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Activation peptide fragment 1 (EC 3 4 21 5) (Activation peptide fragment 2) (Coagulation factor II) (Prothrombin) (Thrombin heavy chain) (Thrombin light chain)

 W5P1L7_SHEEP            Unreviewed;       666 AA.
W5P1L7;
16-APR-2014, integrated into UniProtKB/TrEMBL.
16-APR-2014, sequence version 1.
29-SEP-2021, entry version 59.
RecName: Full=Activation peptide fragment 1 {ECO:0000256|ARBA:ARBA00013849};
EC=3.4.21.5 {ECO:0000256|ARBA:ARBA00012174};
AltName: Full=Activation peptide fragment 2 {ECO:0000256|ARBA:ARBA00013851};
AltName: Full=Coagulation factor II {ECO:0000256|ARBA:ARBA00019447};
AltName: Full=Prothrombin {ECO:0000256|ARBA:ARBA00014840};
AltName: Full=Thrombin heavy chain {ECO:0000256|ARBA:ARBA00022013};
AltName: Full=Thrombin light chain {ECO:0000256|ARBA:ARBA00014325};
Name=F2 {ECO:0000313|Ensembl:ENSOARP00000004316};
Ovis aries (Sheep).
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
Eutheria; Laurasiatheria; Artiodactyla; Ruminantia; Pecora; Bovidae;
Caprinae; Ovis.
NCBI_TaxID=9940 {ECO:0000313|Ensembl:ENSOARP00000004316, ECO:0000313|Proteomes:UP000002356};
[1] {ECO:0000313|Ensembl:ENSOARP00000004316, ECO:0000313|Proteomes:UP000002356}
NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
STRAIN=Texel {ECO:0000313|Ensembl:ENSOARP00000004316,
ECO:0000313|Proteomes:UP000002356};
PubMed=20809919; DOI=10.1111/j.1365-2052.2010.02100.x;
Archibald A.L., Cockett N.E., Dalrymple B.P., Faraut T., Kijas J.W.,
Maddox J.F., McEwan J.C., Hutton Oddy V., Raadsma H.W., Wade C., Wang J.,
Wang W., Xun X.;
"The sheep genome reference sequence: a work in progress.";
Anim. Genet. 41:449-453(2010).
[2] {ECO:0000313|Ensembl:ENSOARP00000004316}
IDENTIFICATION.
Ensembl;
Submitted (FEB-2014) to UniProtKB.
-!- CATALYTIC ACTIVITY:
Reaction=Selective cleavage of Arg-|-Gly bonds in fibrinogen to form
fibrin and release fibrinopeptides A and B.; EC=3.4.21.5;
Evidence={ECO:0000256|ARBA:ARBA00001621};
-!- CAUTION: Lacks conserved residue(s) required for the propagation of
feature annotation. {ECO:0000256|PROSITE-ProRule:PRU00121}.
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EMBL; AMGL01033363; -; NOT_ANNOTATED_CDS; Genomic_DNA.
SMR; W5P1L7; -.
STRING; 9940.ENSOARP00000004316; -.
Ensembl; ENSOART00000004392; ENSOARP00000004316; ENSOARG00000004038.
eggNOG; ENOG502QTSX; Eukaryota.
HOGENOM; CLU_006842_19_4_1; -.
OMA; VMIFRKS; -.
Proteomes; UP000002356; Chromosome 15.
GO; GO:0009897; C:external side of plasma membrane; IEA:Ensembl.
GO; GO:0005615; C:extracellular space; IEA:Ensembl.
GO; GO:0005509; F:calcium ion binding; IEA:InterPro.
GO; GO:0008201; F:heparin binding; IEA:Ensembl.
GO; GO:0001530; F:lipopolysaccharide binding; IEA:Ensembl.
GO; GO:0004252; F:serine-type endopeptidase activity; IEA:UniProtKB-EC.
GO; GO:0005102; F:signaling receptor binding; IEA:Ensembl.
GO; GO:0070053; F:thrombospondin receptor activity; IEA:Ensembl.
GO; GO:0006953; P:acute-phase response; IEA:UniProtKB-KW.
GO; GO:0061844; P:antimicrobial humoral immune response mediated by antimicrobial peptide; IEA:Ensembl.
