GENTAUR Belgium BVBA BE0473327336 Voortstraat 49, 1910 Kampenhout BELGIUM Tel 0032 16 58 90 45
GENTAUR U.S.A Genprice Inc,Logistics 547 Yurok Circle, SanJose, CA 95123
Tel (408) 780-0908, Fax (408) 780-0908, [email protected]

Did you know ? If you order before Friday 14h we deliver 90PCT of the the time next Tuesday, Gentaur another in time delivery

Actin-related protein 2/3 complex subunit 4

 ARPC4_XENLA             Reviewed;         168 AA.
Q641G7; A0A1L8GHV5;
10-OCT-2018, integrated into UniProtKB/Swiss-Prot.
25-OCT-2004, sequence version 1.
02-DEC-2020, entry version 77.
RecName: Full=Actin-related protein 2/3 complex subunit 4;
Name=arpc4 {ECO:0000312|Xenbase:XB-GENE-865976};
ORFNames=XELAEV_18025964mg {ECO:0000312|EMBL:OCT83422.1};
Xenopus laevis (African clawed frog).
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Amphibia;
Batrachia; Anura; Pipoidea; Pipidae; Xenopodinae; Xenopus; Xenopus.
NCBI_TaxID=8355;
[1]
NUCLEOTIDE SEQUENCE [MRNA], FUNCTION, AND SUBCELLULAR LOCATION.
PubMed=17178911; DOI=10.1083/jcb.200604176;
Miyoshi T., Tsuji T., Higashida C., Hertzog M., Fujita A., Narumiya S.,
Scita G., Watanabe N.;
"Actin turnover-dependent fast dissociation of capping protein in the
dendritic nucleation actin network: evidence of frequent filament
severing.";
J. Cell Biol. 175:947-955(2006).
[2]
NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
STRAIN=J;
PubMed=27762356; DOI=10.1038/nature19840;
Session A.M., Uno Y., Kwon T., Chapman J.A., Toyoda A., Takahashi S.,
Fukui A., Hikosaka A., Suzuki A., Kondo M., van Heeringen S.J., Quigley I.,
Heinz S., Ogino H., Ochi H., Hellsten U., Lyons J.B., Simakov O.,
Putnam N., Stites J., Kuroki Y., Tanaka T., Michiue T., Watanabe M.,
Bogdanovic O., Lister R., Georgiou G., Paranjpe S.S., van Kruijsbergen I.,
Shu S., Carlson J., Kinoshita T., Ohta Y., Mawaribuchi S., Jenkins J.,
Grimwood J., Schmutz J., Mitros T., Mozaffari S.V., Suzuki Y., Haramoto Y.,
Yamamoto T.S., Takagi C., Heald R., Miller K., Haudenschild C., Kitzman J.,
Nakayama T., Izutsu Y., Robert J., Fortriede J., Burns K., Lotay V.,
Karimi K., Yasuoka Y., Dichmann D.S., Flajnik M.F., Houston D.W.,
Shendure J., DuPasquier L., Vize P.D., Zorn A.M., Ito M., Marcotte E.M.,
Wallingford J.B., Ito Y., Asashima M., Ueno N., Matsuda Y., Veenstra G.J.,
Fujiyama A., Harland R.M., Taira M., Rokhsar D.S.;
"Genome evolution in the allotetraploid frog Xenopus laevis.";
Nature 538:336-343(2016).
[3]
NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
TISSUE=Embryo;
NIH - Xenopus Gene Collection (XGC) project;
Submitted (SEP-2004) to the EMBL/GenBank/DDBJ databases.
[4]
FUNCTION, SUBCELLULAR LOCATION, IDENTIFICATION IN THE ARP2/3 COMPLEX, AND
IDENTIFICATION BY MASS SPECTROMETRY.
PubMed=29925947; DOI=10.1038/s41586-018-0237-5;
Schrank B.R., Aparicio T., Li Y., Chang W., Chait B.T., Gundersen G.G.,
Gottesman M.E., Gautier J.;
"Nuclear ARP2/3 drives DNA break clustering for homology-directed repair.";
Nature 559:61-66(2018).
-!- FUNCTION: Actin-binding component of the Arp2/3 complex, a multiprotein
complex that mediates actin polymerization upon stimulation by
