GENTAUR Belgium BVBA BE0473327336 Voortstraat 49, 1910 Kampenhout BELGIUM Tel 0032 16 58 90 45
GENTAUR U.S.A Genprice Inc,Logistics 547 Yurok Circle, SanJose, CA 95123
Tel (408) 780-0908, Fax (408) 780-0908, [email protected]

Did you know ? If you order before Friday 14h we deliver 90PCT of the the time next Tuesday, Gentaur another in time delivery

Alpha-synuclein

 SYUA_BOVIN              Reviewed;         140 AA.
Q3T0G8;
10-JAN-2006, integrated into UniProtKB/Swiss-Prot.
11-OCT-2005, sequence version 1.
13-FEB-2019, entry version 103.
RecName: Full=Alpha-synuclein;
Name=SNCA;
Bos taurus (Bovine).
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
Mammalia; Eutheria; Laurasiatheria; Cetartiodactyla; Ruminantia;
Pecora; Bovidae; Bovinae; Bos.
NCBI_TaxID=9913;
[1]
NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
STRAIN=Crossbred X Angus; TISSUE=Ileum;
NIH - Mammalian Gene Collection (MGC) project;
Submitted (AUG-2005) to the EMBL/GenBank/DDBJ databases.
-!- FUNCTION: Neuronal protein that plays several roles in synaptic
activity such as regulation of synaptic vesicle trafficking and
subsequent neurotransmitter release. Participates as a monomer in
synaptic vesicle exocytosis by enhancing vesicle priming, fusion
and dilation of exocytotic fusion pores. Mechanistically, acts by
increasing local Ca(2+) release from microdomains which is
essential for the enhancement of ATP-induced exocytosis. Acts also
as a molecular chaperone in its multimeric membrane-bound state,
assisting in the folding of synaptic fusion components called
SNAREs (Soluble NSF Attachment Protein REceptors) at presynaptic
plasma membrane in conjunction with cysteine string protein-
alpha/DNAJC5. This chaperone activity is important to sustain
normal SNARE-complex assembly during aging. Plays also a role in
the regulation of the dopamine neurotransmission by associating
with the dopamine transporter (DAT1) and thereby modulating its
activity. {ECO:0000250|UniProtKB:P37840}.
-!- SUBUNIT: Soluble monomer. Homotetramer. A dynamic intracellular
population of tetramers and monomers coexists normally and the
tetramer plays an essential role in maintaining homeostasis (By
similarity). Interacts with UCHL1 (By similarity). Interacts with
phospholipase D and histones. Interacts (via N-terminus) with
synphilin-1/SNCAIP; this interaction promotes formation of SNCA
inclusions in the cytoplasm. Interacts with CALM1. Interacts with
STXBP1; this interaction controls SNCA self-replicating
aggregation. Interacts with SNARE components VAMP2 and SNAP25;
these interactions allows SNARE complex assembly and integrity (By
similarity). {ECO:0000250|UniProtKB:P37377,
ECO:0000250|UniProtKB:P37840}.
-!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000250|UniProtKB:P37840}.
Membrane {ECO:0000250|UniProtKB:P37840}. Nucleus
{ECO:0000250|UniProtKB:P37840}. Cell junction, synapse
{ECO:0000250|UniProtKB:P37840}. Secreted
{ECO:0000250|UniProtKB:P37840}. Note=Membrane-bound in
