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Allograft inflammatory factor 1 (AIF-1)

 AIF1_BOVIN              Reviewed;         147 AA.
Q9BDK2;
27-JUN-2006, integrated into UniProtKB/Swiss-Prot.
01-JUN-2001, sequence version 1.
11-DEC-2019, entry version 112.
RecName: Full=Allograft inflammatory factor 1;
Short=AIF-1;
Name=AIF1;
Bos taurus (Bovine).
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
Eutheria; Laurasiatheria; Artiodactyla; Ruminantia; Pecora; Bovidae;
Bovinae; Bos.
NCBI_TaxID=9913;
[1]
NUCLEOTIDE SEQUENCE [MRNA].
PubMed=12773430; DOI=10.1095/biolreprod.102.015065;
Glover M.D., Seidel G.E. Jr.;
"Increased messenger RNA for allograft inflammatory factor-1, LERK-5, and a
novel gene in 17.5-day relative to 15.5-day bovine embryos.";
Biol. Reprod. 69:1002-1012(2003).
[2]
NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
STRAIN=Crossbred X Angus; TISSUE=Ileum;
NIH - Mammalian Gene Collection (MGC) project;
Submitted (AUG-2005) to the EMBL/GenBank/DDBJ databases.
-!- FUNCTION: May play a role in macrophage activation and function.
{ECO:0000250}.
-!- SUBCELLULAR LOCATION: Cytoplasm, cytoskeleton
{ECO:0000250|UniProtKB:O70200}. Cell projection, ruffle membrane
{ECO:0000250|UniProtKB:O70200}; Peripheral membrane protein
{ECO:0000250|UniProtKB:O70200}; Cytoplasmic side
{ECO:0000250|UniProtKB:O70200}. Cell projection, phagocytic cup
{ECO:0000250|UniProtKB:O70200}. Note=Associated with the actin
cytoskeleton at membrane ruffles and at sites of phagocytosis.
{ECO:0000250|UniProtKB:O70200}.
-!- PTM: Phosphorylated on serine residues. {ECO:0000250}.
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EMBL; AF348450; AAK30155.1; -; mRNA.
EMBL; BC102890; AAI02891.1; -; mRNA.
RefSeq; NP_776410.1; NM_173985.2.
SMR; Q9BDK2; -.
STRING; 9913.ENSBTAP00000027388; -.
PaxDb; Q9BDK2; -.
PRIDE; Q9BDK2; -.
Ensembl; ENSBTAT00000027388; ENSBTAP00000027388; ENSBTAG00000020554.
GeneID; 280989; -.
KEGG; bta:280989; -.
CTD; 199; -.
VGNC; VGNC:25759; AIF1.
eggNOG; ENOG410KCUI; Eukaryota.
eggNOG; ENOG411206J; LUCA.
GeneTree; ENSGT00390000013846; -.
HOGENOM; HOG000231928; -.
InParanoid; Q9BDK2; -.
KO; K18617; -.
OMA; DDPKYST; -.
OrthoDB; 1270941at2759; -.
TreeFam; TF320736; -.
Proteomes; UP000009136; Chromosome 23.
Bgee; ENSBTAG00000020554; Expressed in 10 organ(s), highest expression level in spleen.
GO; GO:0005884; C:actin filament; IEA:Ensembl.
GO; GO:0042995; C:cell projection; IBA:GO_Central.
GO; GO:0005737; C:cytoplasm; ISS:UniProtKB.
GO; GO:0005829; C:cytosol; ISS:UniProtKB.
GO; GO:0030027; C:lamellipodium; ISS:UniProtKB.
GO; GO:0005634; C:nucleus; ISS:UniProtKB.
GO; GO:0048471; C:perinuclear region of cytoplasm; IEA:Ensembl.
GO; GO:0001891; C:phagocytic cup; ISS:UniProtKB.
GO; GO:0032587; C:ruffle membrane; IEA:UniProtKB-SubCell.
