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Actin-related protein 2/3 complex subunit 4 (Actin-related protein C4) (Arp2/3 complex 20 kDa subunit) (p20-ARC)

 ARPC4_ARATH             Reviewed;         169 AA.
F4JUL9; O23274;
29-MAY-2013, integrated into UniProtKB/Swiss-Prot.
28-JUN-2011, sequence version 1.
02-DEC-2020, entry version 60.
RecName: Full=Actin-related protein 2/3 complex subunit 4;
AltName: Full=Actin-related protein C4;
AltName: Full=Arp2/3 complex 20 kDa subunit;
Short=p20-ARC;
Name=ARPC4; OrderedLocusNames=At4g14147; ORFNames=dl3115c, FCAALL.159;
Arabidopsis thaliana (Mouse-ear cress).
Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta;
Spermatophyta; Magnoliopsida; eudicotyledons; Gunneridae; Pentapetalae;
rosids; malvids; Brassicales; Brassicaceae; Camelineae; Arabidopsis.
NCBI_TaxID=3702;
[1]
NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
STRAIN=cv. Columbia;
PubMed=9461215; DOI=10.1038/35140;
Bevan M., Bancroft I., Bent E., Love K., Goodman H.M., Dean C.,
Bergkamp R., Dirkse W., van Staveren M., Stiekema W., Drost L., Ridley P.,
Hudson S.-A., Patel K., Murphy G., Piffanelli P., Wedler H., Wedler E.,
Wambutt R., Weitzenegger T., Pohl T., Terryn N., Gielen J., Villarroel R.,
De Clercq R., van Montagu M., Lecharny A., Aubourg S., Gy I., Kreis M.,
Lao N., Kavanagh T., Hempel S., Kotter P., Entian K.-D., Rieger M.,
Schaefer M., Funk B., Mueller-Auer S., Silvey M., James R., Monfort A.,
Pons A., Puigdomenech P., Douka A., Voukelatou E., Milioni D.,
Hatzopoulos P., Piravandi E., Obermaier B., Hilbert H., Duesterhoeft A.,
Moores T., Jones J.D.G., Eneva T., Palme K., Benes V., Rechmann S.,
Ansorge W., Cooke R., Berger C., Delseny M., Voet M., Volckaert G.,
Mewes H.-W., Klosterman S., Schueller C., Chalwatzis N.;
"Analysis of 1.9 Mb of contiguous sequence from chromosome 4 of Arabidopsis
thaliana.";
Nature 391:485-488(1998).
[2]
NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
STRAIN=cv. Columbia;
PubMed=10617198; DOI=10.1038/47134;
Mayer K.F.X., Schueller C., Wambutt R., Murphy G., Volckaert G., Pohl T.,
Duesterhoeft A., Stiekema W., Entian K.-D., Terryn N., Harris B.,
Ansorge W., Brandt P., Grivell L.A., Rieger M., Weichselgartner M.,
de Simone V., Obermaier B., Mache R., Mueller M., Kreis M., Delseny M.,
Puigdomenech P., Watson M., Schmidtheini T., Reichert B., Portetelle D.,
Perez-Alonso M., Boutry M., Bancroft I., Vos P., Hoheisel J.,
Zimmermann W., Wedler H., Ridley P., Langham S.-A., McCullagh B.,
Bilham L., Robben J., van der Schueren J., Grymonprez B., Chuang Y.-J.,
Vandenbussche F., Braeken M., Weltjens I., Voet M., Bastiaens I., Aert R.,
Defoor E., Weitzenegger T., Bothe G., Ramsperger U., Hilbert H., Braun M.,
Holzer E., Brandt A., Peters S., van Staveren M., Dirkse W., Mooijman P.,
Klein Lankhorst R., Rose M., Hauf J., Koetter P., Berneiser S., Hempel S.,
Feldpausch M., Lamberth S., Van den Daele H., De Keyser A., Buysshaert C.,
Gielen J., Villarroel R., De Clercq R., van Montagu M., Rogers J.,
