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ACSL4 isoform 1 (Acyl-CoA synthetase long chain family member 4)

 H2PWH1_PONAB            Unreviewed;       670 AA.
H2PWH1; A0A2J8VAK3;
21-MAR-2012, integrated into UniProtKB/TrEMBL.
09-JAN-2013, sequence version 2.
10-APR-2019, entry version 51.
SubName: Full=ACSL4 isoform 1 {ECO:0000313|EMBL:PNJ54550.1};
Name=ACSL4 {ECO:0000313|Ensembl:ENSPPYP00000023091};
ORFNames=CR201_G0020428 {ECO:0000313|EMBL:PNJ54550.1};
Pongo abelii (Sumatran orangutan) (Pongo pygmaeus abelii).
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
Catarrhini; Hominidae; Pongo.
NCBI_TaxID=9601 {ECO:0000313|Ensembl:ENSPPYP00000023091, ECO:0000313|Proteomes:UP000001595};
[1] {ECO:0000313|Ensembl:ENSPPYP00000023091, ECO:0000313|Proteomes:UP000001595}
NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Wilson R.K., Mardis E.;
"A 6x draft sequence assembly of the Pongo pygmaeus abelii genome.";
Submitted (FEB-2008) to the EMBL/GenBank/DDBJ databases.
[2] {ECO:0000313|Ensembl:ENSPPYP00000023091}
IDENTIFICATION.
Ensembl;
Submitted (FEB-2012) to UniProtKB.
[3] {ECO:0000313|EMBL:PNJ54550.1}
NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
STRAIN=Susie {ECO:0000313|EMBL:PNJ54550.1};
Pollen A., Hastie A., Hormozdiari F., Dougherty M., Liu R.,
Chaisson M., Hoppe E., Hill C., Pang A., Hillier L., Baker C.,
Armstrong J., Shendure J., Paten B., Wilson R., Chao H., Schneider V.,
Ventura M., Kronenberg Z., Murali S., Gordon D., Cantsilieris S.,
Munson K., Nelson B., Raja A., Underwood J., Diekhans M., Fiddes I.,
Haussler D., Eichler E.;
"High-resolution comparative analysis of great ape genomes.";
Submitted (DEC-2017) to the EMBL/GenBank/DDBJ databases.
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EMBL; ABGA01005457; -; NOT_ANNOTATED_CDS; Genomic_DNA.
EMBL; ABGA01005458; -; NOT_ANNOTATED_CDS; Genomic_DNA.
EMBL; ABGA01005459; -; NOT_ANNOTATED_CDS; Genomic_DNA.
EMBL; ABGA01005460; -; NOT_ANNOTATED_CDS; Genomic_DNA.
EMBL; ABGA01005461; -; NOT_ANNOTATED_CDS; Genomic_DNA.
EMBL; ABGA01005462; -; NOT_ANNOTATED_CDS; Genomic_DNA.
EMBL; ABGA01005463; -; NOT_ANNOTATED_CDS; Genomic_DNA.
EMBL; ABGA01005464; -; NOT_ANNOTATED_CDS; Genomic_DNA.
EMBL; ABGA01005465; -; NOT_ANNOTATED_CDS; Genomic_DNA.
EMBL; ABGA01005466; -; NOT_ANNOTATED_CDS; Genomic_DNA.
EMBL; NDHI03003425; PNJ54550.1; -; Genomic_DNA.
RefSeq; XP_002832033.1; XM_002831987.3.
RefSeq; XP_009233442.1; XM_009235167.1.
RefSeq; XP_009233443.1; XM_009235168.1.
ProteinModelPortal; H2PWH1; -.
STRING; 9601.ENSPPYP00000023091; -.
Ensembl; ENSPPYT00000024061; ENSPPYP00000023091; ENSPPYG00000020627.
GeneID; 100462347; -.
KEGG; pon:100462347; -.
CTD; 2182; -.
eggNOG; KOG1256; Eukaryota.
eggNOG; COG1022; LUCA.
GeneTree; ENSGT00940000157427; -.
InParanoid; H2PWH1; -.
KO; K01897; -.
OMA; NHYLNDI; -.
OrthoDB; 293865at2759; -.
TreeFam; TF314012; -.
Proteomes; UP000001595; Chromosome X.
GO; GO:0005811; C:lipid droplet; IEA:Ensembl.
