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ADP-ribosylation factor 1-like 2 (ADP-ribosylation factor-related protein 1.2)

 ARF12_CAEEL             Reviewed;         181 AA.
Q10943;
01-OCT-1996, integrated into UniProtKB/Swiss-Prot.
23-JAN-2007, sequence version 2.
07-APR-2021, entry version 170.
RecName: Full=ADP-ribosylation factor 1-like 2;
AltName: Full=ADP-ribosylation factor-related protein 1.2;
Name=arf-1.2 {ECO:0000312|WormBase:B0336.2};
Synonyms=arf-1 {ECO:0000312|WormBase:B0336.2};
ORFNames=B0336.2 {ECO:0000312|WormBase:B0336.2};
Caenorhabditis elegans.
Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida;
Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae;
Caenorhabditis.
NCBI_TaxID=6239;
[1]
NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
STRAIN=Bristol N2;
PubMed=9851916; DOI=10.1126/science.282.5396.2012;
The C. elegans sequencing consortium;
"Genome sequence of the nematode C. elegans: a platform for investigating
biology.";
Science 282:2012-2018(1998).
[2]
FUNCTION, TISSUE SPECIFICITY, AND DEVELOPMENTAL STAGE.
PubMed=15576487; DOI=10.1096/fj.04-2273com;
Li Y., Kelly W.G., Logsdon J.M. Jr., Schurko A.M., Harfe B.D.,
Hill-Harfe K.L., Kahn R.A.;
"Functional genomic analysis of the ADP-ribosylation factor family of
GTPases: phylogeny among diverse eukaryotes and function in C. elegans.";
FASEB J. 18:1834-1850(2004).
[3]
FUNCTION, AND DISRUPTION PHENOTYPE.
PubMed=15716356; DOI=10.1091/mbc.e04-08-0726;
Poteryaev D., Squirrell J.M., Campbell J.M., White J.G., Spang A.;
"Involvement of the actin cytoskeleton and homotypic membrane fusion in ER
dynamics in Caenorhabditis elegans.";
Mol. Biol. Cell 16:2139-2153(2005).
[4]
FUNCTION, AND DISRUPTION PHENOTYPE.
PubMed=21596567; DOI=10.1016/j.cub.2011.04.025;
Singhvi A., Teuliere J., Talavera K., Cordes S., Ou G., Vale R.D.,
Prasad B.C., Clark S.G., Garriga G.;
"The Arf GAP CNT-2 regulates the apoptotic fate in C. elegans asymmetric
neuroblast divisions.";
Curr. Biol. 21:948-954(2011).
[5]
FUNCTION.
PubMed=22801495; DOI=10.1038/nature11240;
Denning D.P., Hatch V., Horvitz H.R.;
"Programmed elimination of cells by caspase-independent cell extrusion in
C. elegans.";
Nature 488:226-230(2012).
[6]
FUNCTION, AND DISRUPTION PHENOTYPE.
PubMed=25190516; DOI=10.15252/embj.201489039;
Ackema K.B., Hench J., Boeckler S., Wang S.C., Sauder U., Mergentaler H.,
Westermann B., Bard F., Frank S., Spang A.;
"The small GTPase Arf1 modulates mitochondrial morphology and function.";
EMBO J. 33:2659-2675(2014).
-!- FUNCTION: GTP-binding protein involved in protein trafficking; may
modulate vesicle budding and uncoating within the Golgi apparatus.
Involved in endoplasmic reticulum dynamics during embryogenesis
(PubMed:15716356). Also required for adult germline function
(PubMed:15576487). Plays a role in cell shedding during embryogenesis
probably by promoting the endocytosis of cell adhesion molecules
(PubMed:22801495). During neurogenesis, involved in cell autonomous Q.p
neuroblast asymmetric divisions that generate one precursor cell and
one apoptotic cell, probably by controlling endocytosis
(PubMed:21596567). Plays a role in maintaining mitochondrial morphology
(PubMed:25190516). {ECO:0000269|PubMed:15576487,
ECO:0000269|PubMed:15716356, ECO:0000269|PubMed:21596567,
ECO:0000269|PubMed:25190516, ECO:0000305|PubMed:22801495}.
-!- SUBCELLULAR LOCATION: Golgi apparatus {ECO:0000250}.
