Actin-related protein 2/3 complex subunit 4

 A0A2I3T5A0_PANTR        Unreviewed;       173 AA.
 A0A2I3T5A0;
 28-FEB-2018, integrated into UniProtKB/TrEMBL.
 28-FEB-2018, sequence version 1.
 07-OCT-2020, entry version 8.
 RecName: Full=Actin-related protein 2/3 complex subunit 4 {ECO:0000256|PIRNR:PIRNR039100};
 Name=ARPC4 {ECO:0000313|Ensembl:ENSPTRP00000084416,
 ECO:0000313|VGNC:VGNC:11324};
 Pan troglodytes (Chimpanzee).
 Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
 Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
 Pan.
 NCBI_TaxID=9598 {ECO:0000313|Ensembl:ENSPTRP00000084416, ECO:0000313|Proteomes:UP000002277};
 [1] {ECO:0000313|Ensembl:ENSPTRP00000084416, ECO:0000313|Proteomes:UP000002277}
 NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
 PubMed=16136131; DOI=10.1038/nature04072;
 Chimpanzee sequencing and analysis consortium;
 "Initial sequence of the chimpanzee genome and comparison with the human
 genome.";
 Nature 437:69-87(2005).
 [2] {ECO:0000313|Ensembl:ENSPTRP00000084416}
 IDENTIFICATION.
 Ensembl;
 Submitted (JAN-2018) to UniProtKB.
 -!- FUNCTION: Functions as actin-binding component of the Arp2/3 complex
     which is involved in regulation of actin polymerization and together
     with an activating nucleation-promoting factor (NPF) mediates the
     formation of branched actin networks. Seems to contact the mother actin
     filament. {ECO:0000256|PIRNR:PIRNR039100}.
 -!- SUBCELLULAR LOCATION: Cell projection {ECO:0000256|ARBA:ARBA00004316}.
     Cytoplasm, cytoskeleton {ECO:0000256|PIRNR:PIRNR039100}.
 -!- SIMILARITY: Belongs to the ARPC4 family.
     {ECO:0000256|ARBA:ARBA00005919, ECO:0000256|PIRNR:PIRNR039100}.
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 EMBL; AACZ04000065; -; NOT_ANNOTATED_CDS; Genomic_DNA.
 Ensembl; ENSPTRT00000083109; ENSPTRP00000084416; ENSPTRG00000039733.
 VGNC; VGNC:11324; ARPC4.
 GeneTree; ENSGT00390000016233; -.
 Proteomes; UP000002277; Chromosome 3.
 GO; GO:0005885; C:Arp2/3 protein complex; IEA:UniProtKB-UniRule.
 GO; GO:0042995; C:cell projection; IEA:UniProtKB-SubCell.
 GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-KW.
 GO; GO:0051015; F:actin filament binding; IEA:Ensembl.
 GO; GO:0019899; F:enzyme binding; IEA:Ensembl.
 GO; GO:0030674; F:protein-macromolecule adaptor activity; IEA:Ensembl.
 GO; GO:0005200; F:structural constituent of cytoskeleton; IEA:Ensembl.
 GO; GO:0030041; P:actin filament polymerization; IEA:UniProtKB-UniRule.
 GO; GO:0034314; P:Arp2/3 complex-mediated actin nucleation; IEA:UniProtKB-UniRule.
 Gene3D; 3.30.1460.20; -; 1.
 InterPro; IPR034666; ARPC2/4.
 InterPro; IPR008384; ARPC4.
 PANTHER; PTHR22629; PTHR22629; 1.
 Pfam; PF05856; ARPC4; 1.
 PIRSF; PIRSF039100; ARPC4; 1.
 SUPFAM; SSF69645; SSF69645; 1.
 3: Inferred from homology;
 Actin-binding {ECO:0000256|PIRNR:PIRNR039100};
 Cytoplasm {ECO:0000256|PIRNR:PIRNR039100};
 Cytoskeleton {ECO:0000256|PIRNR:PIRNR039100};
 Reference proteome {ECO:0000313|Proteomes:UP000002277}.
 SEQUENCE   173 AA;  20089 MW;  B9B78456C1AB3A25 CRC64;
 MGTATLRPYL SAVRATLQAA LCLENFSSQV VERHNKPEVE VRSSKELLLQ PVTISRNEKE
 KVLIEGSINS VRVSIAVKQA DEIEKILCHK FMRFMMMRAE NFFILRRKPV EGYDISFLIT
 NFHTEQMYKH KLVDFVIHFM EEIDKEISEM KLSVNARARI VAEEFLKNVS RGL

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