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Alanine and proline-rich secreted protein Apa (45/47 kDa antigen) (FAP-B) (Fibronectin attachment protein)

 APA_MYCBP               Reviewed;         325 AA.
P80069; A1KJS2;
01-JUL-1993, integrated into UniProtKB/Swiss-Prot.
01-MAY-2007, sequence version 2.
13-FEB-2019, entry version 74.
RecName: Full=Alanine and proline-rich secreted protein Apa;
AltName: Full=45/47 kDa antigen {ECO:0000303|PubMed:8423100};
AltName: Full=FAP-B;
AltName: Full=Fibronectin attachment protein;
Flags: Precursor;
Name=apa; Synonyms=modD; OrderedLocusNames=BCG_1896;
Mycobacterium bovis (strain BCG / Pasteur 1173P2).
Bacteria; Actinobacteria; Corynebacteriales; Mycobacteriaceae;
Mycobacterium; Mycobacterium tuberculosis complex.
NCBI_TaxID=410289;
[1]
NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
STRAIN=BCG / Pasteur 1173P2;
PubMed=17372194; DOI=10.1073/pnas.0700869104;
Brosch R., Gordon S.V., Garnier T., Eiglmeier K., Frigui W.,
Valenti P., Dos Santos S., Duthoy S., Lacroix C., Garcia-Pelayo C.,
Inwald J.K., Golby P., Garcia J.N., Hewinson R.G., Behr M.A.,
Quail M.A., Churcher C., Barrell B.G., Parkhill J., Cole S.T.;
"Genome plasticity of BCG and impact on vaccine efficacy.";
Proc. Natl. Acad. Sci. U.S.A. 104:5596-5601(2007).
[2]
PROTEIN SEQUENCE OF 40-56.
STRAIN=BCG;
PubMed=8423100;
Romain F., Laqueyrerie A., Militzer P., Pescher P., Chavarot P.,
Lagranderie M., Auregan G., Gheorghiu M., Marchal G.A.;
"Identification of a Mycobacterium bovis BCG 45/47-kilodalton antigen
complex, an immunodominant target for antibody response after
immunization with living bacteria.";
Infect. Immun. 61:742-750(1993).
[3]
FUNCTION, IDENTIFICATION BY MASS SPECTROMETRY, INTERACTION WITH HOST
PSP-A, SUBCELLULAR LOCATION, AND GLYCOSYLATION.
STRAIN=BCG / Pasteur 1173P2;
PubMed=17158455; DOI=10.1074/jbc.M610183200;
Ragas A., Roussel L., Puzo G., Riviere M.;
"The Mycobacterium tuberculosis cell-surface glycoprotein Apa as a
potential adhesin to colonize target cells via the innate immune
system pulmonary C-type lectin surfactant protein A.";
J. Biol. Chem. 282:5133-5142(2007).
-!- FUNCTION: Might function as an adhesin for host (human) cells.
Cell surface Apa binds to human PSP-A (SFTPA1) via its
glycosylated sites where it might down-regulate the immune
response; PSP-A probably binds other bacterial proteins as well
(PubMed:17158455). {ECO:0000269|PubMed:17158455}.
-!- SUBUNIT: Binds to human PSP-A (SFTPA1) via its glycosylated
moiety; binding disappears after treatment with alpha-mannosidase
(PubMed:17158455). {ECO:0000269|PubMed:17158455}.
-!- SUBCELLULAR LOCATION: Secreted. Cell surface
{ECO:0000269|PubMed:17158455}.
-!- PTM: Glycosylated (PubMed:17158455).
{ECO:0000269|PubMed:17158455}.
-!- PTM: Runs as 45 and 47 kDa protein, the nature of the difference
between the 2 forms is not known (PubMed:8423100,
PubMed:17158455). {ECO:0000269|PubMed:17158455,
ECO:0000269|PubMed:8423100}.
-!- SIMILARITY: Belongs to the Apa family. {ECO:0000305}.
-----------------------------------------------------------------------
Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
Distributed under the Creative Commons Attribution (CC BY 4.0) License
-----------------------------------------------------------------------
EMBL; AM408590; CAL71883.1; -; Genomic_DNA.
PIR; A49237; A49237.
RefSeq; WP_003409337.1; NC_008769.1.
EnsemblBacteria; CAL71883; CAL71883; BCG_1896.
KEGG; mbb:BCG_1896; -.
HOGENOM; HOG000049611; -.
OMA; GEFFMPY; -.
BioCyc; MBOV410289:G1G1S-2038-MONOMER; -.
Proteomes; UP000001472; Chromosome.
GO; GO:0009986; C:cell surface; IEA:UniProtKB-SubCell.