-!- TISSUE SPECIFICITY: Expressed in hypodermis, intestine, spermatheca,
uterus, gonadal sheath, vulva cells, pharynx muscle, body wall muscle,
head neurons, ventral nerve cord. {ECO:0000269|PubMed:15576487}.
-!- DEVELOPMENTAL STAGE: First detected in very young embryos with as
little as 48-64 cells. {ECO:0000269|PubMed:15576487}.
-!- DISRUPTION PHENOTYPE: Death during embryogenesis (PubMed:15716356).
Some muscle differentiation occurs although it is poorly organized and
little elongation or morphogenesis is evident (PubMed:15716356). Extra
A/PVM neurons are produced from the precursor Q.pp, which is normally
fated to die, acquiring the fate of its sister Q.pa (PubMed:21596567).
Q.pa and Q.pp have almost similar size caused by a loss of Q.p
asymmetric cell division (PubMed:21596567). In oocytes, plasma membrane
localization of rme-2 is impaired resulting in the loss of vit-2 uptake
which accumulates in the pseudocoelom (PubMed:21596567). RNAi-mediated
knockdown results in a hyper-connected mitochondrial network in body
wall muscle cells (PubMed:25190516). {ECO:0000269|PubMed:15716356,
ECO:0000269|PubMed:21596567, ECO:0000269|PubMed:25190516}.
-!- SIMILARITY: Belongs to the small GTPase superfamily. Arf family.
{ECO:0000305}.
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EMBL; BX284603; CCD61516.1; -; Genomic_DNA.
PIR; T15341; T15341.
RefSeq; NP_498235.1; NM_065834.3.
SMR; Q10943; -.
BioGRID; 41027; 18.
DIP; DIP-24528N; -.
IntAct; Q10943; 3.
STRING; 6239.B0336.2.1; -.
EPD; Q10943; -.
PaxDb; Q10943; -.
PeptideAtlas; Q10943; -.
PRIDE; Q10943; -.
EnsemblMetazoa; B0336.2.1; B0336.2.1; WBGene00000182.
EnsemblMetazoa; B0336.2.2; B0336.2.2; WBGene00000182.
EnsemblMetazoa; B0336.2.3; B0336.2.3; WBGene00000182.
UCSC; B0336.2.1; c. elegans.
WormBase; B0336.2; CE00696; WBGene00000182; arf-1.2.
eggNOG; KOG0070; Eukaryota.
GeneTree; ENSGT00950000183080; -.
HOGENOM; CLU_040729_9_3_1; -.
InParanoid; Q10943; -.
OMA; NDRERIP; -.
OrthoDB; 1362554at2759; -.
PhylomeDB; Q10943; -.
Reactome; R-CEL-1660514; Synthesis of PIPs at the Golgi membrane.
Reactome; R-CEL-199992; trans-Golgi Network Vesicle Budding.
Reactome; R-CEL-432720; Lysosome Vesicle Biogenesis.
Reactome; R-CEL-432722; Golgi Associated Vesicle Biogenesis.
Reactome; R-CEL-6807878; COPI-mediated anterograde transport.
Reactome; R-CEL-6811434; COPI-dependent Golgi-to-ER retrograde traffic.
Reactome; R-CEL-6811438; Intra-Golgi traffic.
PRO; PR:Q10943; -.
Proteomes; UP000001940; Chromosome III.
Bgee; WBGene00000182; Expressed in multi-cellular organism and 5 other tissues.
GO; GO:0005783; C:endoplasmic reticulum; IDA:UniProtKB.
GO; GO:0005794; C:Golgi apparatus; IEA:UniProtKB-SubCell.
GO; GO:0005886; C:plasma membrane; IBA:GO_Central.
GO; GO:0005525; F:GTP binding; IBA:GO_Central.
GO; GO:0009792; P:embryo development ending in birth or egg hatching; IMP:UniProtKB.
GO; GO:0007276; P:gamete generation; IMP:UniProtKB.
GO; GO:0006886; P:intracellular protein transport; IMP:WormBase.
GO; GO:0007005; P:mitochondrion organization; IMP:WormBase.
GO; GO:0048599; P:oocyte development; IMP:WormBase.
GO; GO:1904748; P:regulation of apoptotic process involved in development; IGI:UniProtKB.
