Actin-related protein 2/3 complex subunit 4

 A0A3Q3ANM5_CHICK        Unreviewed;       178 AA.
 A0A3Q3ANM5;
 10-APR-2019, integrated into UniProtKB/TrEMBL.
 10-APR-2019, sequence version 1.
 07-APR-2021, entry version 11.
 RecName: Full=Actin-related protein 2/3 complex subunit 4 {ECO:0000256|PIRNR:PIRNR039100};
 Name=ARPC4 {ECO:0000313|Ensembl:ENSGALP00000070545};
 Gallus gallus (Chicken).
 Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
 Archelosauria; Archosauria; Dinosauria; Saurischia; Theropoda;
 Coelurosauria; Aves; Neognathae; Galloanserae; Galliformes; Phasianidae;
 Phasianinae; Gallus.
 NCBI_TaxID=9031 {ECO:0000313|Ensembl:ENSGALP00000070545, ECO:0000313|Proteomes:UP000000539};
 [1] {ECO:0000313|Ensembl:ENSGALP00000070545, ECO:0000313|Proteomes:UP000000539}
 NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
 STRAIN=Red jungle fowl {ECO:0000313|Ensembl:ENSGALP00000070545,
 ECO:0000313|Proteomes:UP000000539};
 PubMed=15592404; DOI=10.1038/nature03154;
 International Chicken Genome Sequencing Consortium;
 Hillier L.W., Miller W., Birney E., Warren W., Hardison R.C., Ponting C.P.,
 Bork P., Burt D.W., Groenen M.A.M., Delany M.E., Dodgson J.B.,
 Chinwalla A.T., Cliften P.F., Clifton S.W., Delehaunty K.D., Fronick C.,
 Fulton R.S., Graves T.A., Kremitzki C., Layman D., Magrini V.,
 McPherson J.D., Miner T.L., Minx P., Nash W.E., Nhan M.N., Nelson J.O.,
 Oddy L.G., Pohl C.S., Randall-Maher J., Smith S.M., Wallis J.W.,
 Yang S.-P., Romanov M.N., Rondelli C.M., Paton B., Smith J., Morrice D.,
 Daniels L., Tempest H.G., Robertson L., Masabanda J.S., Griffin D.K.,
 Vignal A., Fillon V., Jacobbson L., Kerje S., Andersson L.,
 Crooijmans R.P., Aerts J., van der Poel J.J., Ellegren H., Caldwell R.B.,
 Hubbard S.J., Grafham D.V., Kierzek A.M., McLaren S.R., Overton I.M.,
 Arakawa H., Beattie K.J., Bezzubov Y., Boardman P.E., Bonfield J.K.,
 Croning M.D.R., Davies R.M., Francis M.D., Humphray S.J., Scott C.E.,
 Taylor R.G., Tickle C., Brown W.R.A., Rogers J., Buerstedde J.-M.,
 Wilson S.A., Stubbs L., Ovcharenko I., Gordon L., Lucas S., Miller M.M.,
 Inoko H., Shiina T., Kaufman J., Salomonsen J., Skjoedt K., Wong G.K.-S.,
 Wang J., Liu B., Wang J., Yu J., Yang H., Nefedov M., Koriabine M.,
 Dejong P.J., Goodstadt L., Webber C., Dickens N.J., Letunic I., Suyama M.,
 Torrents D., von Mering C., Zdobnov E.M., Makova K., Nekrutenko A.,
 Elnitski L., Eswara P., King D.C., Yang S.-P., Tyekucheva S.,
 Radakrishnan A., Harris R.S., Chiaromonte F., Taylor J., He J.,
 Rijnkels M., Griffiths-Jones S., Ureta-Vidal A., Hoffman M.M., Severin J.,
 Searle S.M.J., Law A.S., Speed D., Waddington D., Cheng Z., Tuzun E.,
 Eichler E., Bao Z., Flicek P., Shteynberg D.D., Brent M.R., Bye J.M.,
 Huckle E.J., Chatterji S., Dewey C., Pachter L., Kouranov A.,
 Mourelatos Z., Hatzigeorgiou A.G., Paterson A.H., Ivarie R., Brandstrom M.,
 Axelsson E., Backstrom N., Berlin S., Webster M.T., Pourquie O.,
 Reymond A., Ucla C., Antonarakis S.E., Long M., Emerson J.J., Betran E.,
 Dupanloup I., Kaessmann H., Hinrichs A.S., Bejerano G., Furey T.S.,
 Harte R.A., Raney B., Siepel A., Kent W.J., Haussler D., Eyras E.,
 Castelo R., Abril J.F., Castellano S., Camara F., Parra G., Guigo R.,
 Bourque G., Tesler G., Pevzner P.A., Smit A., Fulton L.A., Mardis E.R.,
 Wilson R.K.;
 "Sequence and comparative analysis of the chicken genome provide unique
 perspectives on vertebrate evolution.";
 Nature 432:695-716(2004).
