GENTAUR Belgium BVBA BE0473327336 Voortstraat 49, 1910 Kampenhout BELGIUM Tel 0032 16 58 90 45
GENTAUR U.S.A Genprice Inc,Logistics 547 Yurok Circle, SanJose, CA 95123
Tel (408) 780-0908, Fax (408) 780-0908, [email protected]

Did you know ? If you order before Friday 14h we deliver 90PCT of the the time next Tuesday, Gentaur another in time delivery

Agouti-signaling protein (ASP) (Agouti coat color protein) (Agouti switch protein)

 ASIP_MOUSE              Reviewed;         131 AA.
Q03288; A2ALT3; Q80ST0;
01-OCT-1993, integrated into UniProtKB/Swiss-Prot.
28-JUN-2011, sequence version 2.
08-MAY-2019, entry version 143.
RecName: Full=Agouti-signaling protein;
Short=ASP;
AltName: Full=Agouti coat color protein;
AltName: Full=Agouti switch protein;
Flags: Precursor;
Name=Asip; Synonyms=a;
Mus musculus (Mouse).
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
Muroidea; Muridae; Murinae; Mus; Mus.
NCBI_TaxID=10090;
[1]
NUCLEOTIDE SEQUENCE [MRNA].
PubMed=8449404; DOI=10.1101/gad.7.3.454;
Miller M.W., Duhl D.M., Vrieling H., Cordes S.P., Ollmann M.M.,
Winkes B.M., Barsh G.S.;
"Cloning of the mouse agouti gene predicts a secreted protein
ubiquitously expressed in mice carrying the lethal yellow mutation.";
Genes Dev. 7:454-467(1993).
[2]
NUCLEOTIDE SEQUENCE [MRNA].
PubMed=1473152; DOI=10.1016/S0092-8674(05)80067-4;
Bultman S.J., Michaud E.J., Woychik R.P.;
"Molecular characterization of the mouse agouti locus.";
Cell 71:1195-1204(1992).
[3]
NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
STRAIN=C57BL/6J;
PubMed=19468303; DOI=10.1371/journal.pbio.1000112;
Church D.M., Goodstadt L., Hillier L.W., Zody M.C., Goldstein S.,
She X., Bult C.J., Agarwala R., Cherry J.L., DiCuccio M., Hlavina W.,
Kapustin Y., Meric P., Maglott D., Birtle Z., Marques A.C., Graves T.,
Zhou S., Teague B., Potamousis K., Churas C., Place M., Herschleb J.,
Runnheim R., Forrest D., Amos-Landgraf J., Schwartz D.C., Cheng Z.,
Lindblad-Toh K., Eichler E.E., Ponting C.P.;
"Lineage-specific biology revealed by a finished genome assembly of
the mouse.";
PLoS Biol. 7:E1000112-E1000112(2009).
[4]
NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Mural R.J., Adams M.D., Myers E.W., Smith H.O., Venter J.C.;
Submitted (JUL-2005) to the EMBL/GenBank/DDBJ databases.
[5]
NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
STRAIN=129; TISSUE=Mammary gland;
PubMed=15489334; DOI=10.1101/gr.2596504;
The MGC Project Team;
"The status, quality, and expansion of the NIH full-length cDNA
project: the Mammalian Gene Collection (MGC).";
Genome Res. 14:2121-2127(2004).
[6]
NUCLEOTIDE SEQUENCE [MRNA] OF 1-70.
PubMed=8319910; DOI=10.1101/gad.7.7a.1203;
Michaud E.J., Bultman S.J., Stubbs L.J., Woychik R.P.;
"The embryonic lethality of homozygous lethal yellow mice (Ay/Ay) is
associated with the disruption of a novel RNA-binding protein.";
Genes Dev. 7:1203-1213(1993).
[7]
NUCLEOTIDE SEQUENCE [MRNA] OF 1-16.
STRAIN=C57BL/6J; TISSUE=Spleen;
PubMed=7987393; DOI=10.1038/ng0994-59;
Duhl D.M., Vrieling H., Miller K.A., Wolff G.L., Barsh G.S.;
"Neomorphic agouti mutations in obese yellow mice.";
Nat. Genet. 8:59-65(1994).
