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APC regulator of WNT signaling pathway

 A0A2R9AUR0_PANPA        Unreviewed;      2844 AA.
A0A2R9AUR0;
20-JUN-2018, integrated into UniProtKB/TrEMBL.
20-JUN-2018, sequence version 1.
17-JUN-2020, entry version 17.
SubName: Full=Uncharacterized protein {ECO:0000313|Ensembl:ENSPPAP00000018659};
Name=APC {ECO:0000313|Ensembl:ENSPPAP00000018659};
Pan paniscus (Pygmy chimpanzee) (Bonobo).
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
Pan.
NCBI_TaxID=9597 {ECO:0000313|Ensembl:ENSPPAP00000018659, ECO:0000313|Proteomes:UP000240080};
[1] {ECO:0000313|Ensembl:ENSPPAP00000018659, ECO:0000313|Proteomes:UP000240080}
NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
PubMed=22722832; DOI=10.1038/nature11128;
Prufer K., Munch K., Hellmann I., Akagi K., Miller J.R., Walenz B.,
Koren S., Sutton G., Kodira C., Winer R., Knight J.R., Mullikin J.C.,
Meader S.J., Ponting C.P., Lunter G., Higashino S., Hobolth A., Dutheil J.,
Karakoc E., Alkan C., Sajjadian S., Catacchio C.R., Ventura M.,
Marques-Bonet T., Eichler E.E., Andre C., Atencia R., Mugisha L.,
Junhold J., Patterson N., Siebauer M., Good J.M., Fischer A., Ptak S.E.,
Lachmann M., Symer D.E., Mailund T., Schierup M.H., Andres A.M., Kelso J.,
Paabo S.;
"The bonobo genome compared with the chimpanzee and human genomes.";
Nature 486:527-531(2012).
[2] {ECO:0000313|Ensembl:ENSPPAP00000018659}
IDENTIFICATION.
Ensembl;
Submitted (APR-2018) to UniProtKB.
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EMBL; AJFE02093722; -; NOT_ANNOTATED_CDS; Genomic_DNA.
EMBL; AJFE02093723; -; NOT_ANNOTATED_CDS; Genomic_DNA.
EMBL; AJFE02093724; -; NOT_ANNOTATED_CDS; Genomic_DNA.
RefSeq; XP_003826782.1; XM_003826734.1.
RefSeq; XP_003826783.1; XM_003826735.1.
RefSeq; XP_008950337.1; XM_008952089.2.
Ensembl; ENSPPAT00000041395; ENSPPAP00000018659; ENSPPAG00000032467.
GeneID; 100992823; -.
KEGG; pps:100992823; -.
CTD; 324; -.
GeneTree; ENSGT00530000063749; -.
KO; K02085; -.
OMA; EVPRVYC; -.
Proteomes; UP000240080; Chromosome 5.
GO; GO:0005912; C:adherens junction; IEA:Ensembl.
GO; GO:0030877; C:beta-catenin destruction complex; IEA:Ensembl.
GO; GO:0005923; C:bicellular tight junction; IEA:Ensembl.
GO; GO:0016342; C:catenin complex; IEA:Ensembl.
GO; GO:0005813; C:centrosome; IEA:Ensembl.
GO; GO:0000776; C:kinetochore; IEA:Ensembl.
GO; GO:0030027; C:lamellipodium; IEA:Ensembl.
GO; GO:0016328; C:lateral plasma membrane; IEA:Ensembl.
GO; GO:0005874; C:microtubule; IEA:Ensembl.
GO; GO:0005634; C:nucleus; IEA:Ensembl.
GO; GO:0048471; C:perinuclear region of cytoplasm; IEA:Ensembl.
GO; GO:0032587; C:ruffle membrane; IEA:Ensembl.
GO; GO:0008013; F:beta-catenin binding; IEA:Ensembl.
GO; GO:0070840; F:dynein complex binding; IEA:Ensembl.
GO; GO:0045295; F:gamma-catenin binding; IEA:Ensembl.
GO; GO:0051010; F:microtubule plus-end binding; IEA:Ensembl.
GO; GO:0019901; F:protein kinase binding; IEA:Ensembl.
GO; GO:0019887; F:protein kinase regulator activity; IEA:Ensembl.
GO; GO:0031625; F:ubiquitin protein ligase binding; IEA:Ensembl.
GO; GO:0007050; P:cell cycle arrest; IEA:Ensembl.
GO; GO:0016477; P:cell migration; IEA:Ensembl.
