Actin-related protein 2/3 complex subunit 4

 A0A250YAV2_CASCN        Unreviewed;       168 AA.
 A0A250YAV2;
 22-NOV-2017, integrated into UniProtKB/TrEMBL.
 22-NOV-2017, sequence version 1.
 02-DEC-2020, entry version 18.
 RecName: Full=Actin-related protein 2/3 complex subunit 4 {ECO:0000256|PIRNR:PIRNR039100};
 Name=ARPC4 {ECO:0000313|EMBL:JAV40751.1};
 Castor canadensis (American beaver).
 Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
 Eutheria; Euarchontoglires; Glires; Rodentia; Castorimorpha; Castoridae;
 Castor.
 NCBI_TaxID=51338 {ECO:0000313|EMBL:JAV40751.1};
 [1] {ECO:0000313|EMBL:JAV40751.1}
 NUCLEOTIDE SEQUENCE.
 STRAIN=Ward {ECO:0000313|EMBL:JAV40751.1};
 TISSUE=Leukocyte {ECO:0000313|EMBL:JAV40751.1};
 PubMed=28087693; DOI=10.1534/g3.116.038208;
 Lok S., Paton T.A., Wang Z., Kaur G., Walker S., Yuen R.K., Sung W.W.,
 Whitney J., Buchanan J.A., Trost B., Singh N., Apresto B., Chen N.,
 Coole M., Dawson T.J., Ho K.Y., Hu Z., Pullenayegum S., Samler K.,
 Shipstone A., Tsoi F., Wang T., Pereira S.L., Rostami P., Ryan C.A.,
 Tong A.H., Ng K., Sundaravadanam Y., Simpson J.T., Lim B.K., Engstrom M.D.,
 Dutton C.J., Kerr K.C., Franke M., Rapley W., Wintle R.F., Scherer S.W.;
 "De Novo Genome and Transcriptome Assembly of the Canadian Beaver (Castor
 canadensis).";
 G3 (Bethesda) 7:755-773(2017).
 -!- FUNCTION: Functions as actin-binding component of the Arp2/3 complex
     which is involved in regulation of actin polymerization and together
     with an activating nucleation-promoting factor (NPF) mediates the
     formation of branched actin networks. Seems to contact the mother actin
     filament. {ECO:0000256|PIRNR:PIRNR039100}.
 -!- SUBCELLULAR LOCATION: Cell projection {ECO:0000256|ARBA:ARBA00004316}.
     Cytoplasm, cytoskeleton {ECO:0000256|PIRNR:PIRNR039100}.
 -!- SIMILARITY: Belongs to the ARPC4 family.
     {ECO:0000256|ARBA:ARBA00005919, ECO:0000256|PIRNR:PIRNR039100}.
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 EMBL; GFFW01004037; JAV40751.1; -; Transcribed_RNA.
 RefSeq; XP_020020191.1; XM_020164602.1.
 SMR; A0A250YAV2; -.
 GeneID; 109686996; -.
 KEGG; ccan:109686996; -.
 CTD; 10093; -.
 OrthoDB; 1351067at2759; -.
 GO; GO:0005885; C:Arp2/3 protein complex; IEA:UniProtKB-UniRule.
 GO; GO:0042995; C:cell projection; IEA:UniProtKB-SubCell.
 GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-KW.
 GO; GO:0051015; F:actin filament binding; IEA:Ensembl.
 GO; GO:0019899; F:enzyme binding; IEA:Ensembl.
 GO; GO:0030674; F:protein-macromolecule adaptor activity; IEA:Ensembl.
 GO; GO:0005200; F:structural constituent of cytoskeleton; IEA:Ensembl.
 GO; GO:0030041; P:actin filament polymerization; IEA:UniProtKB-UniRule.
 GO; GO:0034314; P:Arp2/3 complex-mediated actin nucleation; IEA:UniProtKB-UniRule.
 Gene3D; 3.30.1460.20; -; 1.
 InterPro; IPR034666; ARPC2/4.
 InterPro; IPR008384; ARPC4.
 PANTHER; PTHR22629; PTHR22629; 1.
 Pfam; PF05856; ARPC4; 1.
 PIRSF; PIRSF039100; ARPC4; 1.
 SUPFAM; SSF69645; SSF69645; 1.
 3: Inferred from homology;
 Actin-binding {ECO:0000256|PIRNR:PIRNR039100};
 Cytoplasm {ECO:0000256|PIRNR:PIRNR039100};
 Cytoskeleton {ECO:0000256|PIRNR:PIRNR039100}.
 SEQUENCE   168 AA;  19667 MW;  273CCB230AC703DF CRC64;
 MTATLRPYLS AVRATLQAAL CLENFSSQVV ERHNKPEVEV RSSKELLLQP VTISRNEKEK
 VLIEGSINSV RVSIAVKQAD EIEKILCHKF MRFMMMRAEN FFILRRKPVE GYDISFLITN
 FHTEQMYKHK LVDFVIHFME EIDKEISEMK LSVNARARIV AEEFLKNF

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