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ATP-dependent zinc metalloprotease FtsH (EC 3.4.24.-)

 A0A0A3IWR7_9BACI        Unreviewed;       685 AA.
A0A0A3IWR7;
04-FEB-2015, integrated into UniProtKB/TrEMBL.
04-FEB-2015, sequence version 1.
05-JUN-2019, entry version 23.
RecName: Full=ATP-dependent zinc metalloprotease FtsH {ECO:0000256|HAMAP-Rule:MF_01458};
EC=3.4.24.- {ECO:0000256|HAMAP-Rule:MF_01458};
Name=ftsH {ECO:0000256|HAMAP-Rule:MF_01458};
ORFNames=CD30_17450 {ECO:0000313|EMBL:KGR89234.1};
Lysinibacillus massiliensis 4400831 = CIP 108448 = CCUG 49529.
Bacteria; Firmicutes; Bacilli; Bacillales; Bacillaceae;
Lysinibacillus.
NCBI_TaxID=1211035 {ECO:0000313|EMBL:KGR89234.1, ECO:0000313|Proteomes:UP000030595};
[1] {ECO:0000313|EMBL:KGR89234.1, ECO:0000313|Proteomes:UP000030595}
NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
STRAIN=CCUG 49529 {ECO:0000313|EMBL:KGR89234.1,
ECO:0000313|Proteomes:UP000030595};
Zhang F., Wang G., Zhang L.;
"Draft genome sequence of Lysinibacillus massiliensis CCUG 49529.";
Submitted (FEB-2014) to the EMBL/GenBank/DDBJ databases.
-!- FUNCTION: Acts as a processive, ATP-dependent zinc
metallopeptidase for both cytoplasmic and membrane proteins. Plays
a role in the quality control of integral membrane proteins.
{ECO:0000256|HAMAP-Rule:MF_01458}.
-!- COFACTOR:
Name=Zn(2+); Xref=ChEBI:CHEBI:29105;
Evidence={ECO:0000256|HAMAP-Rule:MF_01458};
Note=Binds 1 zinc ion per subunit. {ECO:0000256|HAMAP-
Rule:MF_01458};
-!- SUBUNIT: Homohexamer. {ECO:0000256|HAMAP-Rule:MF_01458}.
-!- SUBCELLULAR LOCATION: Cell membrane {ECO:0000256|HAMAP-
Rule:MF_01458}; Multi-pass membrane protein {ECO:0000256|HAMAP-
Rule:MF_01458}; Cytoplasmic side {ECO:0000256|HAMAP-
Rule:MF_01458}.
-!- SIMILARITY: Belongs to the AAA ATPase family.
{ECO:0000256|RuleBase:RU003651}.
-!- SIMILARITY: In the C-terminal section; belongs to the peptidase
M41 family. {ECO:0000256|HAMAP-Rule:MF_01458}.
-!- SIMILARITY: In the central section; belongs to the AAA ATPase
family. {ECO:0000256|HAMAP-Rule:MF_01458}.
-!- CAUTION: The sequence shown here is derived from an
EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is
preliminary data. {ECO:0000313|EMBL:KGR89234.1}.
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EMBL; JPVQ01000052; KGR89234.1; -; Genomic_DNA.
RefSeq; WP_036179541.1; NZ_JPVQ01000052.1.
STRING; 1211035.CD30_17450; -.
EnsemblBacteria; KGR89234; KGR89234; CD30_17450.
OrthoDB; 190468at2; -.
Proteomes; UP000030595; Unassembled WGS sequence.
GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
GO; GO:0005886; C:plasma membrane; IEA:UniProtKB-SubCell.
GO; GO:0005524; F:ATP binding; IEA:UniProtKB-UniRule.
GO; GO:0016887; F:ATPase activity; IEA:UniProtKB-UniRule.
GO; GO:0004222; F:metalloendopeptidase activity; IEA:InterPro.
GO; GO:0008270; F:zinc ion binding; IEA:UniProtKB-UniRule.
GO; GO:0051301; P:cell division; IEA:UniProtKB-KW.
GO; GO:0030163; P:protein catabolic process; IEA:UniProtKB-UniRule.
Gene3D; 1.20.58.760; -; 1.
HAMAP; MF_01458; FtsH; 1.