GO; GO:0044233; C:mitochondria-associated endoplasmic reticulum membrane; IEA:Ensembl.
GO; GO:0005739; C:mitochondrion; IEA:Ensembl.
GO; GO:0047676; F:arachidonate-CoA ligase activity; IEA:Ensembl.
GO; GO:0004467; F:long-chain fatty acid-CoA ligase activity; IEA:Ensembl.
GO; GO:0031957; F:very long-chain fatty acid-CoA ligase activity; IEA:Ensembl.
GO; GO:0060136; P:embryonic process involved in female pregnancy; IEA:Ensembl.
InterPro; IPR020845; AMP-binding_CS.
InterPro; IPR000873; AMP-dep_Synth/Lig.
Pfam; PF00501; AMP-binding; 1.
PROSITE; PS00455; AMP_BINDING; 1.
4: Predicted;
Complete proteome {ECO:0000313|Proteomes:UP000001595};
Reference proteome {ECO:0000313|Proteomes:UP000001595}.
DOMAIN 79 537 AMP-binding. {ECO:0000259|Pfam:PF00501}.
SEQUENCE 670 AA; 74422 MW; 1ADA8CA2E02B3122 CRC64;
MAKRIKAKPT SDKPGSPYRS VTHFDSLAVI DIPGADTLDK LFDHAVSKFG KKDSLGTREI
LSEENEMQPN GKVFKKLILG NYKWMNYLEV NRRVNNFGSG LTALGLKPKN TIAIFCETRA
EWMIAAQTCF KYNFPLVTLY ATLGKEAVVH GLNESEASYL ITSVELLESK LKTALLDINC
VKHIIYVDNK AVNKAEYPEG FEIHSMQSVE ELGSDPENLG IPPSRPTPSD MAIVMYTSGS
TGRPKGVMMH HSNLIAGMTG QCERIPGLGP KDTYIGYLPL AHVLELTAEI SCFTYGCRIG
YSSPLTLSDQ SSKIKKGSKG DCTVLKPTLM AAVPEIMDRI YKNVMSKVQE MNYIQKTLFK
IGYDYKLEQI KKGYDAPLCN LLLFKKVKAL LGGNVRMMLS GGAPLSPQTH RFMNVCFCCP
IGQGYGLTES CGAGTVTEVT DYTTGRVGAP LICCEIKLKD WQEGGYTIND KPNPRGEIVI
GGQNISMGYF KNEEKTAEDY SVDENGQRWF CTGDIGEFHP DGCLQIIDRK KDLVKLQAGE
YVSLGKVEAA LKNCPLIDNI CAFAKSDQSY VISFVVPNQK RLTLLAQQKG VEGTWVDICN
NPAMEAEILK EIREAANAMK LERFEIPIKV RLSPEPWTPE TGLVTDAFKL KRKELKNHYL
KDIERMYGGK


Related products :

Catalog number Product name Quantity
ACSL4 ACSL1 Gene acyl-CoA synthetase long-chain family member 1
ACSL6 ACSL4 Gene acyl-CoA synthetase long-chain family member 4
CSB-EL001193RA Rat acyl-CoA synthetase long-chain family member 4 (ACSL4) ELISA kit, Species Rat, Sample Type serum, plasma 96T
CSB-EL001193HU Human acyl-CoA synthetase long-chain family member 4 (ACSL4) ELISA kit, Species Human, Sample Type serum, plasma 96T
CSB-EL001193MO Mouse acyl-CoA synthetase long-chain family member 4 (ACSL4) ELISA kit, Species Mouse, Sample Type serum, plasma 96T
ACSM2A ACSL6 Gene acyl-CoA synthetase long-chain family member 6
201-20-0148 ACSL3{acyl-CoA synthetase long-chain family member 3}rabbit.pAb 0.1ml
201-20-0147 ACSL1{acyl-CoA synthetase long-chain family member 1}rabbit.pAb 0.1ml
ACSM1 ACSL5 Gene acyl-CoA synthetase long-chain family member 5
201-20-0149 ACSL5{acyl-CoA synthetase long-chain family member 5}rabbit.pAb 0.1ml
ACSL5 ACSL3 Gene acyl-CoA synthetase long-chain family member 3
abx110794 Polyclonal Rabbit Acyl-Coa Synthetase Long-Chain Family Member 1 Antibody 50 μl
abx110795 Polyclonal Rabbit Acyl-Coa Synthetase Long-Chain Family Member 3 Antibody 50 μl
abx110796 Polyclonal Rabbit Acyl-Coa Synthetase Long-Chain Family Member 5 Antibody 50 μl
GWB-DFB0FA Anti- ACSL1 (acyl-CoA synthetase long-chain family member 1) Antibody
