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Acetyl-coenzyme A transporter 1 (AT-1) (Acetyl-CoA transporter 1) (Solute carrier family 33 member 1)

 ACATN_HUMAN             Reviewed;         549 AA.
O00400; B2R5Q2; D3DNK4;
20-DEC-2005, integrated into UniProtKB/Swiss-Prot.
01-JUL-1997, sequence version 1.
07-APR-2021, entry version 158.
RecName: Full=Acetyl-coenzyme A transporter 1;
Short=AT-1;
Short=Acetyl-CoA transporter 1;
AltName: Full=Solute carrier family 33 member 1;
Name=SLC33A1; Synonyms=ACATN, AT1;
Homo sapiens (Human).
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
Homo.
NCBI_TaxID=9606;
[1]
NUCLEOTIDE SEQUENCE [MRNA], FUNCTION, TISSUE SPECIFICITY, AND SUBCELLULAR
LOCATION.
TISSUE=Melanoma;
PubMed=9096318; DOI=10.1073/pnas.94.7.2897;
Kanamori A., Nakayama J., Fukuda M.N., Stallcup W.B., Sasaki K., Fukuda M.,
Hirabayashi Y.;
"Expression cloning and characterization of a cDNA encoding a novel
membrane protein required for the formation of O-acetylated gangliosides: a
putative acetyl CoA transporter.";
Proc. Natl. Acad. Sci. U.S.A. 94:2897-2902(1997).
[2]
NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
PubMed=14702039; DOI=10.1038/ng1285;
Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R.,
Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H.,
Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.,
Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K.,
Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H.,
Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M.,
Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K.,
Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T.,
Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M.,
Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S.,
Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H.,
Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K.,
Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N.,
Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S.,
Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O.,
Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H.,
Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B.,
Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y.,
Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K.,
Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T.,
Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T.,
Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y.,
Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H.,
Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y.,
Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H.,
Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O.,
Isogai T., Sugano S.;
"Complete sequencing and characterization of 21,243 full-length human
cDNAs.";
Nat. Genet. 36:40-45(2004).
[3]
NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Mural R.J., Istrail S., Sutton G.G., Florea L., Halpern A.L., Mobarry C.M.,
Lippert R., Walenz B., Shatkay H., Dew I., Miller J.R., Flanigan M.J.,
Edwards N.J., Bolanos R., Fasulo D., Halldorsson B.V., Hannenhalli S.,
Turner R., Yooseph S., Lu F., Nusskern D.R., Shue B.C., Zheng X.H.,
Zhong F., Delcher A.L., Huson D.H., Kravitz S.A., Mouchard L., Reinert K.,
Remington K.A., Clark A.G., Waterman M.S., Eichler E.E., Adams M.D.,
Hunkapiller M.W., Myers E.W., Venter J.C.;
Submitted (SEP-2005) to the EMBL/GenBank/DDBJ databases.
[4]
NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
TISSUE=Kidney;
PubMed=15489334; DOI=10.1101/gr.2596504;
The MGC Project Team;
"The status, quality, and expansion of the NIH full-length cDNA project:
the Mammalian Gene Collection (MGC).";
Genome Res. 14:2121-2127(2004).
[5]
PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-22, AND IDENTIFICATION BY
MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
TISSUE=Erythroleukemia;
PubMed=23186163; DOI=10.1021/pr300630k;
Zhou H., Di Palma S., Preisinger C., Peng M., Polat A.N., Heck A.J.,
Mohammed S.;
"Toward a comprehensive characterization of a human cancer cell
phosphoproteome.";
J. Proteome Res. 12:260-271(2013).
[6]
FUNCTION, VARIANT SPG42 ARG-113, AND CHARACTERIZATION OF VARIANT SPG42
ARG-113.
PubMed=25402622; DOI=10.1002/humu.22732;
Mao F., Li Z., Zhao B., Lin P., Liu P., Zhai M., Liu Q., Shao C., Sun W.,
Gong Y.;
"Identification and Functional Analysis of a SLC33A1: c.339T>G
(p.Ser113Arg) Variant in the Original SPG42 Family.";
Hum. Mutat. 36:240-249(2015).