 [2] {ECO:0000313|Ensembl:ENSGALP00000070545}
 IDENTIFICATION.
 STRAIN=Red jungle fowl {ECO:0000313|Ensembl:ENSGALP00000070545};
 Ensembl;
 Submitted (JAN-2019) to UniProtKB.
 -!- FUNCTION: Functions as actin-binding component of the Arp2/3 complex
     which is involved in regulation of actin polymerization and together
     with an activating nucleation-promoting factor (NPF) mediates the
     formation of branched actin networks. Seems to contact the mother actin
     filament. {ECO:0000256|PIRNR:PIRNR039100}.
 -!- SUBCELLULAR LOCATION: Cell projection {ECO:0000256|ARBA:ARBA00004316}.
     Cytoplasm, cytoskeleton {ECO:0000256|PIRNR:PIRNR039100}.
 -!- SIMILARITY: Belongs to the ARPC4 family.
     {ECO:0000256|ARBA:ARBA00005919, ECO:0000256|PIRNR:PIRNR039100}.
 ---------------------------------------------------------------------------
 Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
 Distributed under the Creative Commons Attribution (CC BY 4.0) License
 ---------------------------------------------------------------------------
 EMBL; AADN05000356; -; NOT_ANNOTATED_CDS; Genomic_DNA.
 SMR; A0A3Q3ANM5; -.
 Ensembl; ENSGALT00000101849; ENSGALP00000070545; ENSGALG00000006691.
 GeneTree; ENSGT00390000016233; -.
 OMA; RFMMQRA; -.
 Reactome; R-GGA-2029482; Regulation of actin dynamics for phagocytic cup formation.
 Reactome; R-GGA-3928662; EPHB-mediated forward signaling.
 Reactome; R-GGA-5663213; RHO GTPases Activate WASPs and WAVEs.
 Reactome; R-GGA-8856828; Clathrin-mediated endocytosis.
 Proteomes; UP000000539; Chromosome 12.
 ExpressionAtlas; A0A3Q3ANM5; baseline and differential.
 GO; GO:0005885; C:Arp2/3 protein complex; IEA:UniProtKB-UniRule.
 GO; GO:0042995; C:cell projection; IEA:UniProtKB-SubCell.
 GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-KW.
 GO; GO:0051015; F:actin filament binding; IEA:Ensembl.
 GO; GO:0019899; F:enzyme binding; IEA:Ensembl.
 GO; GO:0030674; F:protein-macromolecule adaptor activity; IEA:Ensembl.
 GO; GO:0005200; F:structural constituent of cytoskeleton; IEA:Ensembl.
 GO; GO:0030041; P:actin filament polymerization; IEA:UniProtKB-UniRule.
 GO; GO:0034314; P:Arp2/3 complex-mediated actin nucleation; IEA:UniProtKB-UniRule.
 Gene3D; 3.30.1460.20; -; 1.
 InterPro; IPR034666; ARPC2/4.
 InterPro; IPR008384; ARPC4.
 PANTHER; PTHR22629; PTHR22629; 1.
 Pfam; PF05856; ARPC4; 1.
 PIRSF; PIRSF039100; ARPC4; 1.
 SUPFAM; SSF69645; SSF69645; 1.
 3: Inferred from homology;
 Actin-binding {ECO:0000256|PIRNR:PIRNR039100};
 Cytoplasm {ECO:0000256|PIRNR:PIRNR039100};
 Cytoskeleton {ECO:0000256|PIRNR:PIRNR039100};
 Reference proteome {ECO:0000313|Proteomes:UP000000539}.
 SEQUENCE   178 AA;  20940 MW;  0E5CC2953C937229 CRC64;
 MTATLRPYLN AVRATLQAAL CLENFSSQVV ERHNKPEVEV RSSKELLLQP VIISRNEKEK
 VLIEGSINSV RVSIAVKQAD EIEKILCHKF MRFMMMRAEN FFILRRKPVE GYDISFLITN
 FHTEQMYKHK LVDFVIHFME EIDKEISEMK LSVNARARIV AEEFLKNVRL WECCFSQQ

Related products :