Actin-related protein 2/3 complex subunit 4

 A0A2R9AFR8_PANPA        Unreviewed;       173 AA.
 A0A2R9AFR8;
 20-JUN-2018, integrated into UniProtKB/TrEMBL.
 20-JUN-2018, sequence version 1.
 07-OCT-2020, entry version 8.
 RecName: Full=Actin-related protein 2/3 complex subunit 4 {ECO:0000256|PIRNR:PIRNR039100};
 Name=ARPC4 {ECO:0000313|Ensembl:ENSPPAP00000016177};
 Pan paniscus (Pygmy chimpanzee) (Bonobo).
 Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
 Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
 Pan.
 NCBI_TaxID=9597 {ECO:0000313|Ensembl:ENSPPAP00000016177, ECO:0000313|Proteomes:UP000240080};
 [1] {ECO:0000313|Ensembl:ENSPPAP00000016177, ECO:0000313|Proteomes:UP000240080}
 NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
 PubMed=22722832; DOI=10.1038/nature11128;
 Prufer K., Munch K., Hellmann I., Akagi K., Miller J.R., Walenz B.,
 Koren S., Sutton G., Kodira C., Winer R., Knight J.R., Mullikin J.C.,
 Meader S.J., Ponting C.P., Lunter G., Higashino S., Hobolth A., Dutheil J.,
 Karakoc E., Alkan C., Sajjadian S., Catacchio C.R., Ventura M.,
 Marques-Bonet T., Eichler E.E., Andre C., Atencia R., Mugisha L.,
 Junhold J., Patterson N., Siebauer M., Good J.M., Fischer A., Ptak S.E.,
 Lachmann M., Symer D.E., Mailund T., Schierup M.H., Andres A.M., Kelso J.,
 Paabo S.;
 "The bonobo genome compared with the chimpanzee and human genomes.";
 Nature 486:527-531(2012).
 [2] {ECO:0000313|Ensembl:ENSPPAP00000016177}
 IDENTIFICATION.
 Ensembl;
 Submitted (APR-2018) to UniProtKB.
 -!- FUNCTION: Functions as actin-binding component of the Arp2/3 complex
     which is involved in regulation of actin polymerization and together
     with an activating nucleation-promoting factor (NPF) mediates the
     formation of branched actin networks. Seems to contact the mother actin
     filament. {ECO:0000256|PIRNR:PIRNR039100}.
 -!- SUBCELLULAR LOCATION: Cell projection {ECO:0000256|ARBA:ARBA00004316}.
     Cytoplasm, cytoskeleton {ECO:0000256|PIRNR:PIRNR039100}.
 -!- SIMILARITY: Belongs to the ARPC4 family.
     {ECO:0000256|ARBA:ARBA00005919, ECO:0000256|PIRNR:PIRNR039100}.
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 EMBL; AJFE02045805; -; NOT_ANNOTATED_CDS; Genomic_DNA.
 EMBL; AJFE02045806; -; NOT_ANNOTATED_CDS; Genomic_DNA.
 Ensembl; ENSPPAT00000038870; ENSPPAP00000016177; ENSPPAG00000031179.
 GeneTree; ENSGT00390000016233; -.
 Proteomes; UP000240080; Chromosome 3.
 GO; GO:0005885; C:Arp2/3 protein complex; IEA:UniProtKB-UniRule.
 GO; GO:0042995; C:cell projection; IEA:UniProtKB-SubCell.
 GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-KW.
 GO; GO:0051015; F:actin filament binding; IEA:Ensembl.
 GO; GO:0019899; F:enzyme binding; IEA:Ensembl.
 GO; GO:0030674; F:protein-macromolecule adaptor activity; IEA:Ensembl.
 GO; GO:0005200; F:structural constituent of cytoskeleton; IEA:Ensembl.
 GO; GO:0030041; P:actin filament polymerization; IEA:UniProtKB-UniRule.
 GO; GO:0034314; P:Arp2/3 complex-mediated actin nucleation; IEA:UniProtKB-UniRule.
 Gene3D; 3.30.1460.20; -; 1.
 InterPro; IPR034666; ARPC2/4.
 InterPro; IPR008384; ARPC4.
 PANTHER; PTHR22629; PTHR22629; 1.
 Pfam; PF05856; ARPC4; 1.
 PIRSF; PIRSF039100; ARPC4; 1.
 SUPFAM; SSF69645; SSF69645; 1.
 3: Inferred from homology;
 Actin-binding {ECO:0000256|PIRNR:PIRNR039100};
 Cytoplasm {ECO:0000256|PIRNR:PIRNR039100};
 Cytoskeleton {ECO:0000256|PIRNR:PIRNR039100};
 Reference proteome {ECO:0000313|Proteomes:UP000240080}.
 SEQUENCE   173 AA;  20089 MW;  B9B78456C1AB3A25 CRC64;
 MGTATLRPYL SAVRATLQAA LCLENFSSQV VERHNKPEVE VRSSKELLLQ PVTISRNEKE
 KVLIEGSINS VRVSIAVKQA DEIEKILCHK FMRFMMMRAE NFFILRRKPV EGYDISFLIT
 NFHTEQMYKH KLVDFVIHFM EEIDKEISEM KLSVNARARI VAEEFLKNVS RGL

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