Cronin A., Quail M.A., Bray-Allen S., Clark L., Doggett J., Hall S.,
Kay M., Lennard N., McLay K., Mayes R., Pettett A., Rajandream M.A.,
Lyne M., Benes V., Rechmann S., Borkova D., Bloecker H., Scharfe M.,
Grimm M., Loehnert T.-H., Dose S., de Haan M., Maarse A.C., Schaefer M.,
Mueller-Auer S., Gabel C., Fuchs M., Fartmann B., Granderath K., Dauner D.,
Herzl A., Neumann S., Argiriou A., Vitale D., Liguori R., Piravandi E.,
Massenet O., Quigley F., Clabauld G., Muendlein A., Felber R., Schnabl S.,
Hiller R., Schmidt W., Lecharny A., Aubourg S., Chefdor F., Cooke R.,
Berger C., Monfort A., Casacuberta E., Gibbons T., Weber N., Vandenbol M.,
Bargues M., Terol J., Torres A., Perez-Perez A., Purnelle B., Bent E.,
Johnson S., Tacon D., Jesse T., Heijnen L., Schwarz S., Scholler P.,
Heber S., Francs P., Bielke C., Frishman D., Haase D., Lemcke K.,
Mewes H.-W., Stocker S., Zaccaria P., Bevan M., Wilson R.K.,
de la Bastide M., Habermann K., Parnell L., Dedhia N., Gnoj L., Schutz K.,
Huang E., Spiegel L., Sekhon M., Murray J., Sheet P., Cordes M.,
Abu-Threideh J., Stoneking T., Kalicki J., Graves T., Harmon G.,
Edwards J., Latreille P., Courtney L., Cloud J., Abbott A., Scott K.,
Johnson D., Minx P., Bentley D., Fulton B., Miller N., Greco T., Kemp K.,
Kramer J., Fulton L., Mardis E., Dante M., Pepin K., Hillier L.W.,
Nelson J., Spieth J., Ryan E., Andrews S., Geisel C., Layman D., Du H.,
Ali J., Berghoff A., Jones K., Drone K., Cotton M., Joshu C., Antonoiu B.,
Zidanic M., Strong C., Sun H., Lamar B., Yordan C., Ma P., Zhong J.,
Preston R., Vil D., Shekher M., Matero A., Shah R., Swaby I.K.,
O'Shaughnessy A., Rodriguez M., Hoffman J., Till S., Granat S., Shohdy N.,
Hasegawa A., Hameed A., Lodhi M., Johnson A., Chen E., Marra M.A.,
Martienssen R., McCombie W.R.;
"Sequence and analysis of chromosome 4 of the plant Arabidopsis thaliana.";
Nature 402:769-777(1999).
[3]
GENOME REANNOTATION.
STRAIN=cv. Columbia;
PubMed=27862469; DOI=10.1111/tpj.13415;
Cheng C.Y., Krishnakumar V., Chan A.P., Thibaud-Nissen F., Schobel S.,
Town C.D.;
"Araport11: a complete reannotation of the Arabidopsis thaliana reference
genome.";
Plant J. 89:789-804(2017).
[4]
TISSUE SPECIFICITY, IDENTIFICATION OF THE ARP2/3 COMPLEX, AND DISRUPTION
PHENOTYPE.
PubMed=12913159; DOI=10.1104/pp.103.028563;
Li S., Blanchoin L., Yang Z., Lord E.M.;
"The putative Arabidopsis arp2/3 complex controls leaf cell
morphogenesis.";
Plant Physiol. 132:2034-2044(2003).
[5]
INTERACTION WITH ARPC2A, AND TISSUE SPECIFICITY.
PubMed=15086808; DOI=10.1111/j.1365-313x.2004.02065.x;
El-Din El-Assal S., Le J., Basu D., Mallery E.L., Szymanski D.B.;
"DISTORTED2 encodes an ARPC2 subunit of the putative Arabidopsis ARP2/3
complex.";
Plant J. 38:526-538(2004).
[6]
REVIEW.
PubMed=15653407; DOI=10.1016/j.pbi.2004.11.004;
Szymanski D.B.;
"Breaking the WAVE complex: the point of Arabidopsis trichomes.";
Curr. Opin. Plant Biol. 8:103-112(2005).
[7]
DISRUPTION PHENOTYPE, FUNCTION, IDENTIFICATION IN THE ARP2/3 COMPLEX, AND
INTERACTION WITH ARP3.
