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Actin-related protein 2/3 complex subunit 4 (Arp2/3 complex 20 kDa subunit) (p20-ARC)

 ARPC4_BOVIN             Reviewed;         168 AA.
Q148J6;
12-DEC-2006, integrated into UniProtKB/Swiss-Prot.
23-JAN-2007, sequence version 3.
07-APR-2021, entry version 107.
RecName: Full=Actin-related protein 2/3 complex subunit 4;
AltName: Full=Arp2/3 complex 20 kDa subunit;
Short=p20-ARC;
Name=ARPC4;
Bos taurus (Bovine).
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
Eutheria; Laurasiatheria; Artiodactyla; Ruminantia; Pecora; Bovidae;
Bovinae; Bos.
NCBI_TaxID=9913;
[1]
NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
STRAIN=Hereford; TISSUE=Basal ganglia;
NIH - Mammalian Gene Collection (MGC) project;
Submitted (JUN-2006) to the EMBL/GenBank/DDBJ databases.
[2]
X-RAY CRYSTALLOGRAPHY (2.0 ANGSTROMS) OF ARP2/3 COMPLEX.
PubMed=11721045; DOI=10.1126/science.1066333;
Robinson R.C., Turbedsky K., Kaiser D.A., Marchand J.-B., Higgs H.N.,
Choe S., Pollard T.D.;
"Crystal structure of Arp2/3 complex.";
Science 294:1679-1684(2001).
[3]
X-RAY CRYSTALLOGRAPHY (2.55 ANGSTROMS) OF ARP2/3 COMPLEX WITH BOUND ATP.
PubMed=15505213; DOI=10.1073/pnas.0407149101;
Nolen B.J., Littlefield R.S., Pollard T.D.;
"Crystal structures of actin-related protein 2/3 complex with bound ATP or
ADP.";
Proc. Natl. Acad. Sci. U.S.A. 101:15627-15632(2004).
-!- FUNCTION: Actin-binding component of the Arp2/3 complex, a multiprotein
complex that mediates actin polymerization upon stimulation by
nucleation-promoting factor (NPF). The Arp2/3 complex mediates the
formation of branched actin networks in the cytoplasm, providing the
force for cell motility. In addition to its role in the cytoplasmic
cytoskeleton, the Arp2/3 complex also promotes actin polymerization in
the nucleus, thereby regulating gene transcription and repair of
damaged DNA. The Arp2/3 complex promotes homologous recombination (HR)
repair in response to DNA damage by promoting nuclear actin
polymerization, leading to drive motility of double-strand breaks
(DSBs). {ECO:0000250|UniProtKB:P59998}.
-!- SUBUNIT: Component of the Arp2/3 complex composed of ACTR2/ARP2,
ACTR3/ARP3, ARPC1B/p41-ARC, ARPC2/p34-ARC, ARPC3/p21-ARC, ARPC4/p20-ARC
and ARPC5/p16-ARC. {ECO:0000269|PubMed:11721045,
ECO:0000269|PubMed:15505213}.
-!- SUBCELLULAR LOCATION: Cytoplasm, cytoskeleton
{ECO:0000250|UniProtKB:P59998}. Cell projection
{ECO:0000250|UniProtKB:P59998}. Nucleus {ECO:0000250|UniProtKB:P59998}.
-!- SIMILARITY: Belongs to the ARPC4 family. {ECO:0000305}.
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EMBL; BC118263; AAI18264.1; -; mRNA.
RefSeq; NP_001069631.1; NM_001076163.1.
PDB; 1K8K; X-ray; 2.00 A; F=1-168.
PDB; 1TYQ; X-ray; 2.55 A; F=1-168.
PDB; 1U2V; X-ray; 2.55 A; F=1-168.
PDB; 2P9I; X-ray; 2.46 A; F=1-168.
PDB; 2P9K; X-ray; 2.59 A; F=1-168.
PDB; 2P9L; X-ray; 2.65 A; F=1-168.