GO; GO:0007166; P:cell surface receptor signaling pathway; IEA:Ensembl.
GO; GO:0051838; P:cytolysis by host of symbiont cells; IEA:Ensembl.
GO; GO:0042730; P:fibrinolysis; IEA:Ensembl.
GO; GO:0048712; P:negative regulation of astrocyte differentiation; IEA:Ensembl.
GO; GO:1900016; P:negative regulation of cytokine production involved in inflammatory response; IEA:Ensembl.
GO; GO:0045861; P:negative regulation of proteolysis; IEA:Ensembl.
GO; GO:0070945; P:neutrophil-mediated killing of gram-negative bacterium; IEA:Ensembl.
GO; GO:0030168; P:platelet activation; IEA:Ensembl.
GO; GO:0030194; P:positive regulation of blood coagulation; IEA:Ensembl.
GO; GO:0030307; P:positive regulation of cell growth; IEA:Ensembl.
GO; GO:0008284; P:positive regulation of cell population proliferation; IEA:Ensembl.
GO; GO:0032967; P:positive regulation of collagen biosynthetic process; IEA:Ensembl.
GO; GO:0090218; P:positive regulation of lipid kinase activity; IEA:Ensembl.
GO; GO:0014068; P:positive regulation of phosphatidylinositol 3-kinase signaling; IEA:Ensembl.
GO; GO:1900738; P:positive regulation of phospholipase C-activating G protein-coupled receptor signaling pathway; IEA:Ensembl.
GO; GO:1900182; P:positive regulation of protein localization to nucleus; IEA:Ensembl.
GO; GO:0001934; P:positive regulation of protein phosphorylation; IEA:Ensembl.
GO; GO:2000379; P:positive regulation of reactive oxygen species metabolic process; IEA:Ensembl.
GO; GO:0051281; P:positive regulation of release of sequestered calcium ion into cytosol; IEA:Ensembl.
GO; GO:0008360; P:regulation of cell shape; IEA:Ensembl.
CDD; cd00108; KR; 2.
CDD; cd00190; Tryp_SPc; 1.
Gene3D; 2.40.10.10; -; 2.
Gene3D; 2.40.20.10; -; 2.
Gene3D; 4.10.140.10; -; 1.
InterPro; IPR035972; GLA-like_dom_SF.
InterPro; IPR000294; GLA_domain.
InterPro; IPR000001; Kringle.
InterPro; IPR013806; Kringle-like.
InterPro; IPR018056; Kringle_CS.
InterPro; IPR038178; Kringle_sf.
InterPro; IPR009003; Peptidase_S1_PA.
InterPro; IPR043504; Peptidase_S1_PA_chymotrypsin.
InterPro; IPR001314; Peptidase_S1A.
InterPro; IPR003966; Prothrombin/thrombin.
InterPro; IPR018992; Thrombin_light_chain.
InterPro; IPR037111; Thrombin_light_chain_sf.
InterPro; IPR001254; Trypsin_dom.
InterPro; IPR018114; TRYPSIN_HIS.
InterPro; IPR033116; TRYPSIN_SER.
PANTHER; PTHR24254:SF10; PTHR24254:SF10; 1.
Pfam; PF00594; Gla; 1.
Pfam; PF00051; Kringle; 2.
Pfam; PF09396; Thrombin_light; 1.
Pfam; PF00089; Trypsin; 1.
PIRSF; PIRSF001149; Thrombin; 1.
PRINTS; PR00722; CHYMOTRYPSIN.
PRINTS; PR00001; GLABLOOD.
PRINTS; PR01505; PROTHROMBIN.
SMART; SM00069; GLA; 1.
SMART; SM00130; KR; 2.
SMART; SM00020; Tryp_SPc; 1.
SUPFAM; SSF50494; SSF50494; 1.
SUPFAM; SSF57440; SSF57440; 2.
SUPFAM; SSF57630; SSF57630; 1.
PROSITE; PS00011; GLA_1; 1.
PROSITE; PS50998; GLA_2; 1.
PROSITE; PS00021; KRINGLE_1; 2.
PROSITE; PS50070; KRINGLE_2; 2.