nucleation-promoting factor (NPF) (PubMed:17178911). The Arp2/3 complex
mediates the formation of branched actin networks in the cytoplasm,
providing the force for cell motility (PubMed:17178911). In addition to
its role in the cytoplasmic cytoskeleton, the Arp2/3 complex also
promotes actin polymerization in the nucleus, thereby regulating gene
transcription and repair of damaged DNA (Probable). The Arp2/3 complex
promotes homologous recombination (HR) repair in response to DNA damage
by promoting nuclear actin polymerization, leading to drive motility of
double-strand breaks (DSBs) (By similarity).
{ECO:0000250|UniProtKB:P59998, ECO:0000269|PubMed:17178911,
ECO:0000305|PubMed:29925947}.
-!- SUBUNIT: Component of the Arp2/3 complex composed of actr2/arp2,
actr3/arp3, arpc1 (arpc1a or arpc1b), arpc2, arpc3, arpc4 and arpc5.
{ECO:0000269|PubMed:29925947}.
-!- SUBCELLULAR LOCATION: Cytoplasm, cytoskeleton
{ECO:0000269|PubMed:17178911}. Cell projection
{ECO:0000269|PubMed:17178911}. Nucleus {ECO:0000269|PubMed:29925947}.
-!- SIMILARITY: Belongs to the ARPC4 family. {ECO:0000305}.
-!- SEQUENCE CAUTION:
Sequence=OCT83422.1; Type=Erroneous gene model prediction; Evidence={ECO:0000305};
---------------------------------------------------------------------------
Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
Distributed under the Creative Commons Attribution (CC BY 4.0) License
---------------------------------------------------------------------------
EMBL; EF011870; ABL63903.1; -; mRNA.
EMBL; CM004473; OCT83422.1; ALT_SEQ; Genomic_DNA.
EMBL; BC082370; AAH82370.1; -; mRNA.
RefSeq; NP_001087956.1; NM_001094487.1.
RefSeq; XP_018114645.1; XM_018259156.1.
SMR; Q641G7; -.
IntAct; Q641G7; 1.
MINT; Q641G7; -.
MaxQB; Q641G7; -.
GeneID; 108714705; -.
GeneID; 494639; -.
KEGG; xla:108714705; -.
KEGG; xla:494639; -.
CTD; 494639; -.
Xenbase; XB-GENE-865976; arpc4.S.
OrthoDB; 1351067at2759; -.
Proteomes; UP000186698; Chromosome 4s.
Proteomes; UP000186698; Unassembled WGS sequence.
GO; GO:0005885; C:Arp2/3 protein complex; IDA:UniProtKB.
GO; GO:0042995; C:cell projection; IEA:UniProtKB-SubCell.
GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-KW.
GO; GO:0005634; C:nucleus; IDA:UniProtKB.
GO; GO:0035861; C:site of double-strand break; IDA:UniProtKB.
GO; GO:0003779; F:actin binding; IEA:UniProtKB-KW.
GO; GO:0030041; P:actin filament polymerization; IEA:InterPro.
GO; GO:0034314; P:Arp2/3 complex-mediated actin nucleation; IEA:InterPro.
Gene3D; 3.30.1460.20; -; 1.
InterPro; IPR034666; ARPC2/4.
InterPro; IPR008384; ARPC4.
PANTHER; PTHR22629; PTHR22629; 1.
Pfam; PF05856; ARPC4; 1.
PIRSF; PIRSF039100; ARPC4; 1.
SUPFAM; SSF69645; SSF69645; 1.
1: Evidence at protein level;
Actin-binding; Cell projection; Cytoplasm; Cytoskeleton; Nucleus;
Reference proteome.
CHAIN 1..168
/note="Actin-related protein 2/3 complex subunit 4"
/id="PRO_0000445563"
SEQUENCE 168 AA; 19692 MW; 719BC7D31BA73A7D CRC64;
MTATLRPYLN AVRATLQAAL CLENFSSQVV ERHNKPEVEV RSSKELLLQP VVISRNEKEK
VLIEGSINSV RVSIAVKQAD EIEKILCHKF MRFMMMRAEN FFILRRKPVE GYDISFLITN
FHTEQMYKHK LVDFVIHFME EIDKEISEMK LSVNARARIV AEEFLKNF


Related products :