GO; GO:0051015; F:actin filament binding; ISS:UniProtKB.
GO; GO:0005509; F:calcium ion binding; IBA:GO_Central.
GO; GO:0051764; P:actin crosslink formation; IEA:Ensembl.
GO; GO:0051017; P:actin filament bundle assembly; ISS:UniProtKB.
GO; GO:0030041; P:actin filament polymerization; ISS:UniProtKB.
GO; GO:0071346; P:cellular response to interferon-gamma; ISS:UniProtKB.
GO; GO:0034599; P:cellular response to oxidative stress; IEA:Ensembl.
GO; GO:0006954; P:inflammatory response; ISS:UniProtKB.
GO; GO:0071672; P:negative regulation of smooth muscle cell chemotaxis; IEA:Ensembl.
GO; GO:0048662; P:negative regulation of smooth muscle cell proliferation; IEA:Ensembl.
GO; GO:0030046; P:parallel actin filament bundle assembly; IEA:Ensembl.
GO; GO:0006911; P:phagocytosis, engulfment; ISS:UniProtKB.
GO; GO:0090197; P:positive regulation of chemokine secretion; IEA:Ensembl.
GO; GO:0090271; P:positive regulation of fibroblast growth factor production; IEA:Ensembl.
GO; GO:1900087; P:positive regulation of G1/S transition of mitotic cell cycle; ISS:UniProtKB.
GO; GO:2000778; P:positive regulation of interleukin-6 secretion; IEA:Ensembl.
GO; GO:0090026; P:positive regulation of monocyte chemotaxis; ISS:UniProtKB.
GO; GO:0071673; P:positive regulation of smooth muscle cell chemotaxis; ISS:UniProtKB.
GO; GO:0048661; P:positive regulation of smooth muscle cell proliferation; ISS:UniProtKB.
GO; GO:2000406; P:positive regulation of T cell migration; ISS:UniProtKB.
GO; GO:0042102; P:positive regulation of T cell proliferation; ISS:UniProtKB.
GO; GO:0016601; P:Rac protein signal transduction; ISS:UniProtKB.
GO; GO:0097178; P:ruffle assembly; ISS:UniProtKB.
InterPro; IPR042433; AIF1/AIF1L.
InterPro; IPR011992; EF-hand-dom_pair.
InterPro; IPR002048; EF_hand_dom.
PANTHER; PTHR10356; PTHR10356; 1.
SUPFAM; SSF47473; SSF47473; 1.
PROSITE; PS50222; EF_HAND_2; 1.
2: Evidence at transcript level;
Acetylation; Calcium; Cell membrane; Cell projection; Cytoplasm;
Cytoskeleton; Membrane; Metal-binding; Phosphoprotein; Reference proteome;
Repeat.
INIT_MET 1
/note="Removed"
/evidence="ECO:0000250|UniProtKB:P81076"
CHAIN 2..147
/note="Allograft inflammatory factor 1"
/id="PRO_0000244410"
DOMAIN 45..80
/note="EF-hand 1"
/evidence="ECO:0000255|PROSITE-ProRule:PRU00448"
DOMAIN 81..115
/note="EF-hand 2; degenerate"
/evidence="ECO:0000255|PROSITE-ProRule:PRU00448"
CA_BIND 58..69
/note="1"
/evidence="ECO:0000255|PROSITE-ProRule:PRU00448"
MOD_RES 2
/note="N-acetylserine"
/evidence="ECO:0000250|UniProtKB:P81076"
MOD_RES 11
/note="N6-acetyllysine"
/evidence="ECO:0000250|UniProtKB:P55008"
MOD_RES 39
/note="Phosphoserine"
/evidence="ECO:0000250|UniProtKB:P55008"
SEQUENCE 147 AA; 16855 MW; 60638F76A18E1BF8 CRC64;
MSETRDLQGG KAFGLRKAQQ EERINEINQQ FLDDPKYSSD EDLPSKLEAF KKKYMEFDLN