PROSITE; PS50240; TRYPSIN_DOM; 1.
PROSITE; PS00134; TRYPSIN_HIS; 1.
PROSITE; PS00135; TRYPSIN_SER; 1.
4: Predicted;
Acute phase {ECO:0000256|ARBA:ARBA00022486};
Blood coagulation {ECO:0000256|ARBA:ARBA00023084};
Disulfide bond {ECO:0000256|ARBA:ARBA00023157,
ECO:0000256|PIRSR:PIRSR001149-4};
Hemostasis {ECO:0000256|ARBA:ARBA00023084};
Hydrolase {ECO:0000256|RuleBase:RU363034};
Kringle {ECO:0000256|ARBA:ARBA00022572, ECO:0000256|PROSITE-
ProRule:PRU00121}; Protease {ECO:0000256|RuleBase:RU363034};
Reference proteome {ECO:0000313|Proteomes:UP000002356};
Serine protease {ECO:0000256|RuleBase:RU363034};
Zymogen {ECO:0000256|ARBA:ARBA00023145}.
DOMAIN 86..132
/note="Gla"
/evidence="ECO:0000259|PROSITE:PS50998"
DOMAIN 150..229
/note="Kringle"
/evidence="ECO:0000259|PROSITE:PS50070"
DOMAIN 256..335
/note="Kringle"
/evidence="ECO:0000259|PROSITE:PS50070"
DOMAIN 408..662
/note="Peptidase S1"
/evidence="ECO:0000259|PROSITE:PS50240"
ACT_SITE 450
/note="Charge relay system"
/evidence="ECO:0000256|PIRSR:PIRSR001149-1"
ACT_SITE 506
/note="Charge relay system"
/evidence="ECO:0000256|PIRSR:PIRSR001149-1"
ACT_SITE 612
/note="Charge relay system"
/evidence="ECO:0000256|PIRSR:PIRSR001149-1"
SITE 242..243
/note="Cleavage; by thrombin"
/evidence="ECO:0000256|PIRSR:PIRSR001149-2"
SITE 371..372
/note="Cleavage; by factor Xa"
/evidence="ECO:0000256|PIRSR:PIRSR001149-2"
SITE 407..408
/note="Cleavage; by factor Xa"
/evidence="ECO:0000256|PIRSR:PIRSR001149-2"
DISULFID 103..108
/evidence="ECO:0000256|PIRSR:PIRSR001149-4"
DISULFID 133..146
/evidence="ECO:0000256|PIRSR:PIRSR001149-4"
DISULFID 151..229
/evidence="ECO:0000256|PIRSR:PIRSR001149-4"
DISULFID 172..212
/evidence="ECO:0000256|PIRSR:PIRSR001149-4"
DISULFID 200..224
/evidence="ECO:0000256|PIRSR:PIRSR001149-4"
DISULFID 257..335
/evidence="ECO:0000256|PIRSR:PIRSR001149-4"
DISULFID 278..318
/evidence="ECO:0000256|PIRSR:PIRSR001149-4"
DISULFID 306..330
/evidence="ECO:0000256|PIRSR:PIRSR001149-4"
DISULFID 380..526
/note="Interchain (between light and heavy chains)"
/evidence="ECO:0000256|PIRSR:PIRSR001149-4"
DISULFID 435..451
/evidence="ECO:0000256|PIRSR:PIRSR001149-4"
DISULFID 580..594
/evidence="ECO:0000256|PIRSR:PIRSR001149-4"
DISULFID 608..638
/evidence="ECO:0000256|PIRSR:PIRSR001149-4"
SEQUENCE 666 AA; 74550 MW; 64A51ABA29DAA458 CRC64;
MAGVGSPAAC PYGPELPTSA SRLISSRWFN INPVGSGPAR REVPGVDTPW LPSCLALAAL
FSLAHSQHVF LAHQQASSLL QRARRANKGF LEELRKGNLE RECLEEPCSR EEAFEALESP
SATDVFWAKY TACESARNPR EKLNECLEGN CAEGVGMNYR GNMSVTRSGI ECQLWRSRYP
HKPEINFTTH PGADLRENFC RNPDGSITGP WCYTTSPTLR REACSVPVCD MDDRVTVEVI
PRSGGSTTSQ SPGLEMCVPD RGRGYQGRLA VTTRGSPCLA WSSEQAKALS KDQDFNPAVP
LVENFCRNPD GDEEGAWCYV AGQPGDFEYC DLDYCGEPVD GDLGDGLGED PDAAIEGRTS
EDHFQPFFNE KTFGAGEADC GLRPLFEKKK LQDKTEAELF ESYIEGRIVE GQDAEVGLAP
WQVMLFRKSP QELLCGASLI SDRWVLTAAH CLLYPPWDKN FTEADLLVRI GKHSRTRYER
KVEKISMLDK IYIHPRYNWK ENLDRDIALL KLKRPIEFSE YIHPVCLPDK ETAAKLLRVG
FKGRVTGWGN RRETWTTSVA EVQPSVLQVV NLPLVERPVC KDSTRIRITE NMFCAGYKPG