[8]
NUCLEOTIDE SEQUENCE [MRNA] OF 1-16.
PubMed=8202545; DOI=10.1073/pnas.91.12.5667;
Vrieling H., Duhl D.M., Millar S.E., Miller K.A., Barsh G.S.;
"Differences in dorsal and ventral pigmentation result from regional
expression of the mouse agouti gene.";
Proc. Natl. Acad. Sci. U.S.A. 91:5667-5671(1994).
-!- FUNCTION: Involved in the regulation of melanogenesis. The binding
of ASP to MC1R precludes alpha-MSH initiated signaling and thus
blocks production of cAMP, leading to a down-regulation of
eumelanogenesis (brown/black pigment) and thus increasing
synthesis of pheomelanin (yellow/red pigment). Causes hair
follicle melanocytes to synthesize phaeomelanin instead of black
or brown pigment eumelanin and produces hairs with a subapical
yellow band on an otherwise black or brown background when
expressed during the mid-portion of hair growth.
-!- SUBCELLULAR LOCATION: Secreted.
-!- TISSUE SPECIFICITY: Epithelial cells of the hair follicles and the
epidermis.
-!- DEVELOPMENTAL STAGE: Widely expressed in embryonic and neonatal
skin.
-!- DOMAIN: The presence of a 'disulfide through disulfide knot'
structurally defines this protein as a knottin. {ECO:0000250}.
-----------------------------------------------------------------------
Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
Distributed under the Creative Commons Attribution (CC BY 4.0) License
-----------------------------------------------------------------------
EMBL; L06451; AAA37201.1; -; mRNA.
EMBL; L06941; -; NOT_ANNOTATED_CDS; mRNA.
EMBL; AL805955; -; NOT_ANNOTATED_CDS; Genomic_DNA.
EMBL; CH466551; EDL06105.1; -; Genomic_DNA.
EMBL; CH466551; EDL06106.1; -; Genomic_DNA.
EMBL; BC009122; -; NOT_ANNOTATED_CDS; mRNA.
EMBL; S63413; AAA15908.1; -; mRNA.
EMBL; S70320; AAP19635.1; -; mRNA.
EMBL; S70326; AAP19636.1; -; mRNA.
EMBL; S70394; AAP19637.1; -; mRNA.
EMBL; S74479; AAP31517.1; -; mRNA.
EMBL; S74489; AAP31519.1; -; mRNA.
EMBL; S74493; AAP31520.1; -; mRNA.
CCDS; CCDS16941.1; -.
PIR; A46298; A46298.
RefSeq; NP_056585.2; NM_015770.3.
SMR; Q03288; -.
STRING; 10090.ENSMUSP00000029123; -.
iPTMnet; Q03288; -.
PhosphoSitePlus; Q03288; -.
PaxDb; Q03288; -.
PRIDE; Q03288; -.
Ensembl; ENSMUST00000029123; ENSMUSP00000029123; ENSMUSG00000027596.
Ensembl; ENSMUST00000109697; ENSMUSP00000105319; ENSMUSG00000027596.
GeneID; 50518; -.
KEGG; mmu:50518; -.
UCSC; uc008njz.1; mouse.
CTD; 50518; -.
MGI; MGI:87853; a.
eggNOG; ENOG410J1GH; Eukaryota.
eggNOG; ENOG410ZCK9; LUCA.
GeneTree; ENSGT00940000154258; -.
HOGENOM; HOG000111779; -.
InParanoid; Q03288; -.
KO; K08725; -.
OMA; AFCQCRL; -.
OrthoDB; 1369753at2759; -.
TreeFam; TF330729; -.
PRO; PR:Q03288; -.
Proteomes; UP000000589; Chromosome 2.
Bgee; ENSMUSG00000027596; Expressed in 32 organ(s), highest expression level in testis.
ExpressionAtlas; Q03288; baseline and differential.
Genevisible; Q03288; MM.
GO; GO:0005623; C:cell; IEA:GOC.
GO; GO:0005576; C:extracellular region; IEA:UniProtKB-SubCell.
GO; GO:0031779; F:melanocortin receptor binding; IPI:MGI.