EDGGIDIMSL KRMMEKLGVP KTHLELKKLI MEVSSGPGET FSYSDFLKMM LGKRSAILKM
ILMYEEKARE QEKPTGLPAK KAISELP


Related products :

Catalog number Product name Quantity
20-321-175222 ALLOGRAFT - INFLAMMATORY FACTOR-1 (AIF-1) - MONOCLONAL ANTIBODY TO HUMAN ALLOGRAFT- INFLAMMATORY FACTOR-1 (AIF-1); AIF-1; Ionized calcium-binding adapter molecule 1; Protein G1 Monoclonal 0.1 mg
EH1425 Allograft inflammatory factor 1 Elisa Kit 96T
GWB-621C02 ALLOGRAFT - INFLAMMATORY FACTOR-1 (AIF-1), Antibody
cyt-697 Recombinant Human Allograft Inflammatory Factor 1 2
CYT-697 Recombinant Human Allograft Inflammatory Factor 1 10µg
CYT-697 Recombinant Human Allograft Inflammatory Factor 1 1mg
RCY-697 Recombinant Human Allograft Inflammatory Factor 1 2
CF31 Allograft Inflammatory Factor 1 AIF1 lmg
CYT-697 Recombinant Human Allograft Inflammatory Factor 1 2µg
E02A0627 Rat Allograft Inflammatory Factor 1 ELISA 96T/kit
cyt-007 Recombinant Human Allograft Inflammatory Factor 1 Like 20
cyt-007 Recombinant Human Allograft Inflammatory Factor 1 Like 1mg
cyt-697 Recombinant Human Allograft Inflammatory Factor 1 1mg
cyt-007 Recombinant Human Allograft Inflammatory Factor 1 Like 5
cyt-697 Recombinant Human Allograft Inflammatory Factor 1 10
CF31 Allograft Inflammatory Factor 1 AIF1 500
RCY-007 Recombinant Human Allograft Inflammatory Factor 1 Like 5
7-00055 Recombinant Human Allograft Inflammatory Factor 1 Like 5
E92288Mu ELISA Kit for Allograft Inflammatory Factor 1 (AIF1) 96T/Kit
7-00052 Recombinant Human Allograft Inflammatory Factor 1 2
E12A0627 Chicken Allograft Inflammatory Factor 1 ELISA 96T/kit
cyt-007 Recombinant Human Allograft Inflammatory Factor 1 Like AIF1L 1mg
cyt-697 Recombinant Human Allograft Inflammatory Factor 1 AIF1 1mg
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Pathways :
WP272: Blood Clotting Cascade
WP1040: Inflammatory Response Pathway
WP1156: Inflammatory Response Pathway
WP444: Signaling of Hepatocyte Growth Factor Receptor
WP530: Cytokines and Inflammatory Response
WP1235: Signaling of Hepatocyte Growth Factor Receptor
WP920: Inflammatory Response Pathway
WP193: Signaling of Hepatocyte Growth Factor Receptor
WP997: Cytokines and Inflammatory Response (BioCarta)
WP2148: Brain derived neurotrophic factor
WP271: Cytokines and Inflammatory Response (BioCarta)
WP40: Inflammatory Response Pathway
WP1113: Cytokines and Inflammatory Response
WP1206: Signaling of Hepatocyte Growth Factor Receptor
WP458: Inflammatory Response Pathway
WP879: Cytokines and Inflammatory Response (BioCarta)
WP1899: Regulation of Insulin-like Growth Factor (IGF) Activity by Insulin-like Growth Factor Binding Proteins (IGFBPs)
WP1983: Splicing factor NOVA regulated synpatic proteins
WP94: Signaling of Hepatocyte Growth Factor Receptor
WP2328: Allograft rejection
WP313: Signaling of Hepatocyte Growth Factor Receptor
