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Acetoacetyl-CoA reductase (EC 1.1.1.36)

 PHAB_CUPNH              Reviewed;         246 AA.
P14697; Q0KBP7;
01-APR-1990, integrated into UniProtKB/Swiss-Prot.
01-APR-1990, sequence version 1.
13-FEB-2019, entry version 132.
RecName: Full=Acetoacetyl-CoA reductase;
EC=1.1.1.36;
Name=phaB {ECO:0000303|PubMed:1476773};
Synonyms=phbB {ECO:0000303|PubMed:2670935};
OrderedLocusNames=H16_A1439;
Cupriavidus necator (strain ATCC 17699 / H16 / DSM 428 / Stanier 337)
(Ralstonia eutropha).
Bacteria; Proteobacteria; Betaproteobacteria; Burkholderiales;
Burkholderiaceae; Cupriavidus.
NCBI_TaxID=381666;
[1]
NUCLEOTIDE SEQUENCE [GENOMIC DNA], IDENTIFICATION, AND FUNCTION.
STRAIN=ATCC 17699 / H16 / DSM 428 / Stanier 337;
PubMed=2670935;
Peoples O.P., Sinskey A.J.;
"Poly-beta-hydroxybutyrate biosynthesis in Alcaligenes eutrophus H16.
Characterization of the genes encoding beta-ketothiolase and
acetoacetyl-CoA reductase.";
J. Biol. Chem. 264:15293-15297(1989).
[2]
NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
STRAIN=ATCC 17699 / H16 / DSM 428 / Stanier 337;
PubMed=16964242; DOI=10.1038/nbt1244;
Pohlmann A., Fricke W.F., Reinecke F., Kusian B., Liesegang H.,
Cramm R., Eitinger T., Ewering C., Poetter M., Schwartz E.,
Strittmatter A., Voss I., Gottschalk G., Steinbuechel A.,
Friedrich B., Bowien B.;
"Genome sequence of the bioplastic-producing 'Knallgas' bacterium
Ralstonia eutropha H16.";
Nat. Biotechnol. 24:1257-1262(2006).
[3]
FUNCTION IN PHB SYNTHESIS, AND PATHWAY.
STRAIN=ATCC 17699 / H16 / DSM 428 / Stanier 337;
PubMed=2670936;
Peoples O.P., Sinskey A.J.;
"Poly-beta-hydroxybutyrate (PHB) biosynthesis in Alcaligenes eutrophus
H16. Identification and characterization of the PHB polymerase gene
(phbC).";
J. Biol. Chem. 264:15298-15303(1989).
[4]
GENE NAME.
PubMed=1476773; DOI=10.1111/j.1574-6968.1992.tb05841.x;
Steinbuechel A., Hustede E., Liebergesell M., Pieper U., Timm A.,
Valentin H.;
"Molecular basis for biosynthesis and accumulation of
polyhydroxyalkanoic acids in bacteria.";
FEMS Microbiol. Rev. 9:217-230(1992).
[5]
X-RAY CRYSTALLOGRAPHY (1.79 ANGSTROMS) OF WILD-TYPE AND MUTANTS LEU-47
AND SER-173 IN COMPLEX WITH ACETOACETYL-COENZYME A AND NADP, FUNCTION,
CATALYTIC ACTIVITY, KINETIC PARAMETERS, SUBUNIT, PATHWAY, AND
MUTAGENESIS OF GLN-47 AND THR-173.
STRAIN=ATCC 17699 / H16 / DSM 428 / Stanier 337;
PubMed=23913421; DOI=10.1128/AEM.01768-13;
Matsumoto K., Tanaka Y., Watanabe T., Motohashi R., Ikeda K.,
Tobitani K., Yao M., Tanaka I., Taguchi S.;
"Directed evolution and structural analysis of NADPH-dependent
acetoacetyl coenzyme A (acetoacetyl-CoA) reductase from Ralstonia
eutropha reveals two mutations responsible for enhanced kinetics.";
Appl. Environ. Microbiol. 79:6134-6139(2013).
[6]
X-RAY CRYSTALLOGRAPHY (1.34 ANGSTROMS) OF APOENZYME AND IN COMPLEXES
WITH ACETOACETYL-COENZYME A AND NADP, SUBUNIT, FUNCTION, CATALYTIC
ACTIVITY, AND MUTAGENESIS OF GLN-47; ASP-94; LYS-99; GLN-147; PHE-148;
GLN-150; THR-173; TYR-185 AND ARG-195.
