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Anti-sigma-E factor RseA (Regulator of SigE) (Sigma-E anti-sigma factor RseA) (Sigma-E factor negative regulatory protein)

 RSEA_SALT1              Reviewed;         216 AA.
D0ZSY8;
22-JAN-2014, integrated into UniProtKB/Swiss-Prot.
19-JAN-2010, sequence version 1.
16-JAN-2019, entry version 46.
RecName: Full=Anti-sigma-E factor RseA;
AltName: Full=Regulator of SigE;
AltName: Full=Sigma-E anti-sigma factor RseA;
AltName: Full=Sigma-E factor negative regulatory protein;
Name=rseA; OrderedLocusNames=STM14_3233;
Salmonella typhimurium (strain 14028s / SGSC 2262).
Bacteria; Proteobacteria; Gammaproteobacteria; Enterobacterales;
Enterobacteriaceae; Salmonella.
NCBI_TaxID=588858;
[1]
NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
STRAIN=14028s / SGSC 2262;
PubMed=19897643; DOI=10.1128/JB.01233-09;
Jarvik T., Smillie C., Groisman E.A., Ochman H.;
"Short-term signatures of evolutionary change in the Salmonella
enterica serovar typhimurium 14028 genome.";
J. Bacteriol. 192:560-567(2010).
[2]
ACTIVITY REGULATION, PROBABLE CLEAVAGE BY DEGS AND RSEP, DISRUPTION
PHENOTYPE, AND FUNCTION.
STRAIN=14028s / SGSC 2262;
PubMed=19170886; DOI=10.1111/j.1365-2958.2009.06597.x;
Muller C., Bang I.S., Velayudhan J., Karlinsey J., Papenfort K.,
Vogel J., Fang F.C.;
"Acid stress activation of the sigma(E) stress response in Salmonella
enterica serovar Typhimurium.";
Mol. Microbiol. 71:1228-1238(2009).
-!- FUNCTION: An anti-sigma factor for extracytoplasmic function (ECF)
sigma factor sigma-E (RpoE). ECF sigma factors are held in an
inactive form by an anti-sigma factor until released by regulated
intramembrane proteolysis (RIP). RIP occurs when an
extracytoplasmic signal (periplasmic or acid stress or heat shock)
triggers a concerted proteolytic cascade to transmit information
and elicit cellular responses. The membrane-spanning regulatory
substrate protein is first cut periplasmically (site-1 protease,
S1P, DegS), then within the membrane itself (site-2 protease, S2P,
RseP), while cytoplasmic proteases finish degrading the anti-sigma
factor, liberating sigma-E (Probable). In this organism acid
stress response does not require DegS degradation.
{ECO:0000269|PubMed:19170886, ECO:0000305}.
-!- ACTIVITY REGULATION: Responds differently to heat shock versus
acid shock; degradation in response to heat shock requires
sequential DegS and RseP action, whereas degradation in response
to acid shock requires only RseP. {ECO:0000269|PubMed:19170886}.
-!- SUBUNIT: Interacts 1:1 with ECF RNA polymerase sigma-E (RpoE);
this inhibits the interaction of sigma-E with the RNA polymerase
catalytic core and leads to a decreased expression of sigma-E-
regulated genes. Interacts with RseB (By similarity).
{ECO:0000250}.
-!- SUBCELLULAR LOCATION: Cell inner membrane {ECO:0000250}; Single-
pass type II membrane protein {ECO:0000250}.
-!- PTM: Sequentially cleaved by DegS (a site-1 protease) in its
periplasmic domain between Val-148 and Ser-149, then by RseP (a
site-2 protease) between positions Ala-108 and Cys-109. The N-
terminal fragment is then degraded by primarily ClpX-ClpP in an
ATP-dependent fashion. Sequential cleavage by DegS, RseP and ClpX-
ClpP frees RpoE from RseA (Probable). {ECO:0000305}.
-!- DISRUPTION PHENOTYPE: Derepression and constitutive activation of
sigma-E function, consequently loss of acid stress response.
{ECO:0000269|PubMed:19170886}.
-!- SIMILARITY: Belongs to the RseA family. {ECO:0000305}.
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EMBL; CP001363; ACY89662.1; -; Genomic_DNA.
RefSeq; WP_001168374.1; NC_016856.1.
ProteinModelPortal; D0ZSY8; -.
SMR; D0ZSY8; -.
EnsemblBacteria; ACY89662; ACY89662; STM14_3233.
KEGG; seo:STM14_3233; -.
PATRIC; fig|588858.6.peg.3000; -.
KO; K03597; -.
OMA; FWHKVRP; -.
BioCyc; SENT588858:STM14_RS14450-MONOMER; -.
Proteomes; UP000002695; Chromosome.
GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
GO; GO:0005886; C:plasma membrane; IEA:UniProtKB-SubCell.
