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Actin-related protein 2/3 complex subunit 4

 A0A287D2P9_ICTTR        Unreviewed;       176 AA.
A0A287D2P9;
22-NOV-2017, integrated into UniProtKB/TrEMBL.
22-NOV-2017, sequence version 1.
07-APR-2021, entry version 10.
RecName: Full=Actin-related protein 2/3 complex subunit 4 {ECO:0000256|PIRNR:PIRNR039100};
Name=ARPC4 {ECO:0000313|Ensembl:ENSSTOP00000027856};
Ictidomys tridecemlineatus (Thirteen-lined ground squirrel) (Spermophilus
tridecemlineatus).
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
Eutheria; Euarchontoglires; Glires; Rodentia; Sciuromorpha; Sciuridae;
Xerinae; Marmotini; Ictidomys.
NCBI_TaxID=43179 {ECO:0000313|Ensembl:ENSSTOP00000027856, ECO:0000313|Proteomes:UP000005215};
[1] {ECO:0000313|Ensembl:ENSSTOP00000027856, ECO:0000313|Proteomes:UP000005215}
NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
The Broad Institute Genome Assembly & Analysis Group;
Computational R&D Group;
and Sequencing Platform;
Di Palma F., Alfoldi J., Johnson J., Berlin A., Gnerre S., Jaffe D.,
MacCallum I., Young S., Walker B.J., Lindblad-Toh K.;
"The Draft Genome of Spermophilus tridecemlineatus.";
Submitted (NOV-2011) to the EMBL/GenBank/DDBJ databases.
[2] {ECO:0000313|Ensembl:ENSSTOP00000027856}
IDENTIFICATION.
Ensembl;
Submitted (OCT-2017) to UniProtKB.
-!- FUNCTION: Functions as actin-binding component of the Arp2/3 complex
which is involved in regulation of actin polymerization and together
with an activating nucleation-promoting factor (NPF) mediates the
formation of branched actin networks. Seems to contact the mother actin
filament. {ECO:0000256|PIRNR:PIRNR039100}.
-!- SUBCELLULAR LOCATION: Cell projection {ECO:0000256|ARBA:ARBA00004316}.
Cytoplasm, cytoskeleton {ECO:0000256|PIRNR:PIRNR039100}.
-!- SIMILARITY: Belongs to the ARPC4 family.
{ECO:0000256|ARBA:ARBA00005919, ECO:0000256|PIRNR:PIRNR039100}.
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EMBL; AGTP01073398; -; NOT_ANNOTATED_CDS; Genomic_DNA.
Ensembl; ENSSTOT00000041872; ENSSTOP00000027856; ENSSTOG00000024608.
GeneTree; ENSGT00390000016233; -.
OMA; RFMMQRA; -.
Proteomes; UP000005215; Unassembled WGS sequence.
GO; GO:0005885; C:Arp2/3 protein complex; IEA:UniProtKB-UniRule.
GO; GO:0042995; C:cell projection; IEA:UniProtKB-SubCell.
GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-KW.
GO; GO:0051015; F:actin filament binding; IEA:Ensembl.
GO; GO:0019899; F:enzyme binding; IEA:Ensembl.
GO; GO:0030674; F:protein-macromolecule adaptor activity; IEA:Ensembl.
GO; GO:0005200; F:structural constituent of cytoskeleton; IEA:Ensembl.
GO; GO:0030041; P:actin filament polymerization; IEA:UniProtKB-UniRule.
GO; GO:0034314; P:Arp2/3 complex-mediated actin nucleation; IEA:UniProtKB-UniRule.
Gene3D; 3.30.1460.20; -; 1.
InterPro; IPR034666; ARPC2/4.
InterPro; IPR008384; ARPC4.
PANTHER; PTHR22629; PTHR22629; 1.
Pfam; PF05856; ARPC4; 1.
PIRSF; PIRSF039100; ARPC4; 1.
SUPFAM; SSF69645; SSF69645; 1.
3: Inferred from homology;
Actin-binding {ECO:0000256|PIRNR:PIRNR039100};
Cytoplasm {ECO:0000256|PIRNR:PIRNR039100};
Cytoskeleton {ECO:0000256|PIRNR:PIRNR039100};
Reference proteome {ECO:0000313|Proteomes:UP000005215}.
SEQUENCE 176 AA; 20391 MW; F1008D870ADB712B CRC64;
TATLRPYLSA VRATLQAALC LENFSSQVVE RHNKPEVEVR SSKELLLQPV TISRNEKEKV
LIEGSINSVR VSIAVKQADE IEKILCHKFM RFMMMRAENF FILRRKPVEG YDISFLITNF
HTEQMYKHKL VDFVIHFMEE IDKEISEMKL SVNARARIVA EEFLKNVSRG PSCFPA


Related products :