dopaminergic neurons. {ECO:0000250|UniProtKB:P37840}.
-!- PTM: Phosphorylated, predominantly on serine residues.
Phosphorylated on Tyr-125 upon osmotic stress (By similarity).
{ECO:0000250}.
-!- PTM: Ubiquitinated. The predominant conjugate is the
diubiquitinated form (By similarity). {ECO:0000250}.
-!- PTM: Acetylation at Met-1 seems to be important for proper folding
and native oligomeric structure. {ECO:0000250}.
-!- SIMILARITY: Belongs to the synuclein family. {ECO:0000305}.
-----------------------------------------------------------------------
Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
Distributed under the Creative Commons Attribution (CC BY 4.0) License
-----------------------------------------------------------------------
EMBL; BC102402; AAI02403.1; -; mRNA.
RefSeq; NP_001029213.1; NM_001034041.2.
RefSeq; XP_005207811.1; XM_005207754.3.
RefSeq; XP_005207812.1; XM_005207755.3.
RefSeq; XP_005207813.1; XM_005207756.3.
RefSeq; XP_005207814.1; XM_005207757.3.
RefSeq; XP_005207815.1; XM_005207758.3.
UniGene; Bt.12770; -.
ProteinModelPortal; Q3T0G8; -.
SMR; Q3T0G8; -.
BioGrid; 159869; 1.
STRING; 9913.ENSBTAP00000021300; -.
PaxDb; Q3T0G8; -.
PRIDE; Q3T0G8; -.
Ensembl; ENSBTAT00000021300; ENSBTAP00000021300; ENSBTAG00000024957.
GeneID; 282857; -.
KEGG; bta:282857; -.
CTD; 6622; -.
VGNC; VGNC:35059; SNCA.
eggNOG; ENOG410IWI2; Eukaryota.
eggNOG; ENOG4111TDZ; LUCA.
GeneTree; ENSGT00940000154211; -.
HOGENOM; HOG000008691; -.
HOVERGEN; HBG000481; -.
InParanoid; Q3T0G8; -.
KO; K04528; -.
OMA; SEAYEMP; -.
OrthoDB; 1544450at2759; -.
TreeFam; TF332776; -.
Proteomes; UP000009136; Chromosome 6.
Bgee; ENSBTAG00000024957; Expressed in 10 organ(s), highest expression level in brain.
GO; GO:0015629; C:actin cytoskeleton; IEA:Ensembl.
GO; GO:0005938; C:cell cortex; IEA:Ensembl.
GO; GO:0030054; C:cell junction; IEA:UniProtKB-KW.
GO; GO:0005829; C:cytosol; ISS:UniProtKB.
GO; GO:0005615; C:extracellular space; ISS:UniProtKB.
GO; GO:0030426; C:growth cone; IEA:Ensembl.
GO; GO:0016234; C:inclusion body; IEA:Ensembl.
GO; GO:0016020; C:membrane; ISS:UniProtKB.
GO; GO:0005739; C:mitochondrion; IEA:GOC.
GO; GO:0043025; C:neuronal cell body; IEA:Ensembl.
GO; GO:0005634; C:nucleus; ISS:UniProtKB.
GO; GO:0048471; C:perinuclear region of cytoplasm; IEA:Ensembl.
GO; GO:0005886; C:plasma membrane; IEA:Ensembl.
GO; GO:0031092; C:platelet alpha granule membrane; IEA:Ensembl.
GO; GO:0098794; C:postsynapse; IEA:GOC.
GO; GO:0099512; C:supramolecular fiber; IEA:Ensembl.
GO; GO:0030672; C:synaptic vesicle membrane; IEA:Ensembl.
GO; GO:0003779; F:actin binding; IEA:Ensembl.
GO; GO:0043014; F:alpha-tubulin binding; IEA:Ensembl.
GO; GO:0050544; F:arachidonic acid binding; IEA:Ensembl.
GO; GO:0005509; F:calcium ion binding; IEA:Ensembl.
GO; GO:0005507; F:copper ion binding; ISS:UniProtKB.
GO; GO:1903136; F:cuprous ion binding; IEA:Ensembl.
GO; GO:0043027; F:cysteine-type endopeptidase inhibitor activity involved in apoptotic process; IEA:Ensembl.
GO; GO:0070840; F:dynein complex binding; IEA:Ensembl.