GO; GO:0016989; F:sigma factor antagonist activity; IEA:InterPro.
GO; GO:0097533; P:cellular stress response to acid chemical; IMP:UniProtKB.
CDD; cd16328; RseA_N; 1.
Gene3D; 1.10.10.880; -; 1.
InterPro; IPR005573; Anti-sigma_E_RseA_C.
InterPro; IPR005572; Anti-sigma_E_RseA_N.
InterPro; IPR036147; Anti-sigma_E_RseA_N_sf.
InterPro; IPR026279; RseA.
Pfam; PF03873; RseA_C; 1.
Pfam; PF03872; RseA_N; 1.
PIRSF; PIRSF016938; RseA; 1.
SUPFAM; SSF89069; SSF89069; 1.
1: Evidence at protein level;
Cell inner membrane; Cell membrane; Coiled coil; Complete proteome;
Membrane; Signal-anchor; Transmembrane; Transmembrane helix.
CHAIN 1 216 Anti-sigma-E factor RseA.
/FTId=PRO_0000424884.
TOPO_DOM 1 104 Cytoplasmic. {ECO:0000255}.
TRANSMEM 105 121 Helical; Signal-anchor for type II
membrane protein. {ECO:0000255}.
TOPO_DOM 122 216 Periplasmic. {ECO:0000255}.
COILED 161 202 {ECO:0000255}.
COMPBIAS 162 216 Gln-rich.
SITE 108 109 Cleavage; by RseP. {ECO:0000250}.
SITE 148 149 Cleavage; by DegS. {ECO:0000250}.
SEQUENCE 216 AA; 24223 MW; 66E1BF61BD7EDC87 CRC64;
MQKEKLSALM DGETLDSELL KALTHDPEMQ KTWESYHLIR DSMRGDTPDV LHFDISARVM
AAIENEPVRQ VSPLIPEAQP APQQWQKMPF WKKVRPWAAQ LTQMGVAACV SLAVIVGVQH
YNGQSETSQQ PETPVFNTLP MMGKASPVSL GVPSEAAPVG SQQQQVQEQR RRINAMLQDY
ELQRRLHSEQ LQFEQAQTQQ AAVQVPGIQT LGTQSQ


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Pathways :
WP654: ATM
WP1046: Signaling of Hepatocyte Growth Factor Receptor
WP1162: Signaling of Hepatocyte Growth Factor Receptor
WP1206: Signaling of Hepatocyte Growth Factor Receptor
WP1235: Signaling of Hepatocyte Growth Factor Receptor
WP1789: Binding of RNA by Insulin-like Growth Factor-2 mRNA Binding Proteins (IGF2BPs/IMPs/VICKZs)
WP1899: Regulation of Insulin-like Growth Factor (IGF) Activity by Insulin-like Growth Factor Binding Proteins (IGFBPs)
WP193: Signaling of Hepatocyte Growth Factor Receptor
WP1983: Splicing factor NOVA regulated synpatic proteins
WP2148: Brain derived neurotrophic factor
WP272: Blood Clotting Cascade
WP313: Signaling of Hepatocyte Growth Factor Receptor
WP444: Signaling of Hepatocyte Growth Factor Receptor
WP810: Signaling of Hepatocyte Growth Factor Receptor
WP927: Signaling of Hepatocyte Growth Factor Receptor
WP94: Signaling of Hepatocyte Growth Factor Receptor
WP1493: Carbon assimilation C4 pathway
WP1689: Porphyrin and chlorophyll metabolism
WP1909: Signal regulatory protein (SIRP) family interactions
WP1963: The effect of Glucocorticoids on target gene expression
WP731: Sterol regulatory element binding protein related
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[rseA mclA yfiJ b2572 JW2556] Anti-sigma-E factor RseA (Regulator of SigE) (Sigma-E anti-sigma factor RseA) (Sigma-E factor negative regulatory protein)
[rseA STM14_3233] Anti-sigma-E factor RseA (Regulator of SigE) (Sigma-E anti-sigma factor RseA) (Sigma-E factor negative regulatory protein)
[rpoE sigE b2573 JW2557] ECF RNA polymerase sigma-E factor (RNA polymerase sigma-E factor) (Sigma-24)
[rpoE sigE STM14_3234] ECF RNA polymerase sigma-E factor (RNA polymerase sigma-E factor)
[rslA Rv0736] Anti-sigma-L factor RslA (Regulator of SigL) (Sigma-L anti-sigma factor RslA)
[rsrA SCO5217] Anti-sigma factor RsrA (Regulator of SigR) (Sigma-R anti-sigma factor RsrA)
[rseA MSMEG_5071 MSMEI_4944] Anti-sigma-E factor RseA (Regulator of SigE) (Sigma-E anti-sigma factor RseA)
