GENTAUR Belgium BVBA BE0473327336 Voortstraat 49, 1910 Kampenhout BELGIUM Tel 0032 16 58 90 45
GENTAUR U.S.A Genprice Inc,Logistics 547 Yurok Circle, SanJose, CA 95123
Tel (408) 780-0908, Fax (408) 780-0908, [email protected]

Did you know ? If you order before Friday 14h we deliver 90PCT of the the time next Tuesday, Gentaur another in time delivery

Adenylosuccinate synthetase (AMPSase) (AdSS) (EC 6.3.4.4) (IMP--aspartate ligase)

 A0A084G0Z5_9PEZI        Unreviewed;       428 AA.
A0A084G0Z5;
29-OCT-2014, integrated into UniProtKB/TrEMBL.
29-OCT-2014, sequence version 1.
08-MAY-2019, entry version 25.
RecName: Full=Adenylosuccinate synthetase {ECO:0000256|HAMAP-Rule:MF_03125};
Short=AMPSase {ECO:0000256|HAMAP-Rule:MF_03125};
Short=AdSS {ECO:0000256|HAMAP-Rule:MF_03125};
EC=6.3.4.4 {ECO:0000256|HAMAP-Rule:MF_03125};
AltName: Full=IMP--aspartate ligase {ECO:0000256|HAMAP-Rule:MF_03125};
ORFNames=SAPIO_CDS7035 {ECO:0000313|EMBL:KEZ41007.1};
Scedosporium apiospermum.
Eukaryota; Fungi; Dikarya; Ascomycota; Pezizomycotina;
Sordariomycetes; Hypocreomycetidae; Microascales; Microascaceae;
Scedosporium.
NCBI_TaxID=563466 {ECO:0000313|EMBL:KEZ41007.1};
[1] {ECO:0000313|EMBL:KEZ41007.1}
NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
STRAIN=IHEM 14462 {ECO:0000313|EMBL:KEZ41007.1};
PubMed=25278533;
Vandeputte P., Ghamrawi S., Rechenmann M., Iltis A., Giraud S.,
Fleury M., Thornton C., Delhaes L., Meyer W., Papon N., Bouchara J.P.;
"Draft Genome Sequence of the Pathogenic Fungus Scedosporium
apiospermum.";
Genome Announc. 2:0-0(2014).
-!- FUNCTION: Plays an important role in the de novo pathway and in
the salvage pathway of purine nucleotide biosynthesis. Catalyzes
the first commited step in the biosynthesis of AMP from IMP.
{ECO:0000256|HAMAP-Rule:MF_03125}.
-!- CATALYTIC ACTIVITY:
Reaction=GTP + IMP + L-aspartate = GDP + 2 H(+) + N(6)-(1,2-
dicarboxyethyl)-AMP + phosphate; Xref=Rhea:RHEA:15753,
ChEBI:CHEBI:15378, ChEBI:CHEBI:29991, ChEBI:CHEBI:37565,
ChEBI:CHEBI:43474, ChEBI:CHEBI:57567, ChEBI:CHEBI:58053,
ChEBI:CHEBI:58189; EC=6.3.4.4; Evidence={ECO:0000256|HAMAP-
Rule:MF_03125};
-!- COFACTOR:
Name=Mg(2+); Xref=ChEBI:CHEBI:18420;
Evidence={ECO:0000256|HAMAP-Rule:MF_03125};
Note=Binds 1 Mg(2+) ion per subunit. {ECO:0000256|HAMAP-
Rule:MF_03125};
-!- PATHWAY: Purine metabolism; AMP biosynthesis via de novo pathway;
AMP from IMP: step 1/2. {ECO:0000256|HAMAP-Rule:MF_03125}.
-!- SUBUNIT: Homodimer. {ECO:0000256|HAMAP-Rule:MF_03125}.
-!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000256|HAMAP-Rule:MF_03125}.
-!- SIMILARITY: Belongs to the adenylosuccinate synthetase family.
{ECO:0000256|HAMAP-Rule:MF_03125}.
-!- CAUTION: The sequence shown here is derived from an
EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is
preliminary data. {ECO:0000313|EMBL:KEZ41007.1}.