GO; GO:0008198; F:ferrous iron binding; IEA:Ensembl.
GO; GO:0042393; F:histone binding; IEA:Ensembl.
GO; GO:0030544; F:Hsp70 protein binding; IEA:Ensembl.
GO; GO:0042802; F:identical protein binding; ISS:UniProtKB.
GO; GO:0019894; F:kinesin binding; IEA:Ensembl.
GO; GO:0000287; F:magnesium ion binding; IEA:Ensembl.
GO; GO:0016491; F:oxidoreductase activity; IEA:Ensembl.
GO; GO:0005543; F:phospholipid binding; IEA:Ensembl.
GO; GO:0051219; F:phosphoprotein binding; IEA:Ensembl.
GO; GO:0000149; F:SNARE binding; IEA:Ensembl.
GO; GO:0048156; F:tau protein binding; IEA:Ensembl.
GO; GO:0008270; F:zinc ion binding; IEA:Ensembl.
GO; GO:0006919; P:activation of cysteine-type endopeptidase activity involved in apoptotic process; IEA:Ensembl.
GO; GO:0008344; P:adult locomotory behavior; IEA:Ensembl.
GO; GO:0071280; P:cellular response to copper ion; IEA:Ensembl.
GO; GO:0034599; P:cellular response to oxidative stress; IEA:Ensembl.
GO; GO:0042416; P:dopamine biosynthetic process; IEA:Ensembl.
GO; GO:0060079; P:excitatory postsynaptic potential; IEA:Ensembl.
GO; GO:0006631; P:fatty acid metabolic process; IEA:Ensembl.
GO; GO:0060291; P:long-term synaptic potentiation; IEA:Ensembl.
GO; GO:0001774; P:microglial cell activation; IEA:Ensembl.
GO; GO:0042775; P:mitochondrial ATP synthesis coupled electron transport; IEA:Ensembl.
GO; GO:0007006; P:mitochondrial membrane organization; IEA:Ensembl.
GO; GO:1904715; P:negative regulation of chaperone-mediated autophagy; IEA:Ensembl.
GO; GO:0051585; P:negative regulation of dopamine uptake involved in synaptic transmission; IEA:Ensembl.
GO; GO:0045920; P:negative regulation of exocytosis; IEA:Ensembl.
GO; GO:0035067; P:negative regulation of histone acetylation; IEA:Ensembl.
GO; GO:0031115; P:negative regulation of microtubule polymerization; IEA:Ensembl.
GO; GO:0032769; P:negative regulation of monooxygenase activity; IEA:Ensembl.
GO; GO:0043524; P:negative regulation of neuron apoptotic process; IEA:Ensembl.
GO; GO:0051622; P:negative regulation of norepinephrine uptake; IEA:Ensembl.
GO; GO:0010642; P:negative regulation of platelet-derived growth factor receptor signaling pathway; IEA:Ensembl.
GO; GO:0051612; P:negative regulation of serotonin uptake; IEA:Ensembl.
GO; GO:0070495; P:negative regulation of thrombin-activated receptor signaling pathway; IEA:Ensembl.
GO; GO:0032410; P:negative regulation of transporter activity; IEA:Ensembl.
GO; GO:0006638; P:neutral lipid metabolic process; IEA:Ensembl.
GO; GO:0006644; P:phospholipid metabolic process; IEA:Ensembl.
GO; GO:0045807; P:positive regulation of endocytosis; IEA:Ensembl.
GO; GO:0045921; P:positive regulation of exocytosis; IEA:Ensembl.
GO; GO:1903284; P:positive regulation of glutathione peroxidase activity; IEA:Ensembl.
GO; GO:1903285; P:positive regulation of hydrogen peroxide catabolic process; IEA:Ensembl.
GO; GO:0050729; P:positive regulation of inflammatory response; IEA:Ensembl.
GO; GO:0060732; P:positive regulation of inositol phosphate biosynthetic process; IEA:Ensembl.