GO; GO:0005576; C:extracellular region; IEA:UniProtKB-SubCell.
GO; GO:0050840; F:extracellular matrix binding; IEA:InterPro.
InterPro; IPR010801; FAP.
Pfam; PF07174; FAP; 1.
1: Evidence at protein level;
Complete proteome; Direct protein sequencing; Glycoprotein; Repeat;
Secreted; Signal.
SIGNAL 1 39 {ECO:0000269|PubMed:8423100}.
CHAIN 40 325 Alanine and proline-rich secreted protein
Apa.
/FTId=PRO_0000064406.
REPEAT 85 88 1.
REPEAT 94 97 2.
REPEAT 104 107 3.
REGION 85 107 3 X 4 AA approximate repeats of [DA]-P-N-
A.
CARBOHYD 49 49 O-linked (Man...) threonine.
{ECO:0000250|UniProtKB:P9WIR7}.
CARBOHYD 57 57 O-linked (Man...) threonine.
{ECO:0000250|UniProtKB:P9WIR7}.
CARBOHYD 66 66 O-linked (Man) threonine.
{ECO:0000250|UniProtKB:P9WIR7}.
CARBOHYD 316 316 O-linked (Man...) threonine.
{ECO:0000250|UniProtKB:P9WIR7}.
CONFLICT 40 40 D -> A (in Ref. 2; AA sequence).
{ECO:0000305}.
CONFLICT 49 50 TT -> PA (in Ref. 2; AA sequence).
{ECO:0000305}.
CONFLICT 53 53 S -> A (in Ref. 2; AA sequence).
{ECO:0000305}.
CONFLICT 56 56 S -> A (in Ref. 2; AA sequence).
{ECO:0000305}.
SEQUENCE 325 AA; 32687 MW; D3419CA5547D91E9 CRC64;
MHQVDPNLTR RKGRLAALAI AAMASASLVT VAVPATANAD PEPAPPVPTT AASPPSTAAA
PPAPATPVAP PPPAAANTPN AQPGDPNAAP PPADPNAPPP PVIAPNAPQP VRIDNPVGGF
SFALPAGWVE SDAAHLDYGS ALLSKTTGDP PFPGQPPPVA NDTRIVLGRL DQKLYASAEA
TDSKAAARLG SDMGEFYMPY PGTRINQETV SLDANGVSGS ASYYEVKFSD PSKPNGQIWT
GVIGSPAANA PDAGPPQRWF VVWLGTANNP VDKGAAKALA ESIRPLVAPP PAPAPAPAEP
APAPAPAGEV APTPTTPTPQ RTLPA


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Pathways :
WP1049: G Protein Signaling Pathways
WP1165: G Protein Signaling Pathways
WP1371: G Protein Signaling Pathways
WP1438: Influenza A virus infection
WP1493: Carbon assimilation C4 pathway
WP1502: Mitochondrial biogenesis
WP1531: Vitamin D synthesis
WP1566: Citrate cycle (TCA cycle)
WP1613: 1,4-Dichlorobenzene degradation
WP1616: ABC transporters
WP1624: Bacterial secretion system
WP1625: Base excision repair
WP1644: DNA replication
WP1650: Fluorobenzoate degradation
WP1654: gamma-Hexachlorocyclohexane degradation
WP1657: Glycerolipid metabolism
WP1659: Glycine, serine and threonine metabolism
WP1661: Glyoxylate and dicarboxylate metabolism
WP1663: Homologous recombination
WP1665: Limonene and pinene degradation
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Related Genes :
[apa modD Rv1860 MTCY359.13] Alanine and proline-rich secreted protein Apa (45 kDa glycoprotein) (45/47 kDa antigen) (Antigen MPT-32) (FAP-B) (Fibronectin attachment protein) (Immunogenic protein MPT32)
[FAP] Prolyl endopeptidase FAP (EC 3.4.21.26) (170 kDa melanoma membrane-bound gelatinase) (Dipeptidyl peptidase FAP) (EC 3.4.14.5) (Fibroblast activation protein alpha) (FAPalpha) (Gelatine degradation protease FAP) (EC 3.4.21.-) (Integral membrane serine protease) (Post-proline cleaving enzyme) (Serine integral membrane protease) (SIMP) (Surface-expressed protease) (Seprase) [Cleaved into: Antiplasmin-cleaving enzyme FAP, soluble form (APCE) (EC 3.4.14.5) (EC 3.4.21.-) (EC 3.4.21.26)]