GS-0025a acyl-CoA synthetase long-chain family member 1 primary antibody, Host: Rabbit 200ul
CSB-EL001192RA Rat acyl-CoA synthetase long-chain family member 3 (ACSL3) ELISA kit, Species Rat, Sample Type serum, plasma 96T
CSB-EL001195RA Rat acyl-CoA synthetase long-chain family member 6 (ACSL6) ELISA kit, Species Rat, Sample Type serum, plasma 96T
CSB-EL001194RA Rat acyl-CoA synthetase long-chain family member 5 (ACSL5) ELISA kit, Species Rat, Sample Type serum, plasma 96T
GWB-AF2E73 Acyl-CoA Synthetase Long-chain Family Member 5 (ACSL5) Goat anti-Human Polyclonal (C-Terminus) Antibody
CSB-EL001195HU Human acyl-CoA synthetase long-chain family member 6 (ACSL6) ELISA kit, Species Human, Sample Type serum, plasma 96T
CSB-EL001195MO Mouse acyl-CoA synthetase long-chain family member 6 (ACSL6) ELISA kit, Species Mouse, Sample Type serum, plasma 96T
CSB-EL001191HU Human acyl-CoA synthetase long-chain family member 1 (ACSL1) ELISA kit, Species Human, Sample Type serum, plasma 96T
CSB-EL001192MO Mouse acyl-CoA synthetase long-chain family member 3 (ACSL3) ELISA kit, Species Mouse, Sample Type serum, plasma 96T
CSB-EL001192HU Human acyl-CoA synthetase long-chain family member 3 (ACSL3) ELISA kit, Species Human, Sample Type serum, plasma 96T

Kits Elisa; taq POLYMERASE

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Pathways :
WP2347: vitamin B5 (pantothenate) and CoA biosynthesis Pathway
WP1577: amino acid conjugation of benzoic acid
WP1708: Terpenoid backbone biosynthesis
WP1996: Linoleate Biosynthesis
WP2199: Seed Development
WP2434: very-long-chain-fatty-acid-biosynthesis
WP521: amino acid conjugation of benzoic acid
WP1002: Electron Transport Chain
WP1020: Fatty Acid Biosynthesis
WP1061: Fatty Acid Beta Oxidation
WP1107: Mitochondrial LC-Fatty Acid Beta-Oxidation
WP111: Electron Transport Chain
WP1119: Electron Transport Chain
WP1139: Fatty Acid Biosynthesis
WP1177: Fatty Acid Beta Oxidation
WP1207: Fatty Acid Beta Oxidation
WP1226: Mitochondrial LC-Fatty Acid Beta-Oxidation
WP1228: Fatty Acid Biosynthesis
WP1237: Fatty Acid Beta Oxidation
WP1269: Fatty Acid Beta Oxidation
WP1307: Fatty Acid Beta Oxidation
WP1339: Electron Transport Chain
WP1352: Fatty Acid Biosynthesis
WP143: Fatty Acid Beta Oxidation
WP1485: Interactions between CFTR and other ion channels

Related Genes :
[ACSL4 ACS4 FACL4 LACS4] Long-chain-fatty-acid--CoA ligase 4 (EC 6.2.1.3) (Long-chain acyl-CoA synthetase 4) (LACS 4)
[ACSBG2 BGR UNQ2443/PRO5005] Long-chain-fatty-acid--CoA ligase ACSBG2 (EC 6.2.1.3) (Acyl-CoA synthetase bubblegum family member 2) (Bubblegum-related protein) (PRTD-NY3)
[Slc27a3 Acsvl3 Fatp3] Solute carrier family 27 member 3 (EC 6.2.1.-) (Long-chain fatty acid transport protein 3) (FATP-3) (Fatty acid transport protein 3) (Very long-chain acyl-CoA synthetase homolog 3) (VLCS-3)
