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Actin-related protein 2/3 complex subunit 4

 G1MCS3_AILME            Unreviewed;       185 AA.
G1MCS3;
19-OCT-2011, integrated into UniProtKB/TrEMBL.
19-OCT-2011, sequence version 1.
07-OCT-2020, entry version 35.
RecName: Full=Actin-related protein 2/3 complex subunit 4 {ECO:0000256|PIRNR:PIRNR039100};
Name=ARPC4 {ECO:0000313|Ensembl:ENSAMEP00000017151};
Ailuropoda melanoleuca (Giant panda).
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
Eutheria; Laurasiatheria; Carnivora; Caniformia; Ursidae; Ailuropoda.
NCBI_TaxID=9646 {ECO:0000313|Ensembl:ENSAMEP00000017151, ECO:0000313|Proteomes:UP000008912};
[1] {ECO:0000313|Ensembl:ENSAMEP00000017151, ECO:0000313|Proteomes:UP000008912}
NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
PubMed=20010809; DOI=10.1038/nature08696;
Li R., Fan W., Tian G., Zhu H., He L., Cai J., Huang Q., Cai Q., Li B.,
Bai Y., Zhang Z., Zhang Y., Wang W., Li J., Wei F., Li H., Jian M., Li J.,
Zhang Z., Nielsen R., Li D., Gu W., Yang Z., Xuan Z., Ryder O.A.,
Leung F.C., Zhou Y., Cao J., Sun X., Fu Y., Fang X., Guo X., Wang B.,
Hou R., Shen F., Mu B., Ni P., Lin R., Qian W., Wang G., Yu C., Nie W.,
Wang J., Wu Z., Liang H., Min J., Wu Q., Cheng S., Ruan J., Wang M.,
Shi Z., Wen M., Liu B., Ren X., Zheng H., Dong D., Cook K., Shan G.,
Zhang H., Kosiol C., Xie X., Lu Z., Zheng H., Li Y., Steiner C.C.,
Lam T.T., Lin S., Zhang Q., Li G., Tian J., Gong T., Liu H., Zhang D.,
Fang L., Ye C., Zhang J., Hu W., Xu A., Ren Y., Zhang G., Bruford M.W.,
Li Q., Ma L., Guo Y., An N., Hu Y., Zheng Y., Shi Y., Li Z., Liu Q.,
Chen Y., Zhao J., Qu N., Zhao S., Tian F., Wang X., Wang H., Xu L., Liu X.,
Vinar T., Wang Y., Lam T.W., Yiu S.M., Liu S., Zhang H., Li D., Huang Y.,
Wang X., Yang G., Jiang Z., Wang J., Qin N., Li L., Li J., Bolund L.,
Kristiansen K., Wong G.K., Olson M., Zhang X., Li S., Yang H., Wang J.,
Wang J.;
"The sequence and de novo assembly of the giant panda genome.";
Nature 463:311-317(2010).
[2] {ECO:0000313|Ensembl:ENSAMEP00000017151}
IDENTIFICATION.
Ensembl;
Submitted (SEP-2011) to UniProtKB.
-!- FUNCTION: Functions as actin-binding component of the Arp2/3 complex
which is involved in regulation of actin polymerization and together
with an activating nucleation-promoting factor (NPF) mediates the
formation of branched actin networks. Seems to contact the mother actin
filament. {ECO:0000256|PIRNR:PIRNR039100}.
-!- SUBCELLULAR LOCATION: Cell projection {ECO:0000256|ARBA:ARBA00004316}.
Cytoplasm, cytoskeleton {ECO:0000256|PIRNR:PIRNR039100}.
-!- SIMILARITY: Belongs to the ARPC4 family.
{ECO:0000256|ARBA:ARBA00005919, ECO:0000256|PIRNR:PIRNR039100}.
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EMBL; ACTA01034204; -; NOT_ANNOTATED_CDS; Genomic_DNA.
STRING; 9646.ENSAMEP00000017151; -.
Ensembl; ENSAMET00000017854; ENSAMEP00000017151; ENSAMEG00000016243.
eggNOG; KOG1876; Eukaryota.
GeneTree; ENSGT00390000016233; -.
HOGENOM; CLU_084855_1_0_1; -.
InParanoid; G1MCS3; -.
OMA; FASKLWT; -.
TreeFam; TF105621; -.
Proteomes; UP000008912; Unassembled WGS sequence.
GO; GO:0005885; C:Arp2/3 protein complex; IEA:UniProtKB-UniRule.
GO; GO:0042995; C:cell projection; IEA:UniProtKB-SubCell.
GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-KW.
GO; GO:0051015; F:actin filament binding; IEA:Ensembl.
GO; GO:0019899; F:enzyme binding; IEA:Ensembl.
GO; GO:0030674; F:protein-macromolecule adaptor activity; IEA:Ensembl.
GO; GO:0005200; F:structural constituent of cytoskeleton; IEA:Ensembl.
GO; GO:0030041; P:actin filament polymerization; IEA:UniProtKB-UniRule.
GO; GO:0034314; P:Arp2/3 complex-mediated actin nucleation; IEA:UniProtKB-UniRule.
Gene3D; 3.30.1460.20; -; 1.
InterPro; IPR034666; ARPC2/4.
InterPro; IPR008384; ARPC4.
PANTHER; PTHR22629; PTHR22629; 1.
Pfam; PF05856; ARPC4; 1.
PIRSF; PIRSF039100; ARPC4; 1.
SUPFAM; SSF69645; SSF69645; 1.
3: Inferred from homology;
Actin-binding {ECO:0000256|PIRNR:PIRNR039100};
Cytoplasm {ECO:0000256|PIRNR:PIRNR039100};
Cytoskeleton {ECO:0000256|PIRNR:PIRNR039100};
Reference proteome {ECO:0000313|Proteomes:UP000008912}.
SEQUENCE 185 AA; 21500 MW; 7DC17F496224227F CRC64;
MVREPGPGPR TPCFASKLWT ATLRPYLSAV RATLQAALCL ENFSSQVVER HNKPEVEVRS
SKELLLQPVT ISRNEKEKVL IEGSINSVRV SIAVKQADEI EKILCHKFMR FMMMRAENFF
ILRRKPVEGY DISFLITNFH TEQMYKHKLV DFVIHFMEEI DKEISEMKLS VNARARIVAE
EFLKN