WP1046: Signaling of Hepatocyte Growth Factor Receptor
WP1162: Signaling of Hepatocyte Growth Factor Receptor
WP453: Inflammatory Response Pathway
WP810: Signaling of Hepatocyte Growth Factor Receptor

Related Genes :
[Aifm1 Aif Pdcd8] Apoptosis-inducing factor 1, mitochondrial (EC 1.1.1.-) (Programmed cell death protein 8)
[AIFM1 AIF PDCD8] Apoptosis-inducing factor 1, mitochondrial (EC 1.1.1.-) (Programmed cell death protein 8)
[S100a8 Caga Mrp8] Protein S100-A8 (Calgranulin-A) (Chemotactic cytokine CP-10) (Leukocyte L1 complex light chain) (Migration inhibitory factor-related protein 8) (MRP-8) (p8) (Pro-inflammatory S100 cytokine) (S100 calcium-binding protein A8)
[Aifm1 Aif Pdcd8] Apoptosis-inducing factor 1, mitochondrial (EC 1.1.1.-) (Programmed cell death protein 8)
[AIF CG7263] Putative apoptosis-inducing factor 1, mitochondrial (DmAIF) (EC 1.1.1.-)
[CCL3 G0S19-1 MIP1A SCYA3] C-C motif chemokine 3 (G0/G1 switch regulatory protein 19-1) (Macrophage inflammatory protein 1-alpha) (MIP-1-alpha) (PAT 464.1) (SIS-beta) (Small-inducible cytokine A3) (Tonsillar lymphocyte LD78 alpha protein) [Cleaved into: MIP-1-alpha(4-69) (LD78-alpha(4-69))]
[MAPK14 CSBP CSBP1 CSBP2 CSPB1 MXI2 SAPK2A] Mitogen-activated protein kinase 14 (MAP kinase 14) (MAPK 14) (EC 2.7.11.24) (Cytokine suppressive anti-inflammatory drug-binding protein) (CSAID-binding protein) (CSBP) (MAP kinase MXI2) (MAX-interacting protein 2) (Mitogen-activated protein kinase p38 alpha) (MAP kinase p38 alpha) (Stress-activated protein kinase 2a) (SAPK2a)
[CSF1] Macrophage colony-stimulating factor 1 (CSF-1) (M-CSF) (MCSF) (Lanimostim) [Cleaved into: Processed macrophage colony-stimulating factor 1]
[CCL4 LAG1 MIP1B SCYA4] C-C motif chemokine 4 (G-26 T-lymphocyte-secreted protein) (HC21) (Lymphocyte activation gene 1 protein) (LAG-1) (MIP-1-beta(1-69)) (Macrophage inflammatory protein 1-beta) (MIP-1-beta) (PAT 744) (Protein H400) (SIS-gamma) (Small-inducible cytokine A4) (T-cell activation protein 2) (ACT-2) [Cleaved into: MIP-1-beta(3-69)]
[NOD2 CARD15 IBD1] Nucleotide-binding oligomerization domain-containing protein 2 (Caspase recruitment domain-containing protein 15) (Inflammatory bowel disease protein 1)
[CCL18 AMAC1 DCCK1 MIP4 PARC SCYA18] C-C motif chemokine 18 (Alternative macrophage activation-associated CC chemokine 1) (AMAC-1) (CC chemokine PARC) (Dendritic cell chemokine 1) (DC-CK1) (Macrophage inflammatory protein 4) (MIP-4) (Pulmonary and activation-regulated chemokine) (Small-inducible cytokine A18) [Cleaved into: CCL18(1-68); CCL18(3-69); CCL18(4-69)]
[CSF1R FMS] Macrophage colony-stimulating factor 1 receptor (CSF-1 receptor) (CSF-1-R) (CSF-1R) (M-CSF-R) (EC 2.7.10.1) (Proto-oncogene c-Fms) (CD antigen CD115)