STRAIN=ATCC 17699 / H16 / DSM 428 / Stanier 337;
PubMed=24211201; DOI=10.1016/j.bbrc.2013.10.150;
Kim J., Chang J.H., Kim E.J., Kim K.J.;
"Crystal structure of (R)-3-hydroxybutyryl-CoA dehydrogenase PhaB from
Ralstonia eutropha.";
Biochem. Biophys. Res. Commun. 443:783-788(2014).
-!- FUNCTION: Catalyzes the chiral reduction of acetoacetyl-CoA to
(R)-3-hydroxybutyryl-CoA. Is involved in the biosynthesis of
polyhydroxybutyrate (PHB), which is accumulated as an
intracellular energy reserve material when cells grow under
conditions of nutrient limitation. {ECO:0000269|PubMed:23913421,
ECO:0000269|PubMed:24211201, ECO:0000269|PubMed:2670935,
ECO:0000269|PubMed:2670936}.
-!- CATALYTIC ACTIVITY:
Reaction=a (3R)-hydroxyacyl-CoA + NADP(+) = a 3-oxoacyl-CoA + H(+)
+ NADPH; Xref=Rhea:RHEA:22256, ChEBI:CHEBI:15378,
ChEBI:CHEBI:57319, ChEBI:CHEBI:57783, ChEBI:CHEBI:58349,
ChEBI:CHEBI:90726; EC=1.1.1.36;
-!- CATALYTIC ACTIVITY:
Reaction=(3R)-hydroxybutanoyl-CoA + NADP(+) = acetoacetyl-CoA +
H(+) + NADPH; Xref=Rhea:RHEA:45796, ChEBI:CHEBI:15378,
ChEBI:CHEBI:57286, ChEBI:CHEBI:57315, ChEBI:CHEBI:57783,
ChEBI:CHEBI:58349; EC=1.1.1.36;
-!- BIOPHYSICOCHEMICAL PROPERTIES:
Kinetic parameters:
KM=5.7 uM for acetoacetyl-CoA {ECO:0000269|PubMed:23913421};
KM=149 uM for NADPH {ECO:0000269|PubMed:23913421};
Note=kcat is 102 sec(-1).;
-!- PATHWAY: Biopolymer metabolism; poly-(R)-3-hydroxybutanoate
biosynthesis. {ECO:0000269|PubMed:23913421,
ECO:0000269|PubMed:2670936}.
-!- SUBUNIT: Homotetramer. {ECO:0000269|PubMed:23913421,
ECO:0000269|PubMed:24211201}.
-!- SUBCELLULAR LOCATION: Cytoplasm.
-!- SIMILARITY: Belongs to the short-chain dehydrogenases/reductases
(SDR) family. {ECO:0000305}.
-----------------------------------------------------------------------
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Distributed under the Creative Commons Attribution (CC BY 4.0) License
-----------------------------------------------------------------------
EMBL; J04987; AAA21973.1; -; Genomic_DNA.
EMBL; AM260479; CAJ92574.1; -; Genomic_DNA.
PIR; B34340; RDALAE.
RefSeq; WP_010810131.1; NC_008313.1.
PDB; 3VZP; X-ray; 1.79 A; A/B/C/D=2-246.
PDB; 3VZQ; X-ray; 2.00 A; A/B=2-246.
PDB; 3VZR; X-ray; 2.90 A; A/B=2-246.
PDB; 3VZS; X-ray; 2.14 A; A/B/C/D=2-246.
PDB; 4N5L; X-ray; 1.65 A; A/B=1-246.
PDB; 4N5M; X-ray; 1.34 A; A/B=1-246.
PDB; 4N5N; X-ray; 1.90 A; A/B=1-246.
PDBsum; 3VZP; -.
PDBsum; 3VZQ; -.
PDBsum; 3VZR; -.
PDBsum; 3VZS; -.
PDBsum; 4N5L; -.
PDBsum; 4N5M; -.
PDBsum; 4N5N; -.
ProteinModelPortal; P14697; -.
SMR; P14697; -.
STRING; 381666.H16_A1439; -.
EnsemblBacteria; CAJ92574; CAJ92574; H16_A1439.