[7]
IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
PubMed=25944712; DOI=10.1002/pmic.201400617;
Vaca Jacome A.S., Rabilloud T., Schaeffer-Reiss C., Rompais M., Ayoub D.,
Lane L., Bairoch A., Van Dorsselaer A., Carapito C.;
"N-terminome analysis of the human mitochondrial proteome.";
Proteomics 15:2519-2524(2015).
[8]
VARIANT [LARGE SCALE ANALYSIS] ALA-400.
PubMed=16959974; DOI=10.1126/science.1133427;
Sjoeblom T., Jones S., Wood L.D., Parsons D.W., Lin J., Barber T.D.,
Mandelker D., Leary R.J., Ptak J., Silliman N., Szabo S., Buckhaults P.,
Farrell C., Meeh P., Markowitz S.D., Willis J., Dawson D., Willson J.K.V.,
Gazdar A.F., Hartigan J., Wu L., Liu C., Parmigiani G., Park B.H.,
Bachman K.E., Papadopoulos N., Vogelstein B., Kinzler K.W.,
Velculescu V.E.;
"The consensus coding sequences of human breast and colorectal cancers.";
Science 314:268-274(2006).
[9]
VARIANT SPG42 ARG-113.
PubMed=19061983; DOI=10.1016/j.ajhg.2008.11.003;
Lin P., Li J., Liu Q., Mao F., Li J., Qiu R., Hu H., Song Y., Yang Y.,
Gao G., Yan C., Yang W., Shao C., Gong Y.;
"A missense mutation in SLC33A1, which encodes the acetyl-CoA transporter,
causes autosomal-dominant spastic paraplegia (SPG42).";
Am. J. Hum. Genet. 83:752-759(2008).
[10]
VARIANT CCHLND PRO-110, AND CHARACTERIZATION OF VARIANT CCHLND PRO-110.
PubMed=22243965; DOI=10.1016/j.ajhg.2011.11.030;
Huppke P., Brendel C., Kalscheuer V., Korenke G.C., Marquardt I.,
Freisinger P., Christodoulou J., Hillebrand M., Pitelet G., Wilson C.,
Gruber-Sedlmayr U., Ullmann R., Haas S., Elpeleg O., Nurnberg G.,
Nurnberg P., Dad S., Moller L.B., Kaler S.G., Gartner J.;
"Mutations in SLC33A1 cause a lethal autosomal-recessive disorder with
congenital cataracts, hearing loss, and low serum copper and
ceruloplasmin.";
Am. J. Hum. Genet. 90:61-68(2012).
[11]
ERRATUM OF PUBMED:22243965.
Huppke P., Brendel C., Kalscheuer V., Korenke G.C., Marquardt I.,
Freisinger P., Christodoulou J., Hillebrand M., Pitelet G., Wilson C.,
Gruber-Sedlmayr U., Ullmann R., Haas S., Elpeleg O., Nurnberg G.,
Nurnberg P., Dad S., Moller L.B., Kaler S.G., Gartner J.;
Am. J. Hum. Genet. 90:378-378(2012).
-!- FUNCTION: Probable acetyl-CoA transporter necessary for O-acetylation
of gangliosides (PubMed:9096318). Negatively regulates BMP signaling
(PubMed:25402622). {ECO:0000269|PubMed:25402622,
ECO:0000269|PubMed:9096318}.
-!- SUBCELLULAR LOCATION: Endoplasmic reticulum membrane
{ECO:0000305|PubMed:9096318}; Multi-pass membrane protein
{ECO:0000305|PubMed:9096318}.
-!- TISSUE SPECIFICITY: Ubiquitous. Detected in heart, brain, placenta,
lung, liver, skeletal muscle, kidney and pancreas. With strongest
signals in pancreas. {ECO:0000269|PubMed:9096318}.
-!- DISEASE: Spastic paraplegia 42, autosomal dominant (SPG42)
[MIM:612539]: A form of spastic paraplegia, a neurodegenerative
disorder characterized by a slow, gradual, progressive weakness and
spasticity of the lower limbs. Rate of progression and the severity of
symptoms are quite variable. Initial symptoms may include difficulty
with balance, weakness and stiffness in the legs, muscle spasms, and
dragging the toes when walking. In some forms of the disorder, bladder
symptoms (such as incontinence) may appear, or the weakness and
stiffness may spread to other parts of the body.