PubMed=19801398; DOI=10.1104/pp.109.143859;
Kotchoni S.O., Zakharova T., Mallery E.L., Le J., El-Din El-Assal S.,
Szymanski D.B.;
"The association of the Arabidopsis actin-related protein2/3 complex with
cell membranes is linked to its assembly status but not its activation.";
Plant Physiol. 151:2095-2109(2009).
-!- FUNCTION: Functions as actin-binding component of the Arp2/3 complex
which is involved in regulation of actin polymerization and together
with an activating nucleation-promoting factor (NPF) mediates the
formation of branched actin networks. Seems to contact the mother actin
filament (By similarity). Arp2/3 complex plays a critical role in the
control of cell morphogenesis via the modulation of cell polarity
development. {ECO:0000250, ECO:0000269|PubMed:19801398}.
-!- SUBUNIT: Component of the Arp2/3 complex composed of ARP2, ARP3,
ARPC1/p41-ARC, ARPC2/p34-ARC, ARPC3/p21-ARC, ARPC4/p20-ARC and
ARPC5/p16-ARC. Interacts with ARPC2A and ARP3.
{ECO:0000269|PubMed:15086808, ECO:0000269|PubMed:19801398}.
-!- INTERACTION:
F4JUL9; Q8LGI3: ARPC2A; NbExp=3; IntAct=EBI-1547718, EBI-1547736;
-!- SUBCELLULAR LOCATION: Cytoplasm, cytoskeleton {ECO:0000250}. Cell
projection {ECO:0000250}.
-!- ALTERNATIVE PRODUCTS:
Event=Alternative initiation; Named isoforms=1;
Comment=A number of isoforms are produced. According to EST
sequences.;
Name=1;
IsoId=F4JUL9-1; Sequence=Displayed;
-!- TISSUE SPECIFICITY: Expressed at low levels in all tissues with a
relatively highest expression in inflorescences.
{ECO:0000269|PubMed:12913159, ECO:0000269|PubMed:15086808}.
-!- DISRUPTION PHENOTYPE: Distorted trichomes and altered epidermal cell
types. {ECO:0000269|PubMed:12913159, ECO:0000269|PubMed:19801398}.
-!- SIMILARITY: Belongs to the ARPC4 family. {ECO:0000305}.
-!- SEQUENCE CAUTION:
Sequence=CAB10194.1; Type=Erroneous gene model prediction; Note=The predicted gene has been split into 3 genes: At4g14145, At4g14147 and At4g14150.; Evidence={ECO:0000305};
Sequence=CAB78457.1; Type=Erroneous gene model prediction; Note=The predicted gene has been split into 3 genes: At4g14145, At4g14147 and At4g14150.; Evidence={ECO:0000305};
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EMBL; Z97335; CAB10194.1; ALT_SEQ; Genomic_DNA.
EMBL; AL161538; CAB78457.1; ALT_SEQ; Genomic_DNA.
EMBL; CP002687; AEE83382.1; -; Genomic_DNA.
EMBL; CP002687; ANM66065.1; -; Genomic_DNA.
RefSeq; NP_001031632.1; NM_001036555.3. [F4JUL9-1]
RefSeq; NP_001319932.1; NM_001340903.1. [F4JUL9-1]
SMR; F4JUL9; -.
BioGRID; 530765; 7.
IntAct; F4JUL9; 5.
STRING; 3702.AT4G14147.2; -.
PRIDE; F4JUL9; -.
ProteomicsDB; 246675; -. [F4JUL9-1]
EnsemblPlants; AT4G14147.1; AT4G14147.1; AT4G14147. [F4JUL9-1]
EnsemblPlants; AT4G14147.3; AT4G14147.3; AT4G14147. [F4JUL9-1]
GeneID; 3770404; -.
Gramene; AT4G14147.1; AT4G14147.1; AT4G14147. [F4JUL9-1]
Gramene; AT4G14147.3; AT4G14147.3; AT4G14147. [F4JUL9-1]
KEGG; ath:AT4G14147; -.
Araport; AT4G14147; -.
eggNOG; KOG1876; Eukaryota.
