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Ankyrin repeat domain-containing protein 54 (Lyn-interacting ankyrin repeat protein)

 ANR54_MOUSE             Reviewed;         299 AA.
Q91WK7; Q3UPC5; Q3UZL7;
06-FEB-2007, integrated into UniProtKB/Swiss-Prot.
01-DEC-2001, sequence version 1.
13-FEB-2019, entry version 126.
RecName: Full=Ankyrin repeat domain-containing protein 54;
AltName: Full=Lyn-interacting ankyrin repeat protein;
Name=Ankrd54; Synonyms=Liar;
Mus musculus (Mouse).
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
Muroidea; Muridae; Murinae; Mus; Mus.
NCBI_TaxID=10090;
[1]
NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
STRAIN=C57BL/6J; TISSUE=Spleen;
PubMed=16141072; DOI=10.1126/science.1112014;
Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N.,
Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K.,
Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M.,
Davis M.J., Wilming L.G., Aidinis V., Allen J.E.,
Ambesi-Impiombato A., Apweiler R., Aturaliya R.N., Bailey T.L.,
Bansal M., Baxter L., Beisel K.W., Bersano T., Bono H., Chalk A.M.,
Chiu K.P., Choudhary V., Christoffels A., Clutterbuck D.R.,
Crowe M.L., Dalla E., Dalrymple B.P., de Bono B., Della Gatta G.,
di Bernardo D., Down T., Engstrom P., Fagiolini M., Faulkner G.,
Fletcher C.F., Fukushima T., Furuno M., Futaki S., Gariboldi M.,
Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E.,
Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N.,
Hill D., Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T.,
Jakt M., Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H.,
Kitano H., Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K.,
Kurochkin I.V., Lareau L.F., Lazarevic D., Lipovich L., Liu J.,
Liuni S., McWilliam S., Madan Babu M., Madera M., Marchionni L.,
Matsuda H., Matsuzawa S., Miki H., Mignone F., Miyake S., Morris K.,
Mottagui-Tabar S., Mulder N., Nakano N., Nakauchi H., Ng P.,
Nilsson R., Nishiguchi S., Nishikawa S., Nori F., Ohara O.,
Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G., Pesole G.,
Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z., Ringwald M.,
Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C.,
Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y.,
Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B.,
Sperling S., Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K.,
Tammoja K., Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A.,
Ueda H.R., van Nimwegen E., Verardo R., Wei C.L., Yagi K.,
Yamanishi H., Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C.,
Grimmond S.M., Teasdale R.D., Liu E.T., Brusic V., Quackenbush J.,
Wahlestedt C., Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y.,
Fukuda S., Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T.,
Iida J., Imamura K., Itoh M., Kato T., Kawaji H., Kawagashira N.,
Kawashima T., Kojima M., Kondo S., Konno H., Nakano K., Ninomiya N.,
Nishio T., Okada M., Plessy C., Shibata K., Shiraki T., Suzuki S.,
Tagami M., Waki K., Watahiki A., Okamura-Oho Y., Suzuki H., Kawai J.,
Hayashizaki Y.;
"The transcriptional landscape of the mammalian genome.";
Science 309:1559-1563(2005).
[2]
NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
TISSUE=Eye;
PubMed=15489334; DOI=10.1101/gr.2596504;
The MGC Project Team;
"The status, quality, and expansion of the NIH full-length cDNA
project: the Mammalian Gene Collection (MGC).";
Genome Res. 14:2121-2127(2004).
[3]
TISSUE SPECIFICITY.
PubMed=17971504; DOI=10.1152/physiolgenomics.00128.2007;
McClintock T.S., Glasser C.E., Bose S.C., Bergman D.A.;
"Tissue expression patterns identify mouse cilia genes.";
Physiol. Genomics 32:198-206(2008).
[4]
FUNCTION, TISSUE SPECIFICITY, SUBCELLULAR LOCATION, MUTAGENESIS OF
ARG-98; ARG-99; LEU-289 AND LEU-291, AND INTERACTION WITH LYN; HCLS1;
ITSN2; VAV1; DBNL AND LASP1.
PubMed=19064729; DOI=10.1182/blood-2008-04-153452;
Samuels A.L., Klinken S.P., Ingley E.;
"Liar, a novel Lyn-binding nuclear/cytoplasmic shuttling protein that
influences erythropoietin-induced differentiation.";
Blood 113:3845-3856(2009).
-!- FUNCTION: Plays an important role in regulating intracellular
signaling events associated with erythroid terminal
differentiation. {ECO:0000269|PubMed:19064729}.