KEGG; reh:H16_A1439; -.
eggNOG; ENOG4105CHR; Bacteria.
eggNOG; ENOG410XNW1; LUCA.
KO; K00023; -.
OMA; LHGFTMA; -.
OrthoDB; 1601931at2; -.
UniPathway; UPA00917; -.
Proteomes; UP000008210; Chromosome 1.
GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
GO; GO:0018454; F:acetoacetyl-CoA reductase activity; IEA:UniProtKB-EC.
GO; GO:0042619; P:poly-hydroxybutyrate biosynthetic process; IEA:UniProtKB-KW.
InterPro; IPR011283; Acetoacetyl-CoA_reductase.
InterPro; IPR036291; NAD(P)-bd_dom_sf.
InterPro; IPR020904; Sc_DH/Rdtase_CS.
InterPro; IPR002347; SDR_fam.
Pfam; PF00106; adh_short; 1.
PRINTS; PR00081; GDHRDH.
PRINTS; PR00080; SDRFAMILY.
SUPFAM; SSF51735; SSF51735; 1.
TIGRFAMs; TIGR01829; AcAcCoA_reduct; 1.
PROSITE; PS00061; ADH_SHORT; 1.
1: Evidence at protein level;
3D-structure; Complete proteome; Cytoplasm; NADP; Oxidoreductase;
PHB biosynthesis; Reference proteome.
CHAIN 1 246 Acetoacetyl-CoA reductase.
/FTId=PRO_0000054748.
NP_BIND 13 15 NADP. {ECO:0000269|PubMed:23913421}.
NP_BIND 60 62 NADP. {ECO:0000269|PubMed:23913421}.
NP_BIND 88 92 NADP. {ECO:0000269|PubMed:23913421}.
NP_BIND 183 186 NADP. {ECO:0000269|PubMed:23913421}.
REGION 147 150 Substrate binding.
REGION 184 185 Substrate binding.
ACT_SITE 153 153 Proton acceptor. {ECO:0000255|PROSITE-
ProRule:PRU10001}.
BINDING 35 35 NADP; via amide nitrogen.
{ECO:0000269|PubMed:23913421}.
BINDING 40 40 NADP. {ECO:0000269|PubMed:23913421}.
BINDING 94 94 Substrate.
BINDING 195 195 Substrate.
MUTAGEN 47 47 Q->L: 2.4-fold increase in activity. 2-
fold decrease in affinity for NADPH and
2.8-fold decrease in affinity for
acetoacetyl-CoA.
{ECO:0000269|PubMed:23913421,
ECO:0000269|PubMed:24211201}.
MUTAGEN 94 94 D->A: About 6% of wild-type activity.
{ECO:0000269|PubMed:24211201}.
MUTAGEN 99 99 K->A: Nearly loss of activity.
{ECO:0000269|PubMed:24211201}.
MUTAGEN 147 147 Q->A: About 30% of wild-type activity.
{ECO:0000269|PubMed:24211201}.
MUTAGEN 148 148 F->A: About 30% of wild-type activity.
{ECO:0000269|PubMed:24211201}.
MUTAGEN 150 150 Q->A: About 20% of wild-type activity.
{ECO:0000269|PubMed:24211201}.
MUTAGEN 173 173 T->S: 3.5-fold increase in activity. 4-
fold decrease in affinity for NADPH and
2.4-fold decrease in affinity for
acetoacetyl-CoA.
{ECO:0000269|PubMed:23913421,
ECO:0000269|PubMed:24211201}.
MUTAGEN 185 185 Y->A: Nearly loss of activity.
{ECO:0000269|PubMed:24211201}.
MUTAGEN 195 195 R->A: Nearly loss of activity.
{ECO:0000269|PubMed:24211201}.
STRAND 5 8 {ECO:0000244|PDB:4N5M}.
TURN 9 12 {ECO:0000244|PDB:4N5M}.
HELIX 14 25 {ECO:0000244|PDB:4N5M}.
STRAND 29 34 {ECO:0000244|PDB:4N5M}.
HELIX 41 50 {ECO:0000244|PDB:4N5M}.
STRAND 56 59 {ECO:0000244|PDB:4N5M}.
HELIX 65 78 {ECO:0000244|PDB:4N5M}.
STRAND 82 87 {ECO:0000244|PDB:4N5M}.
