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AIF1 (Allograft inflammatory factor 1 isoform 3) (Allograft inflammatory factor 1, isoform CRA_c)

 Q4V347_HUMAN            Unreviewed;       147 AA.
Q4V347;
05-JUL-2005, integrated into UniProtKB/TrEMBL.
05-JUL-2005, sequence version 1.
12-AUG-2020, entry version 134.
SubName: Full=AIF1 {ECO:0000313|EMBL:AQY76655.1};
SubName: Full=Allograft inflammatory factor 1 isoform 3 {ECO:0000313|EMBL:ABK35647.1};
SubName: Full=Allograft inflammatory factor 1, isoform CRA_c {ECO:0000313|EMBL:EAX03445.1};
Name=AIF1 {ECO:0000313|EMBL:AFL46387.1};
ORFNames=hCG_43680 {ECO:0000313|EMBL:EAX03445.1};
Homo sapiens (Human).
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
Homo.
NCBI_TaxID=9606 {ECO:0000313|EMBL:ABK35647.1};
[1] {ECO:0000313|EMBL:EAX03445.1}
NUCLEOTIDE SEQUENCE.
PubMed=11181995; DOI=10.1126/science.1058040;
Venter J.C., Adams M.D., Myers E.W., Li P.W., Mural R.J., Sutton G.G.,
Smith H.O., Yandell M., Evans C.A., Holt R.A., Gocayne J.D., Amanatides P.,
Ballew R.M., Huson D.H., Wortman J.R., Zhang Q., Kodira C.D., Zheng X.H.,
Chen L., Skupski M., Subramanian G., Thomas P.D., Zhang J.,
Gabor Miklos G.L., Nelson C., Broder S., Clark A.G., Nadeau J.,
McKusick V.A., Zinder N., Levine A.J., Roberts R.J., Simon M., Slayman C.,
Hunkapiller M., Bolanos R., Delcher A., Dew I., Fasulo D., Flanigan M.,
Florea L., Halpern A., Hannenhalli S., Kravitz S., Levy S., Mobarry C.,
Reinert K., Remington K., Abu-Threideh J., Beasley E., Biddick K.,
Bonazzi V., Brandon R., Cargill M., Chandramouliswaran I., Charlab R.,
Chaturvedi K., Deng Z., Di Francesco V., Dunn P., Eilbeck K.,
Evangelista C., Gabrielian A.E., Gan W., Ge W., Gong F., Gu Z., Guan P.,
Heiman T.J., Higgins M.E., Ji R.R., Ke Z., Ketchum K.A., Lai Z., Lei Y.,
Li Z., Li J., Liang Y., Lin X., Lu F., Merkulov G.V., Milshina N.,
Moore H.M., Naik A.K., Narayan V.A., Neelam B., Nusskern D., Rusch D.B.,
Salzberg S., Shao W., Shue B., Sun J., Wang Z., Wang A., Wang X., Wang J.,
Wei M., Wides R., Xiao C., Yan C., Yao A., Ye J., Zhan M., Zhang W.,
Zhang H., Zhao Q., Zheng L., Zhong F., Zhong W., Zhu S., Zhao S.,
Gilbert D., Baumhueter S., Spier G., Carter C., Cravchik A., Woodage T.,
Ali F., An H., Awe A., Baldwin D., Baden H., Barnstead M., Barrow I.,
Beeson K., Busam D., Carver A., Center A., Cheng M.L., Curry L.,
Danaher S., Davenport L., Desilets R., Dietz S., Dodson K., Doup L.,
Ferriera S., Garg N., Gluecksmann A., Hart B., Haynes J., Haynes C.,
Heiner C., Hladun S., Hostin D., Houck J., Howland T., Ibegwam C.,
Johnson J., Kalush F., Kline L., Koduru S., Love A., Mann F., May D.,
McCawley S., McIntosh T., McMullen I., Moy M., Moy L., Murphy B.,
