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Acyl-coenzyme A synthetase ACSM3, mitochondrial (EC 6.2.1.2) (Acyl-CoA synthetase medium-chain family member 3) (Butyrate--CoA ligase 3) (Butyryl-coenzyme A synthetase 3) (Middle-chain acyl-CoA synthetase 3) (SA rat hypertension-associated protein) (Protein SA)

 ACSM3_RAT               Reviewed;         580 AA.
Q6SKG1; Q62742;
02-OCT-2007, integrated into UniProtKB/Swiss-Prot.
05-JUL-2004, sequence version 1.
16-JAN-2019, entry version 97.
RecName: Full=Acyl-coenzyme A synthetase ACSM3, mitochondrial;
EC=6.2.1.2;
AltName: Full=Acyl-CoA synthetase medium-chain family member 3;
AltName: Full=Butyrate--CoA ligase 3;
AltName: Full=Butyryl-coenzyme A synthetase 3;
AltName: Full=Middle-chain acyl-CoA synthetase 3;
AltName: Full=SA rat hypertension-associated protein;
Short=Protein SA;
Flags: Precursor;
Name=Acsm3; Synonyms=Sah;
Rattus norvegicus (Rat).
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
Muroidea; Muridae; Murinae; Rattus.
NCBI_TaxID=10116;
[1]
NUCLEOTIDE SEQUENCE [GENOMIC DNA].
STRAIN=SHR, and Wistar Kyoto;
PubMed=14739236; DOI=10.1093/nar/gkh197;
Rigatti R., Jia J.-H., Samani N.J., Eperon I.C.;
"Exon repetition: a major pathway for processing mRNA of some genes is
allele-specific.";
Nucleic Acids Res. 32:441-446(2004).
[2]
NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
TISSUE=Kidney;
PubMed=15489334; DOI=10.1101/gr.2596504;
The MGC Project Team;
"The status, quality, and expansion of the NIH full-length cDNA
project: the Mammalian Gene Collection (MGC).";
Genome Res. 14:2121-2127(2004).
[3]
NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 374-479.
PubMed=8535086; DOI=10.1007/BF00352385;
Gu L., Dene H., Rapp J.P.;
"Possible alternative splicing of the rat SA gene.";
Mamm. Genome 6:683-684(1995).
-!- FUNCTION: Has medium-chain fatty acid:CoA ligase activity with
broad substrate specificity (in vitro). Acts on acids from C(4) to
C(11) and on the corresponding 3-hydroxy- and 2,3- or 3,4-
unsaturated acids (in vitro) (By similarity). {ECO:0000250}.
-!- CATALYTIC ACTIVITY:
Reaction=a medium chain fatty acid + ATP + CoA = a medium-chain
fatty acyl-CoA + AMP + diphosphate; Xref=Rhea:RHEA:48340,
ChEBI:CHEBI:30616, ChEBI:CHEBI:33019, ChEBI:CHEBI:57287,
ChEBI:CHEBI:59558, ChEBI:CHEBI:90546, ChEBI:CHEBI:456215;
EC=6.2.1.2;
-!- COFACTOR:
Name=Mg(2+); Xref=ChEBI:CHEBI:18420; Evidence={ECO:0000250};
Name=Mn(2+); Xref=ChEBI:CHEBI:29035; Evidence={ECO:0000250};
-!- SUBCELLULAR LOCATION: Mitochondrion matrix {ECO:0000250}.
-!- SIMILARITY: Belongs to the ATP-dependent AMP-binding enzyme
family. {ECO:0000305}.
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EMBL; AY455861; AAR20710.1; -; Genomic_DNA.
EMBL; AY456695; AAR21570.1; -; Genomic_DNA.
EMBL; BC090325; AAH90325.1; -; mRNA.
EMBL; U19832; AAA95995.1; -; Genomic_DNA.
RefSeq; NP_150234.1; NM_033231.1.
UniGene; Rn.88644; -.
ProteinModelPortal; Q6SKG1; -.
SMR; Q6SKG1; -.
STRING; 10116.ENSRNOP00000020039; -.
iPTMnet; Q6SKG1; -.
PhosphoSitePlus; Q6SKG1; -.
PaxDb; Q6SKG1; -.
PRIDE; Q6SKG1; -.
Ensembl; ENSRNOT00000020039; ENSRNOP00000020039; ENSRNOG00000032246.
GeneID; 24763; -.
KEGG; rno:24763; -.
UCSC; RGD:62086; rat.