Catalog number Product name Quantity
pro-145 Recombinant Human Actin Related Protein 2 per 3 Complex, Subunit 5 1mg
ARPC5_RAT Rat ELISA Kit FOR Actin-related protein 2 per 3 complex subunit 5 96T
pro-145 Recombinant Human Actin Related Protein 2 per 3 Complex, Subunit 5 5
RPR-418 Recombinant Human Actin Related Protein 2 3 Complex, Subunit 2 2
RPR-413 Recombinant Human Actin Related Protein 2 3 Complex, Subunit 3 5
RPR-145 Recombinant Human Actin Related Protein 2 3 Complex, Subunit 5 5
pro-145 Recombinant Human Actin Related Protein 2 per 3 Complex, Subunit 5 20
ARPC2_RAT Rat ELISA Kit FOR Actin-related protein 2 per 3 complex subunit 2 96T
ARPC2_HUMAN Human ELISA Kit FOR Actin-related protein 2 per 3 complex subunit 2 96T
pro-1418 Recombinant Human Actin Related Protein 2 per 3 Complex, Subunit 2 10
CSB-EL002127RA Rat Actin-related protein 2_3 complex subunit 2(ARPC2) ELISA kit 96T
CSB-EL002131RA Rat Actin-related protein 2_3 complex subunit 5(ARPC5) ELISA kit 96T
pro-145 Recombinant Human Actin Related Protein 2_3 Complex, Subunit 5 ARPC5 1mg
pro-1418 Recombinant Human Actin Related Protein 2 per 3 Complex, Subunit 2 100
7-04403 Recombinant Human Actin Related Protein 2_3 Complex, Subunit 5 20
ARPP19 ARPC5L Gene actin related protein 2_3 complex, subunit 5-like
pro-1413 Recombinant Human Actin Related Protein 2 per 3 Complex, Subunit 3 5
pro-145 Recombinant Human Actin Related Protein 2_3 Complex, Subunit 5 ARPC5 5
7-04402 Recombinant Human Actin Related Protein 2_3 Complex, Subunit 5 5
pro-145 Recombinant Human Actin Related Protein 2_3 Complex, Subunit 5 ARPC5 20
CSB-EL002125RA Rat Actin-related protein 2_3 complex subunit 1A(ARPC1A) ELISA kit 96T
E1991m Bovine ELISA Kit FOR Actin-related protein 2 per 3 complex subunit 1A 96T
7-04404 Recombinant Human Actin Related Protein 2_3 Complex, Subunit 5 1mg
pro-1413 Recombinant Human Actin Related Protein 2 per 3 Complex, Subunit 3 20
CSB-RP033244h Recombinant human Actin-related protein 2_3 complex subunit 3 500ug
Pathways :
WP2272: Pathogenic Escherichia coli infection
WP2292: Chemokine signaling pathway
WP1644: DNA replication
WP1566: Citrate cycle (TCA cycle)
WP1694: Pyrimidine metabolism
WP731: Sterol regulatory element binding protein related
WP1693: Purine metabolism
WP2199: Seed Development
WP1663: Homologous recombination
WP1672: Mismatch repair
WP2324: AGE/RAGE pathway
WP1348: Androgen Receptor Signaling Pathway
WP1019: FAS pathway and Stress induction of HSP regulation
WP1625: Base excision repair
WP1892: Protein folding
WP460: Blood Clotting Cascade
WP1381: G13 Signaling Pathway
WP1676: Non-homologous end-joining
WP511: FAS pathway and Stress induction of HSP regulation
WP1438: Influenza A virus infection
WP1685: Peptidoglycan biosynthesis
WP240: Alanine and aspartate metabolism
WP2087: miRNA regulation of DNA Damage Response
WP1102: EBV LMP1 signaling
WP1939: Unfolded Protein Response

Related Genes :

Bibliography :
[33408168] CIDP Antibodies Target Junction Proteins and Identify Patient Subgroups: An Autoantigenomic Approach.
[33388318] mTORC1 and mTORC2 Converge on the Arp2/3 Complex to Promote Kras-Induced Acinar-to-Ductal Metaplasia and Early Pancreatic Carcinogenesis.
[32235494] Proteomic Analysis of Renal Biomarkers of Kidney Allograft Fibrosis-A Study in Renal Transplant Patients.
[32141557] Identification of lung adenocarcinoma-specific exosome RNAs in peripheral blood by RNA-Seq analysis.
[31347661] Influence of metabolic status and genetic merit for fertility on proteomic composition of bovine oviduct fluid†.
[31190401] ARPC4 promotes bladder cancer cell invasion and is associated with lymph node metastasis.
[30850364] Serum Proteomic Signatures of Male Breast Cancer.
[30720048] RBM3 upregulates ARPC2 by binding the 3'UTR and contributes to breast cancer progression.
[30651846] Differential expression of serum proteins in multiple myeloma.
[30170128] Advances and highlights in primary immunodeficiencies in 2017.