-----------------------------------------------------------------------
Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
Distributed under the Creative Commons Attribution (CC BY 4.0) License
-----------------------------------------------------------------------
EMBL; JOWA01000110; KEZ41007.1; -; Genomic_DNA.
RefSeq; XP_016640806.1; XM_016788979.1.
EnsemblFungi; KEZ41007; KEZ41007; SAPIO_CDS7035.
GeneID; 27726107; -.
OrthoDB; 1276527at2759; -.
UniPathway; UPA00075; UER00335.
GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
GO; GO:0004019; F:adenylosuccinate synthase activity; IEA:UniProtKB-UniRule.
GO; GO:0005525; F:GTP binding; IEA:UniProtKB-UniRule.
GO; GO:0000287; F:magnesium ion binding; IEA:UniProtKB-UniRule.
GO; GO:0044208; P:'de novo' AMP biosynthetic process; IEA:UniProtKB-UniPathway.
CDD; cd03108; AdSS; 1.
Gene3D; 1.10.300.10; -; 1.
Gene3D; 3.40.440.10; -; 1.
Gene3D; 3.90.170.10; -; 1.
HAMAP; MF_00011; Adenylosucc_synth; 1.
InterPro; IPR042109; Adenylosuccinate_synth_dom1.
InterPro; IPR042110; Adenylosuccinate_synth_dom2.
InterPro; IPR042111; Adenylosuccinate_synth_dom3.
InterPro; IPR001114; Adenylosuccinate_synthetase.
InterPro; IPR027417; P-loop_NTPase.
PANTHER; PTHR11846; PTHR11846; 1.
Pfam; PF00709; Adenylsucc_synt; 1.
SMART; SM00788; Adenylsucc_synt; 1.
SUPFAM; SSF52540; SSF52540; 1.
TIGRFAMs; TIGR00184; purA; 1.
3: Inferred from homology;
Cytoplasm {ECO:0000256|HAMAP-Rule:MF_03125};
GTP-binding {ECO:0000256|HAMAP-Rule:MF_03125};
Ligase {ECO:0000256|HAMAP-Rule:MF_03125};
Magnesium {ECO:0000256|HAMAP-Rule:MF_03125};
Metal-binding {ECO:0000256|HAMAP-Rule:MF_03125};
Nucleotide-binding {ECO:0000256|HAMAP-Rule:MF_03125};
Purine biosynthesis {ECO:0000256|HAMAP-Rule:MF_03125}.
NP_BIND 13 19 GTP. {ECO:0000256|HAMAP-Rule:MF_03125}.
NP_BIND 41 43 GTP. {ECO:0000256|HAMAP-Rule:MF_03125}.
NP_BIND 330 332 GTP. {ECO:0000256|HAMAP-Rule:MF_03125}.
NP_BIND 414 416 GTP. {ECO:0000256|HAMAP-Rule:MF_03125}.
REGION 14 17 IMP binding. {ECO:0000256|HAMAP-
Rule:MF_03125}.
REGION 39 42 IMP binding. {ECO:0000256|HAMAP-
Rule:MF_03125}.
REGION 298 304 Substrate binding. {ECO:0000256|HAMAP-
Rule:MF_03125}.
ACT_SITE 14 14 Proton acceptor. {ECO:0000256|HAMAP-
Rule:MF_03125}.
ACT_SITE 42 42 Proton donor. {ECO:0000256|HAMAP-
Rule:MF_03125}.
METAL 14 14 Magnesium. {ECO:0000256|HAMAP-
Rule:MF_03125}.
METAL 41 41 Magnesium; via carbonyl oxygen.
{ECO:0000256|HAMAP-Rule:MF_03125}.
BINDING 131 131 IMP. {ECO:0000256|HAMAP-Rule:MF_03125}.
BINDING 145 145 IMP; shared with dimeric partner.
{ECO:0000256|HAMAP-Rule:MF_03125}.
BINDING 223 223 IMP. {ECO:0000256|HAMAP-Rule:MF_03125}.
BINDING 238 238 IMP. {ECO:0000256|HAMAP-Rule:MF_03125}.
BINDING 302 302 IMP. {ECO:0000256|HAMAP-Rule:MF_03125}.
BINDING 304 304 GTP. {ECO:0000256|HAMAP-Rule:MF_03125}.
