 DU39_12815 DU40_12880 DU41_14740 DU42_07270 DU44_01295 DU45_16155 DU46_10990 DU47_01255 DU48_07720 DU49_14655 DU50_12285 DU51_19805 DU54_00670 DU55_05370 DU56_15760 DU57_06830 DU59_03855 DU60_14595 DU61_11015 DU62_06475 DU63_06395 DU64_18510 DU65_03810 DU66_17325 DU68_15815 DU69_04530 DU71_00795 DU72_19440 DU73_09980 DU74_18275 DU75_11940 DU76_10140 DU77_00515 DU78_12025 DU79_00590 DU80_09755 DU81_02350 DU82_01250 DU83_01980 DU84_01080 DU85_13135 DU86_12110 DU88_12415] Multifunctional fusion protein [Includes: ADP-dependent (S)-NAD(P)H-hydrate dehydratase (EC 4.2.1.136) (ADP-dependent NAD(P)HX dehydratase); NAD(P)H-hydrate epimerase (EC 5.1.99.6) (NAD(P)HX epimerase)]
[nnrD nnrE BHS81_24940 BON75_25135 BUE81_24185 BW690_00535 BWI87_05605 C5P01_11605 C9077_14110 C9078_06600 C9120_10815 C9200_11205 C9Z87_12125 CG692_00180 CI641_014360 COD46_22200 CWS33_03515 D2185_07770 D3821_07085 D3O91_01535 D3Y67_00680 D9D20_08295 D9H68_15720 D9H94_06330 D9I11_08035 D9I18_04405 D9J11_13510 DAH30_09295 DAH34_17710 DAH37_06235 DEN89_23315 DEO04_15015 E2119_06500 E3B71_17555 E5P22_06605 EAI42_08035 EAI42_19730 EAI46_08330 EEP23_07485 EL75_3998 EL79_4176 EL80_4091 ELT20_09170 EPS71_04025 EPT01_09990 EXX24_09350 EXX78_19455 EYY19_25305 FQR64_20885 FRV13_14670 FV293_00830 RK56_012375] Multifunctional fusion protein [Includes: ADP-dependent (S)-NAD(P)H-hydrate dehydratase (EC 4.2.1.136) (ADP-dependent NAD(P)HX dehydratase); NAD(P)H-hydrate epimerase (EC 5.1.99.6) (NAD(P)HX epimerase)]
[gale-1 C47B2.6] UDP-glucose 4-epimerase (EC 5.1.3.2) (Galactowaldenase) (UDP-N-acetylgalactosamine 4-epimerase) (UDP-GalNAc 4-epimerase) (UDP-N-acetylglucosamine 4-epimerase) (UDP-GlcNAc 4-epimerase) (EC 5.1.3.7) (UDP-galactose 4-epimerase)
[RHM2 MUM4 At1g53500 F22G10.13 T3F20.18] Trifunctional UDP-glucose 4,6-dehydratase/UDP-4-keto-6-deoxy-D-glucose 3,5-epimerase/UDP-4-keto-L-rhamnose-reductase RHM2 (NDP-rhamnose synthase) (Protein MUCILAGE-MODIFIED 4) (Protein RHAMNOSE BIOSYNTHESIS 2) (Rhamnose biosynthetic enzyme 2) (AtRHM2) (UDP-L-rhamnose synthase MUM4) [Includes: UDP-glucose 4,6-dehydratase (EC 4.2.1.76); UDP-4-keto-6-deoxy-D-glucose 3,5-epimerase/UDP-4-keto-L-rhamnose 4-keto-reductase (EC 1.1.1.-) (EC 5.1.3.-)]
[nnrE nnrD AGK71_18405 AIB59_16950 AIB60_15880 AMA70_13760 C4792_15690 DM038_12275 E2E37_17200 E2E38_17190 E2E40_17530 E2E41_17185 E2E42_17855 E2E43_17200 E2E44_17195 E2E45_17525 E2E46_17205 E2E47_17855 E2E54_17000 E2E57_17200 E2E59_17510 E2E61_17855 E2E69_17520 EGK72_17530 QW66_17005 WP21_13730] Multifunctional fusion protein [Includes: ADP-dependent (S)-NAD(P)H-hydrate dehydratase (EC 4.2.1.136) (ADP-dependent NAD(P)HX dehydratase); NAD(P)H-hydrate epimerase (EC 5.1.99.6) (NAD(P)HX epimerase)]