[Fap] Prolyl endopeptidase FAP (EC 3.4.21.26) (Dipeptidyl peptidase FAP) (EC 3.4.14.5) (Fibroblast activation protein alpha) (FAPalpha) (Gelatine degradation protease FAP) (EC 3.4.21.-) (Integral membrane serine protease) (Post-proline cleaving enzyme) (Serine integral membrane protease) (SIMP) (Surface-expressed protease) (Seprase) [Cleaved into: Antiplasmin-cleaving enzyme FAP, soluble form (APCE) (EC 3.4.14.5) (EC 3.4.21.-) (EC 3.4.21.26)]
[FAP] Prolyl endopeptidase FAP (EC 3.4.21.26) (Dipeptidyl peptidase FAP) (EC 3.4.14.5) (Fibroblast activation protein alpha) (FAPalpha) (Gelatine degradation protease FAP) (EC 3.4.21.-) (Integral membrane serine protease) (Post-proline cleaving enzyme) (Serine integral membrane protease) (SIMP) (Surface-expressed protease) (Seprase) (Z-Pro-prolinal insensitive peptidase) (ZIP) [Cleaved into: Antiplasmin-cleaving enzyme FAP, soluble form (APCE) (EC 3.4.14.5) (EC 3.4.21.-) (EC 3.4.21.26)]
[PMEL D12S53E PMEL17 SILV] Melanocyte protein PMEL (ME20-M) (ME20M) (Melanocyte protein Pmel 17) (Melanocytes lineage-specific antigen GP100) (Melanoma-associated ME20 antigen) (P1) (P100) (Premelanosome protein) (Silver locus protein homolog) [Cleaved into: M-alpha (95 kDa melanocyte-specific secreted glycoprotein) (P26) (Secreted melanoma-associated ME20 antigen) (ME20-S) (ME20S); M-beta]
[fbpC mpt45 Rv0129c MTCI5.03c] Diacylglycerol acyltransferase/mycolyltransferase Ag85C (DGAT) (EC 2.3.1.122) (EC 2.3.1.20) (Acyl-CoA:diacylglycerol acyltransferase) (Antigen 85 complex C) (85C) (Ag85C) (Fibronectin-binding protein C) (Fbps C)
[COL17A1 BP180 BPAG2] Collagen alpha-1(XVII) chain (180 kDa bullous pemphigoid antigen 2) (Bullous pemphigoid antigen 2) [Cleaved into: 120 kDa linear IgA disease antigen (120 kDa linear IgA dermatosis antigen) (Linear IgA disease antigen 1) (LAD-1); 97 kDa linear IgA disease antigen (97 kDa linear IgA bullous dermatosis antigen) (97 kDa LAD antigen) (97-LAD) (Linear IgA bullous disease antigen of 97 kDa) (LABD97)]
[fap1] Fap1 adhesin (Fimbriae-associated protein Fap1) (Serine-rich repeat protein Fap1)
[Pre C,C C core E PC pre-C pre-C/C PreC preC PreC/C preC/C precore-core HBVgp4] Capsid protein (Core antigen) (Core protein) (HBcAg) (p21.5)
[FLRT3 KIAA1469 UNQ856/PRO1865] Leucine-rich repeat transmembrane protein FLRT3 (Fibronectin-like domain-containing leucine-rich transmembrane protein 3)
[FN1 FN] Fibronectin (FN) (Cold-insoluble globulin) (CIG) [Cleaved into: Anastellin; Ugl-Y1; Ugl-Y2; Ugl-Y3]
[PRH1; PRH2] Salivary acidic proline-rich phosphoprotein 1/2 (Db-s) (PRP-1/PRP-2) (Parotid acidic protein) (Pa) (Parotid double-band protein) (Parotid isoelectric focusing variant protein) (PIF-S) (Parotid proline-rich protein 1/2) (Pr1/Pr2) (Protein C) [Cleaved into: Salivary acidic proline-rich phosphoprotein 1/2; Salivary acidic proline-rich phosphoprotein 3/4 (Db-F) (PIF-F) (PRP-3/PRP-4) (Protein A); Peptide P-C]
[pstS1 phoS1 Rv0934 MTCY08D9.05c] Phosphate-binding protein PstS 1 (PBP 1) (PhoS1) (PstS-1) (38-kDa glycolipoprotein) (38-kDa lipoprotein) (P38) (Antigen Ag78) (Protein antigen B) (Pab)
[AKT1S1 PRAS40] Proline-rich AKT1 substrate 1 (40 kDa proline-rich AKT substrate)
[PTK2B FAK2 PYK2 RAFTK] Protein-tyrosine kinase 2-beta (EC 2.7.10.2) (Calcium-dependent tyrosine kinase) (CADTK) (Calcium-regulated non-receptor proline-rich tyrosine kinase) (Cell adhesion kinase beta) (CAK-beta) (CAKB) (Focal adhesion kinase 2) (FADK 2) (Proline-rich tyrosine kinase 2) (Related adhesion focal tyrosine kinase) (RAFTK)