EGKRGDACEG DSGGPFVMKS PSNNRWYQMG IVSWGEGCDR DGKYGFYTHV FRLKRWIQKV
IDRFGS


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Related Genes :
[F2] Prothrombin (EC 3.4.21.5) (Coagulation factor II) [Cleaved into: Activation peptide fragment 1; Activation peptide fragment 2; Thrombin light chain; Thrombin heavy chain]
[PROC] Vitamin K-dependent protein C (EC 3.4.21.69) (Anticoagulant protein C) (Autoprothrombin IIA) (Blood coagulation factor XIV) [Cleaved into: Vitamin K-dependent protein C light chain; Vitamin K-dependent protein C heavy chain; Activation peptide]
[] Venom prothrombin activator pseutarin-C catalytic subunit (PCCS) (vPA) (EC 3.4.21.6) (Venom coagulation factor Xa-like protease) [Cleaved into: Pseutarin-C catalytic subunit light chain; Pseutarin-C catalytic subunit heavy chain]
[F7] Coagulation factor VII (EC 3.4.21.21) (Proconvertin) (Serum prothrombin conversion accelerator) (SPCA) (Eptacog alfa) [Cleaved into: Factor VII light chain; Factor VII heavy chain]
[F10] Coagulation factor X (EC 3.4.21.6) (Stuart factor) (Stuart-Prower factor) [Cleaved into: Factor X light chain; Factor X heavy chain; Activated factor Xa heavy chain]
[F10] Coagulation factor X (EC 3.4.21.6) (Stuart factor) [Cleaved into: Factor X light chain; Factor X heavy chain; Activated factor Xa heavy chain]
[F10] Coagulation factor X (EC 3.4.21.6) (Stuart factor) [Cleaved into: Factor X light chain; Factor X heavy chain; Activated factor Xa heavy chain]
[F10] Coagulation factor X (EC 3.4.21.6) (Stuart factor) [Cleaved into: Factor X light chain; Factor X heavy chain; Activated factor Xa heavy chain]
[F10 FX] Coagulation factor X (EC 3.4.21.6) (Stuart factor) (Virus-activating protease) (VAP) [Cleaved into: Factor X light chain; Factor X heavy chain; Activated factor Xa heavy chain]
[PLG] Plasminogen (EC 3.4.21.7) [Cleaved into: Plasmin heavy chain A; Activation peptide; Angiostatin; Plasmin heavy chain A, short form; Plasmin light chain B]
[F7 Cf7] Coagulation factor VII (EC 3.4.21.21) (Serum prothrombin conversion accelerator) [Cleaved into: Factor VII light chain; Factor VII heavy chain]
[F7] Coagulation factor VII (EC 3.4.21.21) (Serum prothrombin conversion accelerator) [Cleaved into: Factor VII light chain; Factor VII heavy chain]
[F5] Coagulation factor V (Activated protein C cofactor) (Proaccelerin, labile factor) [Cleaved into: Coagulation factor V heavy chain; Coagulation factor V light chain]
[F7] Coagulation factor VII (EC 3.4.21.21) (Serum prothrombin conversion accelerator) [Cleaved into: Factor VII light chain; Factor VII heavy chain]
[F11] Coagulation factor XI (FXI) (EC 3.4.21.27) (Plasma thromboplastin antecedent) (PTA) [Cleaved into: Coagulation factor XIa heavy chain; Coagulation factor XIa light chain]
[F12] Coagulation factor XII (EC 3.4.21.38) (Hageman factor) (HAF) [Cleaved into: Coagulation factor XIIa heavy chain; Beta-factor XIIa part 1; Coagulation factor XIIa light chain (Beta-factor XIIa part 2)]