GO; GO:0031781; F:type 3 melanocortin receptor binding; IPI:MGI.
GO; GO:0031782; F:type 4 melanocortin receptor binding; IPI:MGI.
GO; GO:0008343; P:adult feeding behavior; IMP:MGI.
GO; GO:0006091; P:generation of precursor metabolites and energy; IGI:MGI.
GO; GO:0071514; P:genetic imprinting; IMP:MGI.
GO; GO:0009755; P:hormone-mediated signaling pathway; IEA:InterPro.
GO; GO:0042438; P:melanin biosynthetic process; IMP:MGI.
GO; GO:0032438; P:melanosome organization; IMP:MGI.
GO; GO:0032402; P:melanosome transport; IMP:MGI.
GO; GO:0043473; P:pigmentation; IMP:MGI.
GO; GO:0048023; P:positive regulation of melanin biosynthetic process; IGI:CACAO.
GO; GO:0040030; P:regulation of molecular function, epigenetic; IMP:MGI.
Gene3D; 4.10.760.10; -; 1.
InterPro; IPR007733; Agouti.
InterPro; IPR027300; Agouti_dom.
InterPro; IPR036836; Agouti_dom_sf.
PANTHER; PTHR16551; PTHR16551; 1.
Pfam; PF05039; Agouti; 1.
SMART; SM00792; Agouti; 1.
SUPFAM; SSF57055; SSF57055; 1.
PROSITE; PS60024; AGOUTI_1; 1.
PROSITE; PS51150; AGOUTI_2; 1.
2: Evidence at transcript level;
Complete proteome; Disulfide bond; Glycoprotein; Knottin;
Reference proteome; Secreted; Signal.
SIGNAL 1 22 {ECO:0000255}.
CHAIN 23 131 Agouti-signaling protein.
/FTId=PRO_0000001029.
DOMAIN 92 131 Agouti. {ECO:0000255|PROSITE-
ProRule:PRU00494}.
COMPBIAS 57 85 Arg/Lys-rich (basic).
CARBOHYD 39 39 N-linked (GlcNAc...) asparagine.
{ECO:0000255}.
DISULFID 92 107 {ECO:0000255|PROSITE-ProRule:PRU00494}.
DISULFID 99 113 {ECO:0000255|PROSITE-ProRule:PRU00494}.
DISULFID 106 124 {ECO:0000255|PROSITE-ProRule:PRU00494}.
DISULFID 110 131 {ECO:0000255|PROSITE-ProRule:PRU00494}.
DISULFID 115 122 {ECO:0000255|PROSITE-ProRule:PRU00494}.
CONFLICT 13 13 G -> S (in Ref. 1; AAA37201 and 6;
AAA15908/AAP19635/AAP19636/AAP19637/
AAP31517/AAP31519/AAP31520).
{ECO:0000305}.
SEQUENCE 131 AA; 14313 MW; A7544EEA26734135 CRC64;
MDVTRLLLAT LVGFLCFFTV HSHLALEETL GDDRSLRSNS SMNSLDFSSV SIVALNKKSK
KISRKEAEKR KRSSKKKASM KKVARPPPPS PCVATRDSCK PPAPACCDPC ASCQCRFFGS
ACTCRVLNPN C


Related products :

Catalog number Product name Quantity
orb80700 Human Agouti-Related protein The Human Agouti-related protein is created as recombinant protein with N-terminal fusion of His Tag.The Human Agouti-related protein His-Tagged Fusion Protein, produced i 2
ASIP_RAT Rat ELISA Kit FOR Agouti-signaling protein 96T
ASIP_PIG Pig ELISA Kit FOR Agouti-signaling protein 96T
ASIP_BOVIN Bovine ELISA Kit FOR Agouti-signaling protein 96T
CSB-EL002212DO Dog Agouti-signaling protein(ASIP) ELISA kit 96T
CSB-EL002212CA Cat Agouti-signaling protein(ASIP) ELISA kit 96T
AE55369CA Cat Agouti-signaling protein (ASIP) ELISA Kit 48T
ASMD ASIP Gene agouti signaling protein
E10923b Mouse ELISA Kit FOR Agouti-signaling protein 96T
CSB-EL002212RA Rat Agouti-signaling protein(ASIP) ELISA kit 96T
CSB-EL002212CA Cat Agouti-signaling protein(ASIP) ELISA kit SpeciesCat 96T
CSB-EL002212BO Bovine Agouti-signaling protein(ASIP) ELISA kit 96T