GO; GO:1901216; P:positive regulation of neuron death; IEA:Ensembl.
GO; GO:0001956; P:positive regulation of neurotransmitter secretion; IEA:Ensembl.
GO; GO:0033138; P:positive regulation of peptidyl-serine phosphorylation; IEA:Ensembl.
GO; GO:0071902; P:positive regulation of protein serine/threonine kinase activity; IEA:Ensembl.
GO; GO:0001921; P:positive regulation of receptor recycling; IEA:Ensembl.
GO; GO:0051281; P:positive regulation of release of sequestered calcium ion into cytosol; IEA:Ensembl.
GO; GO:0031648; P:protein destabilization; IEA:Ensembl.
GO; GO:0051262; P:protein tetramerization; IEA:Ensembl.
GO; GO:0031623; P:receptor internalization; IEA:Ensembl.
GO; GO:0050812; P:regulation of acyl-CoA biosynthetic process; IEA:Ensembl.
GO; GO:0014059; P:regulation of dopamine secretion; IEA:Ensembl.
GO; GO:0014048; P:regulation of glutamate secretion; IEA:Ensembl.
GO; GO:0040012; P:regulation of locomotion; IEA:Ensembl.
GO; GO:0048169; P:regulation of long-term neuronal synaptic plasticity; IEA:Ensembl.
GO; GO:0043030; P:regulation of macrophage activation; IEA:Ensembl.
GO; GO:0010517; P:regulation of phospholipase activity; IEA:Ensembl.
GO; GO:1905606; P:regulation of presynapse assembly; IEA:Ensembl.
GO; GO:0022898; P:regulation of transmembrane transporter activity; IEA:Ensembl.
GO; GO:0042493; P:response to drug; IEA:Ensembl.
GO; GO:0034341; P:response to interferon-gamma; IEA:Ensembl.
GO; GO:0070555; P:response to interleukin-1; IEA:Ensembl.
GO; GO:0010040; P:response to iron(II) ion; IEA:Ensembl.
GO; GO:0032496; P:response to lipopolysaccharide; IEA:Ensembl.
GO; GO:0032026; P:response to magnesium ion; IEA:Ensembl.
GO; GO:0035493; P:SNARE complex assembly; IEA:Ensembl.
GO; GO:0050808; P:synapse organization; IEA:Ensembl.
GO; GO:0001963; P:synaptic transmission, dopaminergic; IEA:Ensembl.
GO; GO:0048488; P:synaptic vesicle endocytosis; IEA:Ensembl.
GO; GO:0016079; P:synaptic vesicle exocytosis; IEA:Ensembl.
InterPro; IPR001058; Synuclein.
InterPro; IPR002460; Synuclein_alpha.
PANTHER; PTHR13820; PTHR13820; 1.
PANTHER; PTHR13820:SF5; PTHR13820:SF5; 1.
Pfam; PF01387; Synuclein; 1.
PRINTS; PR01212; ASYNUCLEIN.
PRINTS; PR01211; SYNUCLEIN.
2: Evidence at transcript level;
Acetylation; Cell junction; Complete proteome; Copper; Cytoplasm;
Membrane; Metal-binding; Nucleus; Phosphoprotein; Reference proteome;
Repeat; Secreted; Synapse; Ubl conjugation.
CHAIN 1 140 Alpha-synuclein.
/FTId=PRO_0000184019.
METAL 2 2 Copper. {ECO:0000250}.
METAL 50 50 Copper. {ECO:0000250}.
MOD_RES 1 1 N-acetylmethionine.
{ECO:0000250|UniProtKB:P37840}.
MOD_RES 87 87 Phosphoserine.
{ECO:0000250|UniProtKB:P37840}.
MOD_RES 125 125 Phosphotyrosine; by FYN.
{ECO:0000250|UniProtKB:P37840}.
MOD_RES 129 129 Phosphoserine; by PLK2.
{ECO:0000250|UniProtKB:P37840}.
SEQUENCE 140 AA; 14508 MW; 1F37F1A7B795536C CRC64;
MDVFMKGLSK AKEGVVAAAE KTKQGVAEAA GRTKEGVLYV GSKTKEGVVH GVTTVAEKTK
EQVTNVGEAV VTGVTAVAQK TVEGAGSIAA ATGFGKKDHM GKGEEGASQE GILEDMPVDP
DNEAYEMPSE EGYQDYEPEA


