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Actin-related protein 2/3 complex subunit 4

 M3WSL5_FELCA            Unreviewed;       187 AA.
M3WSL5;
01-MAY-2013, integrated into UniProtKB/TrEMBL.
11-DEC-2019, sequence version 4.
07-APR-2021, entry version 45.
RecName: Full=Actin-related protein 2/3 complex subunit 4 {ECO:0000256|PIRNR:PIRNR039100};
Name=ARPC4 {ECO:0000313|Ensembl:ENSFCAP00000017351,
ECO:0000313|VGNC:VGNC:69349};
Felis catus (Cat) (Felis silvestris catus).
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
Eutheria; Laurasiatheria; Carnivora; Feliformia; Felidae; Felinae; Felis.
NCBI_TaxID=9685 {ECO:0000313|Ensembl:ENSFCAP00000017351, ECO:0000313|Proteomes:UP000011712};
[1] {ECO:0000313|Ensembl:ENSFCAP00000017351, ECO:0000313|Proteomes:UP000011712}
NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
STRAIN=Abyssinian {ECO:0000313|Ensembl:ENSFCAP00000017351,
ECO:0000313|Proteomes:UP000011712};
PubMed=17975172; DOI=10.1101/gr.6380007;
Pontius J.U., Mullikin J.C., Smith D.R., Lindblad-Toh K., Gnerre S.,
Clamp M., Chang J., Stephens R., Neelam B., Volfovsky N., Schaffer A.A.,
Agarwala R., Narfstrom K., Murphy W.J., Giger U., Roca A.L., Antunes A.,
Menotti-Raymond M., Yuhki N., Pecon-Slattery J., Johnson W.E., Bourque G.,
Tesler G., O'Brien S.J.;
"Initial sequence and comparative analysis of the cat genome.";
Genome Res. 17:1675-1689(2007).
[2] {ECO:0000313|Ensembl:ENSFCAP00000017351, ECO:0000313|Proteomes:UP000011712}
NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
STRAIN=Abyssinian {ECO:0000313|Ensembl:ENSFCAP00000017351,
ECO:0000313|Proteomes:UP000011712};
Hillier L.W., Warren W., Obrien S., Wilson R.K.;
"Sequence assembly of the Felis catus genome version 6.2.";
Submitted (SEP-2011) to the EMBL/GenBank/DDBJ databases.
[3] {ECO:0000313|Ensembl:ENSFCAP00000017351}
IDENTIFICATION.
STRAIN=breed Abyssinian {ECO:0000313|Ensembl:ENSFCAP00000017351};
Ensembl;
Submitted (MAR-2013) to UniProtKB.
-!- FUNCTION: Functions as actin-binding component of the Arp2/3 complex
which is involved in regulation of actin polymerization and together
with an activating nucleation-promoting factor (NPF) mediates the
formation of branched actin networks. Seems to contact the mother actin
filament. {ECO:0000256|PIRNR:PIRNR039100}.
-!- SUBCELLULAR LOCATION: Cell projection {ECO:0000256|ARBA:ARBA00004316}.
Cytoplasm, cytoskeleton {ECO:0000256|PIRNR:PIRNR039100}.
-!- SIMILARITY: Belongs to the ARPC4 family.
{ECO:0000256|ARBA:ARBA00005919, ECO:0000256|PIRNR:PIRNR039100}.
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EMBL; AANG04003845; -; NOT_ANNOTATED_CDS; Genomic_DNA.
STRING; 9685.ENSFCAP00000017351; -.
Ensembl; ENSFCAT00000026821; ENSFCAP00000017351; ENSFCAG00000025643.
VGNC; VGNC:69349; ARPC4.
eggNOG; KOG1876; Eukaryota.
GeneTree; ENSGT00390000016233; -.
HOGENOM; CLU_084855_1_0_1; -.
InParanoid; M3WSL5; -.
OMA; FASKLWT; -.
OrthoDB; 1351067at2759; -.
Proteomes; UP000011712; Chromosome A2.
Bgee; ENSFCAG00000025643; Expressed in prefrontal cortex and 11 other tissues.
GO; GO:0005885; C:Arp2/3 protein complex; IEA:UniProtKB-UniRule.
GO; GO:0042995; C:cell projection; IEA:UniProtKB-SubCell.
GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-KW.
GO; GO:0051015; F:actin filament binding; IEA:Ensembl.
GO; GO:0019899; F:enzyme binding; IEA:Ensembl.
GO; GO:0030674; F:protein-macromolecule adaptor activity; IEA:Ensembl.
GO; GO:0005200; F:structural constituent of cytoskeleton; IEA:Ensembl.
GO; GO:0030041; P:actin filament polymerization; IEA:UniProtKB-UniRule.
GO; GO:0034314; P:Arp2/3 complex-mediated actin nucleation; IEA:UniProtKB-UniRule.
Gene3D; 3.30.1460.20; -; 1.
InterPro; IPR034666; ARPC2/4.
InterPro; IPR008384; ARPC4.
PANTHER; PTHR22629; PTHR22629; 1.
Pfam; PF05856; ARPC4; 1.
PIRSF; PIRSF039100; ARPC4; 1.
SUPFAM; SSF69645; SSF69645; 1.
3: Inferred from homology;
Actin-binding {ECO:0000256|PIRNR:PIRNR039100};
Cytoplasm {ECO:0000256|PIRNR:PIRNR039100};
Cytoskeleton {ECO:0000256|PIRNR:PIRNR039100};
Reference proteome {ECO:0000313|Proteomes:UP000011712}.
SEQUENCE 187 AA; 21704 MW; 707D256238CB7A01 CRC64;
MVREPGPGPG TPRCFASKLW TATLRPYLSA VRATLQAALC LENFSSQVVE RHNKPEVEVR
SSKELLLQPV TISRNEKEKV LIEGSINSVR VSIAVKQADE IEKILCHKFM RFMMMRAENF
FILRRKPVEG YDISFLITNF HTEQMYKHKL VDFVIHFMEE IDKEISEMKL SVNARARIVA
EEFLKNF


