Actin-related protein 2/3 complex subunit 4

 G1MCS3_AILME            Unreviewed;       185 AA.
 G1MCS3;
 19-OCT-2011, integrated into UniProtKB/TrEMBL.
 19-OCT-2011, sequence version 1.
 07-OCT-2020, entry version 35.
 RecName: Full=Actin-related protein 2/3 complex subunit 4 {ECO:0000256|PIRNR:PIRNR039100};
 Name=ARPC4 {ECO:0000313|Ensembl:ENSAMEP00000017151};
 Ailuropoda melanoleuca (Giant panda).
 Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
 Eutheria; Laurasiatheria; Carnivora; Caniformia; Ursidae; Ailuropoda.
 NCBI_TaxID=9646 {ECO:0000313|Ensembl:ENSAMEP00000017151, ECO:0000313|Proteomes:UP000008912};
 [1] {ECO:0000313|Ensembl:ENSAMEP00000017151, ECO:0000313|Proteomes:UP000008912}
 NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
 PubMed=20010809; DOI=10.1038/nature08696;
 Li R., Fan W., Tian G., Zhu H., He L., Cai J., Huang Q., Cai Q., Li B.,
 Bai Y., Zhang Z., Zhang Y., Wang W., Li J., Wei F., Li H., Jian M., Li J.,
 Zhang Z., Nielsen R., Li D., Gu W., Yang Z., Xuan Z., Ryder O.A.,
 Leung F.C., Zhou Y., Cao J., Sun X., Fu Y., Fang X., Guo X., Wang B.,
 Hou R., Shen F., Mu B., Ni P., Lin R., Qian W., Wang G., Yu C., Nie W.,
 Wang J., Wu Z., Liang H., Min J., Wu Q., Cheng S., Ruan J., Wang M.,
 Shi Z., Wen M., Liu B., Ren X., Zheng H., Dong D., Cook K., Shan G.,
 Zhang H., Kosiol C., Xie X., Lu Z., Zheng H., Li Y., Steiner C.C.,
 Lam T.T., Lin S., Zhang Q., Li G., Tian J., Gong T., Liu H., Zhang D.,
 Fang L., Ye C., Zhang J., Hu W., Xu A., Ren Y., Zhang G., Bruford M.W.,
 Li Q., Ma L., Guo Y., An N., Hu Y., Zheng Y., Shi Y., Li Z., Liu Q.,
 Chen Y., Zhao J., Qu N., Zhao S., Tian F., Wang X., Wang H., Xu L., Liu X.,
 Vinar T., Wang Y., Lam T.W., Yiu S.M., Liu S., Zhang H., Li D., Huang Y.,
 Wang X., Yang G., Jiang Z., Wang J., Qin N., Li L., Li J., Bolund L.,
 Kristiansen K., Wong G.K., Olson M., Zhang X., Li S., Yang H., Wang J.,
 Wang J.;
 "The sequence and de novo assembly of the giant panda genome.";
 Nature 463:311-317(2010).
 [2] {ECO:0000313|Ensembl:ENSAMEP00000017151}
 IDENTIFICATION.
 Ensembl;
 Submitted (SEP-2011) to UniProtKB.
 -!- FUNCTION: Functions as actin-binding component of the Arp2/3 complex
     which is involved in regulation of actin polymerization and together
     with an activating nucleation-promoting factor (NPF) mediates the
     formation of branched actin networks. Seems to contact the mother actin
     filament. {ECO:0000256|PIRNR:PIRNR039100}.
 -!- SUBCELLULAR LOCATION: Cell projection {ECO:0000256|ARBA:ARBA00004316}.
     Cytoplasm, cytoskeleton {ECO:0000256|PIRNR:PIRNR039100}.
 -!- SIMILARITY: Belongs to the ARPC4 family.
     {ECO:0000256|ARBA:ARBA00005919, ECO:0000256|PIRNR:PIRNR039100}.
 ---------------------------------------------------------------------------
 Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
 Distributed under the Creative Commons Attribution (CC BY 4.0) License
 ---------------------------------------------------------------------------
 EMBL; ACTA01034204; -; NOT_ANNOTATED_CDS; Genomic_DNA.
 STRING; 9646.ENSAMEP00000017151; -.
 Ensembl; ENSAMET00000017854; ENSAMEP00000017151; ENSAMEG00000016243.
 eggNOG; KOG1876; Eukaryota.
 GeneTree; ENSGT00390000016233; -.
 HOGENOM; CLU_084855_1_0_1; -.
 InParanoid; G1MCS3; -.
 OMA; FASKLWT; -.
 TreeFam; TF105621; -.
 Proteomes; UP000008912; Unassembled WGS sequence.
 GO; GO:0005885; C:Arp2/3 protein complex; IEA:UniProtKB-UniRule.
 GO; GO:0042995; C:cell projection; IEA:UniProtKB-SubCell.
 GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-KW.
 GO; GO:0051015; F:actin filament binding; IEA:Ensembl.
 GO; GO:0019899; F:enzyme binding; IEA:Ensembl.
 GO; GO:0030674; F:protein-macromolecule adaptor activity; IEA:Ensembl.
 GO; GO:0005200; F:structural constituent of cytoskeleton; IEA:Ensembl.
 GO; GO:0030041; P:actin filament polymerization; IEA:UniProtKB-UniRule.
 GO; GO:0034314; P:Arp2/3 complex-mediated actin nucleation; IEA:UniProtKB-UniRule.
 Gene3D; 3.30.1460.20; -; 1.
 InterPro; IPR034666; ARPC2/4.
 InterPro; IPR008384; ARPC4.
 PANTHER; PTHR22629; PTHR22629; 1.
 Pfam; PF05856; ARPC4; 1.
 PIRSF; PIRSF039100; ARPC4; 1.
 SUPFAM; SSF69645; SSF69645; 1.
 3: Inferred from homology;
 Actin-binding {ECO:0000256|PIRNR:PIRNR039100};
 Cytoplasm {ECO:0000256|PIRNR:PIRNR039100};
 Cytoskeleton {ECO:0000256|PIRNR:PIRNR039100};
 Reference proteome {ECO:0000313|Proteomes:UP000008912}.
 SEQUENCE   185 AA;  21500 MW;  7DC17F496224227F CRC64;
 MVREPGPGPR TPCFASKLWT ATLRPYLSAV RATLQAALCL ENFSSQVVER HNKPEVEVRS
 SKELLLQPVT ISRNEKEKVL IEGSINSVRV SIAVKQADEI EKILCHKFMR FMMMRAENFF
 ILRRKPVEGY DISFLITNFH TEQMYKHKLV DFVIHFMEEI DKEISEMKLS VNARARIVAE
 EFLKN

Related products :