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Actin-related protein 2/3 complex subunit 4

 A0A2I3HR26_NOMLE        Unreviewed;       187 AA.
A0A2I3HR26;
28-FEB-2018, integrated into UniProtKB/TrEMBL.
28-FEB-2018, sequence version 1.
07-OCT-2020, entry version 8.
RecName: Full=Actin-related protein 2/3 complex subunit 4 {ECO:0000256|PIRNR:PIRNR039100};
Name=ARPC4 {ECO:0000313|Ensembl:ENSNLEP00000045992};
Nomascus leucogenys (Northern white-cheeked gibbon) (Hylobates leucogenys).
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hylobatidae;
Nomascus.
NCBI_TaxID=61853 {ECO:0000313|Ensembl:ENSNLEP00000045992, ECO:0000313|Proteomes:UP000001073};
[1] {ECO:0000313|Ensembl:ENSNLEP00000045992, ECO:0000313|Proteomes:UP000001073}
NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Gibbon Genome Sequencing Consortium;
Submitted (OCT-2012) to the EMBL/GenBank/DDBJ databases.
[2] {ECO:0000313|Ensembl:ENSNLEP00000045992}
IDENTIFICATION.
Ensembl;
Submitted (JAN-2018) to UniProtKB.
-!- FUNCTION: Functions as actin-binding component of the Arp2/3 complex
which is involved in regulation of actin polymerization and together
with an activating nucleation-promoting factor (NPF) mediates the
formation of branched actin networks. Seems to contact the mother actin
filament. {ECO:0000256|PIRNR:PIRNR039100}.
-!- SUBCELLULAR LOCATION: Cell projection {ECO:0000256|ARBA:ARBA00004316}.
Cytoplasm, cytoskeleton {ECO:0000256|PIRNR:PIRNR039100}.
-!- SIMILARITY: Belongs to the ARPC4 family.
{ECO:0000256|ARBA:ARBA00005919, ECO:0000256|PIRNR:PIRNR039100}.
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EMBL; ADFV01025961; -; NOT_ANNOTATED_CDS; Genomic_DNA.
EMBL; ADFV01025962; -; NOT_ANNOTATED_CDS; Genomic_DNA.
EMBL; ADFV01025963; -; NOT_ANNOTATED_CDS; Genomic_DNA.
Ensembl; ENSNLET00000052161; ENSNLEP00000045992; ENSNLEG00000004196.
GeneTree; ENSGT00390000016233; -.
Proteomes; UP000001073; Chromosome 21.
GO; GO:0005885; C:Arp2/3 protein complex; IEA:UniProtKB-UniRule.
GO; GO:0042995; C:cell projection; IEA:UniProtKB-SubCell.
GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-KW.
GO; GO:0051015; F:actin filament binding; IEA:Ensembl.
GO; GO:0019899; F:enzyme binding; IEA:Ensembl.
GO; GO:0030674; F:protein-macromolecule adaptor activity; IEA:Ensembl.
GO; GO:0005200; F:structural constituent of cytoskeleton; IEA:Ensembl.
GO; GO:0030041; P:actin filament polymerization; IEA:UniProtKB-UniRule.
GO; GO:0034314; P:Arp2/3 complex-mediated actin nucleation; IEA:UniProtKB-UniRule.
Gene3D; 3.30.1460.20; -; 1.
InterPro; IPR034666; ARPC2/4.
InterPro; IPR008384; ARPC4.
PANTHER; PTHR22629; PTHR22629; 1.
Pfam; PF05856; ARPC4; 1.
PIRSF; PIRSF039100; ARPC4; 1.
SUPFAM; SSF69645; SSF69645; 1.
3: Inferred from homology;
Actin-binding {ECO:0000256|PIRNR:PIRNR039100};
Cytoplasm {ECO:0000256|PIRNR:PIRNR039100};
Cytoskeleton {ECO:0000256|PIRNR:PIRNR039100};
Reference proteome {ECO:0000313|Proteomes:UP000001073}.
SEQUENCE 187 AA; 21639 MW; 8EAF454F0D79C119 CRC64;
MGTATLRPYL SAVRATLQAA LCLENFSSQV VERHNKPEVE VRSSKELLLQ PVTISRNEKE
KVLIEGSINS VRVSIAVKQA DEIEKILCHK FMRFMMMRAE NFFILRRKPV EGYDISFLIT
NFHTEQMYKH KLVDFVIHFM EEIDKEISEM KLSVNARARI VAEEFLKNVS RGLSAFLSRG
QRIWGSC


Related products :

Catalog number Product name Quantity
pro-145 Recombinant Human Actin Related Protein 2 per 3 Complex, Subunit 5 1mg
ARPC5_RAT Rat ELISA Kit FOR Actin-related protein 2 per 3 complex subunit 5 96T
pro-145 Recombinant Human Actin Related Protein 2 per 3 Complex, Subunit 5 5
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pro-145 Recombinant Human Actin Related Protein 2 per 3 Complex, Subunit 5 20
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pro-1418 Recombinant Human Actin Related Protein 2 per 3 Complex, Subunit 2 10
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pro-1413 Recombinant Human Actin Related Protein 2 per 3 Complex, Subunit 3 5
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Pathways :
WP2272: Pathogenic Escherichia coli infection
WP2292: Chemokine signaling pathway
WP1644: DNA replication
WP1566: Citrate cycle (TCA cycle)
WP1694: Pyrimidine metabolism
WP731: Sterol regulatory element binding protein related
WP1693: Purine metabolism
WP2199: Seed Development
WP1663: Homologous recombination
WP1672: Mismatch repair
WP2324: AGE/RAGE pathway
WP1348: Androgen Receptor Signaling Pathway
WP1019: FAS pathway and Stress induction of HSP regulation
WP1625: Base excision repair
WP1892: Protein folding
WP460: Blood Clotting Cascade
WP1381: G13 Signaling Pathway
WP1676: Non-homologous end-joining
WP511: FAS pathway and Stress induction of HSP regulation
WP1438: Influenza A virus infection
WP1685: Peptidoglycan biosynthesis
WP240: Alanine and aspartate metabolism
WP2087: miRNA regulation of DNA Damage Response
WP1102: EBV LMP1 signaling
WP1939: Unfolded Protein Response

Related Genes :

Bibliography :
[33408168] CIDP Antibodies Target Junction Proteins and Identify Patient Subgroups: An Autoantigenomic Approach.
[33388318] mTORC1 and mTORC2 Converge on the Arp2/3 Complex to Promote Kras-Induced Acinar-to-Ductal Metaplasia and Early Pancreatic Carcinogenesis.
[32235494] Proteomic Analysis of Renal Biomarkers of Kidney Allograft Fibrosis-A Study in Renal Transplant Patients.
[32141557] Identification of lung adenocarcinoma-specific exosome RNAs in peripheral blood by RNA-Seq analysis.
[31347661] Influence of metabolic status and genetic merit for fertility on proteomic composition of bovine oviduct fluid†.
[31190401] ARPC4 promotes bladder cancer cell invasion and is associated with lymph node metastasis.
[30850364] Serum Proteomic Signatures of Male Breast Cancer.
[30720048] RBM3 upregulates ARPC2 by binding the 3'UTR and contributes to breast cancer progression.
[30651846] Differential expression of serum proteins in multiple myeloma.
[30170128] Advances and highlights in primary immunodeficiencies in 2017.