HELIX 97 99 {ECO:0000244|PDB:4N5M}.
HELIX 102 112 {ECO:0000244|PDB:4N5M}.
HELIX 114 130 {ECO:0000244|PDB:4N5M}.
STRAND 133 138 {ECO:0000244|PDB:4N5M}.
HELIX 141 145 {ECO:0000244|PDB:4N5M}.
HELIX 151 171 {ECO:0000244|PDB:4N5M}.
HELIX 172 174 {ECO:0000244|PDB:4N5M}.
STRAND 176 183 {ECO:0000244|PDB:4N5M}.
STRAND 185 188 {ECO:0000244|PDB:4N5M}.
HELIX 189 192 {ECO:0000244|PDB:4N5M}.
HELIX 196 204 {ECO:0000244|PDB:4N5M}.
HELIX 214 225 {ECO:0000244|PDB:4N5M}.
HELIX 227 229 {ECO:0000244|PDB:3VZP}.
STRAND 236 240 {ECO:0000244|PDB:4N5M}.
SEQUENCE 246 AA; 26370 MW; AD6739E0F5C93C06 CRC64;
MTQRIAYVTG GMGGIGTAIC QRLAKDGFRV VAGCGPNSPR REKWLEQQKA LGFDFIASEG
NVADWDSTKT AFDKVKSEVG EVDVLINNAG ITRDVVFRKM TRADWDAVID TNLTSLFNVT
KQVIDGMADR GWGRIVNISS VNGQKGQFGQ TNYSTAKAGL HGFTMALAQE VATKGVTVNT
VSPGYIATDM VKAIRQDVLD KIVATIPVKR LGLPEEIASI CAWLSSEESG FSTGADFSLN
GGLHMG


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Kits Elisa; taq POLYMERASE

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Pathways :
WP1006: metapathway biotransformation
WP1124: metapathway biotransformation
WP1212: metapathway biotransformation
WP1251: metapathway biotransformation
WP1286: metapathway biotransformation
WP1403: AMPK signaling
WP1461: Photosynthetic Carbon Reduction
WP1566: Citrate cycle (TCA cycle)
WP1626: Benzoate degradation via CoA ligation
WP1634: Butanoate metabolism
WP1680: Oxidative phosphorylation
WP1681: Pantothenate and CoA biosynthesis
WP2230: Chlorophyll b degradation
WP2248: anthocyanin biosynthesis
WP2368: HMG-CoA reductase pathway
WP237: Glucocorticoid & Mineralcorticoid Metabolism
WP2409: New Pathway
WP305: Glucocorticoid Metabolism
WP495: Glucocorticoid & Mineralcorticoid Metabolism
WP668: Octadecanoid Pathway
WP702: metapathway biotransformation
WP889: metapathway biotransformation

Related Genes :
[ACAT1 ACAT MAT] Acetyl-CoA acetyltransferase, mitochondrial (EC 2.3.1.9) (Acetoacetyl-CoA thiolase) (T2)
[liuE PA2011] 3-hydroxy-3-isohexenylglutaryl-CoA/hydroxy-methylglutaryl-CoA lyase (HIHG-CoA lyase) (HMG-CoA lyase) (EC 4.1.3.26) (EC 4.1.3.4) ((S)-3-hydroxy-3-methylglutaryl-CoA acetoacetate-lyase) (3-hydroxy-3-(4-methylpent-3-en-1-yl)glutaryl-CoA acetate-lyase)
[FAS2 YPL231W P1409] Fatty acid synthase subunit alpha (EC 2.3.1.86) [Includes: Acyl carrier; 3-oxoacyl-[acyl-carrier-protein] reductase (EC 1.1.1.100) (Beta-ketoacyl reductase); 3-oxoacyl-[acyl-carrier-protein] synthase (EC 2.3.1.41) (Beta-ketoacyl synthase)]
[HSD17B10 ERAB HADH2 MRPP2 SCHAD SDR5C1 XH98G2] 3-hydroxyacyl-CoA dehydrogenase type-2 (EC 1.1.1.35) (17-beta-hydroxysteroid dehydrogenase 10) (17-beta-HSD 10) (EC 1.1.1.51) (2-methyl-3-hydroxybutyryl-CoA dehydrogenase) (MHBD) (3-hydroxy-2-methylbutyryl-CoA dehydrogenase) (EC 1.1.1.178) (3-hydroxyacyl-CoA dehydrogenase type II) (Endoplasmic reticulum-associated amyloid beta-peptide-binding protein) (Mitochondrial ribonuclease P protein 2) (Mitochondrial RNase P protein 2) (Short chain dehydrogenase/reductase family 5C member 1) (Short-chain type dehydrogenase/reductase XH98G2) (Type II HADH)