[F9] Coagulation factor IX (EC 3.4.21.22) (Christmas factor) (Plasma thromboplastin component) (PTC) [Cleaved into: Coagulation factor IXa light chain; Coagulation factor IXa heavy chain]
[F8 F8C] Coagulation factor VIII (Antihemophilic factor) (AHF) (Procoagulant component) [Cleaved into: Factor VIIIa heavy chain, 200 kDa isoform; Factor VIIIa heavy chain, 92 kDa isoform; Factor VIII B chain; Factor VIIIa light chain]
[F10] Coagulation factor X (EC 3.4.21.6) (Stuart factor) [Cleaved into: Factor X light chain; Factor X heavy chain; Activated factor Xa heavy chain]
[F2 ORTSPA_R05543] Activation peptide fragment 1 (EC 3.4.21.5) (Activation peptide fragment 2) (Coagulation factor II) (Prothrombin) (Thrombin heavy chain) (Thrombin light chain) (Fragment)
[F2 EULNIG_R03319] Activation peptide fragment 1 (EC 3.4.21.5) (Activation peptide fragment 2) (Coagulation factor II) (Prothrombin) (Thrombin heavy chain) (Thrombin light chain) (Fragment)
[] Clotting factor B (EC 3.4.21.85) (Coagulation factor B) [Cleaved into: Clotting factor B light chain; Clotting factor B heavy chain]
[F2RL1 GPR11 PAR2] Proteinase-activated receptor 2 (PAR-2) (Coagulation factor II receptor-like 1) (G-protein coupled receptor 11) (Thrombin receptor-like 1) [Cleaved into: Proteinase-activated receptor 2, alternate cleaved 1; Proteinase-activated receptor 2, alternate cleaved 2]
[F13A1 F13A] Coagulation factor XIII A chain (Coagulation factor XIIIa) (EC 2.3.2.13) (Protein-glutamine gamma-glutamyltransferase A chain) (Transglutaminase A chain)
[F10 TrFX] Coagulation factor X (EC 3.4.21.6) [Cleaved into: Factor X light chain; Factor X heavy chain; Activated factor Xa heavy chain]
[F2RL3 PAR4] Proteinase-activated receptor 4 (PAR-4) (Coagulation factor II receptor-like 3) (Thrombin receptor-like 3)
[HABP2 HGFAL PHBP] Hyaluronan-binding protein 2 (EC 3.4.21.-) (Factor VII-activating protease) (Factor seven-activating protease) (FSAP) (Hepatocyte growth factor activator-like protein) (Plasma hyaluronan-binding protein) [Cleaved into: Hyaluronan-binding protein 2 50 kDa heavy chain; Hyaluronan-binding protein 2 50 kDa heavy chain alternate form; Hyaluronan-binding protein 2 27 kDa light chain; Hyaluronan-binding protein 2 27 kDa light chain alternate form]
[F7] Coagulation factor VII (EC 3.4.21.21) (Serum prothrombin conversion accelerator) [Cleaved into: Factor VII light chain; Factor VII heavy chain]
[F2rl1 Par2] Proteinase-activated receptor 2 (PAR-2) (Coagulation factor II receptor-like 1) (Thrombin receptor-like 1)
[F2rl1 Gpcr11 Gpr11 Par2] Proteinase-activated receptor 2 (PAR-2) (Coagulation factor II receptor-like 1) (G-protein coupled receptor 11) (Thrombin receptor-like 1)

Bibliography :
[10373475] Role of regulatory exosite I in binding of thrombin to human factor V, factor Va, factor Va subunits, and activation fragments.
[2268268] Activation of factor V during intrinsic and extrinsic coagulation. Inhibition by heparin, hirudin and D-Phe-Pro-Arg-Ch2Cl.