InterPro; IPR003593; AAA+_ATPase.
InterPro; IPR041569; AAA_lid_3.
InterPro; IPR003959; ATPase_AAA_core.
InterPro; IPR003960; ATPase_AAA_CS.
InterPro; IPR005936; FtsH.
InterPro; IPR027417; P-loop_NTPase.
InterPro; IPR011546; Pept_M41_FtsH_extracell.
InterPro; IPR000642; Peptidase_M41.
InterPro; IPR037219; Peptidase_M41-like.
Pfam; PF00004; AAA; 1.
Pfam; PF17862; AAA_lid_3; 1.
Pfam; PF06480; FtsH_ext; 1.
Pfam; PF01434; Peptidase_M41; 1.
SMART; SM00382; AAA; 1.
SUPFAM; SSF140990; SSF140990; 1.
SUPFAM; SSF52540; SSF52540; 1.
TIGRFAMs; TIGR01241; FtsH_fam; 1.
PROSITE; PS00674; AAA; 1.
3: Inferred from homology;
ATP-binding {ECO:0000256|HAMAP-Rule:MF_01458,
ECO:0000256|RuleBase:RU003651};
Cell cycle {ECO:0000313|EMBL:KGR89234.1};
Cell division {ECO:0000313|EMBL:KGR89234.1};
Cell membrane {ECO:0000256|HAMAP-Rule:MF_01458};
Coiled coil {ECO:0000256|SAM:Coils};
Complete proteome {ECO:0000313|Proteomes:UP000030595};
Hydrolase {ECO:0000256|HAMAP-Rule:MF_01458};
Membrane {ECO:0000256|HAMAP-Rule:MF_01458};
Metal-binding {ECO:0000256|HAMAP-Rule:MF_01458};
Metalloprotease {ECO:0000256|HAMAP-Rule:MF_01458};
Nucleotide-binding {ECO:0000256|HAMAP-Rule:MF_01458,
ECO:0000256|RuleBase:RU003651};
Protease {ECO:0000256|HAMAP-Rule:MF_01458};
Reference proteome {ECO:0000313|Proteomes:UP000030595};
Transmembrane {ECO:0000256|HAMAP-Rule:MF_01458};
Transmembrane helix {ECO:0000256|HAMAP-Rule:MF_01458};
Zinc {ECO:0000256|HAMAP-Rule:MF_01458}.
TRANSMEM 7 25 Helical. {ECO:0000256|HAMAP-
Rule:MF_01458}.
TRANSMEM 112 133 Helical. {ECO:0000256|HAMAP-
Rule:MF_01458}.
DOMAIN 196 335 AAA. {ECO:0000259|SMART:SM00382}.
NP_BIND 204 211 ATP. {ECO:0000256|HAMAP-Rule:MF_01458}.
REGION 603 685 Disordered. {ECO:0000256|MobiDB-
lite:A0A0A3IWR7}.
COILED 77 97 {ECO:0000256|SAM:Coils}.
COMPBIAS 603 619 Polyampholyte. {ECO:0000256|MobiDB-
lite:A0A0A3IWR7}.
COMPBIAS 620 667 Polar. {ECO:0000256|MobiDB-
lite:A0A0A3IWR7}.
COMPBIAS 668 685 Polyampholyte. {ECO:0000256|MobiDB-
lite:A0A0A3IWR7}.
ACT_SITE 427 427 {ECO:0000256|HAMAP-Rule:MF_01458}.
METAL 426 426 Zinc; catalytic. {ECO:0000256|HAMAP-
Rule:MF_01458}.
METAL 430 430 Zinc; catalytic. {ECO:0000256|HAMAP-
Rule:MF_01458}.
METAL 502 502 Zinc; catalytic. {ECO:0000256|HAMAP-
Rule:MF_01458}.