GO; GO:0048259; P:regulation of receptor-mediated endocytosis; IGI:WormBase.
GO; GO:0016192; P:vesicle-mediated transport; IBA:GO_Central.
InterPro; IPR027417; P-loop_NTPase.
InterPro; IPR005225; Small_GTP-bd_dom.
InterPro; IPR006689; Small_GTPase_ARF/SAR.
Pfam; PF00025; Arf; 1.
PRINTS; PR00328; SAR1GTPBP.
SUPFAM; SSF52540; SSF52540; 1.
TIGRFAMs; TIGR00231; small_GTP; 1.
PROSITE; PS51417; ARF; 1.
2: Evidence at transcript level;
ER-Golgi transport; Golgi apparatus; GTP-binding; Lipoprotein; Myristate;
Nucleotide-binding; Protein transport; Reference proteome; Transport.
INIT_MET 1
/note="Removed"
/evidence="ECO:0000255"
CHAIN 2..181
/note="ADP-ribosylation factor 1-like 2"
/id="PRO_0000207405"
NP_BIND 24..31
/note="GTP"
/evidence="ECO:0000250"
NP_BIND 67..71
/note="GTP"
/evidence="ECO:0000250"
NP_BIND 126..129
/note="GTP"
/evidence="ECO:0000250"
BINDING 69
/note="GTP; via amide nitrogen"
/evidence="ECO:0000250"
LIPID 2
/note="N-myristoyl glycine"
/evidence="ECO:0000255"
SEQUENCE 181 AA; 20522 MW; 98FD0886AD9A2459 CRC64;
MGNVFGSLFK GLFGKREMRI LMVGLDAAGK TTILYKLKLG EIVTTIPTIG FNVETVEYKN
ISFTVWDVGG QDKIRPLWRH YFQNTQGLIF VVDSNDRERV GEAREELMRM LAEDELRDAV
LLVFANKQDL PQAMNAAEVT DKLGLHSLRN RSWYIQATCA TSGDGLYEGL DWLSNQLKNR
S


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WP1235: Signaling of Hepatocyte Growth Factor Receptor
WP810: Signaling of Hepatocyte Growth Factor Receptor
WP2199: Seed Development
WP2272: Pathogenic Escherichia coli infection
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Related Genes :
[arf-1.2 arf-1 B0336.2] ADP-ribosylation factor 1-like 2 (ADP-ribosylation factor-related protein 1.2)
[GGA1] ADP-ribosylation factor-binding protein GGA1 (Gamma-adaptin-related protein 1) (Golgi-localized, gamma ear-containing, ARF-binding protein 1)
[evl-20 arl-2 F22B5.1] ADP-ribosylation factor-like protein 2 (Abnormal eversion of vulva protein 20)
[Arfgap1 Arf1gap] ADP-ribosylation factor GTPase-activating protein 1 (ARF GAP 1) (ADP-ribosylation factor 1 GTPase-activating protein) (ARF1 GAP) (ARF1-directed GTPase-activating protein)
[ARFGAP1 ARF1GAP] ADP-ribosylation factor GTPase-activating protein 1 (ARF GAP 1) (ADP-ribosylation factor 1 GTPase-activating protein) (ARF1 GAP) (ARF1-directed GTPase-activating protein)
[ARL4C ARL7] ADP-ribosylation factor-like protein 4C (ADP-ribosylation factor-like protein 7) (ADP-ribosylation factor-like protein LAK)
[ASAP1 DDEF1 KIAA1249 PAG2] Arf-GAP with SH3 domain, ANK repeat and PH domain-containing protein 1 (130 kDa phosphatidylinositol 4,5-bisphosphate-dependent ARF1 GTPase-activating protein) (ADP-ribosylation factor-directed GTPase-activating protein 1) (ARF GTPase-activating protein 1) (Development and differentiation-enhancing factor 1) (DEF-1) (Differentiation-enhancing factor 1) (PIP2-dependent ARF1 GAP)
[Asap1 Ddef1 Kiaa1249 Shag1] Arf-GAP with SH3 domain, ANK repeat and PH domain-containing protein 1 (130 kDa phosphatidylinositol 4,5-bisphosphate-dependent ARF1 GTPase-activating protein) (ADP-ribosylation factor-directed GTPase-activating protein 1) (ARF GTPase-activating protein 1) (Development and differentiation-enhancing factor 1) (DEF-1) (Differentiation-enhancing factor 1) (PIP2-dependent ARF1 GAP)