{ECO:0000269|PubMed:19061983, ECO:0000269|PubMed:25402622}. Note=The
disease is caused by variants affecting the gene represented in this
entry.
-!- DISEASE: Congenital cataracts, hearing loss, and neurodegeneration
(CCHLND) [MIM:614482]: An autosomal recessive disorder characterized by
congenital cataracts, severe psychomotor retardation, and hearing loss
associated with decreased serum ceruloplasmin and copper. Brain MRI
shows cerebral and cerebellar atrophy and hypomyelination.
{ECO:0000269|PubMed:22243965}. Note=The disease is caused by variants
affecting the gene represented in this entry.
-!- SIMILARITY: Belongs to the SLC33A transporter family. {ECO:0000305}.
-!- WEB RESOURCE: Name=Mendelian genes solute carrier family 33 (acetyl-CoA
transporter), member 1 (SLC33A1); Note=Leiden Open Variation Database
(LOVD);
URL="https://databases.lovd.nl/shared/genes/SLC33A1";
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EMBL; D88152; BAA20072.1; -; mRNA.
EMBL; AK312268; BAG35199.1; -; mRNA.
EMBL; CH471052; EAW78743.1; -; Genomic_DNA.
EMBL; CH471052; EAW78744.1; -; Genomic_DNA.
EMBL; BC014416; AAH14416.1; -; mRNA.
CCDS; CCDS3173.1; -.
RefSeq; NP_001177921.1; NM_001190992.1.
RefSeq; NP_004724.1; NM_004733.3.
BioGRID; 114632; 111.
IntAct; O00400; 63.
MINT; O00400; -.
STRING; 9606.ENSP00000376587; -.
BindingDB; O00400; -.
ChEMBL; CHEMBL3638338; -.
TCDB; 2.A.1.25.1; the major facilitator superfamily (mfs).
GlyConnect; 2835; 1 N-Linked glycan (1 site).
GlyGen; O00400; 1 site.
iPTMnet; O00400; -.
PhosphoSitePlus; O00400; -.
SwissPalm; O00400; -.
BioMuta; SLC33A1; -.
EPD; O00400; -.
jPOST; O00400; -.
MassIVE; O00400; -.
MaxQB; O00400; -.
PaxDb; O00400; -.
PeptideAtlas; O00400; -.
PRIDE; O00400; -.
ProteomicsDB; 47866; -.
Antibodypedia; 33630; 171 antibodies.
DNASU; 9197; -.
Ensembl; ENST00000359479; ENSP00000352456; ENSG00000169359.
Ensembl; ENST00000643144; ENSP00000496241; ENSG00000169359.
GeneID; 9197; -.
KEGG; hsa:9197; -.
UCSC; uc003fan.6; human.
CTD; 9197; -.
DisGeNET; 9197; -.
GeneCards; SLC33A1; -.
GeneReviews; SLC33A1; -.
HGNC; HGNC:95; SLC33A1.
HPA; ENSG00000169359; Low tissue specificity.
MalaCards; SLC33A1; -.
MIM; 603690; gene.
MIM; 612539; phenotype.
MIM; 614482; phenotype.
neXtProt; NX_O00400; -.
OpenTargets; ENSG00000169359; -.
Orphanet; 171863; Autosomal dominant spastic paraplegia type 42.
Orphanet; 300313; Congenital cataract-hearing loss-severe developmental delay syndrome.
PharmGKB; PA24432; -.
VEuPathDB; HostDB:ENSG00000169359.13; -.
eggNOG; KOG3574; Eukaryota.
GeneTree; ENSGT00940000154019; -.
HOGENOM; CLU_020502_1_0_1; -.
InParanoid; O00400; -.
OMA; LWFWGIT; -.
OrthoDB; 1300300at2759; -.
PhylomeDB; O00400; -.
TreeFam; TF300008; -.
PathwayCommons; O00400; -.
Reactome; R-HSA-425397; Transport of vitamins, nucleosides, and related molecules.
Reactome; R-HSA-5619061; Defective SLC33A1 causes spastic paraplegia 42 (SPG42).