Related products :

Catalog number Product name Quantity
pro-145 Recombinant Human Actin Related Protein 2 per 3 Complex, Subunit 5 1mg
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pro-145 Recombinant Human Actin Related Protein 2 per 3 Complex, Subunit 5 5
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pro-145 Recombinant Human Actin Related Protein 2 per 3 Complex, Subunit 5 20
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pro-1418 Recombinant Human Actin Related Protein 2 per 3 Complex, Subunit 2 10
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Pathways :
WP2272: Pathogenic Escherichia coli infection
WP2292: Chemokine signaling pathway
WP1644: DNA replication
WP1566: Citrate cycle (TCA cycle)
WP1694: Pyrimidine metabolism
WP731: Sterol regulatory element binding protein related
WP1693: Purine metabolism
WP2199: Seed Development
WP1663: Homologous recombination
WP1672: Mismatch repair
WP2324: AGE/RAGE pathway
WP1348: Androgen Receptor Signaling Pathway
WP1019: FAS pathway and Stress induction of HSP regulation
WP1625: Base excision repair
WP1892: Protein folding
WP460: Blood Clotting Cascade
WP1381: G13 Signaling Pathway
WP1676: Non-homologous end-joining
WP511: FAS pathway and Stress induction of HSP regulation
WP1438: Influenza A virus infection
WP1685: Peptidoglycan biosynthesis
WP240: Alanine and aspartate metabolism
WP2087: miRNA regulation of DNA Damage Response
WP1102: EBV LMP1 signaling
WP1939: Unfolded Protein Response

Related Genes :

Bibliography :
[33408168] CIDP Antibodies Target Junction Proteins and Identify Patient Subgroups: An Autoantigenomic Approach.
[33388318] mTORC1 and mTORC2 Converge on the Arp2/3 Complex to Promote Kras-Induced Acinar-to-Ductal Metaplasia and Early Pancreatic Carcinogenesis.
[32235494] Proteomic Analysis of Renal Biomarkers of Kidney Allograft Fibrosis-A Study in Renal Transplant Patients.
[32141557] Identification of lung adenocarcinoma-specific exosome RNAs in peripheral blood by RNA-Seq analysis.
[31347661] Influence of metabolic status and genetic merit for fertility on proteomic composition of bovine oviduct fluid†.
[31190401] ARPC4 promotes bladder cancer cell invasion and is associated with lymph node metastasis.
[30850364] Serum Proteomic Signatures of Male Breast Cancer.
[30720048] RBM3 upregulates ARPC2 by binding the 3'UTR and contributes to breast cancer progression.
[30651846] Differential expression of serum proteins in multiple myeloma.
[30170128] Advances and highlights in primary immunodeficiencies in 2017.