[al-3 B8P8.010 NCU01427] Geranylgeranyl pyrophosphate synthase (GGPP synthase) (GGPPSase) (EC 2.5.1.-) ((2E,6E)-farnesyl diphosphate synthase) (Albino-3 protein) (Dimethylallyltranstransferase) (EC 2.5.1.1) (Farnesyl diphosphate synthase) (Farnesyltranstransferase) (EC 2.5.1.29) (Geranylgeranyl diphosphate synthase) (Geranyltranstransferase) (EC 2.5.1.10)
[mcl1 RHOS4_03500 RSP_1771] L-malyl-CoA/beta-methylmalyl-CoA lyase (EC 4.1.3.24) ((3S)-malyl-CoA/beta-methylmalyl-CoA lyase) ((S)-citramalyl-CoA lyase) (EC 4.1.3.25)
[aro-1 aro-2 aro-4 aro-5 aro-9 B14H13.20 NCU016321] Pentafunctional AROM polypeptide [Includes: 3-dehydroquinate synthase (DHQS) (EC 4.2.3.4); 3-phosphoshikimate 1-carboxyvinyltransferase (EC 2.5.1.19) (5-enolpyruvylshikimate-3-phosphate synthase) (EPSP synthase) (EPSPS); Shikimate kinase (SK) (EC 2.7.1.71); 3-dehydroquinate dehydratase (3-dehydroquinase) (EC 4.2.1.10); Shikimate dehydrogenase (EC 1.1.1.25)]
[HSD17B8 FABGL HKE6 RING2 SDR30C1] Estradiol 17-beta-dehydrogenase 8 (EC 1.1.1.62) (17-beta-hydroxysteroid dehydrogenase 8) (17-beta-HSD 8) (3-ketoacyl-[acyl-carrier-protein] reductase alpha subunit) (KAR alpha subunit) (3-oxoacyl-[acyl-carrier-protein] reductase) (EC 1.1.1.-) (Protein Ke6) (Ke-6) (Really interesting new gene 2 protein) (Short chain dehydrogenase/reductase family 30C member 1) (Testosterone 17-beta-dehydrogenase 8) (EC 1.1.1.239)
[CBR4 SDR45C1] Carbonyl reductase family member 4 (EC 1.-.-.-) (3-ketoacyl-[acyl-carrier-protein] reductase beta subunit) (KAR beta subunit) (3-oxoacyl-[acyl-carrier-protein] reductase) (EC 1.1.1.-) (Quinone reductase CBR4) (Short chain dehydrogenase/reductase family 45C member 1)
[scu CG7113] 3-hydroxyacyl-CoA dehydrogenase type-2 (EC 1.1.1.35) (17-beta-hydroxysteroid dehydrogenase 10) (17-beta-HSD 10) (EC 1.1.1.51) (3-hydroxy-2-methylbutyryl-CoA dehydrogenase) (EC 1.1.1.178) (3-hydroxyacyl-CoA dehydrogenase type II) (Mitochondrial ribonuclease P protein 2) (Mitochondrial RNase P protein 2) (Scully protein) (Type II HADH)
[] Genome polyprotein [Cleaved into: P3; Protein 3AB; P2; P1; Capsid protein VP0 (VP4-VP2); Capsid protein VP4 (P1A) (Virion protein 4); Capsid protein VP2 (P1B) (Virion protein 2); Capsid protein VP3 (P1C) (Virion protein 3); Capsid protein VP1 (P1D) (Virion protein 1); Protease 2A (P2A) (EC 3.4.22.29) (Picornain 2A) (Protein 2A); Protein 2B (P2B); Protein 2C (P2C) (EC 3.6.1.15); Protein 3A (P3A); Viral protein genome-linked (VPg) (Protein 3B) (P3B); Protein 3CD (EC 3.4.22.28); Protease 3C (P3C) (EC 3.4.22.28); RNA-directed RNA polymerase (RdRp) (EC 2.7.7.48) (3D polymerase) (3Dpol) (Protein 3D) (3D)]