BioGRID-ORCS; 9197; 82 hits in 1007 CRISPR screens.
ChiTaRS; SLC33A1; human.
GenomeRNAi; 9197; -.
Pharos; O00400; Tchem.
PRO; PR:O00400; -.
Proteomes; UP000005640; Chromosome 3.
RNAct; O00400; protein.
Bgee; ENSG00000169359; Expressed in body of pancreas and 234 other tissues.
ExpressionAtlas; O00400; baseline and differential.
Genevisible; O00400; HS.
GO; GO:0005789; C:endoplasmic reticulum membrane; TAS:ProtInc.
GO; GO:0000139; C:Golgi membrane; TAS:Reactome.
GO; GO:0005887; C:integral component of plasma membrane; TAS:ProtInc.
GO; GO:0016020; C:membrane; HDA:UniProtKB.
GO; GO:0008521; F:acetyl-CoA transmembrane transporter activity; TAS:ProtInc.
GO; GO:0015295; F:solute:proton symporter activity; IBA:GO_Central.
GO; GO:0030509; P:BMP signaling pathway; IDA:UniProtKB.
GO; GO:0060395; P:SMAD protein signal transduction; IDA:UniProtKB.
GO; GO:0055085; P:transmembrane transport; TAS:Reactome.
InterPro; IPR024371; AcetylCoA_trans_1-like.
InterPro; IPR004752; AmpG_permease/AT-1.
InterPro; IPR036259; MFS_trans_sf.
PANTHER; PTHR12778; PTHR12778; 1.
Pfam; PF13000; Acatn; 2.
SUPFAM; SSF103473; SSF103473; 1.
1: Evidence at protein level;
Cataract; Deafness; Disease variant; Endoplasmic reticulum; Glycoprotein;
Hereditary spastic paraplegia; Membrane; Neurodegeneration; Phosphoprotein;
Reference proteome; Transmembrane; Transmembrane helix; Transport.
CHAIN 1..549
/note="Acetyl-coenzyme A transporter 1"
/id="PRO_0000076165"
TOPO_DOM 1..74
/note="Cytoplasmic"
/evidence="ECO:0000255"
TRANSMEM 75..95
/note="Helical"
/evidence="ECO:0000255"
TOPO_DOM 96..113
/note="Extracellular"
/evidence="ECO:0000255"
TRANSMEM 114..134
/note="Helical"
/evidence="ECO:0000255"
TOPO_DOM 135..141
/note="Cytoplasmic"
/evidence="ECO:0000255"
TRANSMEM 142..162
/note="Helical"
/evidence="ECO:0000255"
TOPO_DOM 163..175
/note="Extracellular"
/evidence="ECO:0000255"
TRANSMEM 176..196
/note="Helical"
/evidence="ECO:0000255"
TOPO_DOM 197..217
/note="Cytoplasmic"
/evidence="ECO:0000255"
TRANSMEM 218..238
/note="Helical"
/evidence="ECO:0000255"
TOPO_DOM 239..256
/note="Extracellular"
/evidence="ECO:0000255"
TRANSMEM 257..277
/note="Helical"
/evidence="ECO:0000255"
TOPO_DOM 278..299
/note="Cytoplasmic"
/evidence="ECO:0000255"
TRANSMEM 300..320
/note="Helical"
/evidence="ECO:0000255"
TOPO_DOM 321..343
/note="Extracellular"
/evidence="ECO:0000255"
TRANSMEM 344..364
/note="Helical"
/evidence="ECO:0000255"
TOPO_DOM 365..378
/note="Cytoplasmic"
/evidence="ECO:0000255"
TRANSMEM 379..398
/note="Helical"
/evidence="ECO:0000255"
TOPO_DOM 399..404
/note="Extracellular"
/evidence="ECO:0000255"
TRANSMEM 405..425
/note="Helical"
/evidence="ECO:0000255"
TOPO_DOM 426..508
/note="Cytoplasmic"
/evidence="ECO:0000255"
TRANSMEM 509..529
/note="Helical"
/evidence="ECO:0000255"
TOPO_DOM 530..549
/note="Extracellular"
/evidence="ECO:0000255"
MOD_RES 22
/note="Phosphoserine"
/evidence="ECO:0007744|PubMed:23186163"
MOD_RES 42
/note="Phosphoserine"
/evidence="ECO:0000250|UniProtKB:Q99J27"