HOGENOM; CLU_084855_1_0_1; -.
OMA; RFMMQRA; -.
PhylomeDB; F4JUL9; -.
PRO; PR:F4JUL9; -.
Proteomes; UP000006548; Chromosome 4.
ExpressionAtlas; F4JUL9; baseline and differential.
GO; GO:0005885; C:Arp2/3 protein complex; IEA:InterPro.
GO; GO:0042995; C:cell projection; IEA:UniProtKB-SubCell.
GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-KW.
GO; GO:0003779; F:actin binding; IEA:UniProtKB-KW.
GO; GO:0030041; P:actin filament polymerization; IEA:InterPro.
GO; GO:0034314; P:Arp2/3 complex-mediated actin nucleation; IEA:InterPro.
Gene3D; 3.30.1460.20; -; 1.
InterPro; IPR034666; ARPC2/4.
InterPro; IPR008384; ARPC4.
PANTHER; PTHR22629; PTHR22629; 1.
Pfam; PF05856; ARPC4; 1.
PIRSF; PIRSF039100; ARPC4; 1.
SUPFAM; SSF69645; SSF69645; 1.
1: Evidence at protein level;
Actin-binding; Alternative initiation; Cell projection; Cytoplasm;
Cytoskeleton; Reference proteome.
CHAIN 1..169
/note="Actin-related protein 2/3 complex subunit 4"
/id="PRO_0000422531"
SEQUENCE 169 AA; 19858 MW; 5CB3BFF947D083AF CRC64;
MANSLRLYLA CIKNTLEAAM CLQNFPCQEV ERHNKPEVEL KTSPELLLNP VLICRNEAEK
CLIETSINSL RISLKVKQAD ELENILTKKF LRFLSMRAEA FQVLRRKPVQ GYDISFLITN
YHCEEMQKQK LIDFIIQFME DIEKEIRDLK ESVNTRGRLV ATEFLKQFM


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Pathways :
WP2272: Pathogenic Escherichia coli infection
WP2292: Chemokine signaling pathway
WP731: Sterol regulatory element binding protein related
WP1693: Purine metabolism
WP1663: Homologous recombination
WP1672: Mismatch repair
WP1644: DNA replication
WP1566: Citrate cycle (TCA cycle)
WP1694: Pyrimidine metabolism
WP2199: Seed Development
WP1493: Carbon assimilation C4 pathway
WP1689: Porphyrin and chlorophyll metabolism
WP2411: Cancer prevention Q
WP1019: FAS pathway and Stress induction of HSP regulation
WP1650: Fluorobenzoate degradation
WP201: Ptf1a related regulatory pathway
WP1102: EBV LMP1 signaling
WP1657: Glycerolipid metabolism
WP2083: Nicotine Activity on Dopaminergic Neurons
WP788: FAS pathway and Stress induction of HSP regulation
WP1531: Vitamin D synthesis
WP262: EBV LMP1 signaling
WP1571: EBV LMP1 signaling
WP1711: Trinitrotoluene degradation
WP346: Protein Modifications

Related Genes :
[arcD Arc19 arpG DDB_G0269102] Actin-related protein 2/3 complex subunit 4 (Arp2/3 complex 20 kDa subunit) (p20-ARC)
[arcB Arc35 arpE DDB_G0282813] Actin-related protein 2/3 complex subunit 2 (Arp2/3 complex 34 kDa subunit) (p34-ARC)
[arcA Arc40 arpD DDB_G0277825] Actin-related protein 2/3 complex subunit 1 (Arp2/3 complex 41 kDa subunit) (p41-Arc)
[arcE Arc15 arpH DDB_G0288319] Actin-related protein 2/3 complex subunit 5 (Arp2/3 complex 16 kDa subunit) (p16-ARC)
[arcC Arc18 arpF DDB_G0292804] Actin-related protein 2/3 complex subunit 3 (Arp2/3 complex 21 kDa subunit) (p21-ARC)
[arc3 arc21 SPBC1778.08c] Actin-related protein 2/3 complex subunit 3 (Arp2/3 complex 21 kDa subunit) (p21-ARC)
[arpB arp2 DDB_G0272106] Actin-related protein 2 (Actin-like protein 2) (Actin-related protein B)
[ACTR2 ARP2] Actin-related protein 2 (Actin-like protein 2)