Nelson K., Pfannkoch C., Pratts E., Puri V., Qureshi H., Reardon M.,
Rodriguez R., Rogers Y.H., Romblad D., Ruhfel B., Scott R., Sitter C.,
Smallwood M., Stewart E., Strong R., Suh E., Thomas R., Tint N.N., Tse S.,
Vech C., Wang G., Wetter J., Williams S., Williams M., Windsor S.,
Winn-Deen E., Wolfe K., Zaveri J., Zaveri K., Abril J.F., Guigo R.,
Campbell M.J., Sjolander K.V., Karlak B., Kejariwal A., Mi H., Lazareva B.,
Hatton T., Narechania A., Diemer K., Muruganujan A., Guo N., Sato S.,
Bafna V., Istrail S., Lippert R., Schwartz R., Walenz B., Yooseph S.,
Allen D., Basu A., Baxendale J., Blick L., Caminha M., Carnes-Stine J.,
Caulk P., Chiang Y.H., Coyne M., Dahlke C., Mays A., Dombroski M.,
Donnelly M., Ely D., Esparham S., Fosler C., Gire H., Glanowski S.,
Glasser K., Glodek A., Gorokhov M., Graham K., Gropman B., Harris M.,
Heil J., Henderson S., Hoover J., Jennings D., Jordan C., Jordan J.,
Kasha J., Kagan L., Kraft C., Levitsky A., Lewis M., Liu X., Lopez J.,
Ma D., Majoros W., McDaniel J., Murphy S., Newman M., Nguyen T., Nguyen N.,
Nodell M., Pan S., Peck J., Peterson M., Rowe W., Sanders R., Scott J.,
Simpson M., Smith T., Sprague A., Stockwell T., Turner R., Venter E.,
Wang M., Wen M., Wu D., Wu M., Xia A., Zandieh A., Zhu X.;
"The sequence of the human genome.";
Science 291:1304-1351(2001).
[2] {ECO:0000313|EMBL:EAX03445.1}
NUCLEOTIDE SEQUENCE.
Mural R.J., Istrail S., Sutton G., Florea L., Halpern A.L., Mobarry C.M.,
Lippert R., Walenz B., Shatkay H., Dew I., Miller J.R., Flanigan M.J.,
Edwards N.J., Bolanos R., Fasulo D., Halldorsson B.V., Hannenhalli S.,
Turner R., Yooseph S., Lu F., Nusskern D.R., Shue B.C., Zheng X.H.,
Zhong F., Delcher A.L., Huson D.H., Kravitz S.A., Mouchard L., Reinert K.,
Remington K.A., Clark A.G., Waterman M.S., Eichler E.E., Adams M.D.,
Hunkapiller M.W., Myers E.W., Venter J.C.;
Submitted (JUL-2005) to the EMBL/GenBank/DDBJ databases.
[3] {ECO:0000313|EMBL:ABK35647.1}
NUCLEOTIDE SEQUENCE.
Del Galdo F., Artlett C., Jimenez S.A.;
Submitted (SEP-2006) to the EMBL/GenBank/DDBJ databases.
[4] {ECO:0000313|EMBL:AFL46387.1}
NUCLEOTIDE SEQUENCE.
PubMed=22116621; DOI=10.1093/cvr/cvr309;
Berglund L.M., Kotova O., Osmark P., Grufman H., Xing C., Lydrup M.L.,
Goncalves I., Autieri M.V., Gomez M.F.;
"NFAT regulates the expression of AIF-1 and IRT-1: yin and yang splice
variants of neointima formation and atherosclerosis.";
Cardiovasc. Res. 93:414-423(2012).
[5] {ECO:0000313|EMBL:AQY76655.1}
NUCLEOTIDE SEQUENCE.
Norman P.J., Norberg S.J., Nemat-Gorgani N., Ronaghi M., Parham P.;
"CDS alleles of MHC region genes derived from homozygous individuals.";
Submitted (MAR-2017) to the EMBL/GenBank/DDBJ databases.