CARBOHYD 103
/note="N-linked (GlcNAc...) asparagine"
/evidence="ECO:0000255"
VARIANT 110
/note="A -> P (in CCHLND; the mutant protein is present at
normal levels in patient fibroblasts; the mutant protein
fails to localize normally to the Golgi apparatus and
instead shows punctate staining in the cytoplasm;
dbSNP:rs281875283)"
/evidence="ECO:0000269|PubMed:22243965"
/id="VAR_067915"
VARIANT 113
/note="S -> R (in SPG42; significant increase in the amount
of nuclear phosphorylated SMAD1-SMAD5-SMAD8 protein
complex; marked increase of the BMPR1A protein level; no
change for BMPR2 protein level; decrease of BMPR1A
degradation; dbSNP:rs121909484)"
/evidence="ECO:0000269|PubMed:19061983,
ECO:0000269|PubMed:25402622"
/id="VAR_054850"
VARIANT 171
/note="D -> G (in dbSNP:rs3804769)"
/id="VAR_050631"
VARIANT 400
/note="V -> A (in a colorectal cancer sample; somatic
mutation)"
/evidence="ECO:0000269|PubMed:16959974"
/id="VAR_035776"
SEQUENCE 549 AA; 60909 MW; ABDE59DEDEBAA9A5 CRC64;
MSPTISHKDS SRQRRPGNFS HSLDMKSGPL PPGGWDDSHL DSAGREGDRE ALLGDTGTGD
FLKAPQSFRA ELSSILLLLF LYVLQGIPLG LAGSIPLILQ SKNVSYTDQA FFSFVFWPFS
LKLLWAPLVD AVYVKNFGRR KSWLVPTQYI LGLFMIYLST QVDRLLGNTD DRTPDVIALT
VAFFLFEFLA ATQDIAVDGW ALTMLSRENV GYASTCNSVG QTAGYFLGNV LFLALESADF
CNKYLRFQPQ PRGIVTLSDF LFFWGTVFLI TTTLVALLKK ENEVSVVKEE TQGITDTYKL
LFAIIKMPAV LTFCLLILTA KIGFSAADAV TGLKLVEEGV PKEHLALLAV PMVPLQIILP
LIISKYTAGP QPLNTFYKAM PYRLLLGLEY ALLVWWTPKV EHQGGFPIYY YIVVLLSYAL
HQVTVYSMYV SIMAFNAKVS DPLIGGTYMT LLNTVSNLGG NWPSTVALWL VDPLTVKECV
GASNQNCRTP DAVELCKKLG GSCVTALDGY YVESIICVFI GFGWWFFLGP KFKKLQDEGS
SSWKCKRNN


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EIAAB36752 Mouse,Mus musculus,Octn3,Organic cation_carnitine transporter 3,Slc22a21,Slc22a9,Solute carrier family 22 member 21,Solute carrier family 22 member 9
EIAAB39169 Oatp4c1,Rat,Rattus norvegicus,Slc21a20,Slco4c1,Solute carrier family 21 member 20,Solute carrier organic anion transporter family member 4C1
EIAAB37152 Homo sapiens,Human,SIT1,SLC6A20,Sodium- and chloride-dependent transporter XTRP3,Sodium_imino-acid transporter 1,Solute carrier family 6 member 20,Transporter rB21A homolog,XT3,XTRP3
Pathways :
WP1713: Two-component system
WP2347: vitamin B5 (pantothenate) and CoA biosynthesis Pathway
WP1455: Serotonin Transporter Activity
WP1717: Valine, leucine and isoleucine degradation
WP1634: Butanoate metabolism
WP2345: vitamin B7 (biotin) biosynthesis pathway
WP1689: Porphyrin and chlorophyll metabolism
WP1706: Synthesis and degradation of ketone bodies
WP1493: Carbon assimilation C4 pathway
WP1626: Benzoate degradation via CoA ligation
WP2102: Fatty acid metabolism
WP2344: vitamin B6 (pyridoxine, pyridoxal, pyridoxamine) biosynthesis and salvage pathway
WP1680: Oxidative phosphorylation
WP1695: Pyruvate metabolism
WP2349: vitamin B3 (niacin), NAD and NADP biosynthesis pathway
WP1712: Tryptophan metabolism
WP1616: ABC transporters
WP1648: Fatty acid metabolism
WP1690: Propanoate metabolism