GO; GO:0006974; P:cellular response to DNA damage stimulus; IEA:Ensembl.
GO; GO:0008286; P:insulin receptor signaling pathway; IEA:Ensembl.
GO; GO:0000281; P:mitotic cytokinesis; IEA:Ensembl.
GO; GO:0007094; P:mitotic spindle assembly checkpoint; IEA:Ensembl.
GO; GO:0090090; P:negative regulation of canonical Wnt signaling pathway; IEA:Ensembl.
GO; GO:0008285; P:negative regulation of cell population proliferation; IEA:Ensembl.
GO; GO:0045736; P:negative regulation of cyclin-dependent protein serine/threonine kinase activity; IEA:Ensembl.
GO; GO:0007026; P:negative regulation of microtubule depolymerization; IEA:Ensembl.
GO; GO:0043065; P:positive regulation of apoptotic process; IEA:Ensembl.
GO; GO:0030335; P:positive regulation of cell migration; IEA:Ensembl.
GO; GO:0045732; P:positive regulation of protein catabolic process; IEA:Ensembl.
GO; GO:1904781; P:positive regulation of protein localization to centrosome; IEA:Ensembl.
GO; GO:0031274; P:positive regulation of pseudopodium assembly; IEA:Ensembl.
GO; GO:0065003; P:protein-containing complex assembly; IEA:Ensembl.
GO; GO:0051988; P:regulation of attachment of spindle microtubules to kinetochore; IEA:Ensembl.
GO; GO:0016055; P:Wnt signaling pathway; IEA:InterPro.
Gene3D; 1.25.10.10; -; 1.
InterPro; IPR026836; APC.
InterPro; IPR009240; APC_15aa_rpt.
InterPro; IPR009234; APC_basic_dom.
InterPro; IPR026831; APC_dom.
InterPro; IPR026818; Apc_fam.
InterPro; IPR032038; APC_N.
InterPro; IPR036149; APC_N_sf.
InterPro; IPR041257; APC_rep.
InterPro; IPR009223; APC_rpt.
InterPro; IPR011989; ARM-like.
InterPro; IPR016024; ARM-type_fold.
InterPro; IPR000225; Armadillo.
InterPro; IPR009232; EB1-bd.
InterPro; IPR009224; SAMP.
PANTHER; PTHR12607; PTHR12607; 1.
PANTHER; PTHR12607:SF11; PTHR12607:SF11; 1.
Pfam; PF05972; APC_15aa; 3.
Pfam; PF05956; APC_basic; 1.
Pfam; PF16689; APC_N_CC; 1.
Pfam; PF05923; APC_r; 7.
Pfam; PF18797; APC_rep; 1.
Pfam; PF00514; Arm; 2.
Pfam; PF05937; EB1_binding; 1.
Pfam; PF05924; SAMP; 3.
SMART; SM00185; ARM; 7.
SUPFAM; SSF48371; SSF48371; 1.
SUPFAM; SSF58050; SSF58050; 1.
SUPFAM; SSF82931; SSF82931; 1.
PROSITE; PS50176; ARM_REPEAT; 1.
4: Predicted;
Coiled coil {ECO:0000256|SAM:Coils};
Reference proteome {ECO:0000313|Proteomes:UP000240080}.