-!- SUBUNIT: Interacts (via ankyrin repeat region) with LYN (via SH3-
domain) in an activation-independent status of LYN. Forms a
multiprotein complex with LYN and HCLS1. Interacts with TSN2,
VAV1, DBNL AND LASP1. {ECO:0000269|PubMed:19064729}.
-!- SUBCELLULAR LOCATION: Nucleus {ECO:0000269|PubMed:19064729}.
Cytoplasm {ECO:0000269|PubMed:19064729}. Midbody
{ECO:0000269|PubMed:19064729}. Note=Shuttles between nucleus and
cytoplasm during the cell cycle. EPO stimulation induces nuclear
accumulation.
-!- TISSUE SPECIFICITY: Expressed in a variety of hemopoietic cell
lines and tissue with high levels in testis. Highly expressed in
ciliated cells. {ECO:0000269|PubMed:17971504,
ECO:0000269|PubMed:19064729}.
-!- DEVELOPMENTAL STAGE: Expressed in brachial arches, maxillary
process, fore and hind limb buds and in the developing
gastrointestinal tract of day 10 embryos.
-!- SEQUENCE CAUTION:
Sequence=BAE25471.1; Type=Frameshift; Positions=291; Evidence={ECO:0000305};
-----------------------------------------------------------------------
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EMBL; AK133785; BAE21840.1; -; mRNA.
EMBL; AK143625; BAE25471.1; ALT_FRAME; mRNA.
EMBL; BC014743; AAH14743.1; -; mRNA.
CCDS; CCDS37139.1; -.
RefSeq; NP_659098.1; NM_144849.1.
UniGene; Mm.24262; -.
ProteinModelPortal; Q91WK7; -.
SMR; Q91WK7; -.
BioGrid; 230175; 1.
CORUM; Q91WK7; -.
IntAct; Q91WK7; 2.
STRING; 10090.ENSMUSP00000047042; -.
iPTMnet; Q91WK7; -.
PhosphoSitePlus; Q91WK7; -.
EPD; Q91WK7; -.
MaxQB; Q91WK7; -.
PaxDb; Q91WK7; -.
PRIDE; Q91WK7; -.
Ensembl; ENSMUST00000040676; ENSMUSP00000047042; ENSMUSG00000033055.
GeneID; 223690; -.
KEGG; mmu:223690; -.
UCSC; uc007wsi.1; mouse.
CTD; 129138; -.
MGI; MGI:2444209; Ankrd54.
eggNOG; KOG0504; Eukaryota.
eggNOG; COG0666; LUCA.
GeneTree; ENSGT00940000157805; -.
HOGENOM; HOG000008674; -.
HOVERGEN; HBG080858; -.
InParanoid; Q91WK7; -.
KO; K21442; -.
OMA; LHVLWQR; -.
OrthoDB; 1559479at2759; -.
PhylomeDB; Q91WK7; -.
TreeFam; TF330790; -.
PRO; PR:Q91WK7; -.
Proteomes; UP000000589; Chromosome 15.
Bgee; ENSMUSG00000033055; Expressed in 246 organ(s), highest expression level in testis.
ExpressionAtlas; Q91WK7; baseline and differential.
Genevisible; Q91WK7; MM.
GO; GO:0005737; C:cytoplasm; IDA:MGI.
GO; GO:0030496; C:midbody; IDA:MGI.
GO; GO:0005634; C:nucleus; IDA:MGI.
GO; GO:0019887; F:protein kinase regulator activity; IDA:MGI.
GO; GO:0044877; F:protein-containing complex binding; IPI:MGI.
GO; GO:0006913; P:nucleocytoplasmic transport; IDA:MGI.
GO; GO:0045648; P:positive regulation of erythrocyte differentiation; IDA:MGI.
GO; GO:1902531; P:regulation of intracellular signal transduction; IDA:MGI.
GO; GO:0045859; P:regulation of protein kinase activity; IDA:MGI.
CDD; cd00204; ANK; 1.
Gene3D; 1.25.40.20; -; 1.
InterPro; IPR002110; Ankyrin_rpt.
InterPro; IPR020683; Ankyrin_rpt-contain_dom.
InterPro; IPR036770; Ankyrin_rpt-contain_sf.
SMART; SM00248; ANK; 4.
SUPFAM; SSF48403; SSF48403; 1.
PROSITE; PS50297; ANK_REP_REGION; 1.
PROSITE; PS50088; ANK_REPEAT; 2.
1: Evidence at protein level;
Acetylation; ANK repeat; Complete proteome; Cytoplasm; Nucleus;
Phosphoprotein; Reference proteome; Repeat.