-!- SUBCELLULAR LOCATION: Cell projection, ruffle membrane
{ECO:0000256|ARBA:ARBA00004599}; Peripheral membrane protein
{ECO:0000256|ARBA:ARBA00004599}; Cytoplasmic side
{ECO:0000256|ARBA:ARBA00004599}.
-!- CAUTION: Lacks conserved residue(s) required for the propagation of
feature annotation. {ECO:0000256|PROSITE-ProRule:PRU00448}.
---------------------------------------------------------------------------
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EMBL; EF070983; ABK35647.1; -; mRNA.
EMBL; JQ782414; AFL46387.1; -; mRNA.
EMBL; KY500151; AQY76655.1; -; Genomic_DNA.
EMBL; CH471081; EAX03445.1; -; Genomic_DNA.
RefSeq; NP_001614.3; NM_001623.4.
Antibodypedia; 27285; 808 antibodies.
DNASU; 199; -.
GeneID; 199; -.
KEGG; hsa:199; -.
UCSC; uc003nuy.4; human.
CTD; 199; -.
EuPathDB; HostDB:ENSG00000204472.12; -.
PharmGKB; PA24646; -.
HOGENOM; CLU_134149_0_0_1; -.
KO; K18617; -.
OrthoDB; 1557466at2759; -.
BioGRID-ORCS; 199; 2 hits in 856 CRISPR screens.
ChiTaRS; AIF1; human.
GenomeRNAi; 199; -.
Bgee; ENSG00000204472; Expressed in monocyte and 228 other tissues.
GO; GO:0005884; C:actin filament; IEA:Ensembl.
GO; GO:0005829; C:cytosol; IEA:Ensembl.
GO; GO:0030027; C:lamellipodium; IEA:Ensembl.
GO; GO:0005634; C:nucleus; IEA:Ensembl.
GO; GO:0043204; C:perikaryon; IEA:Ensembl.
GO; GO:0001891; C:phagocytic cup; IEA:Ensembl.
GO; GO:0032587; C:ruffle membrane; IEA:Ensembl.
GO; GO:0051015; F:actin filament binding; IEA:Ensembl.
GO; GO:0005509; F:calcium ion binding; IEA:Ensembl.
GO; GO:0051764; P:actin crosslink formation; IEA:Ensembl.
GO; GO:0031668; P:cellular response to extracellular stimulus; IEA:Ensembl.
GO; GO:0032870; P:cellular response to hormone stimulus; IEA:Ensembl.
GO; GO:0071447; P:cellular response to hydroperoxide; IEA:Ensembl.
GO; GO:0071346; P:cellular response to interferon-gamma; IEA:Ensembl.
GO; GO:0071315; P:cellular response to morphine; IEA:Ensembl.
GO; GO:0021549; P:cerebellum development; IEA:Ensembl.
GO; GO:0006954; P:inflammatory response; IEA:Ensembl.
GO; GO:0043066; P:negative regulation of apoptotic process; IEA:Ensembl.
GO; GO:0010629; P:negative regulation of gene expression; IEA:Ensembl.
GO; GO:0030046; P:parallel actin filament bundle assembly; IEA:Ensembl.
GO; GO:0006911; P:phagocytosis, engulfment; IEA:Ensembl.
GO; GO:0030335; P:positive regulation of cell migration; IEA:Ensembl.
GO; GO:0014739; P:positive regulation of muscle hyperplasia; IEA:Ensembl.
GO; GO:0045429; P:positive regulation of nitric oxide biosynthetic process; IEA:Ensembl.
GO; GO:0001934; P:positive regulation of protein phosphorylation; IEA:Ensembl.
GO; GO:0048661; P:positive regulation of smooth muscle cell proliferation; IEA:Ensembl.
GO; GO:0016601; P:Rac protein signal transduction; IEA:Ensembl.
GO; GO:0048678; P:response to axon injury; IEA:Ensembl.
GO; GO:0051602; P:response to electrical stimulus; IEA:Ensembl.
GO; GO:0051384; P:response to glucocorticoid; IEA:Ensembl.
GO; GO:0097178; P:ruffle assembly; IEA:Ensembl.