PDB; 2P9N; X-ray; 2.85 A; F=1-168.
PDB; 2P9P; X-ray; 2.90 A; F=1-168.
PDB; 2P9S; X-ray; 2.68 A; F=1-168.
PDB; 2P9U; X-ray; 2.75 A; F=1-168.
PDB; 3DXK; X-ray; 2.70 A; F=1-168.
PDB; 3DXM; X-ray; 2.85 A; F=1-168.
PDB; 3RSE; X-ray; 2.65 A; F=1-168.
PDB; 3UKR; X-ray; 2.48 A; F=1-168.
PDB; 3UKU; X-ray; 2.75 A; F=1-168.
PDB; 3ULE; X-ray; 2.50 A; F=1-168.
PDB; 4JD2; X-ray; 3.08 A; F=1-168.
PDB; 4XEI; X-ray; 3.87 A; F=1-168.
PDB; 4XF2; X-ray; 5.00 A; F/Y=1-168.
PDB; 6DEC; X-ray; 4.60 A; F/N=1-168.
PDBsum; 1K8K; -.
PDBsum; 1TYQ; -.
PDBsum; 1U2V; -.
PDBsum; 2P9I; -.
PDBsum; 2P9K; -.
PDBsum; 2P9L; -.
PDBsum; 2P9N; -.
PDBsum; 2P9P; -.
PDBsum; 2P9S; -.
PDBsum; 2P9U; -.
PDBsum; 3DXK; -.
PDBsum; 3DXM; -.
PDBsum; 3RSE; -.
PDBsum; 3UKR; -.
PDBsum; 3UKU; -.
PDBsum; 3ULE; -.
PDBsum; 4JD2; -.
PDBsum; 4XEI; -.
PDBsum; 4XF2; -.
PDBsum; 6DEC; -.
SMR; Q148J6; -.
DIP; DIP-29794N; -.
IntAct; Q148J6; 2.
STRING; 9913.ENSBTAP00000010469; -.
PaxDb; Q148J6; -.
PRIDE; Q148J6; -.
Ensembl; ENSBTAT00000070990; ENSBTAP00000064283; ENSBTAG00000007964.
GeneID; 539459; -.
KEGG; bta:539459; -.
CTD; 10093; -.
eggNOG; KOG1876; Eukaryota.
GeneTree; ENSGT00390000016233; -.
HOGENOM; CLU_084855_1_0_1; -.
InParanoid; Q148J6; -.
OMA; RFMMQRA; -.
OrthoDB; 1351067at2759; -.
TreeFam; TF105621; -.
Reactome; R-BTA-2029482; Regulation of actin dynamics for phagocytic cup formation.
Reactome; R-BTA-5663213; RHO GTPases Activate WASPs and WAVEs.
EvolutionaryTrace; Q148J6; -.
Proteomes; UP000009136; Chromosome 22.
Bgee; ENSBTAG00000007964; Expressed in placenta and 19 other tissues.
ExpressionAtlas; Q148J6; baseline and differential.
GO; GO:0005885; C:Arp2/3 protein complex; ISS:UniProtKB.
GO; GO:0042995; C:cell projection; IEA:UniProtKB-SubCell.
GO; GO:0005829; C:cytosol; TAS:Reactome.
GO; GO:0005634; C:nucleus; ISS:UniProtKB.
GO; GO:0035861; C:site of double-strand break; ISS:UniProtKB.
GO; GO:0003779; F:actin binding; IEA:UniProtKB-KW.
GO; GO:0030041; P:actin filament polymerization; IEA:InterPro.
GO; GO:0034314; P:Arp2/3 complex-mediated actin nucleation; IEA:InterPro.
Gene3D; 3.30.1460.20; -; 1.
InterPro; IPR034666; ARPC2/4.
InterPro; IPR008384; ARPC4.
PANTHER; PTHR22629; PTHR22629; 1.
Pfam; PF05856; ARPC4; 1.
PIRSF; PIRSF039100; ARPC4; 1.