INIT_MET 1 1 Removed. {ECO:0000250|UniProtKB:Q6NXT1}.
CHAIN 2 299 Ankyrin repeat domain-containing protein
54.
/FTId=PRO_0000274494.
REPEAT 108 137 ANK 1.
REPEAT 141 170 ANK 2.
REPEAT 174 203 ANK 3.
REPEAT 207 239 ANK 4.
REGION 140 240 LYN-binding.
MOTIF 98 116 Nuclear localization signal (NLS).
MOTIF 282 292 Nuclear export signal (NES).
MOD_RES 2 2 N-acetylalanine.
{ECO:0000250|UniProtKB:Q6NXT1}.
MOD_RES 62 62 Phosphoserine.
{ECO:0000250|UniProtKB:Q6NXT1}.
MUTAGEN 98 98 R->A: Increases the cytoplasmic protein
content; when associated with A-99.
{ECO:0000269|PubMed:19064729}.
MUTAGEN 99 99 R->A: Increases the cytoplasmic protein
content; when associated with A-98.
{ECO:0000269|PubMed:19064729}.
MUTAGEN 289 289 L->A: Accumulation within the nucleus;
when associated with A-291.
{ECO:0000269|PubMed:19064729}.
MUTAGEN 291 291 L->A: Accumulation within the nucleus;
when associated with A-289.
{ECO:0000269|PubMed:19064729}.
CONFLICT 173 173 G -> N (in Ref. 1; BAE21840).
{ECO:0000305}.
SEQUENCE 299 AA; 32486 MW; 88E91A10F1953AC3 CRC64;
MAATGGGADD ESRSGRSSSD GECAVAPEPL AEAGGLVSFA DFGVSLGSGA GLPGRSVGRA
QSSLRYLQVL WQQDVEPRDE LRCKIPAGRL RRAARPHRRL GPTGKEVHAL KRLRDSANAN
DVETVQQLLE DGADPCAADD KGRTALHFAS CNGNDQIVQL LLDHGADPNQ QDGLGNTPLH
LAACTNHVPV ITTLLRGGAR VDALDRAGRT PLHLAKSKLN ILQEGHSQCL EAVRLEVKQI
IHMLREYLER LGRHEQRERL DDLCTRLQMT STKEQVDEVT DLLASFTSLS LQMQSMEKR


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Pathways :
WP1689: Porphyrin and chlorophyll metabolism
WP1049: G Protein Signaling Pathways
WP1165: G Protein Signaling Pathways
WP1371: G Protein Signaling Pathways
WP1438: Influenza A virus infection
WP1493: Carbon assimilation C4 pathway
WP1502: Mitochondrial biogenesis
WP1531: Vitamin D synthesis
WP1566: Citrate cycle (TCA cycle)
WP1613: 1,4-Dichlorobenzene degradation
WP1616: ABC transporters
WP1624: Bacterial secretion system
WP1625: Base excision repair
WP1644: DNA replication
WP1650: Fluorobenzoate degradation
WP1654: gamma-Hexachlorocyclohexane degradation
WP1657: Glycerolipid metabolism
WP1659: Glycine, serine and threonine metabolism
WP1661: Glyoxylate and dicarboxylate metabolism
WP1663: Homologous recombination
WP1665: Limonene and pinene degradation
WP1672: Mismatch repair
WP1673: Naphthalene and anthracene degradation
WP1675: Nitrogen metabolism
WP1676: Non-homologous end-joining

Related Genes :
[PIA2 ANK6 At5g61230 MAF19.22] Phytochrome-interacting ankyrin-repeat protein 2 [Cleaved into: Protein ANKYRIN REPEAT 6, mitochondrial]
[Ankrd17 Foe Gtar Kiaa0697] Ankyrin repeat domain-containing protein 17 (Ankyrin repeat domain-containing protein FOE) (Gene trap ankyrin repeat protein)
[KANK1 ANKRD15 KANK KIAA0172] KN motif and ankyrin repeat domain-containing protein 1 (Ankyrin repeat domain-containing protein 15) (Kidney ankyrin repeat-containing protein)
[RIPK4 ANKRD3 DIK] Receptor-interacting serine/threonine-protein kinase 4 (EC 2.7.11.1) (Ankyrin repeat domain-containing protein 3) (PKC-delta-interacting protein kinase)
[mask CG33106] Ankyrin repeat and KH domain-containing protein mask (Multiple ankyrin repeat single KH domain-containing protein)