Related products :

Catalog number Product name Quantity
hSNCA-ELISA Alpha-Synuclein (α-Synuclein, Alpha Synuclein, SNCA; Human) High Sensitivity ELISA Assay Kit
32-216 SNCG(also designated gamma-synuclein or breast cancer-specific protein 1),with 127-amino acid protein(about 14kDa), belongs to the synuclein family, which also includes alpha- and beta- synuclein.Thre 0.1 mg
32-215 Alpha-synuclein (SNCA), with 140-amino acid protein (about 15kDa), belongs to the synuclein family, which also includes beta- and gamma-synuclein. SNCA is a soluble protein, expressed principally in t 0.1 mL
PD17 BV-Synuclein. Recombinant baculovirus expressing alpha synuclein, Host: Spodoptera frugiperda, Trichoplusia ni 1 ml
PD17 BV-Synuclein. Recombinant baculovirus expressing alpha synuclein. 1 ml
SCH-AHP1537 RABBIT ANTI RAT ALPHA SYNUCLEIN (pSer129), Product Type Polyclonal Antibody, Specificity ALPHA SYNUCLEIN , Target Species Rat, Host Rabbit, Format Purified, Isotypes Polyclonal IgG, Applications 0.1 ml
AHP1537 RABBIT ANTI RAT ALPHA SYNUCLEIN (pSer129), Product Type Polyclonal Antibody, Specificity ALPHA SYNUCLEIN , Target Species Rat, Host Rabbit, Format Purified, Isotypes Polyclonal IgG, Applications 0.1 ml
20-002-35023 alpha-Synuclein (anti-alpha-Synuclein. 61-95 aa. clone 5C2) - Non-A beta component of AD amyloid; Non-A4 component of amyloid precursor; NACP Monoclonal 0.1 ml
AHP493 GOAT ANTI HUMAN ALPHA SYNUCLEIN, Product Type Polyclonal Antibody, Specificity ALPHA SYNUCLEIN, Target Species Human, Host Goat, Format Serum, Isotypes Polyclonal IgG, Applications E, P, Clone 0.1 ml
SCH-AHP493 GOAT ANTI HUMAN ALPHA SYNUCLEIN, Product Type Polyclonal Antibody, Specificity ALPHA SYNUCLEIN, Target Species Human, Host Goat, Format Serum, Isotypes Polyclonal IgG, Applications E, P, Clone 0.1 ml
20-272-192257 alpha Synuclein - Mouse monoclonal [4B12] to alpha Synuclein; Non-A beta component of AD amyloid; Non-A4 component of amyloid precursor; NACP Monoclonal 0.1 ml
RSNCA-ELISA Rabbit Alpha-Synuclein (α-Synuclein, SNCA) High Sensitivity ELISA Assay Kit (2x96T)
orb72136 Synuclein alpha peptide This is Synuclein alpha peptide. For research use only. 1 mg
20-272-192256 alpha Synuclein - Mouse monoclonal [4D6] to alpha Synuclein; Non-A beta component of AD amyloid; Non-A4 component of amyloid precursor; NACP Monoclonal 0.1 ml
18-272-196445 alpha Synuclein - Rabbit polyclonal to alpha Synuclein; Non-A beta component of AD amyloid; Non-A4 component of amyloid precursor; NACP Polyclonal 0.5 ml
orb80933 Human Alphalpha Synuclein protein alpha Synuclein Human Recombinant produced in E.coli is a single, non-glycosylated polypeptide chain of 140 amino acids having a molecular mass of 14.4kDa. The Recomb 20
18-272-196446 alpha Synuclein prediluted - Rabbit polyclonal to alpha Synuclein prediluted; Non-A beta component of AD amyloid; Non-A4 component of amyloid precursor; NACP Polyclonal 7 ml
48-658 Alpha-Synuclein Antibody 0.05 mg
50-241 Alpha synuclein Antibody 0.1 mL
Q06241M MAb to Synuclein Alpha 100ul
Q06604M MAb to Synuclein Alpha 100ul
pro-393 Recombinant Human Alpha-Synuclein 1mg
GWB-DA182E Alpha-Synuclein, Antibody
BMRB-9026-B1 Synuclein alpha 0.5mL
pro-163 Recombinant Human Alpha-Synuclein 61-140 1mg

Kits Elisa; taq POLYMERASE

Search in Google:

google

Share this page:
share on twitter rss feedsfacebookgoogle gentaur



Quick order!
Enter catalog number :