WP1708: Terpenoid backbone biosynthesis
WP1834: Interactions of the immunoglobulin superfamily (IgSF) member proteins
WP1502: Mitochondrial biogenesis
WP211: BMP signaling pathway
WP462: Panothenate and Coenzyme A Biosynthesis
WP1799: Costimulation by the CD28 family

Related Genes :
[SLC33A1 ACATN AT1] Acetyl-coenzyme A transporter 1 (AT-1) (Acetyl-CoA transporter 1) (Solute carrier family 33 member 1)
[Slc2a1 Glut1] Solute carrier family 2, facilitated glucose transporter member 1 (Glucose transporter type 1, erythrocyte/brain) (GLUT-1) (GT1)
[SLC22A18 BWR1A BWSCR1A HET IMPT1 ITM ORCTL2 SLC22A1L TSSC5] Solute carrier family 22 member 18 (Beckwith-Wiedemann syndrome chromosomal region 1 candidate gene A protein) (Efflux transporter-like protein) (Imprinted multi-membrane-spanning polyspecific transporter-related protein 1) (Organic cation transporter-like protein 2) (ORCTL-2) (Solute carrier family 22 member 1-like) (Tumor-suppressing STF cDNA 5 protein) (Tumor-suppressing subchromosomal transferable fragment candidate gene 5 protein) (p45-Beckwith-Wiedemann region 1 A) (p45-BWR1A)
[acdAI PF1540] Acetate--CoA ligase [ADP-forming] I subunit alpha (EC 6.2.1.13) (ADP-forming acetyl coenzyme A synthetase I subunit alpha) (ACS I subunit alpha)
[SLCO1B1 LST1 OATP1B1 OATP2 OATPC SLC21A6] Solute carrier organic anion transporter family member 1B1 (Liver-specific organic anion transporter 1) (LST-1) (OATP-C) (Sodium-independent organic anion-transporting polypeptide 2) (OATP-2) (Solute carrier family 21 member 6)
[acdBI PF1787] Acetate--CoA ligase [ADP-forming] I subunit beta (EC 6.2.1.13) (ADP-forming acetyl coenzyme A synthetase I subunit beta) (ACS I subunit beta)
[Slco1a3 Oatp1a3 Slc21a4] Solute carrier organic anion transporter family member 1A3 (OAT-K2) (Sodium-independent organic anion transporter K1) (OAT-K1) (Solute carrier family 21 member 4) (rOAT-K)
[SLC23A2 KIAA0238 NBTL1 SLC23A1 SVCT2 YSPL2] Solute carrier family 23 member 2 (Na(+)/L-ascorbic acid transporter 2) (Nucleobase transporter-like 1 protein) (Sodium-dependent vitamin C transporter 2) (hSVCT2) (Yolk sac permease-like molecule 2)
[Slco1b2 Oatp1b2 Slc21a10] Solute carrier organic anion transporter family member 1B2 (Liver-specific organic anion transporter 1) (rLST-1) (Sodium-independent organic anion-transporting polypeptide 4) (OATP-4) (Solute carrier family 21 member 10)
[SLCO1B3 LST2 OATP1B3 OATP8 SLC21A8] Solute carrier organic anion transporter family member 1B3 (Liver-specific organic anion transporter 2) (LST-2) (Organic anion transporter 8) (Organic anion-transporting polypeptide 8) (OATP-8) (Solute carrier family 21 member 8)
[SLC46A1 HCP1 PCFT] Proton-coupled folate transporter (G21) (Heme carrier protein 1) (PCFT/HCP1) (Solute carrier family 46 member 1)
[SLCO4C1 OATP4C1 OATPX SLC21A20] Solute carrier organic anion transporter family member 4C1 (OATP-H) (Organic anion transporter M1) (OATP-M1) (Solute carrier family 21 member 20)