CSB-EL002212HO Horse Agouti-signaling protein(ASIP) ELISA kit 96T
003-54 Agouti Signaling Protein (ASP)(87_132)_Amide (Human) _ 100ug 100 µg
CSB-EL002212PI Pig Agouti-signaling protein(ASIP) ELISA kit SpeciesPig 96T
CSB-EL002212DO Dog Agouti-signaling protein(ASIP) ELISA kit SpeciesDog 96T
CSB-EL002212RA Rat Agouti-signaling protein(ASIP) ELISA kit SpeciesRat 96T
CSB-EL002212HU Human Agouti-signaling protein(ASIP) ELISA kit 96T
CSB-EL002212MO Mouse Agouti-signaling protein(ASIP) ELISA kit 96T
AE55368BO Bovine Agouti-signaling protein (ASIP) ELISA Kit 48T
CSB-EL002212RH Monkey Agouti-signaling protein(ASIP) ELISA kit SpeciesMonkey 96T
CSB-EL002212HO Horse Agouti-signaling protein(ASIP) ELISA kit SpeciesHorse 96T
CSB-EL002212BO Bovine Agouti-signaling protein(ASIP) ELISA kit SpeciesBovine 96T
CSB-EL002212MO Mouse Agouti-signaling protein(ASIP) ELISA kit SpeciesMouse 96T
CSB-EL002212HU Human Agouti-signaling protein(ASIP) ELISA kit SpeciesHuman 96T
Pathways :
WP1165: G Protein Signaling Pathways
WP1371: G Protein Signaling Pathways
WP2272: Pathogenic Escherichia coli infection
WP1049: G Protein Signaling Pathways
WP232: G Protein Signaling Pathways
WP2203: TSLP Signaling Pathway
WP35: G Protein Signaling Pathways
WP211: BMP signaling pathway
WP2032: TSH signaling pathway
WP931: G Protein Signaling Pathways
WP73: G Protein Signaling Pathways
WP2292: Chemokine signaling pathway
WP813: G Protein Signaling Pathways
WP1673: Naphthalene and anthracene degradation
WP1566: Citrate cycle (TCA cycle)
WP2324: AGE/RAGE pathway
WP1613: 1,4-Dichlorobenzene degradation
WP2199: Seed Development
WP1678: Nucleotide excision repair
WP2218: sGC
WP1690: Propanoate metabolism
WP1625: Base excision repair
WP1654: gamma-Hexachlorocyclohexane degradation
WP1694: Pyrimidine metabolism
WP1502: Mitochondrial biogenesis

Related Genes :
[Asip a] Agouti-signaling protein (ASP) (Agouti coat color protein) (Agouti switch protein)
[Cd36 Fat] Platelet glycoprotein 4 (Adipocyte membrane protein) (Fatty acid translocase) (Fatty acid transport protein) (Glycoprotein IIIb) (GPIIIB) (PAS IV) (PAS-4) (Platelet glycoprotein IV) (GPIV) (CD antigen CD36)
[Tnf Tnfa Tnfsf2] Tumor necrosis factor (Cachectin) (TNF-alpha) (Tumor necrosis factor ligand superfamily member 2) (TNF-a) [Cleaved into: Tumor necrosis factor, membrane form (N-terminal fragment) (NTF); Intracellular domain 1 (ICD1); Intracellular domain 2 (ICD2); C-domain 1; C-domain 2; Tumor necrosis factor, soluble form]
[Fads2 Fadsd6] Acyl-CoA 6-desaturase (EC 1.14.19.3) (Delta(6) fatty acid desaturase) (D6D) (Delta(6) desaturase) (Delta-6 desaturase) (Fatty acid desaturase 2)
[MT-CYB COB CYTB MTCYB] Cytochrome b (Complex III subunit 3) (Complex III subunit III) (Cytochrome b-c1 complex subunit 3) (Ubiquinol-cytochrome-c reductase complex cytochrome b subunit)
[RAG1] V(D)J recombination-activating protein 1 (EC 2.3.2.27) (EC 3.1.-.-) (Fragment)