[RHM1 ROL1 At1g78570 T30F21.10] Trifunctional UDP-glucose 4,6-dehydratase/UDP-4-keto-6-deoxy-D-glucose 3,5-epimerase/UDP-4-keto-L-rhamnose-reductase RHM1 (Protein REPRESSOR OF LRX1 1) (Rhamnose biosynthetic enzyme 1) (AtRHM1) [Includes: UDP-glucose 4,6-dehydratase (EC 4.2.1.76); UDP-4-keto-6-deoxy-D-glucose 3,5-epimerase/UDP-4-keto-L-rhamnose 4-keto-reductase (EC 1.1.1.-) (EC 5.1.3.-)]
[nnrE nnrD D9D31_07925 D9E34_14890 D9G48_11635 D9I88_12170 DD762_20765 E5S46_22610] Multifunctional fusion protein [Includes: ADP-dependent (S)-NAD(P)H-hydrate dehydratase (EC 4.2.1.136) (ADP-dependent NAD(P)HX dehydratase); NAD(P)H-hydrate epimerase (EC 5.1.99.6) (NAD(P)HX epimerase)]
[RB0258 SM_b20268] Probable 4-hydroxyproline 2-epimerase (4Hyp 2-epimerase) (4HypE) (EC 5.1.1.8)
[dprE1 MSMEG_6382 MSMEI_6214 LJ00_31545] Decaprenylphosphoryl-beta-D-ribose oxidase (EC 1.1.98.3) (Decaprenylphospho-beta-D-ribofuranose 2-dehydrogenase) (Decaprenylphosphoryl-beta-D-ribofuranose 2'-epimerase subunit DprE1) (Decaprenyl-phosphoribose 2'-epimerase subunit 1) (Decaprenylphosphoryl-beta-D-ribofuranose 2'-oxidase) (Decaprenylphosphoryl-beta-D-ribose 2-epimerase flavoprotein subunit) (FAD-dependent decaprenylphosphoryl-beta-D-ribofuranose 2-oxidase)
[] Genome polyprotein [Cleaved into: Capsid protein C (Capsid protein) (Core protein); Protein prM (Precursor membrane protein); Peptide pr (Peptide precursor); Small envelope protein M (Matrix protein); Envelope protein E; Non-structural protein 1 (NS1); Non-structural protein 2A (NS2A); Serine protease subunit NS2B (Flavivirin protease NS2B regulatory subunit) (Non-structural protein 2B); Serine protease NS3 (EC 3.4.21.91) (EC 3.6.1.15) (EC 3.6.4.13) (Flavivirin protease NS3 catalytic subunit) (Non-structural protein 3); Non-structural protein 4A (NS4A); Peptide 2k; Non-structural protein 4B (NS4B); RNA-directed RNA polymerase NS5 (EC 2.1.1.56) (EC 2.1.1.57) (EC 2.7.7.48) (Non-structural protein 5)]
[GALE] UDP-glucose 4-epimerase (EC 5.1.3.2) (Galactowaldenase) (UDP-N-acetylgalactosamine 4-epimerase) (UDP-GalNAc 4-epimerase) (UDP-N-acetylglucosamine 4-epimerase) (UDP-GlcNAc 4-epimerase) (EC 5.1.3.7) (UDP-galactose 4-epimerase)
[] Genome polyprotein [Cleaved into: Core protein p21 (Capsid protein C) (p21); Core protein p19; Envelope glycoprotein E1 (gp32) (gp35); Envelope glycoprotein E2 (NS1) (gp68) (gp70); p7; Protease NS2-3 (p23) (EC 3.4.22.-); Serine protease NS3 (EC 3.4.21.98) (EC 3.6.1.15) (EC 3.6.4.13) (Hepacivirin) (NS3P) (p70); Non-structural protein 4A (NS4A) (p8); Non-structural protein 4B (NS4B) (p27); Non-structural protein 5A (NS5A) (p56); RNA-directed RNA polymerase (EC 2.7.7.48) (NS5B) (p68)]
[nnr nnrD nnrE OR1_02963] Multifunctional fusion protein [Includes: ADP-dependent (S)-NAD(P)H-hydrate dehydratase (EC 4.2.1.136) (ADP-dependent NAD(P)HX dehydratase); NAD(P)H-hydrate epimerase (EC 5.1.99.6) (NAD(P)HX epimerase)]