InterPro; IPR042433; AIF1/AIF1L.
InterPro; IPR011992; EF-hand-dom_pair.
InterPro; IPR002048; EF_hand_dom.
PANTHER; PTHR10356; PTHR10356; 1.
SUPFAM; SSF47473; SSF47473; 1.
PROSITE; PS50222; EF_HAND_2; 1.
2: Evidence at transcript level;
Actin-binding {ECO:0000256|ARBA:ARBA00023203};
Calcium {ECO:0000256|ARBA:ARBA00022837};
Metal-binding {ECO:0000256|ARBA:ARBA00022723}.
DOMAIN 45..80
/note="EF-hand"
/evidence="ECO:0000259|PROSITE:PS50222"
REGION 128..147
/note="Disordered"
/evidence="ECO:0000256|SAM:MobiDB-lite"
SEQUENCE 147 AA; 16703 MW; 0104CCF092074E8F CRC64;
MSQTRDLQGG KAFGLLKAQQ EERLDEINKQ FLDDPKYSSD EDLPSKLEGF KEKYMEFDLN
GNGDIDIMSL KRMLEKLGVP KTHLELKKLI GEVSSGSGET FSYPDFLRMM LGKRSAILKM
ILMYEEKARE KEKPTGPPAK KAISELP


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Pathways :
WP444: Signaling of Hepatocyte Growth Factor Receptor
WP997: Cytokines and Inflammatory Response (BioCarta)
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WP1156: Inflammatory Response Pathway
WP1235: Signaling of Hepatocyte Growth Factor Receptor
WP272: Blood Clotting Cascade
WP193: Signaling of Hepatocyte Growth Factor Receptor
WP530: Cytokines and Inflammatory Response
WP94: Signaling of Hepatocyte Growth Factor Receptor
WP2148: Brain derived neurotrophic factor
WP1113: Cytokines and Inflammatory Response
WP927: Signaling of Hepatocyte Growth Factor Receptor
WP1206: Signaling of Hepatocyte Growth Factor Receptor
WP271: Cytokines and Inflammatory Response (BioCarta)
WP40: Inflammatory Response Pathway
WP1899: Regulation of Insulin-like Growth Factor (IGF) Activity by Insulin-like Growth Factor Binding Proteins (IGFBPs)
WP458: Inflammatory Response Pathway
WP810: Signaling of Hepatocyte Growth Factor Receptor
WP1983: Splicing factor NOVA regulated synpatic proteins
WP1046: Signaling of Hepatocyte Growth Factor Receptor
WP920: Inflammatory Response Pathway
WP1162: Signaling of Hepatocyte Growth Factor Receptor
WP2328: Allograft rejection

Related Genes :
[CCL20 LARC MIP3A SCYA20] C-C motif chemokine 20 (Beta-chemokine exodus-1) (CC chemokine LARC) (Liver and activation-regulated chemokine) (Macrophage inflammatory protein 3 alpha) (MIP-3-alpha) (Small-inducible cytokine A20) [Cleaved into: CCL20(1-67); CCL20(1-64); CCL20(2-70)]
[CCL4 LAG1 MIP1B SCYA4] C-C motif chemokine 4 (G-26 T-lymphocyte-secreted protein) (HC21) (Lymphocyte activation gene 1 protein) (LAG-1) (MIP-1-beta(1-69)) (Macrophage inflammatory protein 1-beta) (MIP-1-beta) (PAT 744) (Protein H400) (SIS-gamma) (Small-inducible cytokine A4) (T-cell activation protein 2) (ACT-2) [Cleaved into: MIP-1-beta(3-69)]
[MAPK14 CSBP CSBP1 CSBP2 CSPB1 MXI2 SAPK2A] Mitogen-activated protein kinase 14 (MAP kinase 14) (MAPK 14) (EC 2.7.11.24) (Cytokine suppressive anti-inflammatory drug-binding protein) (CSAID-binding protein) (CSBP) (MAP kinase MXI2) (MAX-interacting protein 2) (Mitogen-activated protein kinase p38 alpha) (MAP kinase p38 alpha) (Stress-activated protein kinase 2a) (SAPK2a)