[RAG1] V(D)J recombination-activating protein 1 (EC 2.3.2.27) (EC 3.1.-.-) (Fragment)
[Atrnl1 Alp Atrnl Kiaa0534] Attractin-like protein 1
[KMT2A ALL1 CXXC7 HRX HTRX MLL MLL1 TRX1] Histone-lysine N-methyltransferase 2A (Lysine N-methyltransferase 2A) (EC 2.1.1.43) (ALL-1) (CXXC-type zinc finger protein 7) (Myeloid/lymphoid or mixed-lineage leukemia) (Myeloid/lymphoid or mixed-lineage leukemia protein 1) (Trithorax-like protein) (Zinc finger protein HRX) [Cleaved into: MLL cleavage product N320 (N-terminal cleavage product of 320 kDa) (p320); MLL cleavage product C180 (C-terminal cleavage product of 180 kDa) (p180)]
[Ap2m1] AP-2 complex subunit mu (AP-2 mu chain) (Adaptor protein complex AP-2 subunit mu) (Adaptor-related protein complex 2 subunit mu) (Clathrin assembly protein complex 2 mu medium chain) (Clathrin coat assembly protein AP50) (Clathrin coat-associated protein AP50) (Mu2-adaptin) (Plasma membrane adaptor AP-2 50 kDa protein)
[APEX1 APE APE1 APEX APX HAP1 REF1] DNA-(apurinic or apyrimidinic site) lyase (EC 3.1.-.-) (EC 4.2.99.18) (APEX nuclease) (APEN) (Apurinic-apyrimidinic endonuclease 1) (AP endonuclease 1) (APE-1) (REF-1) (Redox factor-1) [Cleaved into: DNA-(apurinic or apyrimidinic site) lyase, mitochondrial]
[CD84 SLAMF5] SLAM family member 5 (Cell surface antigen MAX.3) (Hly9-beta) (Leukocyte differentiation antigen CD84) (Signaling lymphocytic activation molecule 5) (CD antigen CD84)
[SHH] Sonic hedgehog protein (SHH) (HHG-1) (Shh unprocessed N-terminal signaling and C-terminal autoprocessing domains) (ShhNC) [Cleaved into: Sonic hedgehog protein N-product (ShhN) (Shh N-terminal processed signaling domains) (ShhNp)]
[] RNA2 polyprotein (Genome polyprotein M) (M RNA polyprotein) (Middle component RNA polyprotein) (P2) [Cleaved into: VP58 (P58); Movement protein (MP) (48 kDa protein); Large capsid protein (LCP) (Coat protein VP37) (L subunit) (Large coat protein); Small capsid protein precursor (S subunit); Mature small capsid protein (SCP) (Coat protein VP23) (Small capsid protein, N-terminus part) (Small coat protein, N-terminus part); Small capsid protein C-terminus part (Small coat protein C-terminus part)]
[Shh Hhg1] Sonic hedgehog protein (SHH) (HHG-1) (Shh unprocessed N-terminal signaling and C-terminal autoprocessing domains) (ShhNC) [Cleaved into: Sonic hedgehog protein N-product (ShhN) (Shh N-terminal processed signaling domains) (ShhNp) (Sonic hedgehog protein 19 kDa product)]
[APEX1 APE APEX BAP1 REF1] DNA-(apurinic or apyrimidinic site) lyase (EC 3.1.-.-) (EC 4.2.99.18) (APEX nuclease) (APEN) (Apurinic-apyrimidinic endonuclease 1) (AP endonuclease 1) (REF-1) (Redox factor-1) [Cleaved into: DNA-(apurinic or apyrimidinic site) lyase, mitochondrial]
[CD244 2B4] Natural killer cell receptor 2B4 (NK cell activation-inducing ligand) (NAIL) (NK cell type I receptor protein 2B4) (NKR2B4) (h2B4) (SLAM family member 4) (SLAMF4) (Signaling lymphocytic activation molecule 4) (CD antigen CD244)