DOMAIN 4..55
/note="APC_N_CC"
/evidence="ECO:0000259|Pfam:PF16689"
REPEAT 660..702
/note="ARM"
/evidence="ECO:0000256|PROSITE-ProRule:PRU00259"
DOMAIN 2225..2576
/note="APC_basic"
/evidence="ECO:0000259|Pfam:PF05956"
DOMAIN 2671..2844
/note="EB1_binding"
/evidence="ECO:0000259|Pfam:PF05937"
REGION 239..305
/note="Disordered"
/evidence="ECO:0000256|SAM:MobiDB-lite"
REGION 828..878
/note="Disordered"
/evidence="ECO:0000256|SAM:MobiDB-lite"
REGION 923..943
/note="Disordered"
/evidence="ECO:0000256|SAM:MobiDB-lite"
REGION 958..987
/note="Disordered"
/evidence="ECO:0000256|SAM:MobiDB-lite"
REGION 1099..1168
/note="Disordered"
/evidence="ECO:0000256|SAM:MobiDB-lite"
REGION 1190..1244
/note="Disordered"
/evidence="ECO:0000256|SAM:MobiDB-lite"
REGION 1312..1376
/note="Disordered"
/evidence="ECO:0000256|SAM:MobiDB-lite"
REGION 1403..1475
/note="Disordered"
/evidence="ECO:0000256|SAM:MobiDB-lite"
REGION 1526..1637
/note="Disordered"
/evidence="ECO:0000256|SAM:MobiDB-lite"
REGION 1663..1717
/note="Disordered"
/evidence="ECO:0000256|SAM:MobiDB-lite"
REGION 1729..1952
/note="Disordered"
/evidence="ECO:0000256|SAM:MobiDB-lite"
REGION 1965..2012
/note="Disordered"
/evidence="ECO:0000256|SAM:MobiDB-lite"
REGION 2044..2072
/note="Disordered"
/evidence="ECO:0000256|SAM:MobiDB-lite"
REGION 2148..2636
/note="Disordered"
/evidence="ECO:0000256|SAM:MobiDB-lite"
REGION 2667..2715
/note="Disordered"
/evidence="ECO:0000256|SAM:MobiDB-lite"
REGION 2730..2844
/note="Disordered"
/evidence="ECO:0000256|SAM:MobiDB-lite"
COILED 6..54
/evidence="ECO:0000256|SAM:Coils"
COILED 134..168
/evidence="ECO:0000256|SAM:Coils"
COILED 207..227
/evidence="ECO:0000256|SAM:Coils"
COILED 530..550
/evidence="ECO:0000256|SAM:Coils"
COMPBIAS 244..262
/note="Polyampholyte"
/evidence="ECO:0000256|SAM:MobiDB-lite"
COMPBIAS 266..304
/note="Polar"
/evidence="ECO:0000256|SAM:MobiDB-lite"
COMPBIAS 842..857
/note="Polyampholyte"
/evidence="ECO:0000256|SAM:MobiDB-lite"
COMPBIAS 926..943
/note="Polar"
/evidence="ECO:0000256|SAM:MobiDB-lite"
COMPBIAS 958..975
/note="Polar"
/evidence="ECO:0000256|SAM:MobiDB-lite"
COMPBIAS 1101..1130
/note="Polar"
/evidence="ECO:0000256|SAM:MobiDB-lite"
COMPBIAS 1132..1168
/note="Polyampholyte"
/evidence="ECO:0000256|SAM:MobiDB-lite"
COMPBIAS 1325..1350
/note="Polar"
/evidence="ECO:0000256|SAM:MobiDB-lite"
COMPBIAS 1357..1374
/note="Polar"
/evidence="ECO:0000256|SAM:MobiDB-lite"
COMPBIAS 1433..1447
/note="Pro-rich"
/evidence="ECO:0000256|SAM:MobiDB-lite"
COMPBIAS 1536..1562
/note="Polyampholyte"
/evidence="ECO:0000256|SAM:MobiDB-lite"
COMPBIAS 1615..1629
/note="Polar"
/evidence="ECO:0000256|SAM:MobiDB-lite"
COMPBIAS 1680..1694
/note="Polyampholyte"
/evidence="ECO:0000256|SAM:MobiDB-lite"
COMPBIAS 1695..1712
/note="Polar"
/evidence="ECO:0000256|SAM:MobiDB-lite"
