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ATP-dependent zinc metalloprotease FtsH (EC 3.4.24.-)

 H0BLG4_9ACTN            Unreviewed;       674 AA.
H0BLG4;
22-FEB-2012, integrated into UniProtKB/TrEMBL.
22-FEB-2012, sequence version 1.
28-MAR-2018, entry version 34.
RecName: Full=ATP-dependent zinc metalloprotease FtsH {ECO:0000256|HAMAP-Rule:MF_01458};
EC=3.4.24.- {ECO:0000256|HAMAP-Rule:MF_01458};
Name=ftsH {ECO:0000256|HAMAP-Rule:MF_01458};
ORFNames=SPW_6059 {ECO:0000313|EMBL:EHM25510.1};
Streptomyces sp. W007.
Bacteria; Actinobacteria; Streptomycetales; Streptomycetaceae;
Streptomyces.
NCBI_TaxID=1055352 {ECO:0000313|EMBL:EHM25510.1, ECO:0000313|Proteomes:UP000004626};
[1] {ECO:0000313|EMBL:EHM25510.1, ECO:0000313|Proteomes:UP000004626}
NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
STRAIN=W007 {ECO:0000313|EMBL:EHM25510.1,
ECO:0000313|Proteomes:UP000004626};
PubMed=22374958; DOI=10.1128/JB.06701-11;
Qin S., Zhang H., Li F., Zhu B., Zheng H.;
"Draft Genome Sequence of Marine Streptomyces sp. Strain W007, Which
Produces Angucyclinone Antibiotics with a Benz[a]anthracene
Skeleton.";
J. Bacteriol. 194:1628-1629(2012).
-!- FUNCTION: Acts as a processive, ATP-dependent zinc
metallopeptidase for both cytoplasmic and membrane proteins. Plays
a role in the quality control of integral membrane proteins.
{ECO:0000256|HAMAP-Rule:MF_01458}.
-!- COFACTOR:
Name=Zn(2+); Xref=ChEBI:CHEBI:29105;
Evidence={ECO:0000256|HAMAP-Rule:MF_01458};
Note=Binds 1 zinc ion per subunit. {ECO:0000256|HAMAP-
Rule:MF_01458};
-!- SUBUNIT: Homohexamer. {ECO:0000256|HAMAP-Rule:MF_01458}.
-!- SUBCELLULAR LOCATION: Cell membrane {ECO:0000256|HAMAP-
Rule:MF_01458}; Multi-pass membrane protein {ECO:0000256|HAMAP-
Rule:MF_01458}; Cytoplasmic side {ECO:0000256|HAMAP-
Rule:MF_01458}.
-!- SIMILARITY: Belongs to the AAA ATPase family.
{ECO:0000256|RuleBase:RU003651}.
-!- SIMILARITY: In the C-terminal section; belongs to the peptidase
M41 family. {ECO:0000256|HAMAP-Rule:MF_01458}.
-!- SIMILARITY: In the central section; belongs to the AAA ATPase
family. {ECO:0000256|HAMAP-Rule:MF_01458}.
-!- CAUTION: Lacks conserved residue(s) required for the propagation
of feature annotation. {ECO:0000256|HAMAP-Rule:MF_01458}.
-!- CAUTION: The sequence shown here is derived from an
EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is
preliminary data. {ECO:0000313|EMBL:EHM25510.1}.
-----------------------------------------------------------------------
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EMBL; AGSW01000214; EHM25510.1; -; Genomic_DNA.
MEROPS; M41.015; -.
EnsemblBacteria; EHM25510; EHM25510; SPW_6059.
PATRIC; fig|1055352.3.peg.6203; -.
Proteomes; UP000004626; Unassembled WGS sequence.
GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
GO; GO:0005886; C:plasma membrane; IEA:UniProtKB-SubCell.
GO; GO:0005524; F:ATP binding; IEA:UniProtKB-UniRule.
GO; GO:0016887; F:ATPase activity; IEA:UniProtKB-UniRule.
GO; GO:0004222; F:metalloendopeptidase activity; IEA:InterPro.
GO; GO:0008270; F:zinc ion binding; IEA:UniProtKB-UniRule.
GO; GO:0051301; P:cell division; IEA:UniProtKB-KW.