[COPA] Coatomer subunit alpha (Alpha-coat protein) (Alpha-COP) (HEP-COP) (HEPCOP) [Cleaved into: Xenin (Xenopsin-related peptide); Proxenin]
[AGT SERPINA8] Angiotensinogen (Serpin A8) [Cleaved into: Angiotensin-1 (Angiotensin 1-10) (Angiotensin I) (Ang I); Angiotensin-2 (Angiotensin 1-8) (Angiotensin II) (Ang II); Angiotensin-3 (Angiotensin 2-8) (Angiotensin III) (Ang III) (Des-Asp[1]-angiotensin II); Angiotensin-4 (Angiotensin 3-8) (Angiotensin IV) (Ang IV); Angiotensin 1-9; Angiotensin 1-7; Angiotensin 1-5; Angiotensin 1-4]
[Cd244 2b4 Nmrk] Natural killer cell receptor 2B4 (NK cell type I receptor protein 2B4) (NKR2B4) (Non-MHC restricted killing associated) (SLAM family member 4) (SLAMF4) (Signaling lymphocytic activation molecule 4) (CD antigen CD244)
[Oprm1 Ror-b] Mu-type opioid receptor (M-OR-1) (MOR-1) (Opioid receptor B)
[COPB2] Coatomer subunit beta' (Beta'-coat protein) (Beta'-COP) (p102)
[Coro1a Coro1] Coronin-1A (Coronin-like protein A) (Clipin-A) (Coronin-like protein p57) (Tryptophan aspartate-containing coat protein) (TACO)
[AP2S1 AP17 CLAPS2] AP-2 complex subunit sigma (Adaptor protein complex AP-2 subunit sigma) (Adaptor-related protein complex 2 subunit sigma) (Clathrin assembly protein 2 sigma small chain) (Clathrin coat assembly protein AP17) (Clathrin coat-associated protein AP17) (HA2 17 kDa subunit) (Plasma membrane adaptor AP-2 17 kDa protein) (Sigma2-adaptin)
[Swap70 Kiaa0640] Switch-associated protein 70 (SWAP-70)
[RAG1] V(D)J recombination-activating protein 1 (EC 2.3.2.27) (EC 3.1.-.-) (Fragment)
[Agt Serpina8] Angiotensinogen (Serpin A8) [Cleaved into: Angiotensin-1 (Angiotensin 1-10) (Angiotensin I) (Ang I); Angiotensin-2 (Angiotensin 1-8) (Angiotensin II) (Ang II); Angiotensin-3 (Angiotensin 2-8) (Angiotensin III) (Ang III) (Des-Asp[1]-angiotensin II); Angiotensin-4 (Angiotensin 3-8) (Angiotensin IV) (Ang IV); Angiotensin 1-9; Angiotensin 1-7; Angiotensin 1-5; Angiotensin 1-4]
[Agt Serpina8] Angiotensinogen (Serpin A8) [Cleaved into: Angiotensin-1 (Angiotensin 1-10) (Angiotensin I) (Ang I); Angiotensin-2 (Angiotensin 1-8) (Angiotensin II) (Ang II); Angiotensin-3 (Angiotensin 2-8) (Angiotensin III) (Ang III) (Des-Asp[1]-angiotensin II); Angiotensin-4 (Angiotensin 3-8) (Angiotensin IV) (Ang IV); Angiotensin 1-9; Angiotensin 1-7; Angiotensin 1-5; Angiotensin 1-4]
[AP2M1 CLAPM1 KIAA0109] AP-2 complex subunit mu (AP-2 mu chain) (Adaptin-mu2) (Adaptor protein complex AP-2 subunit mu) (Adaptor-related protein complex 2 subunit mu) (Clathrin assembly protein complex 2 mu medium chain) (Clathrin coat assembly protein AP50) (Clathrin coat-associated protein AP50) (HA2 50 kDa subunit) (Plasma membrane adaptor AP-2 50 kDa protein)
[SH2D1A DSHP SAP] SH2 domain-containing protein 1A (Duncan disease SH2-protein) (Signaling lymphocytic activation molecule-associated protein) (SLAM-associated protein) (T-cell signal transduction molecule SAP)

Bibliography :
No related Items