SEQUENCE 685 AA; 75529 MW; 4C518593D6C0256F CRC64;
MNRIFRYTIF YLLIFLVIIG IFGTFNGGRA PSEQLTYHEF LNALETGKIT EATIQPASGV
LVVEGKLQGY KEDETFVVNL LDNNQDLLTK INEASENNPK IVILKQPETG GWVQFFTGII
PFIIIIILFF FLLSQSQGGG NKVMNFGKSK AKLYDSEKKK VRFNDVAGAD EEKAELVEVV
DFLKDHRKFT DMGARIPKGI LLVGPPGTGK TLLARAVAGE AGVPFFSISG SDFVEMFVGV
GASRVRDLFE NAKKNAPCII FIDEIDAVGR QRGAGLGGGH DEREQTLNQL LVEMDGFGVN
EGIIIIAATN RPDILDPALL RPGRFDRQIT VGRPDVKGRE AILKVHARNK PLRDDVDLKA
IATRTPGFSG ADLENLLNEA ALVATRRNKK KIDMSDIDEA TDRVIAGPAK TSRVISEKER
NIVAFHEAGH VVVGLTLDQA EKVHKVTIVP RGQAGGYAVM LPKEDRYFMT KPELLDKIAG
LLGGRVAEDI TFGEVSTGAH NDFQRATSIA RSMVTEYGMS DKLGPMQFGS SQGGNVFLGR
DFNSEQNYSD SIAYEIDKEM QAIIVEQYER TKQILTEKRD LLTLIAKTLL EVETLDAQQI
EHLRDHGKLP ERADYSNADE EGTEQQADPQ SNVTEANDTV VEISGSTSLE QQINREPVDP
TTSDLPNEKT VTEDRNKGIQ EDTNK


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WP2199: Seed Development
WP1625: Base excision repair
WP1678: Nucleotide excision repair
WP710: DNA damage response (only ATM dependent)
WP1619: Amino sugar and nucleotide sugar metabolism
WP1676: Non-homologous end-joining
WP2344: vitamin B6 (pyridoxine, pyridoxal, pyridoxamine) biosynthesis and salvage pathway
WP1493: Carbon assimilation C4 pathway
WP1672: Mismatch repair

Related Genes :
[ftsH2 slr0228] ATP-dependent zinc metalloprotease FtsH 2 (EC 3.4.24.-)
[YME1L1 FTSH1 YME1L UNQ1868/PRO4304] ATP-dependent zinc metalloprotease YME1L1 (EC 3.4.24.-) (ATP-dependent metalloprotease FtsH1) (Meg-4) (Presenilin-associated metalloprotease) (PAMP) (YME1-like protein 1)
[ftsH hflB mrsC std tolZ b3178 JW3145] ATP-dependent zinc metalloprotease FtsH (EC 3.4.24.-) (Cell division protease FtsH)
[FTSH1 AAA FTSH At1g50250 F14I3.14] ATP-dependent zinc metalloprotease FTSH 1, chloroplastic (AtFTSH1) (EC 3.4.24.-)
[FTSH8 At1g06430 F12K11.22 F12K11_24] ATP-dependent zinc metalloprotease FTSH 8, chloroplastic (AtFTSH8) (EC 3.4.24.-)
[FTSH5 FTSH2 VAR1 At5g42270 K5J14.7] ATP-dependent zinc metalloprotease FTSH 5, chloroplastic (AtFTSH5) (EC 3.4.24.-) (Protein VARIEGATED 1)
[FTSH4 At2g26140 T19L18.5] ATP-dependent zinc metalloprotease FTSH 4, mitochondrial (AtFTSH4) (EC 3.4.24.-)
[FTSH2 VAR2 At2g30950 F7F1.16] ATP-dependent zinc metalloprotease FTSH 2, chloroplastic (AtFTSH2) (EC 3.4.24.-) (Protein VARIEGATED 2)
[FTSH11 At5g53170 MFH8.11] ATP-dependent zinc metalloprotease FTSH 11, chloroplastic/mitochondrial (AtFTSH11) (EC 3.4.24.-)
[Yme1l1] ATP-dependent zinc metalloprotease YME1L1 (EC 3.4.24.-) (ATP-dependent metalloprotease FtsH1) (YME1-like protein 1)
[ftsH TTHA1492] ATP-dependent zinc metalloprotease FtsH (EC 3.4.24.-)
[ftsH BSU00690] ATP-dependent zinc metalloprotease FtsH (EC 3.4.24.-) (Cell division protease FtsH)
[FTSH3 At2g29080 T9I4.16] ATP-dependent zinc metalloprotease FTSH 3, mitochondrial (AtFTSH3) (EC 3.4.24.-)