SUPFAM; SSF69645; SSF69645; 1.
1: Evidence at protein level;
3D-structure; Acetylation; Actin-binding; Cell projection; Cytoplasm;
Cytoskeleton; Nucleus; Reference proteome.
INIT_MET 1
/note="Removed"
/evidence="ECO:0000250|UniProtKB:P59998"
CHAIN 2..168
/note="Actin-related protein 2/3 complex subunit 4"
/id="PRO_0000269565"
MOD_RES 2
/note="N-acetylthreonine"
/evidence="ECO:0000250|UniProtKB:P59998"
HELIX 5..19
/evidence="ECO:0007744|PDB:1K8K"
STRAND 28..30
/evidence="ECO:0007744|PDB:1K8K"
HELIX 37..40
/evidence="ECO:0007744|PDB:1K8K"
HELIX 44..46
/evidence="ECO:0007744|PDB:1K8K"
STRAND 51..58
/evidence="ECO:0007744|PDB:1K8K"
STRAND 60..75
/evidence="ECO:0007744|PDB:1K8K"
HELIX 81..96
/evidence="ECO:0007744|PDB:1K8K"
TURN 97..100
/evidence="ECO:0007744|PDB:1K8K"
STRAND 102..104
/evidence="ECO:0007744|PDB:3UKR"
STRAND 113..119
/evidence="ECO:0007744|PDB:1K8K"
HELIX 120..125
/evidence="ECO:0007744|PDB:1K8K"
HELIX 128..165
/evidence="ECO:0007744|PDB:1K8K"
SEQUENCE 168 AA; 19667 MW; 273CCB230AC703DF CRC64;
MTATLRPYLS AVRATLQAAL CLENFSSQVV ERHNKPEVEV RSSKELLLQP VTISRNEKEK
VLIEGSINSV RVSIAVKQAD EIEKILCHKF MRFMMMRAEN FFILRRKPVE GYDISFLITN
FHTEQMYKHK LVDFVIHFME EIDKEISEMK LSVNARARIV AEEFLKNF


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Related Genes :
[arcD Arc19 arpG DDB_G0269102] Actin-related protein 2/3 complex subunit 4 (Arp2/3 complex 20 kDa subunit) (p20-ARC)
[arcB Arc35 arpE DDB_G0282813] Actin-related protein 2/3 complex subunit 2 (Arp2/3 complex 34 kDa subunit) (p34-ARC)
[arcA Arc40 arpD DDB_G0277825] Actin-related protein 2/3 complex subunit 1 (Arp2/3 complex 41 kDa subunit) (p41-Arc)
[arcE Arc15 arpH DDB_G0288319] Actin-related protein 2/3 complex subunit 5 (Arp2/3 complex 16 kDa subunit) (p16-ARC)
[arcC Arc18 arpF DDB_G0292804] Actin-related protein 2/3 complex subunit 3 (Arp2/3 complex 21 kDa subunit) (p21-ARC)
[arc3 arc21 SPBC1778.08c] Actin-related protein 2/3 complex subunit 3 (Arp2/3 complex 21 kDa subunit) (p21-ARC)
[arpB arp2 DDB_G0272106] Actin-related protein 2 (Actin-like protein 2) (Actin-related protein B)
[ACTR2 ARP2] Actin-related protein 2 (Actin-like protein 2)
[ARPC4] Actin-related protein 2/3 complex subunit 4 (Arp2/3 complex 20 kDa subunit) (p20-ARC)
[Actr2 Arp2] Actin-related protein 2 (Actin-like protein 2)
[Actr2 Arp2] Actin-related protein 2 (Actin-like protein 2)
[AP4M1 MUARP2] AP-4 complex subunit mu-1 (AP-4 adaptor complex mu subunit) (Adaptor-related protein complex 4 subunit mu-1) (Mu subunit of AP-4) (Mu-adaptin-related protein 2) (mu-ARP2) (Mu4-adaptin) (mu4)
[Casp4 Casp11 Caspl Ich3] Caspase-4 (CASP-4) (EC 3.4.22.64) (Caspase-11) (CASP-11) (Protease ICH-3) [Cleaved into: Caspase-4 subunit p10; Caspase-4 subunit p20]
