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A-kinase anchor protein 12 (AKAP-12) (Germ cell lineage protein gercelin) (Src-suppressed C kinase substrate) (SSeCKS)

 AKA12_MOUSE             Reviewed;        1684 AA.
Q9WTQ5; Q80SS4; Q810D4; Q8BPK4; Q99MP1;
02-OCT-2007, integrated into UniProtKB/Swiss-Prot.
01-NOV-1999, sequence version 1.
03-JUL-2019, entry version 122.
RecName: Full=A-kinase anchor protein 12;
Short=AKAP-12;
AltName: Full=Germ cell lineage protein gercelin;
AltName: Full=Src-suppressed C kinase substrate;
Short=SSeCKS;
Name=Akap12; Synonyms=Gag12, Ssecks;
Mus musculus (Mouse).
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
Muroidea; Muridae; Murinae; Mus; Mus.
NCBI_TaxID=10090;
[1]
NUCLEOTIDE SEQUENCE [MRNA] (ISOFORMS 1 AND 2), AND TISSUE SPECIFICITY.
TISSUE=Testis;
PubMed=11429284; DOI=10.1016/S0925-4773(01)00384-7;
Camus A., Mesbah K., Rallu M., Babinet C., Barra J.;
"Gene trap insertion reveals two open reading frames in the mouse
SSeCKS gene: the form predominantly detected in the nervous system is
suppressed by the insertion while the other, specific of the testis,
remains expressed.";
Mech. Dev. 105:79-91(2001).
[2]
NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1).
STRAIN=BALB/cJ; TISSUE=Testis;
PubMed=11799143; DOI=10.1177/002215540205000212;
Kitamura H., Okita K., Fujikura D., Mori K., Iwanaga T., Saito M.;
"Induction of Src-suppressed C kinase substrate (SSeCKS) in vascular
endothelial cells by bacterial lipopolysaccharide.";
J. Histochem. Cytochem. 50:245-255(2002).
[3]
NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1).
TISSUE=Testis;
Nishina Y., Motoda Y.;
"Mouse testicular cell specific gene, GAG12.";
Submitted (MAR-1999) to the EMBL/GenBank/DDBJ databases.
[4]
NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 2).
TISSUE=Testis;
Tsuchida J., Tanaka H., Yomogida K., Nozaki M., Maeda N., Matsui Y.,
Nishimune Y.;
"Molecular cloning and characterization of the mouse germ cell lineage
protein cDNA, gercelin, encoding the cytoplasmic AKAP, Gercelin /
SSeCKS and the potential germ cell-specific nuclear antigen, GENA.";
Submitted (AUG-2001) to the EMBL/GenBank/DDBJ databases.
[5]
NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 1-605 (ISOFORM 1).
STRAIN=C57BL/6J; TISSUE=Eye;
PubMed=16141072; DOI=10.1126/science.1112014;
Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N.,
Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K.,
Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M.,
Davis M.J., Wilming L.G., Aidinis V., Allen J.E.,
Ambesi-Impiombato A., Apweiler R., Aturaliya R.N., Bailey T.L.,
Bansal M., Baxter L., Beisel K.W., Bersano T., Bono H., Chalk A.M.,
Chiu K.P., Choudhary V., Christoffels A., Clutterbuck D.R.,
Crowe M.L., Dalla E., Dalrymple B.P., de Bono B., Della Gatta G.,
di Bernardo D., Down T., Engstrom P., Fagiolini M., Faulkner G.,
Fletcher C.F., Fukushima T., Furuno M., Futaki S., Gariboldi M.,
Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E.,
Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N.,
Hill D., Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T.,
Jakt M., Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H.,
Kitano H., Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K.,
Kurochkin I.V., Lareau L.F., Lazarevic D., Lipovich L., Liu J.,
Liuni S., McWilliam S., Madan Babu M., Madera M., Marchionni L.,
Matsuda H., Matsuzawa S., Miki H., Mignone F., Miyake S., Morris K.,
Mottagui-Tabar S., Mulder N., Nakano N., Nakauchi H., Ng P.,
Nilsson R., Nishiguchi S., Nishikawa S., Nori F., Ohara O.,
Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G., Pesole G.,
Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z., Ringwald M.,
Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C.,
Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y.,
Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B.,
Sperling S., Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K.,
Tammoja K., Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A.,
Ueda H.R., van Nimwegen E., Verardo R., Wei C.L., Yagi K.,
Yamanishi H., Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C.,
Grimmond S.M., Teasdale R.D., Liu E.T., Brusic V., Quackenbush J.,
Wahlestedt C., Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y.,
Fukuda S., Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T.,
Iida J., Imamura K., Itoh M., Kato T., Kawaji H., Kawagashira N.,
Kawashima T., Kojima M., Kondo S., Konno H., Nakano K., Ninomiya N.,
Nishio T., Okada M., Plessy C., Shibata K., Shiraki T., Suzuki S.,
Tagami M., Waki K., Watahiki A., Okamura-Oho Y., Suzuki H., Kawai J.,
Hayashizaki Y.;
"The transcriptional landscape of the mammalian genome.";
Science 309:1559-1563(2005).