[CCL20 LARC MIP3A SCYA20] C-C motif chemokine 20 (Beta-chemokine exodus-1) (CC chemokine LARC) (Liver and activation-regulated chemokine) (Macrophage inflammatory protein 3 alpha) (MIP-3-alpha) (Small-inducible cytokine A20) [Cleaved into: CCL20(1-67); CCL20(1-64); CCL20(2-70)]
[CCL4L1 CCL4L LAG1 SCYA4L1; CCL4L2 CCL4L SCYA4L2] C-C motif chemokine 4-like (Lymphocyte activation gene 1 protein) (LAG-1) (Macrophage inflammatory protein 1-beta) (MIP-1-beta) (Monocyte adherence-induced protein 5-alpha) (Small-inducible cytokine A4-like)
[aif DDB_G0288247] Apoptosis-inducing factor 1, mitochondrial (EC 1.1.1.-) (Ddaif)
[CXCL2 GRO2 GROB MIP2A SCYB2] C-X-C motif chemokine 2 (Growth-regulated protein beta) (Gro-beta) (Macrophage inflammatory protein 2-alpha) (MIP2-alpha) [Cleaved into: GRO-beta(5-73) (GRO-beta-T) (Hematopoietic synergistic factor) (HSF) (SB-251353)]
[CCL15 MIP5 NCC3 SCYA15] C-C motif chemokine 15 (Chemokine CC-2) (HCC-2) (Leukotactin-1) (LKN-1) (MIP-1 delta) (Macrophage inflammatory protein 5) (MIP-5) (Mrp-2b) (NCC-3) (Small-inducible cytokine A15) [Cleaved into: CCL15(22-92); CCL15(25-92); CCL15(29-92)]
[Oprm1 Mor Oprm] Mu-type opioid receptor (M-OR-1) (MOR-1)
[CCR1 CMKBR1 CMKR1 SCYAR1] C-C chemokine receptor type 1 (C-C CKR-1) (CC-CKR-1) (CCR-1) (CCR1) (HM145) (LD78 receptor) (Macrophage inflammatory protein 1-alpha receptor) (MIP-1alpha-R) (RANTES-R) (CD antigen CD191)
[Ccr1 Cmkbr1] C-C chemokine receptor type 1 (C-C CKR-1) (CC-CKR-1) (CCR-1) (CCR1) (Macrophage inflammatory protein 1-alpha receptor) (MIP-1alpha-R) (RANTES-R) (CD antigen CD191)
[stk-1 bur1 B20D17.070 NCU01435] Serine/threonine-protein kinase bur1 (EC 2.7.11.22) (EC 2.7.11.23) (Serine-threonine kinase 1)
[al-3 B8P8.010 NCU01427] Geranylgeranyl pyrophosphate synthase (GGPP synthase) (GGPPSase) (EC 2.5.1.-) ((2E,6E)-farnesyl diphosphate synthase) (Albino-3 protein) (Dimethylallyltranstransferase) (EC 2.5.1.1) (Farnesyl diphosphate synthase) (Farnesyltranstransferase) (EC 2.5.1.29) (Geranylgeranyl diphosphate synthase) (Geranyltranstransferase) (EC 2.5.1.10)
[APEX1 APE APE1 APEX APX HAP1 REF1] DNA-(apurinic or apyrimidinic site) lyase (EC 3.1.-.-) (EC 4.2.99.18) (APEX nuclease) (APEN) (Apurinic-apyrimidinic endonuclease 1) (AP endonuclease 1) (APE-1) (REF-1) (Redox factor-1) [Cleaved into: DNA-(apurinic or apyrimidinic site) lyase, mitochondrial]
[Apex1 Ape Apex Ref1] DNA-(apurinic or apyrimidinic site) lyase (EC 3.1.-.-) (EC 4.2.99.18) (APEX nuclease) (APEN) (Apurinic-apyrimidinic endonuclease 1) (AP endonuclease 1) (REF-1) (Redox factor-1) [Cleaved into: DNA-(apurinic or apyrimidinic site) lyase, mitochondrial]
[APEX1 APE APEX BAP1 REF1] DNA-(apurinic or apyrimidinic site) lyase (EC 3.1.-.-) (EC 4.2.99.18) (APEX nuclease) (APEN) (Apurinic-apyrimidinic endonuclease 1) (AP endonuclease 1) (REF-1) (Redox factor-1) [Cleaved into: DNA-(apurinic or apyrimidinic site) lyase, mitochondrial]