[HMG1 HMGR1 At1g76490 F14G6.9 F15M4.1] 3-hydroxy-3-methylglutaryl-coenzyme A reductase 1 (AtHMGR1) (HMG-CoA reductase 1) (EC 1.1.1.34)
[iolA mmsA yxdA BSU39760 E83A] Malonate-semialdehyde dehydrogenase (MSA dehydrogenase) (EC 1.2.1.-) (Methylmalonate-semialdehyde dehydrogenase) (MMSA dehydrogenase) (MMSDH) (MSDH) (EC 1.2.1.27)
[hchA A8C65_13880 A9R57_25255 AKG99_20940 AMK83_16550 B7C53_22525 B9M99_11580 B9T59_01945 BJJ90_15205 BMT49_12710 BMT53_00170 BUE81_10670 BW690_17225 BZL69_29425 C2U48_24800 C5715_19445 C5N07_21380 C6669_19295 C7B06_02290 C7B07_03930 CDL37_00765 CG691_19145 CG705_13560 CG706_14580 CIJ94_05515 COD46_23180 CRD98_26150 D3I61_11545 DL800_09215 DNQ41_14245 DQE83_22775 DTL43_21780 DTL84_23375 DTM25_06080 EC95NR1_00961 ERS085379_01273 ERS085386_05041 HMPREF3040_01583 HW43_13705 NCTC10082_04431 NCTC10418_03071 NCTC10767_03558 NCTC11022_01867 NCTC11126_04427 NCTC11181_05650 NCTC12950_02263 NCTC13462_05714 NCTC8985_00529 NCTC9111_05933 NCTC9703_00277 PU06_24500 SAMEA3472055_03589 SAMEA3472056_01268 SAMEA3472070_00654 SAMEA3472080_04213 SAMEA3472090_03376 SAMEA3472110_00060 SAMEA3472112_00448 SAMEA3752372_00752 SAMEA3753106_00003 SAMEA3753391_00513 UN91_23615 WQ89_10695] Protein/nucleic acid deglycase HchA (EC 3.1.2.-) (EC 3.5.1.-) (EC 3.5.1.124) (Maillard deglycase)
[PRKAA1 AMPK1] 5'-AMP-activated protein kinase catalytic subunit alpha-1 (AMPK subunit alpha-1) (EC 2.7.11.1) (Acetyl-CoA carboxylase kinase) (ACACA kinase) (EC 2.7.11.27) (Hydroxymethylglutaryl-CoA reductase kinase) (HMGCR kinase) (EC 2.7.11.31) (Tau-protein kinase PRKAA1) (EC 2.7.11.26)
[Hsd17b10 Erab Hadh2] 3-hydroxyacyl-CoA dehydrogenase type-2 (EC 1.1.1.35) (17-beta-hydroxysteroid dehydrogenase 10) (17-beta-HSD 10) (EC 1.1.1.51) (3-hydroxy-2-methylbutyryl-CoA dehydrogenase) (EC 1.1.1.178) (3-hydroxyacyl-CoA dehydrogenase type II) (Endoplasmic reticulum-associated amyloid beta-peptide-binding protein) (Mitochondrial ribonuclease P protein 2) (Mitochondrial RNase P protein 2) (Type II HADH)
[gag-pol] Gag-Pol polyprotein (Pr160Gag-Pol) [Cleaved into: Matrix protein p17 (MA); Capsid protein p24 (CA); Spacer peptide 1 (SP1) (p2); Nucleocapsid protein p7 (NC); Transframe peptide (TF); p6-pol (p6*); Protease (EC 3.4.23.16) (PR) (Retropepsin); Reverse transcriptase/ribonuclease H (EC 2.7.7.49) (EC 2.7.7.7) (EC 3.1.26.13) (Exoribonuclease H) (EC 3.1.13.2) (p66 RT); p51 RT; p15; Integrase (IN) (EC 2.7.7.-) (EC 3.1.-.-)]
[Prkaa1 Ampk1] 5'-AMP-activated protein kinase catalytic subunit alpha-1 (AMPK subunit alpha-1) (EC 2.7.11.1) (Acetyl-CoA carboxylase kinase) (ACACA kinase) (EC 2.7.11.27) (Hydroxymethylglutaryl-CoA reductase kinase) (HMGCR kinase) (EC 2.7.11.31) (Tau-protein kinase PRKAA1) (EC 2.7.11.26)