[6]
NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 139-1684 (ISOFORMS 1/2).
STRAIN=FVB/N; TISSUE=Mammary tumor;
PubMed=15489334; DOI=10.1101/gr.2596504;
The MGC Project Team;
"The status, quality, and expansion of the NIH full-length cDNA
project: the Mammalian Gene Collection (MGC).";
Genome Res. 14:2121-2127(2004).
[7]
IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
TISSUE=Embryonic brain;
PubMed=15345747; DOI=10.1074/mcp.M400085-MCP200;
Ballif B.A., Villen J., Beausoleil S.A., Schwartz D., Gygi S.P.;
"Phosphoproteomic analysis of the developing mouse brain.";
Mol. Cell. Proteomics 3:1093-1101(2004).
[8]
PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-467, AND IDENTIFICATION
BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
TISSUE=Brain;
PubMed=16452087; DOI=10.1074/mcp.T500041-MCP200;
Trinidad J.C., Specht C.G., Thalhammer A., Schoepfer R.,
Burlingame A.L.;
"Comprehensive identification of phosphorylation sites in postsynaptic
density preparations.";
Mol. Cell. Proteomics 5:914-922(2006).
[9]
PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-682; SER-683 AND
SER-684, AND IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE
ANALYSIS].
TISSUE=Teratocarcinoma;
PubMed=17622165; DOI=10.1021/pr070122r;
Smith J.C., Duchesne M.A., Tozzi P., Ethier M., Figeys D.;
"A differential phosphoproteomic analysis of retinoic acid-treated P19
cells.";
J. Proteome Res. 6:3174-3186(2007).
[10]
PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT TYR-353, AND IDENTIFICATION
BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
TISSUE=Embryonic fibroblast;
PubMed=19131326; DOI=10.1074/mcp.M800451-MCP200;
Sweet S.M., Bailey C.M., Cunningham D.L., Heath J.K., Cooper H.J.;
"Large scale localization of protein phosphorylation by use of
electron capture dissociation mass spectrometry.";
Mol. Cell. Proteomics 8:904-912(2009).
[11]
PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-18; SER-22; SER-27;
SER-234; SER-270; SER-273; SER-350; SER-371; SER-467; SER-489;
SER-584; SER-631; SER-634; SER-637; SER-682; SER-733; SER-767;
SER-786; THR-871; SER-873; SER-1351 AND SER-1645, AND IDENTIFICATION
BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
TISSUE=Brain, Brown adipose tissue, Heart, Kidney, Liver, Lung,
Pancreas, Spleen, and Testis;
PubMed=21183079; DOI=10.1016/j.cell.2010.12.001;
Huttlin E.L., Jedrychowski M.P., Elias J.E., Goswami T., Rad R.,
Beausoleil S.A., Villen J., Haas W., Sowa M.E., Gygi S.P.;
"A tissue-specific atlas of mouse protein phosphorylation and
expression.";
Cell 143:1174-1189(2010).
-!- FUNCTION: Anchoring protein that mediates the subcellular
compartmentation of protein kinase A (PKA) and protein kinase C
(PKC). {ECO:0000250}.
-!- SUBUNIT: Binds to dimeric RII-alpha regulatory subunit of PKC.
{ECO:0000250}.
-!- SUBCELLULAR LOCATION: Cytoplasm, cytoskeleton {ECO:0000250}.
Membrane {ECO:0000250|UniProtKB:Q02952}; Lipid-anchor
{ECO:0000250|UniProtKB:Q02952}.