[CSF1R FMS] Macrophage colony-stimulating factor 1 receptor (CSF-1 receptor) (CSF-1-R) (CSF-1R) (M-CSF-R) (EC 2.7.10.1) (Proto-oncogene c-Fms) (CD antigen CD115)
[CCL4L1 CCL4L LAG1 SCYA4L1; CCL4L2 CCL4L SCYA4L2] C-C motif chemokine 4-like (Lymphocyte activation gene 1 protein) (LAG-1) (Macrophage inflammatory protein 1-beta) (MIP-1-beta) (Monocyte adherence-induced protein 5-alpha) (Small-inducible cytokine A4-like)
[CSF1] Macrophage colony-stimulating factor 1 (CSF-1) (M-CSF) (MCSF) (Lanimostim) [Cleaved into: Processed macrophage colony-stimulating factor 1]
[NOD2 CARD15 IBD1] Nucleotide-binding oligomerization domain-containing protein 2 (Caspase recruitment domain-containing protein 15) (Inflammatory bowel disease protein 1)
[S100a8 Caga Mrp8] Protein S100-A8 (Calgranulin-A) (Chemotactic cytokine CP-10) (Leukocyte L1 complex light chain) (Migration inhibitory factor-related protein 8) (MRP-8) (p8) (Pro-inflammatory S100 cytokine) (S100 calcium-binding protein A8)
[CCL3 G0S19-1 MIP1A SCYA3] C-C motif chemokine 3 (G0/G1 switch regulatory protein 19-1) (Macrophage inflammatory protein 1-alpha) (MIP-1-alpha) (PAT 464.1) (SIS-beta) (Small-inducible cytokine A3) (Tonsillar lymphocyte LD78 alpha protein) [Cleaved into: MIP-1-alpha(4-69) (LD78-alpha(4-69))]
[CXCL2 GRO2 GROB MIP2A SCYB2] C-X-C motif chemokine 2 (Growth-regulated protein beta) (Gro-beta) (Macrophage inflammatory protein 2-alpha) (MIP2-alpha) [Cleaved into: GRO-beta(5-73) (GRO-beta-T) (Hematopoietic synergistic factor) (HSF) (SB-251353)]
[Nfkb1] Nuclear factor NF-kappa-B p105 subunit (DNA-binding factor KBF1) (EBP-1) (NF-kappa-B1 p84/NF-kappa-B1 p98) (Nuclear factor of kappa light polypeptide gene enhancer in B-cells 1) [Cleaved into: Nuclear factor NF-kappa-B p50 subunit]
[CCL18 AMAC1 DCCK1 MIP4 PARC SCYA18] C-C motif chemokine 18 (Alternative macrophage activation-associated CC chemokine 1) (AMAC-1) (CC chemokine PARC) (Dendritic cell chemokine 1) (DC-CK1) (Macrophage inflammatory protein 4) (MIP-4) (Pulmonary and activation-regulated chemokine) (Small-inducible cytokine A18) [Cleaved into: CCL18(1-68); CCL18(3-69); CCL18(4-69)]
[CCL15 MIP5 NCC3 SCYA15] C-C motif chemokine 15 (Chemokine CC-2) (HCC-2) (Leukotactin-1) (LKN-1) (MIP-1 delta) (Macrophage inflammatory protein 5) (MIP-5) (Mrp-2b) (NCC-3) (Small-inducible cytokine A15) [Cleaved into: CCL15(22-92); CCL15(25-92); CCL15(29-92)]
[Ccr1 Cmkbr1] C-C chemokine receptor type 1 (C-C CKR-1) (CC-CKR-1) (CCR-1) (CCR1) (Macrophage inflammatory protein 1-alpha receptor) (MIP-1alpha-R) (RANTES-R) (CD antigen CD191)