[Acsm1 Bucs1 Lae Macs1] Acyl-coenzyme A synthetase ACSM1, mitochondrial (EC 6.2.1.2) (Acyl-CoA synthetase medium-chain family member 1) (Butyrate--CoA ligase 1) (Butyryl-coenzyme A synthetase 1) (Lipoate-activating enzyme) (Middle-chain acyl-CoA synthetase 1)
[fadD oldD b1805 JW1794] Long-chain-fatty-acid--CoA ligase (EC 6.2.1.3) (Long-chain acyl-CoA synthetase) (Acyl-CoA synthetase)
[Acsl3 Acs3 Facl3] Long-chain-fatty-acid--CoA ligase 3 (EC 6.2.1.3) (Brain acyl-CoA synthetase II) (Long-chain acyl-CoA synthetase 3) (LACS 3)
[ACSL5 ACS5 FACL5 UNQ633/PRO1250] Long-chain-fatty-acid--CoA ligase 5 (EC 6.2.1.3) (Long-chain acyl-CoA synthetase 5) (LACS 5)
[Acsm3 Sa Sah] Acyl-coenzyme A synthetase ACSM3, mitochondrial (EC 6.2.1.2) (Acyl-CoA synthetase medium-chain family member 3) (Butyrate--CoA ligase 3) (Butyryl-coenzyme A synthetase 3) (Middle-chain acyl-CoA synthetase 3) (Protein SA homolog)
[fadD13 Rv3089] Long-chain-fatty-acid--CoA ligase FadD13 (EC 6.2.1.3) (Fatty acyl-CoA ligase) (FACL) (FACL13) (Fatty acyl-CoA synthetase) (ACS) (FACS) (Very-long-chain fatty-acyl-CoA synthetase) (ACSVL)
[ACSM1 BUCS1 LAE MACS1] Acyl-coenzyme A synthetase ACSM1, mitochondrial (EC 6.2.1.2) (Acyl-CoA synthetase medium-chain family member 1) (Butyrate--CoA ligase 1) (Butyryl-coenzyme A synthetase 1) (Lipoate-activating enzyme) (Middle-chain acyl-CoA synthetase 1)
[ACSM2A ACSM2 MACS2] Acyl-coenzyme A synthetase ACSM2A, mitochondrial (EC 6.2.1.2) (Acyl-CoA synthetase medium-chain family member 2A) (Butyrate--CoA ligase 2A) (Butyryl-coenzyme A synthetase 2A) (Middle-chain acyl-CoA synthetase 2A)
[ACSM3 SAH] Acyl-coenzyme A synthetase ACSM3, mitochondrial (EC 6.2.1.2) (Acyl-CoA synthetase medium-chain family member 3) (Butyrate--CoA ligase 3) (Butyryl-coenzyme A synthetase 3) (Middle-chain acyl-CoA synthetase 3) (Protein SA homolog)
[ACSM1 BUCS1 LAE MACS1] Acyl-coenzyme A synthetase ACSM1, mitochondrial (EC 6.2.1.2) (Acyl-CoA synthetase medium-chain family member 1) (Butyrate--CoA ligase 1) (Butyryl-coenzyme A synthetase 1) (Lipoate-activating enzyme) (Middle-chain acyl-CoA synthetase 1) (XL-III) (Xenobiotic/medium-chain fatty acid:CoA ligase XL-3) (XM-ligase 3)
[ELOVL5 ELOVL2 PRO0530] Elongation of very long chain fatty acids protein 5 (EC 2.3.1.199) (3-keto acyl-CoA synthase ELOVL5) (ELOVL fatty acid elongase 5) (ELOVL FA elongase 5) (Fatty acid elongase 1) (hELO1) (Very long chain 3-ketoacyl-CoA synthase 5) (Very long chain 3-oxoacyl-CoA synthase 5)
[ACSM2B ACSM2 HYST1046] Acyl-coenzyme A synthetase ACSM2B, mitochondrial (EC 6.2.1.2) (Acyl-CoA synthetase medium-chain family member 2B) (Butyrate--CoA ligase 2B) (Butyryl-coenzyme A synthetase 2B) (Middle-chain acyl-CoA synthetase 2B) (Xenobiotic/medium-chain fatty acid-CoA ligase HXM-A)
[ELOVL4] Elongation of very long chain fatty acids protein 4 (EC 2.3.1.199) (3-keto acyl-CoA synthase ELOVL4) (ELOVL fatty acid elongase 4) (ELOVL FA elongase 4) (Very long chain 3-ketoacyl-CoA synthase 4) (Very long chain 3-oxoacyl-CoA synthase 4)