[Actr2 Arp2] Actin-related protein 2 (Actin-like protein 2)
[Actr2 Arp2] Actin-related protein 2 (Actin-like protein 2)
[arpC aclA act DDB_G0283755] Actin-related protein 3 (Actin-like protein 3) (Actin-related protein C)
[env] Envelope glycoprotein gp160 (Env polyprotein) [Cleaved into: Surface protein gp120 (SU) (Glycoprotein 120) (gp120); Transmembrane protein gp41 (TM) (Glycoprotein 41) (gp41)]
[env] Envelope glycoprotein gp160 (Env polyprotein) [Cleaved into: Surface protein gp120 (SU) (Glycoprotein 120) (gp120); Transmembrane protein gp41 (TM) (Glycoprotein 41) (gp41)]
[ARPC4] Actin-related protein 2/3 complex subunit 4 (Arp2/3 complex 20 kDa subunit) (p20-ARC)
[AP4M1 MUARP2] AP-4 complex subunit mu-1 (AP-4 adaptor complex mu subunit) (Adaptor-related protein complex 4 subunit mu-1) (Mu subunit of AP-4) (Mu-adaptin-related protein 2) (mu-ARP2) (Mu4-adaptin) (mu4)
[nef] Protein Nef (3'ORF) (Negative factor) (F-protein) [Cleaved into: C-terminal core protein]
[Smarcc1 Baf155 Srg3] SWI/SNF complex subunit SMARCC1 (BRG1-associated factor 155) (SWI/SNF complex 155 kDa subunit) (SWI/SNF-related matrix-associated actin-dependent regulator of chromatin subfamily C member 1) (SWI3-related protein) (BAF155)
[ARPC3] Actin-related protein 2/3 complex subunit 3 (Arp2/3 complex 21 kDa subunit) (p21-ARC)
[ARPC5] Actin-related protein 2/3 complex subunit 5 (Arp2/3 complex 16 kDa subunit) (p16-ARC)
[Actr3 Arp3] Actin-related protein 3 (Actin-like protein 3)
[ARPC2] Actin-related protein 2/3 complex subunit 2 (Arp2/3 complex 34 kDa subunit) (p34-ARC)
[ACTR3 ARP3] Actin-related protein 3 (Actin-like protein 3)
[Actr3 Arp3] Actin-related protein 3 (Actin-like protein 3)
[Casp4 Casp11 Caspl Ich3] Caspase-4 (CASP-4) (EC 3.4.22.64) (Caspase-11) (CASP-11) (Protease ICH-3) [Cleaved into: Caspase-4 subunit p10; Caspase-4 subunit p20]
[nef] Protein Nef (3'ORF) (Negative factor) (F-protein) [Cleaved into: C-terminal core protein]
[CARMIL2 LRRC16C RLTPR] Capping protein, Arp2/3 and myosin-I linker protein 2 (Capping protein regulator and myosin 1 linker 2) (F-actin-uncapping protein RLTPR) (Leucine-rich repeat-containing protein 16C) (RGD, leucine-rich repeat, tropomodulin and proline-rich-containing protein)
[Carmil2 Lrrc16c Rltpr] Capping protein, Arp2/3 and myosin-I linker protein 2 (Capping protein regulator and myosin 1 linker 2) (F-actin-uncapping protein RLTPR) (Leucine-rich repeat-containing protein 16C) (RGD, leucine-rich repeat, tropomodulin and proline-rich-containing protein)
[SMARCC2 BAF170] SWI/SNF complex subunit SMARCC2 (BRG1-associated factor 170) (BAF170) (SWI/SNF complex 170 kDa subunit) (SWI/SNF-related matrix-associated actin-dependent regulator of chromatin subfamily C member 2)
[ACTR2 ARP2] Actin-related protein 2 (Actin-like protein 2)
[ACTL6A BAF53 BAF53A INO80K] Actin-like protein 6A (53 kDa BRG1-associated factor A) (Actin-related protein Baf53a) (ArpNbeta) (BRG1-associated factor 53A) (BAF53A) (INO80 complex subunit K)

Bibliography :