-!- ALTERNATIVE PRODUCTS:
Event=Alternative splicing; Named isoforms=2;
Name=1; Synonyms=Alpha;
IsoId=Q9WTQ5-1; Sequence=Displayed;
Name=2; Synonyms=Gamma;
IsoId=Q9WTQ5-2; Sequence=VSP_028135;
-!- TISSUE SPECIFICITY: Isoform 1 is predominantly found in the
nervous system. Isoform 3 is testis specific.
{ECO:0000269|PubMed:11429284}.
-!- SEQUENCE CAUTION:
Sequence=BAC66465.1; Type=Frameshift; Positions=28, 43; Evidence={ECO:0000305};
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EMBL; AF326228; AAK16150.1; -; mRNA.
EMBL; AF326230; AAK16152.1; -; mRNA.
EMBL; AB020886; BAA76894.1; -; mRNA.
EMBL; AB025278; BAC66465.1; ALT_FRAME; mRNA.
EMBL; AB051563; BAB72161.1; -; mRNA.
EMBL; AB070852; BAB72164.1; -; mRNA.
EMBL; AB070853; BAB72165.1; -; mRNA.
EMBL; AK053844; BAC35553.1; -; mRNA.
EMBL; BC042461; AAH42461.1; -; mRNA.
EMBL; BC043939; AAH43939.1; -; mRNA.
CCDS; CCDS56673.1; -. [Q9WTQ5-1]
RefSeq; NP_112462.1; NM_031185.3. [Q9WTQ5-1]
SMR; Q9WTQ5; -.
BioGrid; 219914; 11.
ELM; Q9WTQ5; -.
IntAct; Q9WTQ5; 12.
MINT; Q9WTQ5; -.
STRING; 10090.ENSMUSP00000035829; -.
iPTMnet; Q9WTQ5; -.
PhosphoSitePlus; Q9WTQ5; -.
SwissPalm; Q9WTQ5; -.
jPOST; Q9WTQ5; -.
PaxDb; Q9WTQ5; -.
PeptideAtlas; Q9WTQ5; -.
PRIDE; Q9WTQ5; -.
Ensembl; ENSMUST00000045730; ENSMUSP00000035829; ENSMUSG00000038587. [Q9WTQ5-1]
Ensembl; ENSMUST00000215696; ENSMUSP00000150261; ENSMUSG00000038587. [Q9WTQ5-2]
GeneID; 83397; -.
KEGG; mmu:83397; -.
UCSC; uc007ehh.1; mouse. [Q9WTQ5-1]
CTD; 9590; -.
MGI; MGI:1932576; Akap12.
eggNOG; ENOG410IFC9; Eukaryota.
eggNOG; ENOG4110Y3C; LUCA.
GeneTree; ENSGT00730000111244; -.
HOGENOM; HOG000293190; -.
InParanoid; Q9WTQ5; -.
KO; K16528; -.
OMA; HSTPDAE; -.
OrthoDB; 158752at2759; -.
PhylomeDB; Q9WTQ5; -.
TreeFam; TF105411; -.
PRO; PR:Q9WTQ5; -.
Proteomes; UP000000589; Chromosome 10.
Bgee; ENSMUSG00000038587; Expressed in 273 organ(s), highest expression level in urinary bladder.
ExpressionAtlas; Q9WTQ5; baseline and differential.
Genevisible; Q9WTQ5; MM.
GO; GO:0005737; C:cytoplasm; ISO:MGI.
GO; GO:0005856; C:cytoskeleton; IEA:UniProtKB-SubCell.
GO; GO:0005829; C:cytosol; ISO:MGI.
GO; GO:0043025; C:neuronal cell body; ISO:MGI.
GO; GO:0005886; C:plasma membrane; ISO:MGI.
GO; GO:0098685; C:Schaffer collateral - CA1 synapse; IDA:SynGO.
GO; GO:0008179; F:adenylate cyclase binding; ISO:MGI.
GO; GO:0051018; F:protein kinase A binding; IEA:InterPro.
GO; GO:0030159; F:receptor signaling complex adaptor activity; TAS:MGI.
GO; GO:0007193; P:adenylate cyclase-inhibiting G protein-coupled receptor signaling pathway; ISO:MGI.
GO; GO:0071347; P:cellular response