SEQUENCE 428 AA; 46975 MW; 2AEA023A4591B95F CRC64;
MGSIDVVLGA AWGDEGKGKL VDILSGTAQI CARAQGGHNA GHSIVANGVS YDFHLLPSGL
MNPNCLNLIG SGVVVHVPTF FSELETVEKK GLQNVHSRIF ISDRCHIDFD LHCAVDAAEE
LELGSESIGT TKRGIGPCYA SMATRSGITM SEMFRPDVFE HRLRKLADAY KKRFGDKLVY
DVEDEIERFK GYRERLANYV IDAVTFMNDA QQRGARILIE GSQAIMLDVN YGTYPYVTSS
NTGLGGIIVG LGLNPRKLGD VIGTVKAYTT RVGAGPFATE DTGAVGTHLQ EVGREWGVST
GRRRRCGWLD LVQIKYSHML NHYTALNLTK LDVLDDMETI KVAVGYKNPQ TGAELPTFPA
DMDLLGQVEV VYKELPGWKA STSKVQKFEE LPKGAQDYIK FIEEYVGVRI RWIGTGPGRE
DMIDRGSS


Related products :

Catalog number Product name Quantity
EIAAB33188 Adenylosuccinate synthetase isozyme 2,Adenylosuccinate synthetase, acidic isozyme,Adenylosuccinate synthetase, liver isozyme,ADSS,AdSS 2,ADSS2,AMPSase 2,IMP--aspartate ligase 2,L-type adenylosuccinate
EIAAB33186 Adenylosuccinate synthetase isozyme 2,Adenylosuccinate synthetase, acidic isozyme,Adenylosuccinate synthetase, liver isozyme,Adss,AdSS 2,Adss2,AMPSase 2,IMP--aspartate ligase 2,L-type adenylosuccinate
EIAAB33190 Adenylosuccinate synthetase isozyme 2,Adenylosuccinate synthetase, acidic isozyme,Adenylosuccinate synthetase, liver isozyme,ADSS,AdSS 2,ADSS2,AMPSase 2,Homo sapiens,Human,IMP--aspartate ligase 2,L-ty
EIAAB33189 Adenylosuccinate synthetase isozyme 2,Adenylosuccinate synthetase, acidic isozyme,Adenylosuccinate synthetase, liver isozyme,ADSS,AdSS 2,ADSS2,AMPSase 2,Bos taurus,Bovine,IMP--aspartate ligase 2,L-typ
EIAAB33187 Adenylosuccinate synthetase isozyme 2,Adenylosuccinate synthetase, acidic isozyme,Adenylosuccinate synthetase, liver isozyme,ADSS,AdSS 2,ADSS2,AMPSase 2,Chicken,Gallus gallus,IMP--aspartate ligase 2,L
EIAAB33185 Adenylosuccinate synthetase isozyme 1,Adenylosuccinate synthetase, basic isozyme,Adenylosuccinate synthetase, muscle isozyme,AdSS 1,ADSS1,ADSSL1,AMPSase 1,Homo sapiens,Human,IMP--aspartate ligase 1,M-
EIAAB33183 Adenylosuccinate synthetase isozyme 1,Adenylosuccinate synthetase, basic isozyme,Adenylosuccinate synthetase, muscle isozyme,AdSS 1,Adss1,Adssl1,AMPSase 1,IMP--aspartate ligase 1,Mouse,M-type adenylos
EIAAB33182 Adenylosuccinate synthetase isozyme 1,Adenylosuccinate synthetase, basic isozyme,Adenylosuccinate synthetase, muscle isozyme,AdSS 1,ADSS1,ADSSL1,AMPSase 1,IMP--aspartate ligase 1,M-type adenylosuccina
EIAAB33184 Adenylosuccinate synthetase isozyme 1,Adenylosuccinate synthetase, basic isozyme,Adenylosuccinate synthetase, muscle isozyme,AdSS 1,ADSS1,ADSSL1,AMPSase 1,Bos taurus,Bovine,IMP--aspartate ligase 1,M-t
CSB-EL001398PI Pig Adenylosuccinate synthetase isozyme 2(ADSS) ELISA kit SpeciesPig 96T
CSB-EL001398CH Chicken Adenylosuccinate synthetase isozyme 2(ADSS) ELISA kit 96T
CSB-EL001398BO Bovine Adenylosuccinate synthetase isozyme 2(ADSS) ELISA kit 96T
CSB-EL001398MO Mouse Adenylosuccinate synthetase isozyme 2(ADSS) ELISA kit 96T