[FTSH6 At5g15250 F8M21.140] ATP-dependent zinc metalloprotease FTSH 6, chloroplastic (AtFTSH6) (EC 3.4.24.-)
[FTSH10 At1g07510 F22G5.10 F22G5_9] ATP-dependent zinc metalloprotease FTSH 10, mitochondrial (AtFTSH10) (EC 3.4.24.-)
[FTSHI4 EMB3144 At5g64580 MUB3.10] Probable inactive ATP-dependent zinc metalloprotease FTSHI 4, chloroplastic (AtFTSHI4) (Protein EMBRYO DEFECTIVE 3144) (Protein FTSH INACTIVE PROTEASE 4)
[FTSHI2 EMB2083 At3g16290 MYA6.12 T2O4.19] Probable inactive ATP-dependent zinc metalloprotease FTSHI 2, chloroplastic (AtFTSHI2) (Protein EMBRYO DEFECTIVE 2083) (Protein FTSH INACTIVE PROTEASE 2)
[FTSHI5 EMB2458 At3g04340 T6K12.4] Probable inactive ATP-dependent zinc metalloprotease FTSHI 5, chloroplastic (AtFTSHI5) (Protein EMBRYO DEFECTIVE 2458) (Protein FTSH INACTIVE PROTEASE 5)
[FTSHI1 ARC1 At4g23940 T19F6.22 T32A16.10] Probable inactive ATP-dependent zinc metalloprotease FTSHI 1, chloroplastic (AtFTSHI1) (Protein ACCUMULATION AND REPLICATION OF CHLOROPLASTS 1) (Protein ARC1) (Protein FTSH INACTIVE PROTEASE 1)
[ftsH CCNA_03334] ATP-dependent zinc metalloprotease FtsH (EC 3.4.24.-)
[Yme1l1] ATP-dependent zinc metalloprotease YME1L1 (EC 3.4.24.-) (ATP-dependent metalloprotease FtsH1) (Meg-4) (YME1-like protein 1)
[ftsH OR16_10039] ATP-dependent zinc metalloprotease FtsH (EC 3.4.24.-)
[ftsH OR214_04183] ATP-dependent zinc metalloprotease FtsH (EC 3.4.24.-)
[ftsH OR221_2072] ATP-dependent zinc metalloprotease FtsH (EC 3.4.24.-)
[ftsH] ATP-dependent zinc metalloprotease FtsH (EC 3.4.24.-)
[ftsH_1 ftsH ACS78_23645 BTA37_25940 C2I27_21865 C2I28_08460 C3744_16440 CJ194_25985 CN367_03590 CN383_09400 CN890_10855 CN918_36045 CN955_25430 CN973_27940 CN978_15505 CN981_18770 COA18_09410 COC52_27870 COC53_00050 COC61_07375 COC62_29335 COD13_30225 COD15_07545 COE08_25975 COE31_22325 COE55_17410 COE67_10570 COI68_20230 COI84_20435 COJ00_28415 COJ19_27915 COJ21_25215 COJ23_19135 COJ36_26285 COJ70_23275 COJ90_29430 COJ92_22900 COK01_02400 COK03_28065 COK68_25895 COK90_07700 COL08_29140 NCTC6005_00331] ATP-dependent zinc metalloprotease FtsH (EC 3.4.24.-)
[ftsH OR37_00881] ATP-dependent zinc metalloprotease FtsH (EC 3.4.24.-)
[ftsH OR214_04113] ATP-dependent zinc metalloprotease FtsH (EC 3.4.24.-)
[ftsH OR214_04601] ATP-dependent zinc metalloprotease FtsH (EC 3.4.24.-)
[SPCC965.04c] ATP-dependent zinc metalloprotease YME1 homolog (EC 3.4.24.-)

Bibliography :
[11827531] Identification of glutamic acid 479 as the gluzincin coordinator of zinc in FtsH (HflB).
[10788805] FtsH recognizes proteins with unfolded structure and hydrolyzes the carboxyl side of hydrophobic residues.
[10715327] The thylakoid FtsH protease plays a role in the light-induced turnover of the photosystem II D1 protein.
[9212469] Light-stimulated degradation of an unassembled Rieske FeS protein by a thylakoid-bound protease: the possible role of the FtsH protease.