CTD; 6296; -.
RGD; 62086; Acsm3.
eggNOG; KOG1175; Eukaryota.
eggNOG; COG0365; LUCA.
GeneTree; ENSGT00940000157930; -.
HOGENOM; HOG000229982; -.
HOVERGEN; HBG053031; -.
InParanoid; Q6SKG1; -.
KO; K01896; -.
OMA; EMMKHAS; -.
OrthoDB; 683933at2759; -.
PRO; PR:Q6SKG1; -.
Proteomes; UP000002494; Chromosome 1.
Bgee; ENSRNOG00000032246; Expressed in 9 organ(s), highest expression level in liver.
Genevisible; Q6SKG1; RN.
GO; GO:0005759; C:mitochondrial matrix; IBA:GO_Central.
GO; GO:0003996; F:acyl-CoA ligase activity; IBA:GO_Central.
GO; GO:0005524; F:ATP binding; IEA:UniProtKB-KW.
GO; GO:0047760; F:butyrate-CoA ligase activity; IEA:UniProtKB-EC.
GO; GO:0015645; F:fatty acid ligase activity; IBA:GO_Central.
GO; GO:0004321; F:fatty-acyl-CoA synthase activity; IBA:GO_Central.
GO; GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
GO; GO:0006637; P:acyl-CoA metabolic process; IBA:GO_Central.
GO; GO:0006633; P:fatty acid biosynthetic process; IBA:GO_Central.
InterPro; IPR025110; AMP-bd_C.
InterPro; IPR020845; AMP-binding_CS.
InterPro; IPR000873; AMP-dep_Synth/Lig.
Pfam; PF00501; AMP-binding; 1.
Pfam; PF13193; AMP-binding_C; 1.
PROSITE; PS00455; AMP_BINDING; 1.
2: Evidence at transcript level;
Acetylation; ATP-binding; Complete proteome; Fatty acid metabolism;
Ligase; Lipid metabolism; Magnesium; Metal-binding; Mitochondrion;
Nucleotide-binding; Reference proteome; Transit peptide.
TRANSIT 1 21 Mitochondrion. {ECO:0000255}.
CHAIN 22 580 Acyl-coenzyme A synthetase ACSM3,
mitochondrial.
/FTId=PRO_0000306100.
NP_BIND 229 237 ATP. {ECO:0000250}.
NP_BIND 368 373 ATP. {ECO:0000250}.
BINDING 455 455 ATP. {ECO:0000250}.
BINDING 470 470 ATP. {ECO:0000250}.
BINDING 566 566 ATP. {ECO:0000250}.
MOD_RES 67 67 N6-succinyllysine.
{ECO:0000250|UniProtKB:Q3UNX5}.
MOD_RES 100 100 N6-succinyllysine.
{ECO:0000250|UniProtKB:Q3UNX5}.
MOD_RES 151 151 N6-acetyllysine.
{ECO:0000250|UniProtKB:Q3UNX5}.
SEQUENCE 580 AA; 65713 MW; E2F46C5C530D6278 CRC64;
MAMLLRARCF HRLAIPDPRR ILYKDYRTAI PQNFSNYESM KHDFKIEIPE YFNFAKDVLD
QWTNTEKTGK RLSNPAFWWV DGNGKEVRWS FEELGSLSRK FANILTEACS LQRGDRVMVI
LPKIPEWWLA NVACLRTGTV LIPGTTQLTQ KDILYRLQSS KSKCIITDDT LAPAVDIVAA
KCENLHSKLI VSQHSREGWG NLKEMMKYAS DSHTCVDTKH NELMAIYFTS GTTGPPKMIG
HTHSSFGLGL SVNGRFWLDL IASDVMWNTS DTGWAKSAWS SVFSPWTQGA CVFAHYLPRF
DSTSILQTLS KFPITVFCSA PTAYRMLIQN DITSYKFNSL KHCVSAGEPI NPEVMEQWKK
KTGLDIYEGY GQTETVLICG NFKGMKIKPG SMGKPSPAFN VEILDENGTI LPPGQEGDIA
VQVLPDRPFG LFTHYVDNPS KTASTLRGNF YITGDRGYMD EDGYFWFVAR SDDVILSSGY
RIGPFEVESA LIEHPSIAES AVVSSPDPIR GEVVKAFIVL NPDYKLHDQE QLKKEIQEHV
KKTTAPYKYP RKIEFIEELP KTVSGKVKRN ELRRKEWTTT


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