[Gale CG12030] UDP-glucose 4-epimerase (EC 5.1.3.2) (Galactowaldenase) (UDP-N-acetylgalactosamine 4-epimerase) (UDP-GalNAc 4-epimerase) (UDP-N-acetylglucosamine 4-epimerase) (UDP-GlcNAc 4-epimerase) (EC 5.1.3.7) (UDP-galactose 4-epimerase)
[nnrD nnrE AAK29_03900 AAP89_05840 ABO94_01565 AF480_07765 AF488_05090 AF489_07365 AIC76_06085 AU613_19740 AXR84_01570 AXU58_10920 C2253_18275 CD48_07910 CE87_06780 CET98_09415 CQG18_08240 CVR97_09130 D4369_15145 D4380_09245 D4401_11025 D4E62_13720 D6360_03350 D7F20_11640 D7H43_04630 DD95_00965 DJ388_06195 DKJ11_05470 DKU57_01580 DLM31_11065 DNV30_04380 DO698_19585 DOJ90_18650 DOQ88_01565 DPJ93_03465 DQ848_05195 DRM14_08770 DSF69_15325 DSR36_05850 DUW48_06000 E2F01_04790 EBO41_07550 EBP31_08230 EGU67_08300 EHB24_09765 EHC98_12620 EIW53_01560 F0A00_21030 F0A01_09290 F0A02_15435 F0A03_18395 F0A04_08910 F0A05_09115 F0A06_07555 F0A07_12150 F0A08_13720 F0U66_06280 FKA80_06060 FKA81_05910 FKA82_06420 FKA84_04510 FKA85_06380 FKA86_03880 FKA87_03295 FKA88_12600 FKA89_15550 FKA90_12260 FKA91_10325 FKA92_07955 FKA93_07670 FKA95_12880 FKA96_14025 FKA97_07125 FKA98_23560 FKA99_13345 FKB00_06085 FKB01_13225 FKB02_08510 FKB03_12620 FKB12_09435 FKB15_05065 FKB18_07160 FKB19_02895 FYL66_03345 FYL68_04630 FYL69_13940 FYL71_03975 FYL73_03095 FYL74_03285 FYL75_23345 FYL77_06855 FYL81_11510 FYL84_16655 FYL90_06060 FYL92_06415 FYL93_02130 FYL94_23640 FYL96_05755 FYM06_00440 FYM08_08130 FYM09_08290 FYM12_07290 FYM54_18865 FZ992_12665 FZ993_13550 FZ994_02220 FZ995_10615 FZ996_20835 FZ997_18315 FZ998_12030 FZ999_00665 GW08_09055 JO10_09775 LZ63_09450 NG18_03560 NU83_22805 QA89_08905 QB40_12620 QD15_05050 RJ78_04885 Y934_12275 YG50_02255 YI33_06175 YR17_04460 ZB89_05280 ZC54_10955] Multifunctional fusion protein [Includes: ADP-dependent (S)-NAD(P)H-hydrate dehydratase (EC 4.2.1.136) (ADP-dependent NAD(P)HX dehydratase); NAD(P)H-hydrate epimerase (EC 5.1.99.6) (NAD(P)HX epimerase)]
[nnrE nnrD A6581_03005 BTQ04_18255 BWP17_13485 C5P44_18675 C9080_09145 C9E67_27615 CDC27_22640 CRE06_02245 CVH05_06805 D4M06_23395 D7K63_02170 D7K66_01520 D9H70_08725 D9L89_02165 D9X97_13480 DAH26_05170 DAH49_08770 DL455_22110 DMI04_22175 DNB37_06865 DOY56_08285 DTL90_17285 DXX80_015190 EB509_04120 EB510_02725 EB515_02120 ECs5142 ED225_08520 ED607_06855 ED611_08790 ED903_07005 ED944_02120 EEA45_03685 EF173_02115 EO241_14890 EXM29_20650 EXX06_20710 EXX23_19010 EXX53_17380 EXX55_21245 EXX87_19040] Multifunctional fusion protein [Includes: ADP-dependent (S)-NAD(P)H-hydrate dehydratase (EC 4.2.1.136) (ADP-dependent NAD(P)HX dehydratase); NAD(P)H-hydrate epimerase (EC 5.1.99.6) (NAD(P)HX epimerase)]
