Actin-related protein 2/3 complex subunit 4

 E2QWU0_CANLF            Unreviewed;       186 AA.
 E2QWU0;
 30-NOV-2010, integrated into UniProtKB/TrEMBL.
 11-DEC-2019, sequence version 3.
 10-FEB-2021, entry version 63.
 RecName: Full=Actin-related protein 2/3 complex subunit 4 {ECO:0000256|PIRNR:PIRNR039100};
 Name=ARPC4 {ECO:0000313|Ensembl:ENSCAFP00000007935,
 ECO:0000313|VGNC:VGNC:54574};
 Canis lupus familiaris (Dog) (Canis familiaris).
 Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
 Eutheria; Laurasiatheria; Carnivora; Caniformia; Canidae; Canis.
 NCBI_TaxID=9615 {ECO:0000313|Ensembl:ENSCAFP00000007935, ECO:0000313|Proteomes:UP000002254};
 [1] {ECO:0000313|Ensembl:ENSCAFP00000007935, ECO:0000313|Proteomes:UP000002254}
 NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
 STRAIN=Boxer {ECO:0000313|Ensembl:ENSCAFP00000007935,
 ECO:0000313|Proteomes:UP000002254};
 PubMed=16341006; DOI=10.1038/nature04338;
 Broad Sequencing Platform;
 Lindblad-Toh K., Wade C.M., Mikkelsen T.S., Karlsson E.K., Jaffe D.B.,
 Kamal M., Clamp M., Chang J.L., Kulbokas E.J. III, Zody M.C., Mauceli E.,
 Xie X., Breen M., Wayne R.K., Ostrander E.A., Ponting C.P., Galibert F.,
 Smith D.R., deJong P.J., Kirkness E.F., Alvarez P., Biagi T., Brockman W.,
 Butler J., Chin C.-W., Cook A., Cuff J., Daly M.J., DeCaprio D., Gnerre S.,
 Grabherr M., Kellis M., Kleber M., Bardeleben C., Goodstadt L., Heger A.,
 Hitte C., Kim L., Koepfli K.-P., Parker H.G., Pollinger J.P.,
 Searle S.M.J., Sutter N.B., Thomas R., Webber C., Baldwin J., Abebe A.,
 Abouelleil A., Aftuck L., Ait-Zahra M., Aldredge T., Allen N., An P.,
 Anderson S., Antoine C., Arachchi H., Aslam A., Ayotte L., Bachantsang P.,
 Barry A., Bayul T., Benamara M., Berlin A., Bessette D., Blitshteyn B.,
 Bloom T., Blye J., Boguslavskiy L., Bonnet C., Boukhgalter B., Brown A.,
 Cahill P., Calixte N., Camarata J., Cheshatsang Y., Chu J., Citroen M.,
 Collymore A., Cooke P., Dawoe T., Daza R., Decktor K., DeGray S.,
 Dhargay N., Dooley K., Dooley K., Dorje P., Dorjee K., Dorris L.,
 Duffey N., Dupes A., Egbiremolen O., Elong R., Falk J., Farina A., Faro S.,
 Ferguson D., Ferreira P., Fisher S., FitzGerald M., Foley K., Foley C.,
 Franke A., Friedrich D., Gage D., Garber M., Gearin G., Giannoukos G.,
 Goode T., Goyette A., Graham J., Grandbois E., Gyaltsen K., Hafez N.,
 Hagopian D., Hagos B., Hall J., Healy C., Hegarty R., Honan T., Horn A.,
 Houde N., Hughes L., Hunnicutt L., Husby M., Jester B., Jones C., Kamat A.,
 Kanga B., Kells C., Khazanovich D., Kieu A.C., Kisner P., Kumar M.,
 Lance K., Landers T., Lara M., Lee W., Leger J.-P., Lennon N., Leuper L.,
 LeVine S., Liu J., Liu X., Lokyitsang Y., Lokyitsang T., Lui A.,
 Macdonald J., Major J., Marabella R., Maru K., Matthews C., McDonough S.,
 Mehta T., Meldrim J., Melnikov A., Meneus L., Mihalev A., Mihova T.,
 Miller K., Mittelman R., Mlenga V., Mulrain L., Munson G., Navidi A.,
 Naylor J., Nguyen T., Nguyen N., Nguyen C., Nguyen T., Nicol R., Norbu N.,
 Norbu C., Novod N., Nyima T., Olandt P., O'Neill B., O'Neill K., Osman S.,
 Oyono L., Patti C., Perrin D., Phunkhang P., Pierre F., Priest M.,
 Rachupka A., Raghuraman S., Rameau R., Ray V., Raymond C., Rege F.,
 Rise C., Rogers J., Rogov P., Sahalie J., Settipalli S., Sharpe T.,
 Shea T., Sheehan M., Sherpa N., Shi J., Shih D., Sloan J., Smith C.,
 Sparrow T., Stalker J., Stange-Thomann N., Stavropoulos S., Stone C.,
 Stone S., Sykes S., Tchuinga P., Tenzing P., Tesfaye S., Thoulutsang D.,
 Thoulutsang Y., Topham K., Topping I., Tsamla T., Vassiliev H.,
 Venkataraman V., Vo A., Wangchuk T., Wangdi T., Weiand M., Wilkinson J.,
 Wilson A., Yadav S., Yang S., Yang X., Young G., Yu Q., Zainoun J.,
 Zembek L., Zimmer A., Lander E.S.;
 "Genome sequence, comparative analysis and haplotype structure of the
 domestic dog.";
 Nature 438:803-819(2005).