Gentaur; yes we can

Pathways :
WP2359: Parkin-Ubiquitin Proteasomal System pathway
WP1003: Ovarian Infertility Genes
WP1047: TNF-alpha NF-kB Signaling Pathway
WP1120: Ovarian Infertility Genes
WP1163: TNF-alpha NF-kB Signaling Pathway
WP1209: EBV LMP1 signaling
WP1224: EBV LMP1 signaling
WP1225: estrogen signalling
WP1340: Ovarian Infertility Genes
WP1369: TNF-alpha NF-kB Signaling Pathway
WP1434: Osteopontin Signaling
WP1487: TNF-alpha and mucus production in lung epythelium
WP1531: Vitamin D synthesis
WP1566: Citrate cycle (TCA cycle)
WP1571: EBV LMP1 signaling
WP1584: Type II diabetes mellitus
WP1614: 1- and 2-Methylnaphthalene degradation
WP1618: alpha-Linolenic acid metabolism
WP1655: Geraniol degradation
WP1772: Apoptosis Modulation and Signaling
WP1835: Interferon alpha/beta signaling
WP1904: RIG-I/MDA5 mediated induction of IFN-alpha/beta pathways
WP1963: The effect of Glucocorticoids on target gene expression
WP210: Cytoplasmic Ribosomal Proteins
WP2100: AhR pathway

Related Genes :
[SNCA NACP PARK1] Alpha-synuclein (Non-A beta component of AD amyloid) (Non-A4 component of amyloid precursor) (NACP)
[Snca Syn] Alpha-synuclein (Non-A beta component of AD amyloid) (Non-A4 component of amyloid precursor) (NACP)
[Snca] Alpha-synuclein
[SNCA] Alpha-synuclein
[SNCA] Alpha-synuclein
[SNCA] Alpha-synuclein
[SNCA] Alpha-synuclein
[SNCA] Alpha-synuclein
[SNCA] Alpha-synuclein
[SNCA] Alpha-synuclein
[Sncg] Gamma-synuclein (Persyn) (Sensory neuron synuclein)
[SNCAIP] Synphilin-1 (Sph1) (Alpha-synuclein-interacting protein)
[SNCA] Alpha-synuclein
[SNCA] Alpha-synuclein
[SNCA] Alpha-synuclein
[SNCA] Alpha-synuclein
[SNCA] Alpha-synuclein
[SNCA] Synuclein alpha
[SNCA] Alpha-synuclein
[SNCA] Alpha-synuclein
[SNCA] Alpha-synuclein
[SNCA] Alpha-synuclein
[SNCA] Alpha-synuclein
[SNCA] Alpha-synuclein
[SNCA] Alpha-synuclein
[SNCA] Alpha-synuclein
[SNCA] Alpha-synuclein
[SNCA] Alpha-synuclein
[SNCA] Alpha-synuclein
[SNCA] Alpha-synuclein

Bibliography :
[30878495] Reprint of "Ganglioside lipids accelerate α-synuclein amyloid formation".
[30878283] Co-translational, Post-translational, and Non-catalytic Roles of N-Terminal Acetyltransferases.
[30877973] Therapeutic potentials of plant iridoids in Alzheimer's and Parkinson's diseases: A review.
[30877431] Alpha-synuclein suppresses mitochondrial protease ClpP to trigger mitochondrial oxidative damage and neurotoxicity.
[30875980] Modulation of Disordered Proteins with a Focus on Neurodegenerative Diseases and Other Pathologies.
[30875755] Prion and Prion-Like Protein Strains: Deciphering the Molecular Basis of Heterogeneity in Neurodegeneration.
[30873322] Mechanical and thermodynamic properties of Aβ, Aβ, and α-synuclein fibrils: a coarse-grained method to complement experimental studies.
[30872688] Probing Membrane Association of α-Synuclein Domains with VDAC Nanopore Reveals Unexpected Binding Pattern.
[30871620] Pathogenic alpha-synuclein aggregates preferentially bind to mitochondria and affect cellular respiration.
[30868473] Chronic Use of β-Blockers and the Risk of Parkinson's Disease.
?>