[nnr nnrD nnrE BHV80_07630 CK234_02041 DW105_22015 DW783_06900 DW857_12270 DW935_15075 DWV70_13170 DWW27_12225 DWX60_10735 DWY53_18150 DWZ06_10195 DWZ36_20490 DWZ72_15350 DXA04_08775 DXB34_15415 DXC16_15575 DXC44_16465 EAJ12_17260 ERS852457_04220 ERS852556_03990 SAMN04487923_104912] Multifunctional fusion protein [Includes: ADP-dependent (S)-NAD(P)H-hydrate dehydratase (EC 4.2.1.136) (ADP-dependent NAD(P)HX dehydratase); NAD(P)H-hydrate epimerase (EC 5.1.99.6) (NAD(P)HX epimerase)]
[nnrE nnrD B9M99_07915 CIJ94_19180 D2188_20860 D9J60_12150 DU321_10380 EQ830_14685 FNJ83_25735 HMPREF3040_03054] Multifunctional fusion protein [Includes: ADP-dependent (S)-NAD(P)H-hydrate dehydratase (EC 4.2.1.136) (ADP-dependent NAD(P)HX dehydratase); NAD(P)H-hydrate epimerase (EC 5.1.99.6) (NAD(P)HX epimerase)]
[nnrD nnrE EO96_08705] Multifunctional fusion protein [Includes: ADP-dependent (S)-NAD(P)H-hydrate dehydratase (EC 4.2.1.136) (ADP-dependent NAD(P)HX dehydratase); NAD(P)H-hydrate epimerase (EC 5.1.99.6) (NAD(P)HX epimerase)]
[rep 1a-1b] Replicase polyprotein 1ab (ORF1ab polyprotein) [Cleaved into: Nsp1 (EC 3.4.22.-); Nsp1-alpha papain-like cysteine proteinase (EC 3.4.22.-) (PCP1-alpha); Nsp1-beta papain-like cysteine proteinase (EC 3.4.22.-) (PCP1-beta); Nsp2 cysteine proteinase (EC 3.4.19.12) (EC 3.4.22.-) (CP2) (CP); Non-structural protein 3 (Nsp3); Serine protease nsp4 (3CLSP) (EC 3.4.21.-) (3C-like serine proteinase) (Nsp4); Non-structural protein 5-6-7 (Nsp5-6-7); Non-structural protein 5 (Nsp5); Non-structural protein 6 (Nsp6); Non-structural protein 7-alpha (Nsp7-alpha); Non-structural protein 7-beta (Nsp7-beta); Non-structural protein 8 (Nsp8); RNA-directed RNA polymerase (Pol) (RdRp) (EC 2.7.7.48) (Nsp9); Helicase nsp10 (Hel) (EC 3.6.4.12) (EC 3.6.4.13) (Nsp10); Non-structural protein 11 (Nsp11); Non-structural protein 12 (Nsp12)]
[nnrE nnrD LD85_0067] Multifunctional fusion protein [Includes: ADP-dependent (S)-NAD(P)H-hydrate dehydratase (EC 4.2.1.136) (ADP-dependent NAD(P)HX dehydratase); NAD(P)H-hydrate epimerase (EC 5.1.99.6) (NAD(P)HX epimerase)]
[hchA A9819_11910 ACN81_03425 AML35_08765 AW059_23935 BANRA_00208 BANRA_00433 BANRA_02614 BHF46_18455 BMT91_24760 BON76_21885 BvCmsC61A_00149 BvCmsKSNP120_04693 BvCmsKSP026_03873 BvCmsKSP076_04891 C7B08_25495 CR538_10415 D2F89_25795 D3Y67_22910 D9G42_11130 D9I97_22010 D9J11_25195 DP258_02540 E3B71_05970 EC3234A_36c00010 EC382_21100 ECTO6_01955 EHH55_07135 EPS71_23885 FORC82_1921 FV293_07100 NCTC8500_02249 NCTC9117_02637 NCTC9969_02156 SAMEA3472108_01151 SAMEA3484427_04795 SAMEA3484429_02051 SAMEA3752557_05476 SAMEA3752559_04333] Protein/nucleic acid deglycase HchA (EC 3.1.2.-) (EC 3.5.1.-) (EC 3.5.1.124) (Maillard deglycase)

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