GO; GO:0030163; P:protein catabolic process; IEA:UniProtKB-UniRule.
HAMAP; MF_01458; FtsH; 1.
InterPro; IPR003593; AAA+_ATPase.
InterPro; IPR003959; ATPase_AAA_core.
InterPro; IPR003960; ATPase_AAA_CS.
InterPro; IPR005936; FtsH.
InterPro; IPR027417; P-loop_NTPase.
InterPro; IPR000642; Peptidase_M41.
InterPro; IPR037219; Peptidase_M41-like.
Pfam; PF00004; AAA; 1.
Pfam; PF01434; Peptidase_M41; 1.
SMART; SM00382; AAA; 1.
SUPFAM; SSF140990; SSF140990; 1.
SUPFAM; SSF52540; SSF52540; 1.
TIGRFAMs; TIGR01241; FtsH_fam; 1.
PROSITE; PS00674; AAA; 1.
3: Inferred from homology;
ATP-binding {ECO:0000256|HAMAP-Rule:MF_01458,
ECO:0000256|RuleBase:RU003651};
Cell cycle {ECO:0000313|EMBL:EHM25510.1};
Cell division {ECO:0000313|EMBL:EHM25510.1};
Cell membrane {ECO:0000256|HAMAP-Rule:MF_01458};
Complete proteome {ECO:0000313|Proteomes:UP000004626};
Hydrolase {ECO:0000256|HAMAP-Rule:MF_01458};
Membrane {ECO:0000256|HAMAP-Rule:MF_01458};
Metal-binding {ECO:0000256|HAMAP-Rule:MF_01458};
Metalloprotease {ECO:0000256|HAMAP-Rule:MF_01458};
Nucleotide-binding {ECO:0000256|HAMAP-Rule:MF_01458,
ECO:0000256|RuleBase:RU003651};
Protease {ECO:0000256|HAMAP-Rule:MF_01458};
Transmembrane {ECO:0000256|HAMAP-Rule:MF_01458};
Transmembrane helix {ECO:0000256|HAMAP-Rule:MF_01458};
Zinc {ECO:0000256|HAMAP-Rule:MF_01458}.
TRANSMEM 110 130 Helical. {ECO:0000256|HAMAP-
Rule:MF_01458}.
DOMAIN 194 333 AAA. {ECO:0000259|SMART:SM00382}.
NP_BIND 202 209 ATP. {ECO:0000256|HAMAP-Rule:MF_01458}.
ACT_SITE 425 425 {ECO:0000256|HAMAP-Rule:MF_01458}.
METAL 424 424 Zinc; catalytic. {ECO:0000256|HAMAP-
Rule:MF_01458}.
METAL 428 428 Zinc; catalytic. {ECO:0000256|HAMAP-
Rule:MF_01458}.
METAL 500 500 Zinc; catalytic. {ECO:0000256|HAMAP-
Rule:MF_01458}.
SEQUENCE 674 AA; 72709 MW; 3F49744673059BDF CRC64;
MWIVLAVLAV VVLMQVVGSS GGYKTVDTGK VIQAISKDQV EQAKLTTGDE QILKIELKDG
QKLEGESGSK FQASYIGNQG VELADTLQQK FENGDIEKGY TVSPSKQSPF VSILLSLLPF
VLIVVVFLFL MNQMQGGGSK VMQFGKSKAK LITKDTPKTT FADVAGSDEA VEELHEIKEF
LQEPAKFQAV GAKIPKGVLL YGPPGTGKTL LARAVAGEAG VPFYSISGSD FVEMFVGVGA
SRVRDLFEQA KANAPAIVFV DEIDAVGRHR GAGMGGGHDE REQTLNQLLV EMDGFDVKGG
VILIAATNRP DILDPALLRP GRFDRQIAVD RPDMQGRLEI LKVHQKGKPV AEGVDLGAVA
RRTPGFTGAD LSNVLNEAAL LTARGNKKLI DNESLDEAID RVVAGPQKRT RIMSEKEKKI
TAYHEGGHAL VAAASPQSDP VHKITILSRG RALGYTMVLP EEDKYSTTRN EMLDQLAYML
GGRAAEELVF HDPTTGAAND IEKATATARA MVTQYGMTER LGAIKFGGDN SEPFLGREMG
HQRDYSEEVA ALVDEEVKKL IETAHNDAWE ILVENRDILD ALVLELLEKE TLGKDEIAEI
FAPLVRRPAR PAWTGSARRT PSTRPPVLSP KELALTNGAS VANGSATPPE IAPTDLTKDI
ASSTEAIPEE RPES


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Kits Elisa; taq POLYMERASE

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Pathways :