[APEX1 APE APEX BAP1 REF1] DNA-(apurinic or apyrimidinic site) lyase (EC 3.1.-.-) (EC 4.2.99.18) (APEX nuclease) (APEN) (Apurinic-apyrimidinic endonuclease 1) (AP endonuclease 1) (REF-1) (Redox factor-1) [Cleaved into: DNA-(apurinic or apyrimidinic site) lyase, mitochondrial]
[APEX1 APE APEX BAP1 REF1] DNA-(apurinic or apyrimidinic site) lyase (EC 3.1.-.-) (EC 4.2.99.18) (APEX nuclease) (APEN) (Apurinic-apyrimidinic endonuclease 1) (AP endonuclease 1) (REF-1) (Redox factor-1) [Cleaved into: DNA-(apurinic or apyrimidinic site) lyase, mitochondrial]
[APEX1 APE APEX BAP1 REF1] DNA-(apurinic or apyrimidinic site) lyase (EC 3.1.-.-) (EC 4.2.99.18) (APEX nuclease) (APEN) (Apurinic-apyrimidinic endonuclease 1) (AP endonuclease 1) (REF-1) (Redox factor-1) [Cleaved into: DNA-(apurinic or apyrimidinic site) lyase, mitochondrial]
[Apex1 Ape Apex Ref1] DNA-(apurinic or apyrimidinic site) lyase (EC 3.1.-.-) (EC 4.2.99.18) (APEX nuclease) (APEN) (Apurinic-apyrimidinic endonuclease 1) (AP endonuclease 1) (REF-1) (Redox factor-1) [Cleaved into: DNA-(apurinic or apyrimidinic site) lyase, mitochondrial]
[aro-1 aro-2 aro-4 aro-5 aro-9 B14H13.20 NCU016321] Pentafunctional AROM polypeptide [Includes: 3-dehydroquinate synthase (DHQS) (EC 4.2.3.4); 3-phosphoshikimate 1-carboxyvinyltransferase (EC 2.5.1.19) (5-enolpyruvylshikimate-3-phosphate synthase) (EPSP synthase) (EPSPS); Shikimate kinase (SK) (EC 2.7.1.71); 3-dehydroquinate dehydratase (3-dehydroquinase) (EC 4.2.1.10); Shikimate dehydrogenase (EC 1.1.1.25)]

Bibliography :
[32057519] Extracellular allograft inflammatory factor-1 (AIF-1) potentiates Th1 cell differentiation and inhibits Treg response in human peripheral blood mononuclear cells from normal subjects.
[31830499] Role of allograft inflammatory factor-1 in pathogenesis of diseases.
[31389223] Effects of AIF-1 inflammatory factors on the regulation of proliferation of breast cancer cells.
[30761680] Role of allograft inflammatory factor-1 in the regulation of inflammation and oxidative stress in primary peritoneal mesothelial cells.
[30368505] AIF-1 and RNASET2 Play Complementary Roles in the Innate Immune Response of Medicinal Leech.
[30304710] Nucleus-translocated matrix metalloprotease 1 regulates innate immune response in Pacific abalone (Haliotis discus hannai).
[30258845] The Role of Allograft Inflammatory Factor-1 in the Effects of Experimental Diabetes on B Cell Functions in the Heart.
[30252881] AIF-1 gene does not confer susceptibility to Behçet's disease: Analysis of extended haplotypes in Sardinian population.
[30188879] Expression of Allograft Inflammatory Factor-1 (AIF-1) in Hepatocellular Carcinoma.
[30108663] Tualang Honey Reduced Neuroinflammation and Caspase-3 Activity in Rat Brain after Kainic Acid-Induced Status Epilepticus.