 [2] {ECO:0000313|Ensembl:ENSCAFP00000007935}
 IDENTIFICATION.
 STRAIN=Boxer {ECO:0000313|Ensembl:ENSCAFP00000007935};
 Ensembl;
 Submitted (JUL-2011) to UniProtKB.
 -!- FUNCTION: Functions as actin-binding component of the Arp2/3 complex
     which is involved in regulation of actin polymerization and together
     with an activating nucleation-promoting factor (NPF) mediates the
     formation of branched actin networks. Seems to contact the mother actin
     filament. {ECO:0000256|PIRNR:PIRNR039100}.
 -!- SUBCELLULAR LOCATION: Cell projection {ECO:0000256|ARBA:ARBA00004316}.
     Cytoplasm, cytoskeleton {ECO:0000256|PIRNR:PIRNR039100}.
 -!- SIMILARITY: Belongs to the ARPC4 family.
     {ECO:0000256|ARBA:ARBA00005919, ECO:0000256|PIRNR:PIRNR039100}.
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 EMBL; AAEX03012078; -; NOT_ANNOTATED_CDS; Genomic_DNA.
 STRING; 9612.ENSCAFP00000007935; -.
 PaxDb; E2QWU0; -.
 PRIDE; E2QWU0; -.
 Ensembl; ENSCAFT00000008564; ENSCAFP00000007935; ENSCAFG00000023650.
 VGNC; VGNC:54574; ARPC4.
 eggNOG; KOG1876; Eukaryota.
 GeneTree; ENSGT00390000016233; -.
 HOGENOM; CLU_084855_1_0_1; -.
 InParanoid; E2QWU0; -.
 OrthoDB; 1351067at2759; -.
 TreeFam; TF105621; -.
 Reactome; R-CFA-2029482; Regulation of actin dynamics for phagocytic cup formation.
 Reactome; R-CFA-3928662; EPHB-mediated forward signaling.
 Reactome; R-CFA-5663213; RHO GTPases Activate WASPs and WAVEs.
 Reactome; R-CFA-8856828; Clathrin-mediated endocytosis.
 Proteomes; UP000002254; Chromosome 20.
 Bgee; ENSCAFG00000023650; Expressed in blood and 52 other tissues.
 GO; GO:0005885; C:Arp2/3 protein complex; IEA:UniProtKB-UniRule.
 GO; GO:0042995; C:cell projection; IEA:UniProtKB-SubCell.
 GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-KW.
 GO; GO:0051015; F:actin filament binding; IEA:Ensembl.
 GO; GO:0019899; F:enzyme binding; IEA:Ensembl.
 GO; GO:0030674; F:protein-macromolecule adaptor activity; IEA:Ensembl.
 GO; GO:0005200; F:structural constituent of cytoskeleton; IEA:Ensembl.
 GO; GO:0030041; P:actin filament polymerization; IEA:UniProtKB-UniRule.
 GO; GO:0034314; P:Arp2/3 complex-mediated actin nucleation; IEA:UniProtKB-UniRule.
 Gene3D; 3.30.1460.20; -; 1.
 InterPro; IPR034666; ARPC2/4.
 InterPro; IPR008384; ARPC4.
 PANTHER; PTHR22629; PTHR22629; 1.
 Pfam; PF05856; ARPC4; 1.
 PIRSF; PIRSF039100; ARPC4; 1.
 SUPFAM; SSF69645; SSF69645; 1.
 3: Inferred from homology;
 Actin-binding {ECO:0000256|PIRNR:PIRNR039100};
 Cytoplasm {ECO:0000256|PIRNR:PIRNR039100};
 Cytoskeleton {ECO:0000256|PIRNR:PIRNR039100};
 Reference proteome {ECO:0000313|Proteomes:UP000002254}.
 SEQUENCE   186 AA;  21493 MW;  AFFB7DE6848172FB CRC64;
 MVSEPGPAPG TPCFASKLWT ATLRPYLSAV RATLQAALCL ENFSSQVVER HNKPEVEVRS
 SKELLLQPVT ISRNEKEKVL IEGSINSVRV SIAVKQADEI EKILCHKFMR FMMMRAENFF
 ILRRKPVEGY DISFLITNFH TEQMYKHKLV DFVIHFMEEI DKEISEMKLS VNARARIVAE
 EFLKNF

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