WP1493: Carbon assimilation C4 pathway
WP1619: Amino sugar and nucleotide sugar metabolism
WP1625: Base excision repair
WP1672: Mismatch repair
WP1676: Non-homologous end-joining
WP1678: Nucleotide excision repair
WP2199: Seed Development
WP2344: vitamin B6 (pyridoxine, pyridoxal, pyridoxamine) biosynthesis and salvage pathway
WP710: DNA damage response (only ATM dependent)

Related Genes :
[YME1L1 FTSH1 YME1L UNQ1868/PRO4304] ATP-dependent zinc metalloprotease YME1L1 (EC 3.4.24.-) (ATP-dependent metalloprotease FtsH1) (Meg-4) (Presenilin-associated metalloprotease) (PAMP) (YME1-like protein 1)
[ftsH hflB mrsC std tolZ b3178 JW3145] ATP-dependent zinc metalloprotease FtsH (EC 3.4.24.-) (Cell division protease FtsH)
[FTSH1 AAA FTSH At1g50250 F14I3.14] ATP-dependent zinc metalloprotease FTSH 1, chloroplastic (AtFTSH1) (EC 3.4.24.-)
[FTSH5 FTSH2 VAR1 At5g42270 K5J14.7] ATP-dependent zinc metalloprotease FTSH 5, chloroplastic (AtFTSH5) (EC 3.4.24.-) (Protein VARIEGATED 1)
[ftsH2 slr0228] ATP-dependent zinc metalloprotease FtsH 2 (EC 3.4.24.-)
[FTSH8 At1g06430 F12K11.22 F12K11_24] ATP-dependent zinc metalloprotease FTSH 8, chloroplastic (AtFTSH8) (EC 3.4.24.-)
[FTSH4 At2g26140 T19L18.5] ATP-dependent zinc metalloprotease FTSH 4, mitochondrial (AtFTSH4) (EC 3.4.24.-)
[FTSH2 VAR2 At2g30950 F7F1.16] ATP-dependent zinc metalloprotease FTSH 2, chloroplastic (AtFTSH2) (EC 3.4.24.-) (Protein VARIEGATED 2)
[FTSH11 At5g53170 MFH8.11] ATP-dependent zinc metalloprotease FTSH 11, chloroplastic/mitochondrial (AtFTSH11) (EC 3.4.24.-)
[Yme1l1] ATP-dependent zinc metalloprotease YME1L1 (EC 3.4.24.-) (ATP-dependent metalloprotease FtsH1) (YME1-like protein 1)
[ftsH BSU00690] ATP-dependent zinc metalloprotease FtsH (EC 3.4.24.-) (Cell division protease FtsH)
[ftsH TTHA1492] ATP-dependent zinc metalloprotease FtsH (EC 3.4.24.-)
[FTSH3 At2g29080 T9I4.16] ATP-dependent zinc metalloprotease FTSH 3, mitochondrial (AtFTSH3) (EC 3.4.24.-)
[FTSH6 At5g15250 F8M21.140] ATP-dependent zinc metalloprotease FTSH 6, chloroplastic (AtFTSH6) (EC 3.4.24.-)
[FTSH10 At1g07510 F22G5.10 F22G5_9] ATP-dependent zinc metalloprotease FTSH 10, mitochondrial (AtFTSH10) (EC 3.4.24.-)
[FTSHI4 EMB3144 At5g64580 MUB3.10] Probable inactive ATP-dependent zinc metalloprotease FTSHI 4, chloroplastic (AtFTSHI4) (Protein EMBRYO DEFECTIVE 3144) (Protein FTSH INACTIVE PROTEASE 4)
[ftsH CCNA_03334] ATP-dependent zinc metalloprotease FtsH (EC 3.4.24.-)
[Yme1l1] ATP-dependent zinc metalloprotease YME1L1 (EC 3.4.24.-) (ATP-dependent metalloprotease FtsH1) (Meg-4) (YME1-like protein 1)