Related products :

Catalog number Product name Quantity
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Pathways :
WP2272: Pathogenic Escherichia coli infection
WP2292: Chemokine signaling pathway
WP1644: DNA replication
WP1566: Citrate cycle (TCA cycle)
WP1694: Pyrimidine metabolism
WP731: Sterol regulatory element binding protein related
WP1693: Purine metabolism
WP2199: Seed Development
WP1663: Homologous recombination
WP1672: Mismatch repair
WP2324: AGE/RAGE pathway
WP1348: Androgen Receptor Signaling Pathway
WP1019: FAS pathway and Stress induction of HSP regulation
WP1625: Base excision repair
WP1892: Protein folding
WP460: Blood Clotting Cascade
WP1381: G13 Signaling Pathway
WP1676: Non-homologous end-joining
WP511: FAS pathway and Stress induction of HSP regulation
WP1438: Influenza A virus infection
WP1685: Peptidoglycan biosynthesis
WP240: Alanine and aspartate metabolism
WP2087: miRNA regulation of DNA Damage Response
WP1102: EBV LMP1 signaling
WP1939: Unfolded Protein Response

Related Genes :

Bibliography :
[33408168] CIDP Antibodies Target Junction Proteins and Identify Patient Subgroups: An Autoantigenomic Approach.
[33388318] mTORC1 and mTORC2 Converge on the Arp2/3 Complex to Promote Kras-Induced Acinar-to-Ductal Metaplasia and Early Pancreatic Carcinogenesis.
[32235494] Proteomic Analysis of Renal Biomarkers of Kidney Allograft Fibrosis-A Study in Renal Transplant Patients.
[32141557] Identification of lung adenocarcinoma-specific exosome RNAs in peripheral blood by RNA-Seq analysis.
[31347661] Influence of metabolic status and genetic merit for fertility on proteomic composition of bovine oviduct fluid†.
[31190401] ARPC4 promotes bladder cancer cell invasion and is associated with lymph node metastasis.
[30850364] Serum Proteomic Signatures of Male Breast Cancer.
[30720048] RBM3 upregulates ARPC2 by binding the 3'UTR and contributes to breast cancer progression.
[30651846] Differential expression of serum proteins in multiple myeloma.
[30170128] Advances and highlights in primary immunodeficiencies in 2017.