CSB-EL001398HU Human Adenylosuccinate synthetase isozyme 2(ADSS) ELISA kit 96T
CSB-EL001398CH Chicken Adenylosuccinate synthetase isozyme 2(ADSS) ELISA kit SpeciesChicken 96T
CSB-EL001398HU Human Adenylosuccinate synthetase isozyme 2(ADSS) ELISA kit SpeciesHuman 96T
CSB-EL001398MO Mouse Adenylosuccinate synthetase isozyme 2(ADSS) ELISA kit SpeciesMouse 96T
CSB-EL001398BO Bovine Adenylosuccinate synthetase isozyme 2(ADSS) ELISA kit SpeciesBovine 96T
PURA2_BOVIN ELISA Kit FOR Adenylosuccinate synthetase isozyme 2; organism: Bovine; gene name: ADSS 96T
AE01 ADSS Gene adenylosuccinate synthase
201-20-0214 ADSS{adenylosuccinate synthase}rabbit.pAb 0.1ml
QY-E00879 Human Adenylosuccinate Synthase(ADSS)ELISA Kit 96T
UB-E00879 Human Adenylosuccinate Synthase(ADSS)ELISA Kit 96T
201-12-3095 Human Adenylosuccinate Synthase(ADSS)ELISA Kit 96T
CSB-EL001398PI Pig adenylosuccinate synthase (ADSS) ELISA kit, Species Pig, Sample Type serum, plasma 96T
Pathways :
WP2185: Purine metabolism
WP739: Non-homologous end joining
WP1617: Alanine, aspartate and glutamate metabolism
WP1676: Non-homologous end-joining
WP1097: Non-homologous end joining
WP87: Nucleotide Metabolism
WP1996: Linoleate Biosynthesis
WP1208: Non-homologous end joining
WP2211: Geranylgeranyldiphosphate biosynthesis II (plastidic)
WP1277: Non-homologous end joining
WP321: Nucleotide Metabolism
WP1493: Carbon assimilation C4 pathway
WP1577: amino acid conjugation of benzoic acid
WP521: amino acid conjugation of benzoic acid
WP106: Alanine and aspartate metabolism
WP861: Non-homologous end joining
WP1672: Mismatch repair
WP1708: Terpenoid backbone biosynthesis
WP1201: Non-homologous end joining
WP1242: Non-homologous end joining
WP2199: Seed Development
WP296: TCA Cycle - biocyc
WP146: Nucleotide Metabolism
WP1570: Non-homologous end joining
WP438: Non-homologous end joining

Related Genes :
[ADSSL1 ADSS1] Adenylosuccinate synthetase isozyme 1 (AMPSase 1) (AdSS 1) (EC 6.3.4.4) (Adenylosuccinate synthetase, basic isozyme) (Adenylosuccinate synthetase, muscle isozyme) (M-type adenylosuccinate synthetase) (IMP--aspartate ligase 1)
[PURA] Multifunctional fusion protein [Includes: Adenylosuccinate synthetase, chloroplastic (AMPSase) (AdSS) (EC 6.3.4.4) (IMP--aspartate ligase); Pescadillo homolog]
[purA MSMEG_0759 MSMEI_0743] Adenylosuccinate synthetase (AMPSase) (AdSS) (EC 6.3.4.4) (IMP--aspartate ligase)
[] Adenylosuccinate synthetase (AMPSase) (AdSS) (EC 6.3.4.4) (IMP--aspartate ligase)
[NCU09789] Adenylosuccinate synthetase (AMPSase) (AdSS) (EC 6.3.4.4) (IMP--aspartate ligase)
[purA OR1_04047] Adenylosuccinate synthetase (AMPSase) (AdSS) (EC 6.3.4.4) (IMP--aspartate ligase)
[purA OR214_00185] Adenylosuccinate synthetase (AMPSase) (AdSS) (EC 6.3.4.4) (IMP--aspartate ligase)