[ARID4B BRCAA1 RBBP1L1 RBP1L1 SAP180] AT-rich interactive domain-containing protein 4B (ARID domain-containing protein 4B) (180 kDa Sin3-associated polypeptide) (Sin3-associated polypeptide p180) (Breast cancer-associated antigen BRCAA1) (Histone deacetylase complex subunit SAP180) (Retinoblastoma-binding protein 1-like 1)
[ITGB1 FNRB MDF2 MSK12] Integrin beta-1 (Fibronectin receptor subunit beta) (Glycoprotein IIa) (GPIIA) (VLA-4 subunit beta) (CD antigen CD29)
[BAG6 BAT3 G3] Large proline-rich protein BAG6 (BAG family molecular chaperone regulator 6) (BCL2-associated athanogene 6) (BAG-6) (HLA-B-associated transcript 3) (Protein G3) (Protein Scythe)
[env] Envelope glycoprotein gp160 (Env polyprotein) [Cleaved into: Surface protein gp120 (SU) (Glycoprotein 120) (gp120); Transmembrane protein gp41 (TM) (Glycoprotein 41) (gp41)]
[MMP9 CLG4B] Matrix metalloproteinase-9 (MMP-9) (EC 3.4.24.35) (92 kDa gelatinase) (92 kDa type IV collagenase) (Gelatinase B) (GELB) [Cleaved into: 67 kDa matrix metalloproteinase-9; 82 kDa matrix metalloproteinase-9]
[HRG] Histidine-rich glycoprotein (Histidine-proline-rich glycoprotein) (HPRG)
[env] Envelope glycoprotein gp160 (Env polyprotein) [Cleaved into: Surface protein gp120 (SU) (Glycoprotein 120) (gp120); Transmembrane protein gp41 (TM) (Glycoprotein 41) (gp41)]
[] Bradykinin-potentiating and C-type natriuretic peptides (Brain BPP-CNP) (bBPP-CNP) (Evasin-CNP) [Cleaved into: Bradykinin-potentiating peptide 13a+QQWA (BPP-13a+QQWA); Bradykinin-potentiating peptide 13a+QWA (BPP-13a+QWA); Bradykinin-potentiating peptide 13a (BPP-13a); Bradykinin-potentiating peptide 10c+QQWA (BPP-10c+QQWA); Bradykinin-potentiating peptide 10c (BPP-10c) (BPP-2) (Evasin-10c); Bradykinin-potentiating peptide 12b (BPP-12b) (Evasin-12b); Bradykinin-potentiating peptide AP; Bradykinin-potentiating peptide APL (BPP-APL); Bradykinin-potentiating peptide 11e (BPP-11e) (Evasin-11e); Bradykinin-potentiating peptide 5a (BPP-5a) (Bradykinin-potentiating peptide Va) (BPPVa) (Evasin-5a) (Proline-rich peptide 5a) (Bj-PRO-5a) (PRO-5a); Poly-His-poly-Gly peptide 1 (pHpG-1); C-type natriuretic peptide (Bj-CNP)]
[Or22b AN12 DOR22A.2 dor67 Or22A.2 CG4231] Odorant receptor 22b
[esxB cfp10 lhp mtsA10 Rv3874 MTV027.09] ESAT-6-like protein EsxB (10 kDa culture filtrate antigen CFP-10) (CFP-10) (Secreted antigenic protein MTSA-10)
[DST BP230 BP240 BPAG1 DMH DT KIAA0728] Dystonin (230 kDa bullous pemphigoid antigen) (230/240 kDa bullous pemphigoid antigen) (Bullous pemphigoid antigen 1) (BPA) (Bullous pemphigoid antigen) (Dystonia musculorum protein) (Hemidesmosomal plaque protein)
[HSP90AA1 HSP90A HSPC1 HSPCA] Heat shock protein HSP 90-alpha (Heat shock 86 kDa) (HSP 86) (HSP86) (Lipopolysaccharide-associated protein 2) (LAP-2) (LPS-associated protein 2) (Renal carcinoma antigen NY-REN-38)
[Bag6 Bat3] Large proline-rich protein BAG6 (BAG family molecular chaperone regulator 6) (BCL2-associated athanogene 6) (BAG-6) (HLA-B-associated transcript 3) (Protein Scythe)
[C4BPA C4BP] C4b-binding protein alpha chain (C4bp) (Proline-rich protein) (PRP)
[tat] Protein Tat (Transactivating regulatory protein)

Bibliography :
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