[FAA2 FAM1 YER015W] Long-chain-fatty-acid--CoA ligase 2 (EC 6.2.1.3) (Fatty acid activator 2) (Long-chain acyl-CoA synthetase 2)
[ACSS2 ACAS2] Acetyl-coenzyme A synthetase, cytoplasmic (EC 6.2.1.1) (Acetate--CoA ligase) (Acetyl-CoA synthetase) (ACS) (AceCS) (Acyl-CoA synthetase short-chain family member 2) (Acyl-activating enzyme)
[HADHA HADH] Trifunctional enzyme subunit alpha, mitochondrial (78 kDa gastrin-binding protein) (TP-alpha) [Includes: Long-chain enoyl-CoA hydratase (EC 4.2.1.17); Long chain 3-hydroxyacyl-CoA dehydrogenase (EC 1.1.1.211)]
[CBR4 SDR45C1] Carbonyl reductase family member 4 (EC 1.-.-.-) (3-ketoacyl-[acyl-carrier-protein] reductase beta subunit) (KAR beta subunit) (3-oxoacyl-[acyl-carrier-protein] reductase) (EC 1.1.1.-) (Quinone reductase CBR4) (Short chain dehydrogenase/reductase family 45C member 1)
[Acot3 Pte1a Pte2 Pte2a] Acyl-coenzyme A thioesterase 3 (Acyl-CoA thioesterase 3) (EC 3.1.2.2) (PTE-Ia) (Peroxisomal acyl-coenzyme A thioester hydrolase 2a) (Peroxisomal long-chain acyl-CoA thioesterase 2)
[Acot1 Cte1] Acyl-coenzyme A thioesterase 1 (Acyl-CoA thioesterase 1) (EC 3.1.2.2) (CTE-I) (Inducible cytosolic acyl-coenzyme A thioester hydrolase) (Long chain acyl-CoA thioester hydrolase) (Long chain acyl-CoA hydrolase)
[Acsm2] Acyl-coenzyme A synthetase ACSM2, mitochondrial (EC 6.2.1.2) (Acyl-CoA synthetase medium-chain family member 2) (Butyrate--CoA ligase 2) (Butyryl-coenzyme A synthetase 2) (Middle-chain acyl-CoA synthetase 2)
[Acot4 Pte1b Pte2b] Acyl-coenzyme A thioesterase 4 (Acyl-CoA thioesterase 4) (EC 3.1.2.2) (PTE-2b) (Peroxisomal acyl coenzyme A thioester hydrolase Ib) (Peroxisomal long-chain acyl-CoA thioesterase Ib) (PTE-Ib)
[ELOVL7] Elongation of very long chain fatty acids protein 7 (EC 2.3.1.199) (3-keto acyl-CoA synthase ELOVL7) (ELOVL fatty acid elongase 7) (ELOVL FA elongase 7) (Very long chain 3-ketoacyl-CoA synthase 7) (Very long chain 3-oxoacyl-CoA synthase 7)
[FAA1 YOR317W O6136] Long-chain-fatty-acid--CoA ligase 1 (EC 6.2.1.3) (Fatty acid activator 1) (Long-chain acyl-CoA synthetase 1)
[ACSF3 PSEC0197] Acyl-CoA synthetase family member 3, mitochondrial (EC 6.2.1.-)
[ACSM5 MACS3] Acyl-coenzyme A synthetase ACSM5, mitochondrial (EC 6.2.1.2) (Acyl-CoA synthetase medium-chain family member 5)
[ACADVL VLCAD] Very long-chain specific acyl-CoA dehydrogenase, mitochondrial (VLCAD) (EC 1.3.8.9)
[DHRS4 SDR25C2 UNQ851/PRO1800] Dehydrogenase/reductase SDR family member 4 (EC 1.1.1.184) (NADPH-dependent carbonyl reductase/NADP-retinol dehydrogenase) (CR) (PHCR) (NADPH-dependent retinol dehydrogenase/reductase) (NRDR) (humNRDR) (Peroxisomal short-chain alcohol dehydrogenase) (PSCD) (SCAD-SRL) (Short chain dehydrogenase/reductase family 25C member 2) (Short-chain dehydrogenase/reductase family member 4)

Bibliography :
[16428347] Distinct transcriptional regulation of long-chain acyl-CoA synthetase isoforms and cytosolic thioesterase 1 in the rodent heart by fatty acids and insulin.