[purA OR37_04057] Adenylosuccinate synthetase (AMPSase) (AdSS) (EC 6.3.4.4) (IMP--aspartate ligase)
[purA OR16_10419] Adenylosuccinate synthetase (AMPSase) (AdSS) (EC 6.3.4.4) (IMP--aspartate ligase)
[AZE42_05716] Adenylosuccinate synthetase (AMPSase) (AdSS) (EC 6.3.4.4) (IMP--aspartate ligase)
[purA OR221_0234] Adenylosuccinate synthetase (AMPSase) (AdSS) (EC 6.3.4.4) (IMP--aspartate ligase)
[purA SAMN04487830_10346] Adenylosuccinate synthetase (AMPSase) (AdSS) (EC 6.3.4.4) (IMP--aspartate ligase)
[PURA VITISV_016911] Adenylosuccinate synthetase, chloroplastic (AMPSase) (AdSS) (EC 6.3.4.4) (IMP--aspartate ligase)
[PURA] Adenylosuccinate synthetase, chloroplastic (AMPSase) (AdSS) (EC 6.3.4.4) (IMP--aspartate ligase)
[PURA] Adenylosuccinate synthetase, chloroplastic (AMPSase) (AdSS) (EC 6.3.4.4) (IMP--aspartate ligase)
[purA_2 purA ACTI_22510] Adenylosuccinate synthetase (AMPSase) (AdSS) (EC 6.3.4.4) (IMP--aspartate ligase)
[purA BTA37_18565 C2I28_07900 C3744_14710 CIB87_24795 CN383_20295 CN890_20100 CN918_09870 CN955_28535 CN973_06550 CN978_17280 CN981_21940 COA18_02170 COC52_09280 COC53_13845 COC61_07890 COC62_04265 COD13_22225 COD15_05425 COE08_03590 COE31_25585 COE55_04170 COE67_08335 COI68_22175 COI84_05495 COJ00_21345 COJ19_23090 COJ21_10995 COJ23_13690 COJ70_06960 COJ90_00145 COJ92_26995 COK01_18435 COK03_02065 COK68_19475 COK90_02100 COL08_25790 NCTC6005_05628 SAMN04487776_10529] Adenylosuccinate synthetase (AMPSase) (AdSS) (EC 6.3.4.4) (IMP--aspartate ligase)
[purA HPHPA4_0369] Adenylosuccinate synthetase (AMPSase) (AdSS) (EC 6.3.4.4) (IMP--aspartate ligase)
[purA HPHPH4_0370] Adenylosuccinate synthetase (AMPSase) (AdSS) (EC 6.3.4.4) (IMP--aspartate ligase)
[purA HPHPP4_0466] Adenylosuccinate synthetase (AMPSase) (AdSS) (EC 6.3.4.4) (IMP--aspartate ligase)
[purA OR16_04412] Adenylosuccinate synthetase (AMPSase) (AdSS) (EC 6.3.4.4) (IMP--aspartate ligase)
[K503DRAFT_856010] Adenylosuccinate synthetase (AMPSase) (AdSS) (EC 6.3.4.4) (IMP--aspartate ligase)
[purA ATE51_00572 NCTC11366_00379] Adenylosuccinate synthetase (AMPSase) (AdSS) (EC 6.3.4.4) (IMP--aspartate ligase)
[purA Loa_00803] Adenylosuccinate synthetase (AMPSase) (AdSS) (EC 6.3.4.4) (IMP--aspartate ligase)
[purA_1 purA ACTI_04900] Adenylosuccinate synthetase (AMPSase) (AdSS) (EC 6.3.4.4) (IMP--aspartate ligase)
[purA D5R95_08855] Adenylosuccinate synthetase (AMPSase) (AdSS) (EC 6.3.4.4) (IMP--aspartate ligase)
[purA GY22_12185] Adenylosuccinate synthetase (AMPSase) (AdSS) (EC 6.3.4.4) (IMP--aspartate ligase)
[purA SAMN04515668_3802] Adenylosuccinate synthetase (AMPSase) (AdSS) (EC 6.3.4.4) (IMP--aspartate ligase)
[purA TAM4_496] Adenylosuccinate synthetase (AMPSase) (AdSS) (EC 6.3.4.4) (IMP--aspartate ligase)
[purA HPHPH6_0362] Adenylosuccinate synthetase (AMPSase) (AdSS) (EC 6.3.4.4) (IMP--aspartate ligase)

Bibliography :
No related Items