[] Genome polyprotein [Cleaved into: Core protein p21 (Capsid protein C) (p21); Core protein p19; Envelope glycoprotein E1 (gp32) (gp35); Envelope glycoprotein E2 (NS1) (gp68) (gp70); p7; Protease NS2-3 (p23) (EC 3.4.22.-); Serine protease NS3 (EC 3.4.21.98) (EC 3.6.1.15) (EC 3.6.4.13) (Hepacivirin) (NS3P) (p70); Non-structural protein 4A (NS4A) (p8); Non-structural protein 4B (NS4B) (p27); Non-structural protein 5A (NS5A) (p56); RNA-directed RNA polymerase (EC 2.7.7.48) (NS5B) (p68)]
[Pik3cd] Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform (PI3-kinase subunit delta) (PI3K-delta) (PI3Kdelta) (PtdIns-3-kinase subunit delta) (EC 2.7.1.153) (Phosphatidylinositol 4,5-bisphosphate 3-kinase 110 kDa catalytic subunit delta) (PtdIns-3-kinase subunit p110-delta) (p110delta)
[] Genome polyprotein [Cleaved into: Core protein p21 (Capsid protein C) (p21); Core protein p19; Envelope glycoprotein E1 (gp32) (gp35); Envelope glycoprotein E2 (NS1) (gp68) (gp70); p7; Protease NS2-3 (p23) (EC 3.4.22.-); Serine protease NS3 (EC 3.4.21.98) (EC 3.6.1.15) (EC 3.6.4.13) (Hepacivirin) (NS3P) (p70); Non-structural protein 4A (NS4A) (p8); Non-structural protein 4B (NS4B) (p27); Non-structural protein 5A (NS5A) (p56); RNA-directed RNA polymerase (EC 2.7.7.48) (NS5B) (p68)]
[Lpcat2 Aytl1 Aytl1a Lpcat2a] Lysophosphatidylcholine acyltransferase 2 (LPC acyltransferase 2) (LPCAT-2) (LysoPC acyltransferase 2) (EC 2.3.1.23) (1-acylglycerol-3-phosphate O-acyltransferase 11) (1-AGP acyltransferase 11) (1-AGPAT 11) (EC 2.3.1.51) (1-acylglycerophosphocholine O-acyltransferase) (1-alkenylglycerophosphocholine O-acyltransferase) (EC 2.3.1.25) (1-alkylglycerophosphocholine O-acetyltransferase) (EC 2.3.1.67) (Acetyl-CoA:lyso-platelet-activating factor acetyltransferase) (Acetyl-CoA:lyso-PAF acetyltransferase) (Lyso-PAF acetyltransferase) (LysoPAFAT) (Acyltransferase-like 1)
[Oprm1 Mor Oprm] Mu-type opioid receptor (M-OR-1) (MOR-1)
[Pik3cg Pi3kg1] Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform (PI3-kinase subunit gamma) (PI3K-gamma) (PI3Kgamma) (PtdIns-3-kinase subunit gamma) (EC 2.7.1.153) (Phosphatidylinositol 4,5-bisphosphate 3-kinase 110 kDa catalytic subunit gamma) (PtdIns-3-kinase subunit p110-gamma) (p110gamma) (Phosphoinositide-3-kinase catalytic gamma polypeptide) (Serine/threonine protein kinase PIK3CG) (EC 2.7.11.1) (p120-PI3K)
[Elf3 Ert Esx Jen] ETS-related transcription factor Elf-3 (E74-like factor 3) (Epithelial-restricted with serine box) (Epithelium-restricted Ets protein ESX) (Epithelium-specific Ets transcription factor 1) (ESE-1)
[Cxcr4 Cmkar4 Lestr Sdf1r] C-X-C chemokine receptor type 4 (CXC-R4) (CXCR-4) (Fusin) (Leukocyte-derived seven transmembrane domain receptor) (LESTR) (Pre-B-cell-derived chemokine receptor) (PB-CKR) (Stromal cell-derived factor 1 receptor) (SDF-1 receptor) (CD antigen CD184)