COMPBIAS 1749..1763
/note="Polar"
/evidence="ECO:0000256|SAM:MobiDB-lite"
COMPBIAS 1787..1832
/note="Polyampholyte"
/evidence="ECO:0000256|SAM:MobiDB-lite"
COMPBIAS 1863..1895
/note="Polyampholyte"
/evidence="ECO:0000256|SAM:MobiDB-lite"
COMPBIAS 1896..1938
/note="Polar"
/evidence="ECO:0000256|SAM:MobiDB-lite"
COMPBIAS 1979..1996
/note="Polyampholyte"
/evidence="ECO:0000256|SAM:MobiDB-lite"
COMPBIAS 2053..2069
/note="Polyampholyte"
/evidence="ECO:0000256|SAM:MobiDB-lite"
COMPBIAS 2171..2192
/note="Polyampholyte"
/evidence="ECO:0000256|SAM:MobiDB-lite"
COMPBIAS 2201..2226
/note="Polar"
/evidence="ECO:0000256|SAM:MobiDB-lite"
COMPBIAS 2235..2250
/note="Polar"
/evidence="ECO:0000256|SAM:MobiDB-lite"
COMPBIAS 2259..2427
/note="Polar"
/evidence="ECO:0000256|SAM:MobiDB-lite"
COMPBIAS 2462..2502
/note="Polar"
/evidence="ECO:0000256|SAM:MobiDB-lite"
COMPBIAS 2520..2534
/note="Polyampholyte"
/evidence="ECO:0000256|SAM:MobiDB-lite"
COMPBIAS 2558..2581
/note="Polar"
/evidence="ECO:0000256|SAM:MobiDB-lite"
COMPBIAS 2582..2597
/note="Polyampholyte"
/evidence="ECO:0000256|SAM:MobiDB-lite"
COMPBIAS 2618..2636
/note="Polar"
/evidence="ECO:0000256|SAM:MobiDB-lite"
COMPBIAS 2670..2687
/note="Polar"
/evidence="ECO:0000256|SAM:MobiDB-lite"
COMPBIAS 2698..2712
/note="Polar"
/evidence="ECO:0000256|SAM:MobiDB-lite"
COMPBIAS 2738..2814
/note="Polar"
/evidence="ECO:0000256|SAM:MobiDB-lite"
COMPBIAS 2824..2844
/note="Polar"
/evidence="ECO:0000256|SAM:MobiDB-lite"
SEQUENCE 2844 AA; 311773 MW; 4259806292D2AFEE CRC64;
MAAASYDQLL KQVEALKMEN SNLRQELEDN SNHLTKLETE ASNMKEVLKQ LQGSIEDEAM
ASSGQIDLLE RLKELNLDSS NFPGVKLRSK MSLRSYGSRE GSVSSRSGEC SPVPMGSFPR
RGFVNGSRES TGYLEELEKE RSLLLADLDK EEKEKDWYYA QLQNLTKRID SLPLTENFSL
QTDMTRRQLE YEARQIRVAM EEQLGTCQDM EKRAQRRIAR IQQIEKDILR IRQLLQSQAT
EAERSSQNKH ETGSHDAERQ NEGQGVGEIN MATSGNGQGS TTRMDHETAS VLSSSSTHSA
PRRLTSHLGT KVEMVYSLLS MLGTHDKDDM SRTLLAMSSS QDSCISMRQS GCLPLLIQLL
HGNDKDSVLL GNSRGSKEAR ARASAALHNI IHSQPDDKRG RREIRVLHLL EQIRAYCETC
WEWQEAHEQG MDQDKNPMPA PVEHQICPAV CVLMKLSFDE EHRHAMNELG GLQAIAELLQ
VDCEMYGLTN DHYSITLRRY AGMALTNLTF GDVANKATLC SMKGCMRALV AQLKSESEDL
QQVIASVLRN LSWRADVNSK KTLREVGSVK ALMECALEVK KESTLKSVLS ALWNLSAHCT
ENKADICAVD GALAFLVGTL TYRSQTNTLA IIESGGGILR NVSSLIATNE DHRQILRENN
CLQTLLQHLK SHSLTIVSNA CGTLWNLSAR NPKDQEALWD MGAVSMLKNL IHSKHKMIAM
GSAAALRNLM ANRPAKYKDA NIMSPGSSLP SLHVRKQKAL EAELDAQHLS ETFDNIDNLS
PKASHRSKQR HKQSLYGDYV FDTNRHDDNR SDNFNTGNMT VLSPYLNTTV LPSSSSSRGS
LDSSRSEKDR SLERERGIGL GNYHPATENP GTSSKRGLQI STTAAQIAKV MEEVSAIHTS
QEDRSSGSTT ELHCVTDERN ALRRSSAAHT HSNTYNFTKS ENSNRTCSMP YAKLEYKRSS
NDSLNSVSSS DGYGKRGQMK PSIESYSEDD ESKFCSYGQY PADLAHKIHS ANHMDDNDGE
LDTPINYSLK YSDEQLNSGR QSPSQNERWA RPKHIIEDEI KQSEQRQSRN QSTTYPVYTE
STDDKHLKFQ PHFGQQECVS PYRSRGANGS ETNRVGSNHG INQNVSQSLC QEDDYEDDKP