[FTSHI1 ARC1 At4g23940 T19F6.22 T32A16.10] Probable inactive ATP-dependent zinc metalloprotease FTSHI 1, chloroplastic (AtFTSHI1) (Protein ACCUMULATION AND REPLICATION OF CHLOROPLASTS 1) (Protein ARC1) (Protein FTSH INACTIVE PROTEASE 1)
[FTSHI5 EMB2458 At3g04340 T6K12.4] Probable inactive ATP-dependent zinc metalloprotease FTSHI 5, chloroplastic (AtFTSHI5) (Protein EMBRYO DEFECTIVE 2458) (Protein FTSH INACTIVE PROTEASE 5)
[FTSHI2 EMB2083 At3g16290 MYA6.12 T2O4.19] Probable inactive ATP-dependent zinc metalloprotease FTSHI 2, chloroplastic (AtFTSHI2) (Protein EMBRYO DEFECTIVE 2083) (Protein FTSH INACTIVE PROTEASE 2)
[ftsH] ATP-dependent zinc metalloprotease FtsH (EC 3.4.24.-)
[ftsH OR214_04183] ATP-dependent zinc metalloprotease FtsH (EC 3.4.24.-)
[ftsH OR16_10039] ATP-dependent zinc metalloprotease FtsH (EC 3.4.24.-)
[ftsH OR37_00881] ATP-dependent zinc metalloprotease FtsH (EC 3.4.24.-)
[PREP1 ZNMP1 At3g19170 MVI11.6 MVI11.7 MVI11_8] Presequence protease 1, chloroplastic/mitochondrial (AtPreP1) (PreP 1) (EC 3.4.24.-) (Zinc metalloprotease 1) (AtZnMP1)
[ftsH OR1_03673] ATP-dependent zinc metalloprotease FtsH (EC 3.4.24.-)
[gag-pol] Gag-Pol polyprotein (Pr160Gag-Pol) [Cleaved into: Matrix protein p17 (MA); Capsid protein p24 (CA); Spacer peptide 1 (SP1) (p2); Nucleocapsid protein p7 (NC); Transframe peptide (TF); p6-pol (p6*); Protease (EC 3.4.23.16) (PR) (Retropepsin); Reverse transcriptase/ribonuclease H (EC 2.7.7.49) (EC 2.7.7.7) (EC 3.1.26.13) (Exoribonuclease H) (EC 3.1.13.2) (p66 RT); p51 RT; p15; Integrase (IN) (EC 2.7.7.-) (EC 3.1.-.-)]
[SPCC965.04c] ATP-dependent zinc metalloprotease YME1 homolog (EC 3.4.24.-)
[ftsH_1 ftsH ACS78_23645 BTA37_25940 C2I27_21865 C2I28_08460 C3744_16440 CJ194_25985 CN367_03590 CN383_09400 CN890_10855 CN918_36045 CN955_25430 CN973_27940 CN978_15505 CN981_18770 COA18_09410 COC52_27870 COC53_00050 COC61_07375 COC62_29335 COD13_30225 COD15_07545 COE08_25975 COE31_22325 COE55_17410 COE67_10570 COI68_20230 COI84_20435 COJ00_28415 COJ19_27915 COJ21_25215 COJ23_19135 COJ36_26285 COJ70_23275 COJ90_29430 COJ92_22900 COK01_02400 COK03_28065 COK68_25895 COK90_07700 COL08_29140 NCTC6005_00331] ATP-dependent zinc metalloprotease FtsH (EC 3.4.24.-)

Bibliography :
[11827531] Identification of glutamic acid 479 as the gluzincin coordinator of zinc in FtsH (HflB).
[10788805] FtsH recognizes proteins with unfolded structure and hydrolyzes the carboxyl side of hydrophobic residues.
[10715327] The thylakoid FtsH protease plays a role in the light-induced turnover of the photosystem II D1 protein.
[9212469] Light-stimulated degradation of an unassembled Rieske FeS protein by a thylakoid-bound protease: the possible role of the FtsH protease.