[rseP ecfE yaeL b0176 JW0171] Regulator of sigma-E protease RseP (EC 3.4.24.-) (S2P endopeptidase) (Site-2 protease RseP) (S2P protease RseP) (Site-2-type intramembrane protease)
[sigF Rv3286c] RNA polymerase sigma factor SigF (Sigma factor SigF) (Alternative RNA polymerase sigma factor SigF) (RNA polymerase sigma-F factor) (Sigma-F factor) (Stress response/stationary phase sigma factor SigF)
[sigR SCO5216] ECF RNA polymerase sigma factor SigR (ECF sigma factor SigR) (Alternative RNA polymerase sigma factor SigR) (RNA polymerase sigma-R factor) (Sigma-R factor)
[rshA Rv3221A] Anti-sigma factor RshA (Regulator of SigH) (Sigma-H anti-sigma factor RshA)
[sigC Rv2069 MTCY49.08] ECF RNA polymerase sigma factor SigC (ECF sigma factor SigC) (Alternative RNA polymerase sigma factor SigC) (RNA polymerase sigma-C factor) (Sigma-C factor)
[rsbW usfX Rv3287c] Anti-sigma-F factor RsbW (Anti-sigma-F factor UsfX) (Regulator of SigF) (Sigma-F anti-sigma factor RsbW)
[SIGF SIG6 SOLDAT8 At2g36990 T1J8] RNA polymerase sigma factor sigF, chloroplastic (Sigma factor F) (Sigma-F) (Protein SINGLET OXYGEN-LINKED DEATH ACTIVATOR 8) (RNA polymerase sigma factor sig6) (Atsig6) (Sigma factor 6)
[sigE MSMEG_5072 MSMEI_4945] ECF RNA polymerase sigma factor SigE (ECF sigma factor SigE) (Alternative RNA polymerase sigma factor SigE) (RNA polymerase sigma-E factor) (Sigma-E factor)
[GCN4 AAS3 ARG9 YEL009C] General control protein GCN4 (Amino acid biosynthesis regulatory protein)
[rpoH fam hin htpR b3461 JW3426] RNA polymerase sigma factor RpoH (Heat shock regulatory protein F33.4) (RNA polymerase sigma-32 factor)
[FLO11 MAL5 MUC1 S1 S2 YIR019C] Flocculation protein FLO11 (Flo11p) (Flocculin-11) (Mucin-like protein 1)
[MPR1] N-acetyltransferase MPR1 (EC 2.3.1.271) ((S)-1-pyrroline-5-carboxylate acetyltransferase) (L-azetidine-2-carboxylate acetyltransferase) (AZC acetyltransferase) (Sigma1278b gene for proline-analog resistance 1)
[rpoS appR katF nur otsX sigS b2741 JW5437] RNA polymerase sigma factor RpoS (Sigma S) (Sigma-38)
[RSP5 MDP1 NPI1 YER125W SYGP-ORF41] E3 ubiquitin-protein ligase RSP5 (EC 2.3.2.26) (HECT-type E3 ubiquitin transferase RSP5) (Reverses SPT-phenotype protein 5)
[sigL Rv0735] ECF RNA polymerase sigma factor SigL (ECF sigma factor SigL) (Alternative RNA polymerase sigma factor SigL) (RNA polymerase sigma-L factor) (Sigma-L factor)
[csfB gin yaaM BSU00240] Anti-sigma-G factor Gin (Protein CsfB)
[sigM Rv3911] ECF RNA polymerase sigma factor SigM (ECF sigma factor SigM) (Alternative RNA polymerase sigma factor SigM) (RNA polymerase sigma-M factor) (Sigma-M factor)
[sigW ybbL BSU01730] ECF RNA polymerase sigma factor SigW (ECF sigma factor SigW) (Alternative RNA polymerase sigma factor SigW) (RNA polymerase sigma-W factor) (Sigma-W factor)
[sigH rpoE MSMEG_1914 MSMEI_1874] ECF RNA polymerase sigma factor SigH (ECF sigma factor SigH) (Alternative RNA polymerase sigma factor SigH) (RNA polymerase sigma-H factor) (Sigma-H factor)
[NPR1 YNL183C N1631] Nitrogen permease reactivator protein (EC 2.7.11.1) (Serine/threonine-protein kinase NPR1)
[GPB2 KRH1 YAL056W] Guanine nucleotide-binding protein subunit beta 2 (Gbeta mimic kelch protein 2)
[rpoE RHOS4_27100 RSP_1092] ECF RNA polymerase sigma factor RpoE (Alternative RNA polymerase sigma factor RpoE) (RNA polymerase sigma-E factor) (Sigma-24)
[rshA MSMEG_1915 MSMEI_1875] Anti-sigma factor RshA (Regulator of SigH) (Sigma-H anti-sigma factor RshA)

Bibliography :