TNYSERYSEE EQHEEEERPT NYSIKYNEEK HHVDQPIDYS LKYATDIPSS QKQSFSFSKS
SSGQSSKTEH MSSSSENTST PSSNAKRQNQ LHPSSAQSRS GQTQKAATCK VSSINQETIQ
TYCVEDTPIC FSRCSSLSSL SSAEDEIGCN QTTQEADSAN TLQIAEIKEK IGTRSAEDPV
SEVPAVSQHT RTKSSRLQGS SLSSESARHK AVEFSSGAKS PSKSGAQTPK SPPEHYVQET
PLMFSRCTSV SSLDSFESRS IASSVQSEPC SGMVSGIISP SDLPDSPGQT MPPSRSKTPP
PPPQTAQTKR EVPKNKAPTA EKRESGPKQA AVNAAVQRVQ VLPDADTLLH FATESTPDGF
SCSSSLSALS LDEPFIQKDV ELRIMPPVQE NDNGNETESE QPKESNENQE KEAEKTIDSE
KDLLDDSDGD DIEILEECII SAMPTKSSRK AKKPAQTASK LPPPVARKPS QLPVYKLLPS
QNRLQPQKHV SFTPGDDMPR VYCVEGTPIN FSTATSLSDL TIESPPNELA AGEGVRGGAQ
SGEFEKRDTI PTEGRSTDEA QGGKTSSVTI PELDDNKAEE GDILAECINS AMPKGKSHKP
FRVKKIMDQV QQASASSSAP NKNQLDGKKK KPTSPVKPIP QNTEYRTRVR KNADSKNNLN
AERVFSDNKD SKKQNLKNNS KDFNDKLPNN EDRVRGSFAF DSPHHYTPIE GTPYCFSRND
SLSSLDFDDD DVDLSREKAE LRKAKENKES EAKVTSHTEL TSNQQSANKT QAIAKQPINR
GQPKPILQKQ STFPQSSKDI PDRGAATDEK LQNFAIENTP VCFSHNSSLS SLSDIDQENN
NNKENEPIKE TEPPDSQGEP SKPQASGYAP KSFHVEDTPV CFSRNSSLSS LSIDSEDDLL
QECISSAMPK KKKPSRLKGD HEKHSPRNMG GILAEDLTLD LKDIQRPDSE HGLSPDSENF
DWKAIQEGAN SIVSSLHQAA AAACLSRQAS SDSDSILSLK SGISLGSPFH LTPDQEEKPF
TSNKGPRILK PGEKSTLETK KIESESKGIK GGKKVYKSLI TGKVRSNSEI SGQMKQPLQA
NMPSISRGRT MIHIPGVRNS SSSTSPVSKK GPPLKTPASK SPSEGQTATT SPRGAKPSVK
SELSPVARQT SQIGGTSKAP SRSGSRDSTP SRPAQQPLSR PIQSPGRNSI SPGRNGISPP
NKLSQLPRTS SPSTASTKSS GSGKMSYTSP GRQMSQQNLT KQTGLSKNAS SIPRSESASK
GLNQMNNGNG ANKKVELSRM SSTKSSGSES DRSERPVLVR QSTFIKEAPS PTLRRKLEES
ASFESLSPSS RPASPTRSQA QTPVLSPSLP DMSLSTHSSV QAGGWRKLPP NLSPTIEYND
GRPAKRHDIA RSHSESPSRL PINRSGTWKR EHSKHSSSLP RVSTWRRTGS SSSILSASSE
SSEKAKSEDE KHVNSISGTK QSKENQVSAK GTWRKIKENE ISPTNSTSQT VSSGATNGAE
SKTLIYQMAP AVSKTEDVWV RIEDCPINNP RSGRSPTGNT PPVIDSVSEK GNPNIKDSKD
NQAKQNMGNG SVPMRTVGLE NRLNSFIQVD APDQKGTEIK PGQNNPVPVS ETNESSIVER
TPFSSSSSSK HSSPSGTVAA RVTPFNYNPS PRKSSADSTS ARPSQIPTPV NNNTKKRDSK
TDSTESSGTQ SPKRHSGSYL VTSV


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[] APC regulator of WNT signaling pathway
[Ccn4 Elm1 Wisp1] CCN family member 4 (ELM-1) (WNT1-inducible-signaling pathway protein 1) (WISP-1)
[CCN5 CT58 CTGFL WISP2 UNQ228/PRO261] CCN family member 5 (Connective tissue growth factor-like protein) (CTGF-L) (Connective tissue growth factor-related protein 58) (WNT1-inducible-signaling pathway protein 2) (WISP-2)
[CCN6 WISP3 UNQ462/PRO790/PRO956] Cellular communication network factor 6 (CCN family member 6) (WNT1-inducible-signaling pathway protein 3) (WISP-3)
[Apc2] APC regulator of WNT-signaling pathway 2
[Dkk1 DKK1 Dkk1_predicted LOC100912050 NEWGENE_1307313 rCG_48380] Dickkopf WNT-signaling pathway inhibitor 1 (Dickkopf homolog 1 (Xenopus laevis) (Predicted)) (Dickkopf-like protein 1)
[] APC regulator of WNT signaling pathway

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