Catalog number Product name Quantity
pro-145 Recombinant Human Actin Related Protein 2 per 3 Complex, Subunit 5 1mg
ARPC5_RAT Rat ELISA Kit FOR Actin-related protein 2 per 3 complex subunit 5 96T
pro-145 Recombinant Human Actin Related Protein 2 per 3 Complex, Subunit 5 5
RPR-418 Recombinant Human Actin Related Protein 2 3 Complex, Subunit 2 2
RPR-413 Recombinant Human Actin Related Protein 2 3 Complex, Subunit 3 5
RPR-145 Recombinant Human Actin Related Protein 2 3 Complex, Subunit 5 5
pro-145 Recombinant Human Actin Related Protein 2 per 3 Complex, Subunit 5 20
ARPC2_RAT Rat ELISA Kit FOR Actin-related protein 2 per 3 complex subunit 2 96T
ARPC2_HUMAN Human ELISA Kit FOR Actin-related protein 2 per 3 complex subunit 2 96T
pro-1418 Recombinant Human Actin Related Protein 2 per 3 Complex, Subunit 2 10
CSB-EL002127RA Rat Actin-related protein 2_3 complex subunit 2(ARPC2) ELISA kit 96T
CSB-EL002131RA Rat Actin-related protein 2_3 complex subunit 5(ARPC5) ELISA kit 96T
pro-145 Recombinant Human Actin Related Protein 2_3 Complex, Subunit 5 ARPC5 1mg
pro-1418 Recombinant Human Actin Related Protein 2 per 3 Complex, Subunit 2 100
7-04403 Recombinant Human Actin Related Protein 2_3 Complex, Subunit 5 20
ARPP19 ARPC5L Gene actin related protein 2_3 complex, subunit 5-like
pro-1413 Recombinant Human Actin Related Protein 2 per 3 Complex, Subunit 3 5
pro-145 Recombinant Human Actin Related Protein 2_3 Complex, Subunit 5 ARPC5 5
7-04402 Recombinant Human Actin Related Protein 2_3 Complex, Subunit 5 5
pro-145 Recombinant Human Actin Related Protein 2_3 Complex, Subunit 5 ARPC5 20
CSB-EL002125RA Rat Actin-related protein 2_3 complex subunit 1A(ARPC1A) ELISA kit 96T
E1991m Bovine ELISA Kit FOR Actin-related protein 2 per 3 complex subunit 1A 96T
7-04404 Recombinant Human Actin Related Protein 2_3 Complex, Subunit 5 1mg
pro-1413 Recombinant Human Actin Related Protein 2 per 3 Complex, Subunit 3 20
CSB-RP033244h Recombinant human Actin-related protein 2_3 complex subunit 3 500ug
Pathways :
WP2272: Pathogenic Escherichia coli infection
WP2292: Chemokine signaling pathway
WP1644: DNA replication
WP1566: Citrate cycle (TCA cycle)
WP1694: Pyrimidine metabolism
WP731: Sterol regulatory element binding protein related
WP1693: Purine metabolism
WP2199: Seed Development
WP1663: Homologous recombination
WP1672: Mismatch repair
WP2324: AGE/RAGE pathway
WP1348: Androgen Receptor Signaling Pathway
WP1019: FAS pathway and Stress induction of HSP regulation
WP1625: Base excision repair
WP1892: Protein folding
WP460: Blood Clotting Cascade
WP1381: G13 Signaling Pathway
WP1676: Non-homologous end-joining
WP511: FAS pathway and Stress induction of HSP regulation
WP1438: Influenza A virus infection
WP1685: Peptidoglycan biosynthesis
WP240: Alanine and aspartate metabolism
WP2087: miRNA regulation of DNA Damage Response
WP1102: EBV LMP1 signaling
WP1939: Unfolded Protein Response

Related Genes :

Bibliography :
[33408168] CIDP Antibodies Target Junction Proteins and Identify Patient Subgroups: An Autoantigenomic Approach.
[33388318] mTORC1 and mTORC2 Converge on the Arp2/3 Complex to Promote Kras-Induced Acinar-to-Ductal Metaplasia and Early Pancreatic Carcinogenesis.
[32235494] Proteomic Analysis of Renal Biomarkers of Kidney Allograft Fibrosis-A Study in Renal Transplant Patients.
[32141557] Identification of lung adenocarcinoma-specific exosome RNAs in peripheral blood by RNA-Seq analysis.
[31347661] Influence of metabolic status and genetic merit for fertility on proteomic composition of bovine oviduct fluid†.
[31190401] ARPC4 promotes bladder cancer cell invasion and is associated with lymph node metastasis.
[30850364] Serum Proteomic Signatures of Male Breast Cancer.
[30720048] RBM3 upregulates ARPC2 by binding the 3'UTR and contributes to breast cancer progression.
[30651846] Differential expression of serum proteins in multiple myeloma.
[30170128] Advances and highlights in primary immunodeficiencies in 2017.