[ARL2BP BART BART1] ADP-ribosylation factor-like protein 2-binding protein (ARF-like 2-binding protein) (ARL2-binding protein) (Binder of ARF2 protein 1)
[Arl6ip1 Arl6ip] ADP-ribosylation factor-like protein 6-interacting protein 1 (ARL-6-interacting protein 1) (Aip-1) (Protein TBX2)
[ARFIP2 POR1] Arfaptin-2 (ADP-ribosylation factor-interacting protein 2) (Partner of RAC1) (Protein POR1)
[ARFGEF2 ARFGEP2 BIG2] Brefeldin A-inhibited guanine nucleotide-exchange protein 2 (Brefeldin A-inhibited GEP 2) (ADP-ribosylation factor guanine nucleotide-exchange factor 2)
[ARF1] ADP-ribosylation factor 1
[ARF4 ARF2] ADP-ribosylation factor 4
[ARFGEF1 ARFGEP1 BIG1] Brefeldin A-inhibited guanine nucleotide-exchange protein 1 (Brefeldin A-inhibited GEP 1) (ADP-ribosylation factor guanine nucleotide-exchange factor 1) (p200 ARF guanine nucleotide exchange factor) (p200 ARF-GEP1)
[Arl6ip5 Aip5 Jwa Pra2 Praf3] PRA1 family protein 3 (ADP-ribosylation factor-like protein 6-interacting protein 5) (ARL-6-interacting protein 5) (Aip-5) (Addicsin) (GTRAP3-18) (Glutamate transporter EAAC1-interacting protein) (Prenylated Rab acceptor protein 2) (Protein JWa)
[ARFIP1] Arfaptin-1 (ADP-ribosylation factor-interacting protein 1)
[Arfgef2 Arfgep2 Big2] Brefeldin A-inhibited guanine nucleotide-exchange protein 2 (Brefeldin A-inhibited GEP 2) (ADP-ribosylation factor guanine nucleotide-exchange factor 2)
[AGD3 FKD2 SFC VAN3 At5g13300 T31B5.120] ADP-ribosylation factor GTPase-activating protein AGD3 (ARF GAP AGD3) (Protein ARF-GAP DOMAIN 3) (AtAGD3) (Protein FORKED 2) (Protein SCARFACE) (Protein VASCULAR NETWORK 3)
[Asap1 Ddef1] Arf-GAP with SH3 domain, ANK repeat and PH domain-containing protein 1 (130 kDa phosphatidylinositol 4,5-bisphosphate-dependent ARF1 GTPase-activating protein) (ADP-ribosylation factor-directed GTPase-activating protein 1) (ARF GTPase-activating protein 1) (Development and differentiation-enhancing factor 1) (DEF-1) (Differentiation-enhancing factor 1) (PIP2-dependent ARF1 GAP)
[ARL1] ADP-ribosylation factor-like protein 1
[ARL6IP1 ARL6IP ARMER KIAA0069] ADP-ribosylation factor-like protein 6-interacting protein 1 (ARL-6-interacting protein 1) (Aip-1) (Apoptotic regulator in the membrane of the endoplasmic reticulum)
[Arfgef1] Brefeldin A-inhibited guanine nucleotide-exchange protein 1 (BIG1) (Brefeldin A-inhibited GEP 1) (ADP-ribosylation factor guanine nucleotide-exchange factor 1)
[ARFGEF1 ARFGEP1 BIG1] Brefeldin A-inhibited guanine nucleotide-exchange protein 1 (Brefeldin A-inhibited GEP 1) (ADP-ribosylation factor guanine nucleotide-exchange factor 1) (p200 ARF guanine nucleotide exchange factor) (p200 ARF-GEP1)
[ARL2] ADP-ribosylation factor-like protein 2
[arl6 si:dkey-24h22.2 zgc:101762] ADP-ribosylation factor-like protein 6
[ARL3 ARFL3] ADP-ribosylation factor-like protein 3
[Arf4] ADP-ribosylation factor 4
[Arf4] ADP-ribosylation factor 4
[Arl3] ADP-ribosylation factor-like protein 3

Bibliography :