[Ankrd27 Varp] Ankyrin repeat domain-containing protein 27 (VPS9 domain-containing protein) (VPS9-ankyrin-repeat protein)
[ANKRD17 GTAR KIAA0697] Ankyrin repeat domain-containing protein 17 (Gene trap ankyrin repeat protein) (Serologically defined breast cancer antigen NY-BR-16)
[ANKRD1 C193 CARP HA1A2] Ankyrin repeat domain-containing protein 1 (Cardiac ankyrin repeat protein) (Cytokine-inducible gene C-193 protein) (Cytokine-inducible nuclear protein)
[ANKRD1 CARP] Ankyrin repeat domain-containing protein 1 (Cardiac ankyrin repeat protein)
[MIB1 DIP1 KIAA1323 ZZANK2] E3 ubiquitin-protein ligase MIB1 (EC 2.3.2.27) (DAPK-interacting protein 1) (DIP-1) (Mind bomb homolog 1) (RING-type E3 ubiquitin transferase MIB1) (Zinc finger ZZ type with ankyrin repeat domain protein 2)
[Kidins220 Arms] Kinase D-interacting substrate of 220 kDa (Ankyrin repeat-rich membrane-spanning protein)
[TNNI3K CARK] Serine/threonine-protein kinase TNNI3K (EC 2.7.11.1) (Cardiac ankyrin repeat kinase) (Cardiac troponin I-interacting kinase) (TNNI3-interacting kinase)
[KIDINS220 ARMS KIAA1250] Kinase D-interacting substrate of 220 kDa (Ankyrin repeat-rich membrane-spanning protein)
[LYN JTK8] Tyrosine-protein kinase Lyn (EC 2.7.10.2) (Lck/Yes-related novel protein tyrosine kinase) (V-yes-1 Yamaguchi sarcoma viral related oncogene homolog) (p53Lyn) (p56Lyn)
[ASB2] Ankyrin repeat and SOCS box protein 2 (ASB-2)
[HACE1 KIAA1320] E3 ubiquitin-protein ligase HACE1 (EC 2.3.2.26) (HECT domain and ankyrin repeat-containing E3 ubiquitin-protein ligase 1) (HECT-type E3 ubiquitin transferase HACE1)
[lem-3 rad-1 F42H11.2] Ankyrin repeat and LEM domain-containing protein 1 homolog (EC 3.1.-.-) (LEM-domain containing protein 3)
[ANKRD27 PP12899] Ankyrin repeat domain-containing protein 27 (VPS9 domain-containing protein)
[Shank3 Prosap2] SH3 and multiple ankyrin repeat domains protein 3 (Shank3) (Proline-rich synapse-associated protein 2) (ProSAP2) (SPANK-2)
[ANKLE2 KIAA0692 LEM4] Ankyrin repeat and LEM domain-containing protein 2 (LEM domain-containing protein 4)
[Hace1 Kiaa1320] E3 ubiquitin-protein ligase HACE1 (EC 2.3.2.26) (HECT domain and ankyrin repeat-containing E3 ubiquitin-protein ligase 1) (HECT-type E3 ubiquitin transferase HACE1)
[Lyn] Tyrosine-protein kinase Lyn (EC 2.7.10.2) (V-yes-1 Yamaguchi sarcoma viral related oncogene homolog) (p53Lyn) (p56Lyn)
[Lyn] Tyrosine-protein kinase Lyn (EC 2.7.10.2) (V-yes-1 Yamaguchi sarcoma viral related oncogene homolog) (p53Lyn) (p56Lyn)
[ANKIB1 KIAA1386] Ankyrin repeat and IBR domain-containing protein 1 (EC 2.3.2.31)
[SHANK3 KIAA1650 PROSAP2 PSAP2] SH3 and multiple ankyrin repeat domains protein 3 (Shank3) (Proline-rich synapse-associated protein 2) (ProSAP2)
[ANKRA2 ANKRA] Ankyrin repeat family A protein 2 (RFXANK-like protein 2)
[ANK2 ANKB] Ankyrin-2 (ANK-2) (Ankyrin-B) (Brain ankyrin) (Non-erythroid ankyrin)
[Shank3 Kiaa1650 Prosap2] SH3 and multiple ankyrin repeat domains protein 3 (Shank3) (Proline-rich synapse-associated protein 2) (ProSAP2) (SPANK-2)
[Asb4] Ankyrin repeat and SOCS box protein 4 (ASB-4)
[lem-4 lem-4l Y55F3BR.8] Ankyrin repeat and LEM domain-containing protein 2 homolog (LEM domain-containing protein 4-like)

Bibliography :