[Lpcat1 Aytl2] Lysophosphatidylcholine acyltransferase 1 (LPC acyltransferase 1) (LPCAT-1) (LysoPC acyltransferase 1) (mLPCAT1) (EC 2.3.1.23) (1-acylglycerol-3-phosphate O-acyltransferase) (EC 2.3.1.51) (1-acylglycerophosphocholine O-acyltransferase) (1-alkenylglycerophosphocholine O-acyltransferase) (EC 2.3.1.25) (1-alkylglycerophosphocholine O-acetyltransferase) (EC 2.3.1.67) (Acetyl-CoA:lyso-platelet-activating factor acetyltransferase) (Acetyl-CoA:lyso-PAF acetyltransferase) (Lyso-PAF acetyltransferase) (LysoPAFAT) (Acyltransferase-like 2)
[Nfe2l1 Nrf1] Endoplasmic reticulum membrane sensor NFE2L1 (Locus control region-factor 1) (LCR-F1) (Nuclear factor erythroid 2-related factor 1) (NF-E2-related factor 1) (NFE2-related factor 1) (Nuclear factor, erythroid derived 2, like 1) [Cleaved into: Transcription factor NRF1]
[Kit Sl] Mast/stem cell growth factor receptor Kit (SCFR) (EC 2.7.10.1) (Proto-oncogene c-Kit) (Tyrosine-protein kinase Kit) (CD antigen CD117)
[CXCR4] C-X-C chemokine receptor type 4 (CXC-R4) (CXCR-4) (FB22) (Fusin) (HM89) (LCR1) (Leukocyte-derived seven transmembrane domain receptor) (LESTR) (Lipopolysaccharide-associated protein 3) (LAP-3) (LPS-associated protein 3) (NPYRL) (Stromal cell-derived factor 1 receptor) (SDF-1 receptor) (CD antigen CD184)
[] Genome polyprotein [Cleaved into: Core protein p21 (Capsid protein C) (p21); Core protein p19; Envelope glycoprotein E1 (gp32) (gp35); Envelope glycoprotein E2 (NS1) (gp68) (gp70); p7; Protease NS2-3 (p23) (EC 3.4.22.-); Serine protease NS3 (EC 3.4.21.98) (EC 3.6.1.15) (EC 3.6.4.13) (Hepacivirin) (NS3P) (p70); Non-structural protein 4A (NS4A) (p8); Non-structural protein 4B (NS4B) (p27); Non-structural protein 5A (NS5A) (p56); RNA-directed RNA polymerase (EC 2.7.7.48) (NS5B) (p68)]
[Kitlg Kitl Mgf Sl Slf] Kit ligand (Hematopoietic growth factor KL) (Mast cell growth factor) (MGF) (Steel factor) (Stem cell factor) (SCF) (c-Kit ligand) [Cleaved into: Soluble KIT ligand (sKITLG)]
[] Genome polyprotein [Cleaved into: Core protein p21 (Capsid protein C) (p21); Core protein p19; Envelope glycoprotein E1 (gp32) (gp35); Envelope glycoprotein E2 (NS1) (gp68) (gp70); Viroporin p7; Protease NS2-3 (p23) (EC 3.4.22.-); Serine protease NS3 (EC 3.4.21.98) (EC 3.6.1.15) (EC 3.6.4.13) (Hepacivirin) (NS3P) (p70); Non-structural protein 4A (NS4A) (p8); Non-structural protein 4B (NS4B) (p27); Non-structural protein 5A (NS5A) (p56); RNA-directed RNA polymerase (EC 2.7.7.48) (NS5B) (p68)]
[SLC9A3R1 NHERF NHERF1] Na(+)/H(+) exchange regulatory cofactor NHE-RF1 (NHERF-1) (Ezrin-radixin-moesin-binding phosphoprotein 50) (EBP50) (Regulatory cofactor of Na(+)/H(+) exchanger) (Sodium-hydrogen exchanger regulatory factor 1) (Solute carrier family 9 isoform A3 regulatory factor 1)

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