[arpC aclA act DDB_G0283755] Actin-related protein 3 (Actin-like protein 3) (Actin-related protein C)
[Casp7 Lice2 Mch3] Caspase-7 (CASP-7) (EC 3.4.22.60) (Apoptotic protease Mch-3) (Cysteine protease LICE2) [Cleaved into: Caspase-7 subunit p20; Caspase-7 subunit p11]
[carmil DDB_G0292386] Protein CARMIL (dDcarmil) (Capping protein, arp2/3 and myosin I linker) (Leucine-rich repeat-containing protein p116) (p116)
[ARPC3] Actin-related protein 2/3 complex subunit 3 (Arp2/3 complex 21 kDa subunit) (p21-ARC)
[ARPC5] Actin-related protein 2/3 complex subunit 5 (Arp2/3 complex 16 kDa subunit) (p16-ARC)
[ARPC2] Actin-related protein 2/3 complex subunit 2 (Arp2/3 complex 34 kDa subunit) (p34-ARC)
[CASP4 ICH2] Caspase-4 (CASP-4) (EC 3.4.22.57) (ICE and Ced-3 homolog 2) (ICH-2) (ICE(rel)-II) (Mih1) (Protease TX) [Cleaved into: Caspase-4 subunit p10; Caspase-4 subunit p20]
[env] Envelope glycoprotein gp160 (Env polyprotein) [Cleaved into: Surface protein gp120 (SU) (Glycoprotein 120) (gp120); Transmembrane protein gp41 (TM) (Glycoprotein 41) (gp41)]
[env] Envelope glycoprotein gp160 (Env polyprotein) [Cleaved into: Surface protein gp120 (SU) (Glycoprotein 120) (gp120); Transmembrane protein gp41 (TM) (Glycoprotein 41) (gp41)]
[S] Spike glycoprotein (S glycoprotein) (E2) (Peplomer protein) [Cleaved into: Spike protein S1; Spike protein S2; Spike protein S2']
[env] Envelope glycoprotein gp160 (Env polyprotein) [Cleaved into: Surface protein gp120 (SU) (Glycoprotein 120) (gp120); Transmembrane protein gp41 (TM) (Glycoprotein 41) (gp41)]
[CASP7 MCH3] Caspase-7 (CASP-7) (EC 3.4.22.60) (Apoptotic protease Mch-3) (CMH-1) (ICE-like apoptotic protease 3) (ICE-LAP3) [Cleaved into: Caspase-7 subunit p20; Caspase-7 subunit p11]
[env] Envelope glycoprotein gp160 (Env polyprotein) [Cleaved into: Surface protein gp120 (SU) (Glycoprotein 120) (gp120); Transmembrane protein gp41 (TM) (Glycoprotein 41) (gp41)]
[CARMIL2 LRRC16C RLTPR] Capping protein, Arp2/3 and myosin-I linker protein 2 (Capping protein regulator and myosin 1 linker 2) (F-actin-uncapping protein RLTPR) (Leucine-rich repeat-containing protein 16C) (RGD, leucine-rich repeat, tropomodulin and proline-rich-containing protein)
[Carmil2 Lrrc16c Rltpr] Capping protein, Arp2/3 and myosin-I linker protein 2 (Capping protein regulator and myosin 1 linker 2) (F-actin-uncapping protein RLTPR) (Leucine-rich repeat-containing protein 16C) (RGD, leucine-rich repeat, tropomodulin and proline-rich-containing protein)
[MCA2 Tb927.6.940] Metacaspase-2 (EC 3.4.22.-) (TbMCA2) [Cleaved into: Large subunit p20; Small subunit p10]
[nef] Protein Nef (3'ORF) (Negative factor) (F-protein) [Cleaved into: C-terminal core protein]

Bibliography :
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