[Slc2a1 Glut1] Solute carrier family 2, facilitated glucose transporter member 1 (Glucose transporter type 1, erythrocyte/brain) (GLUT-1)
[SLC22A1 OCT1] Solute carrier family 22 member 1 (Organic cation transporter 1) (hOCT1)
[Slc22a1 Oct1] Solute carrier family 22 member 1 (Organic cation transporter 1) (rOCT1)
[SLC25A33] Solute carrier family 25 member 33 (Bone marrow stromal cell mitochondrial carrier protein) (BMSC-MCP) (HuBMSC-MCP) (Protein PNC1)
[Slc22a1 Lx1 Oct1] Solute carrier family 22 member 1 (Organic cation transporter 1) (mOCT1)
[SLC2A1 GLUT1] Solute carrier family 2, facilitated glucose transporter member 1 (Glucose transporter type 1, erythrocyte/brain) (GLUT-1) (HepG2 glucose transporter)
[SLC52A1 GPR172B PAR2 RFT1] Solute carrier family 52, riboflavin transporter, member 1 (Porcine endogenous retrovirus A receptor 2) (PERV-A receptor 2) (huPAR-2) (Protein GPR172B) (Riboflavin transporter 1) (hRFT1)
[Slc40a1 Fpn1 Ireg1 Slc11a3 Slc39a1] Solute carrier family 40 member 1 (Ferroportin-1) (Iron-regulated transporter 1) (Metal transporter protein 1) (MTP1)
[Slco1c1 Bsat1 Oatp1c1 Oatpf Slc21a14] Solute carrier organic anion transporter family member 1C1 (BBB-specific anion transporter type 1) (Blood-brain barrier-specific anion transporter 1) (Solute carrier family 21 member 14) (Thyroxine transporter)
[SLC2A1 GLUT1] Solute carrier family 2, facilitated glucose transporter member 1 (Glucose transporter type 1, erythrocyte/brain) (GLUT-1)
[SLC2A1 GLUT1] Solute carrier family 2, facilitated glucose transporter member 1 (Glucose transporter type 1, erythrocyte/brain) (GLUT-1)
[SLC23A1 SVCT1 YSPL3] Solute carrier family 23 member 1 (Na(+)/L-ascorbic acid transporter 1) (Sodium-dependent vitamin C transporter 1) (hSVCT1) (Yolk sac permease-like molecule 3)
[ACS At5g36880 F5H8.15] Acetyl-coenzyme A synthetase, chloroplastic/glyoxysomal (EC 6.2.1.1) (Acetate--CoA ligase) (Acetyl-CoA synthetase)
[SLC27A5 ACSB ACSVL6 FACVL3 FATP5] Bile acyl-CoA synthetase (BACS) (EC 6.2.1.7) (Bile acid-CoA ligase) (BA-CoA ligase) (BAL) (Cholate--CoA ligase) (Fatty acid transport protein 5) (FATP-5) (Fatty-acid-coenzyme A ligase, very long-chain 3) (Solute carrier family 27 member 5) (Very long-chain acyl-CoA synthetase homolog 2) (VLCS-H2) (VLCSH2) (Very long-chain acyl-CoA synthetase-related protein) (VLACS-related) (VLACSR)
[Slc23a1 Svct1] Solute carrier family 23 member 1 (Na(+)/L-ascorbic acid transporter 1) (Sodium-dependent vitamin C transporter 1)
[SLC40A1 FPN1 IREG1 SLC11A3 MSTP079] Solute carrier family 40 member 1 (Ferroportin-1) (Iron-regulated transporter 1)
[SLC6A18 XTRP2] Inactive sodium-dependent neutral amino acid transporter B(0)AT3 (Sodium- and chloride-dependent transporter XTRP2) (Solute carrier family 6 member 18) (System B(0) neutral amino acid transporter AT3)
[SLC6A19 B0AT1] Sodium-dependent neutral amino acid transporter B(0)AT1 (Solute carrier family 6 member 19) (System B(0) neutral amino acid transporter AT1)

Bibliography :