[Hsd17b10 Erab Hadh2] 3-hydroxyacyl-CoA dehydrogenase type-2 (EC 1.1.1.35) (17-beta-hydroxysteroid dehydrogenase 10) (17-beta-HSD 10) (EC 1.1.1.51) (3-hydroxy-2-methylbutyryl-CoA dehydrogenase) (EC 1.1.1.178) (3-hydroxyacyl-CoA dehydrogenase type II) (Endoplasmic reticulum-associated amyloid beta-peptide-binding protein) (Mitochondrial ribonuclease P protein 2) (Mitochondrial RNase P protein 2) (Type II HADH)
[glmU OR1_01412] Bifunctional protein GlmU [Includes: Glucosamine-1-phosphate N-acetyltransferase (EC 2.3.1.157); UDP-N-acetylglucosamine pyrophosphorylase (EC 2.7.7.23) (N-acetylglucosamine-1-phosphate uridyltransferase)]
[al-2 B22I21.230 NCU00585] Bifunctional lycopene cyclase/phytoene synthase (Protein albino-2) [Includes: Lycopene beta-cyclase (EC 5.5.1.19) (Carotene cyclase) (Lycopene cyclase); Phytoene synthase (EC 2.5.1.32)]
[dim-5 29E8.110 NCU04402] Histone-lysine N-methyltransferase, H3 lysine-9 specific dim-5 (EC 2.1.1.43) (Histone H3-K9 methyltransferase dim-5) (H3-K9-HMTase dim-5) (HKMT)
[PRKAA1 AMPK1] 5'-AMP-activated protein kinase catalytic subunit alpha-1 (AMPK subunit alpha-1) (EC 2.7.11.1) (AMPK 63 kDa subunit) (Acetyl-CoA carboxylase kinase) (ACACA kinase) (EC 2.7.11.27) (Hydroxymethylglutaryl-CoA reductase kinase) (HMGCR kinase) (EC 2.7.11.31) (Tau-protein kinase PRKAA1) (EC 2.7.11.26) (Fragments)
[HMGCR] 3-hydroxy-3-methylglutaryl-coenzyme A reductase (HMG-CoA reductase) (EC 1.1.1.34)
[fox-2 NCU08828] Peroxisomal hydratase-dehydrogenase-epimerase (HDE) (Multifunctional beta-oxidation protein) (MFP) [Includes: 2-enoyl-CoA hydratase (EC 4.2.1.119); (3R)-3-hydroxyacyl-CoA dehydrogenase (EC 1.1.1.n12)]
[Hmgcr] 3-hydroxy-3-methylglutaryl-coenzyme A reductase (HMG-CoA reductase) (EC 1.1.1.34)
[CRY2 PHH1 SEL20 At1g04400 F19P19.14] Cryptochrome-2 (Atcry2) (Blue light photoreceptor) (Protein PHR homolog 1) (AtPHH1) (Protein SUPPRESSOR OF elf3 20)
[inhA Rv1484 MTCY277.05] Enoyl-[acyl-carrier-protein] reductase [NADH] (ENR) (Enoyl-ACP reductase) (EC 1.3.1.9) (FAS-II enoyl-ACP reductase) (NADH-dependent 2-trans-enoyl-ACP reductase)
[Prkaa1] 5'-AMP-activated protein kinase catalytic subunit alpha-1 (AMPK subunit alpha-1) (EC 2.7.11.1) (Acetyl-CoA carboxylase kinase) (ACACA kinase) (EC 2.7.11.27) (Hydroxymethylglutaryl-CoA reductase kinase) (HMGCR kinase) (EC 2.7.11.31) (Tau-protein kinase PRKAA1) (EC 2.7.11.26)
[PRKAA1] 5'-AMP-activated protein kinase catalytic subunit alpha-1 (AMPK subunit alpha-1) (EC 2.7.11.1) (Acetyl-CoA carboxylase kinase) (ACACA kinase) (EC 2.7.11.27) (Hydroxymethylglutaryl-CoA reductase kinase) (HMGCR kinase) (EC 2.7.11.31) (Tau-protein kinase PRKAA1) (EC 2.7.11.26) (Fragment)

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